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Academic Article
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Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction.
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Academic Article
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Cutting edge: cells that carry A null allele for toll-like receptor 2 are capable of responding to endotoxin.
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Academic Article
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Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2.
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Academic Article
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Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis.
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Academic Article
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Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products.
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Academic Article
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The CD14 ligands lipoarabinomannan and lipopolysaccharide differ in their requirement for Toll-like receptors.
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Academic Article
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A novel synthetic acyclic lipid A-like agonist activates cells via the lipopolysaccharide/toll-like receptor 4 signaling pathway.
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Academic Article
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Structure and function of Toll-like receptor proteins.
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Academic Article
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Differential effects of a Toll-like receptor antagonist on Mycobacterium tuberculosis-induced macrophage responses.
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Academic Article
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Membrane-associated proteins of a lipopolysaccharide-deficient mutant of Neisseria meningitidis activate the inflammatory response through toll-like receptor 2.
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Academic Article
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Toll-like receptor 2-dependent inhibition of macrophage class II MHC expression and antigen processing by 19-kDa lipoprotein of Mycobacterium tuberculosis.
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Academic Article
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Differential roles of TLR2 and TLR4 in the host response to Gram-negative bacteria: lessons from a lipopolysaccharide-deficient mutant of Neisseria meningitidis.
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Academic Article
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Lipopolysaccharides from periodontopathic bacteria Porphyromonas gingivalis and Capnocytophaga ochracea are antagonists for human toll-like receptor 4.
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Academic Article
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Cutting edge: Immune stimulation by neisserial porins is toll-like receptor 2 and MyD88 dependent.
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Academic Article
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Innate immune recognition of lipopolysaccharide by endothelial cells.
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Academic Article
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Induction of cytokine production in human T cells and monocytes by highly purified lipoteichoic acid: involvement of Toll-like receptors and CD14.
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Academic Article
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Cutting edge: the immunostimulatory activity of the lung surfactant protein-A involves Toll-like receptor 4.
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Academic Article
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Toll-like receptor (TLR) signaling in response to Aspergillus fumigatus.
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Academic Article
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Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction.
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Academic Article
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Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cells.
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Academic Article
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Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection.
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Academic Article
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IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.
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Academic Article
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Lysines 128 and 132 enable lipopolysaccharide binding to MD-2, leading to Toll-like receptor-4 aggregation and signal transduction.
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Academic Article
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Biological activities of Bacteroides forsythus lipoproteins and their possible pathological roles in periodontal disease.
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Academic Article
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Relationship between structures and biological activities of mycoplasmal diacylated lipopeptides and their recognition by toll-like receptors 2 and 6.
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Academic Article
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Non-mannose-capped lipoarabinomannan induces lung inflammation via toll-like receptor 2.
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Academic Article
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Expression of functional TLR4 confers proinflammatory responsiveness to Trypanosoma cruzi glycoinositolphospholipids and higher resistance to infection with T. cruzi.
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Academic Article
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Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation.
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Academic Article
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Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9.
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Academic Article
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Activation of toll-like receptor (TLR)2, TLR4, and TLR9 in the mammalian cornea induces MyD88-dependent corneal inflammation.
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Academic Article
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The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling.
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Academic Article
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MyD88 is critical for the development of innate and adaptive immunity during acute lymphocytic choriomeningitis virus infection.
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Academic Article
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Proinflammatory phenotype of vascular smooth muscle cells: role of efficient Toll-like receptor 4 signaling.
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Academic Article
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Human cardiac inflammatory responses triggered by Coxsackie B viruses are mainly Toll-like receptor (TLR) 8-dependent.
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Academic Article
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The apoptotic response to pneumolysin is Toll-like receptor 4 dependent and protects against pneumococcal disease.
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Academic Article
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Toll-like receptor 2 mediates persistent chemokine release by Chlamydia pneumoniae-infected vascular smooth muscle cells.
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Academic Article
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Toll-like receptor 2 mediates inflammatory cytokine induction but not sensitization for liver injury by Propioni- bacterium acnes.
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Academic Article
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Human toll-like receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide.
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Academic Article
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Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide.
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Academic Article
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Comparative toll-like receptor 4-mediated innate host defense to Bordetella infection.
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Academic Article
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Meningococcal porin PorB binds to TLR2 and requires TLR1 for signaling.
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Academic Article
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Gingipains inactivate a cell surface ligand on Porphyromonas gingivalis that induces TLR2-and TLR4-independent signaling.
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Academic Article
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The biology of Toll-like receptors.
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Academic Article
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A mechanism for neurodegeneration induced by group B streptococci through activation of the TLR2/MyD88 pathway in microglia.
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Academic Article
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Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus.
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Academic Article
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MD-2 expression is not required for cell surface targeting of Toll-like receptor 4 (TLR4).
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Academic Article
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Toll-like receptor 4 mediates intracellular signaling without TNF-alpha release in response to Cryptococcus neoformans polysaccharide capsule.
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Academic Article
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Toll-like receptor-dependent discrimination of streptococci.
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Academic Article
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TLR9 and the recognition of self and non-self nucleic acids.
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Academic Article
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A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2.
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Academic Article
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Innate immune responses to endosymbiotic Wolbachia bacteria in Brugia malayi and Onchocerca volvulus are dependent on TLR2, TLR6, MyD88, and Mal, but not TLR4, TRIF, or TRAM.
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Academic Article
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Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9.
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Academic Article
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Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE.
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Academic Article
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Immunology. The shape of things to come.
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Academic Article
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YopJ targets TRAF proteins to inhibit TLR-mediated NF-kappaB, MAPK and IRF3 signal transduction.
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Academic Article
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Activation of TLR2 and TLR4 by glycosylphosphatidylinositols derived from Toxoplasma gondii.
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Academic Article
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Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite.
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Academic Article
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Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling.
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Academic Article
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Phagocytosis and intracellular killing of MD-2 opsonized gram-negative bacteria depend on TLR4 signaling.
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Academic Article
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Bacterial fimbriae stimulate proinflammatory activation in the endothelium through distinct TLRs.
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Academic Article
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Lipoteichoic acid-induced lung inflammation depends on TLR2 and the concerted action of TLR4 and the platelet-activating factor receptor.
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Academic Article
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Chlamydia pneumoniae and chlamydial heat shock protein 60 stimulate proliferation of human vascular smooth muscle cells via toll-like receptor 4 and p44/p42 mitogen-activated protein kinase activation.
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Academic Article
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Induction of tolerance to lipopolysaccharide and mycobacterial components in Chinese hamster ovary/CD14 cells is not affected by overexpression of Toll-like receptors 2 or 4.
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Academic Article
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Structural requirements of muramylpeptides for induction of Toll-like receptor 2-mediated NF-kappaB activation in CHO cells.
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Academic Article
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TIRAP: how Toll receptors fraternize.
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Academic Article
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Malaria primes the innate immune response due to interferon-gamma induced enhancement of toll-like receptor expression and function.
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Academic Article
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Recombinant Ov-ASP-1, a Th1-biased protein adjuvant derived from the helminth Onchocerca volvulus, can directly bind and activate antigen-presenting cells.
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Academic Article
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Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide.
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Academic Article
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A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling.
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Academic Article
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Mal connects TLR2 to PI3Kinase activation and phagocyte polarization.
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Academic Article
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MyD88 adaptor-like is not essential for TLR2 signaling and inhibits signaling by TLR3.
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Academic Article
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Novel engagement of CD14 and multiple toll-like receptors by group B streptococci.
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Academic Article
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CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.
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Academic Article
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LBP, CD14, TLR4 and the murine innate immune response to a peritoneal Salmonella infection.
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Academic Article
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MD-2 residues tyrosine 42, arginine 69, aspartic acid 122, and leucine 125 provide species specificity for lipid IVA.
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Academic Article
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Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress.
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Academic Article
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Activation of the NLRP3 inflammasome by group B streptococci.
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Academic Article
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Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production.
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Academic Article
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DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation.
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Academic Article
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An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration.
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Academic Article
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Mediators of innate immune recognition of bacteria concentrate in lipid rafts and facilitate lipopolysaccharide-induced cell activation.
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Academic Article
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Involvement of toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers.
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Academic Article
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Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways.
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Academic Article
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A novel host-parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarization.
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Academic Article
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Combined action of nucleic acid-sensing Toll-like receptors and TLR11/TLR12 heterodimers imparts resistance to Toxoplasma gondii in mice.
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Academic Article
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Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2.
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Academic Article
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The antifungal drug amphotericin B promotes inflammatory cytokine release by a Toll-like receptor- and CD14-dependent mechanism.
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Academic Article
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Heat-killed Brucella abortus induces TNF and IL-12p40 by distinct MyD88-dependent pathways: TNF, unlike IL-12p40 secretion, is Toll-like receptor 2 dependent.
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Academic Article
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Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkappa B signaling.
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Academic Article
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LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF.
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Academic Article
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Receptor "cross talk" in innate immunity.
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Academic Article
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Cell distributions and functions of Toll-like receptor 4 studied by fluorescent gene constructs.
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Academic Article
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TLR9 signals after translocating from the ER to CpG DNA in the lysosome.
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Academic Article
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Haemophilus influenzae type b-outer membrane protein complex glycoconjugate vaccine induces cytokine production by engaging human toll-like receptor 2 (TLR2) and requires the presence of TLR2 for optimal immunogenicity.
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Academic Article
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Dual role of TLR2 and myeloid differentiation factor 88 in a mouse model of invasive group B streptococcal disease.
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Academic Article
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Innate immune responses to Rhodococcus equi.
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Academic Article
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The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades.
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Academic Article
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Stimulation of toll-like receptor 2 by Coxiella burnetii is required for macrophage production of pro-inflammatory cytokines and resistance to infection.
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Academic Article
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Mechanisms of TLR9 activation.
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Academic Article
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Endotoxin recognition and signal transduction by the TLR4/MD2-complex.
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Academic Article
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Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105.
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Academic Article
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Role of lipoteichoic acid in the phagocyte response to group B streptococcus.
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Academic Article
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A Leptospira interrogans enzyme with similarity to yeast Ste14p that methylates the 1-phosphate group of lipid A.
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Academic Article
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Pharmacological inhibition of endotoxin responses is achieved by targeting the TLR4 coreceptor, MD-2.
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Academic Article
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Inhibition of TLR-4/MD-2 signaling by RP105/MD-1.
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Academic Article
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The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction.
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Academic Article
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Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling.
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Academic Article
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HMGB1 signals through toll-like receptor (TLR) 4 and TLR2.
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Academic Article
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MD-2.
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Academic Article
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Flavivirus activation of plasmacytoid dendritic cells delineates key elements of TLR7 signaling beyond endosomal recognition.
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Academic Article
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NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1.
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Academic Article
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Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on Toll-like receptor 4, CD44, and MD-2.
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Academic Article
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Ligand-induced conformational changes allosterically activate Toll-like receptor 9.
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Academic Article
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Plasmodium falciparum infection causes proinflammatory priming of human TLR responses.
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Academic Article
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MUC1 mucin is a negative regulator of toll-like receptor signaling.
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Academic Article
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Failure of TLR4-driven NF-kappa B activation to stimulate virus replication in models of HIV type 1 activation.
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Academic Article
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Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis.
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Academic Article
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Lymphocytic choriomeningitis virus (LCMV) infection of CNS glial cells results in TLR2-MyD88/Mal-dependent inflammatory responses.
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Academic Article
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Lipoproteins are critical TLR2 activating toxins in group B streptococcal sepsis.
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Academic Article
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Analysis of the activity to induce toll-like receptor (TLR)2- and TLR4-mediated stimulation of supragingival plaque.
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Academic Article
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Recruitment and endo-lysosomal activation of TLR9 in dendritic cells infected with Trypanosoma cruzi.
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Academic Article
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TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis.
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Academic Article
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TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway.
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Academic Article
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MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinflammatory responses.
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Academic Article
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Alternating 2'-O-ribose methylation is a universal approach for generating non-stimulatory siRNA by acting as TLR7 antagonist.
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Academic Article
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MD-2-mediated ionic interactions between lipid A and TLR4 are essential for receptor activation.
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Academic Article
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TLR2 mediates recognition of live Staphylococcus epidermidis and clearance of bacteremia.
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Academic Article
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Viral inhibitory peptide of TLR4, a peptide derived from vaccinia protein A46, specifically inhibits TLR4 by directly targeting MyD88 adaptor-like and TRIF-related adaptor molecule.
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Academic Article
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TLR3-mediated IFN-? gene induction is negatively regulated by the TLR adaptor MyD88 adaptor-like.
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Academic Article
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Requirement of UNC93B1 reveals a critical role for TLR7 in host resistance to primary infection with Trypanosoma cruzi.
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Academic Article
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Genome-wide expression profiling and mutagenesis studies reveal that lipopolysaccharide responsiveness appears to be absolutely dependent on TLR4 and MD-2 expression and is dependent upon intermolecular ionic interactions.
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Academic Article
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Toll-like receptor (TLR) 2 mediates inflammatory responses to oligomerized RrgA pneumococcal pilus type 1 protein.
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Academic Article
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UNC93B1 and nucleic acid-sensing Toll-like receptors mediate host resistance to infection with Leishmania major.
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Academic Article
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Interferon-? and granulocyte/monocyte colony-stimulating factor production by natural killer cells involves different signaling pathways and the adaptor stimulator of interferon genes (STING).
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Concept
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Toll-Like Receptor 6
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Concept
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Toll-Like Receptor 4
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Concept
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Toll-Like Receptor 9
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Concept
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Toll-Like Receptor 3
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Concept
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Toll-Like Receptor 2
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Concept
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Toll-Like Receptor 7
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Concept
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Toll-Like Receptor 5
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Concept
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Toll-Like Receptor 1
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Concept
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Toll-Like Receptor 8
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Academic Article
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Dual engagement of the NLRP3 and AIM2 inflammasomes by plasmodium-derived hemozoin and DNA during malaria.
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Academic Article
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TRIF signaling is essential for TLR4-driven IgE class switching.
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Academic Article
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Metalloproteinase-dependent TLR2 ectodomain shedding is involved in soluble toll-like receptor 2 (sTLR2) production.
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Academic Article
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MD-2 is required for disulfide HMGB1-dependent TLR4 signaling.
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Academic Article
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Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4.
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Academic Article
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miR-718 represses proinflammatory cytokine production through targeting phosphatase and tensin homolog (PTEN).
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Academic Article
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The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2.
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Academic Article
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Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptors.
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Academic Article
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Clostridioides difficile Toxin A Remodels Membranes and Mediates DNA Entry Into Cells to Activate Toll-Like Receptor 9 Signaling.
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Academic Article
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The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways.
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