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Search Results to Gyongyi Szabo MD, PhD

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One or more keywords matched the following properties of Szabo, Gyongyi

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Background

Education:

MD, University Medical School Debrecen, Hungary
PhD, Hungarian Academy of Sciences (Immunology/Medicine)

Post-Graduate Training:

Internal Medicine Residency, University of Massachusetts Medical Center Worcester, MA

Gastroenterology and Hepatology Fellowship, Division of Gastroenterology, University of Massachusetts Medical Center, Worcester, MA

Current Research Activities

Bench Research:

Photo: Gyongyi Szabo
  1. Immune alterations induced by acute alcohol consumption: My laboratory is one of the few focusing on immunomodulation by moderate alcohol use in humans. In addition to understanding mechanisms for the increased susceptibility to infections after alcohol use, results from our investigations have relevance to decreased cardiovascular morbidity after moderate alcohol use as well as to accelerated liver disease in chronic hepatitis C virus infection. My laboratory studies changes in the interaction between accessory cells (monocytes and dendritic cells) and T lymphocytes after moderate alcohol use. The overall aim of our studies is to delineate the effect of alcohol on antigen presenting cell function and determine role of cytokine and co-stimulatory molecules leading to decreased antigen-specific T cell proliferation and impaired antimicrobial defense after alcohol use.
  2. Intracellular signaling pathways in leukocytes mediating altered cytokine production after alcohol use. We are studying intracellular signaling mechanisms leading to decreased NF- B activation in monocytic and immune cells after acute alcohol treatment in relation to signals mediated by toll-like receptors. Recent interest is to define the NF-kB-mediated intracellular mechanisms that lead to the opposite effects of acute and chronic alcohol use on pro-inflammatory cytokine production.
  3. Immune mechanisms leading to increased liver injury in HCV plus alcohol. The hypothesis is that impaired dendritic cell costimulatory activity is a pivotal defect of host response to hepatitis C infection and alcohol further reduces immunity by inhibiting maturation and functions of myeloid dendritic cells in HCV.
  4. Immunopathogenesis of liver injury in obese mice: This is a developing project to investigate the hypothesis that leptin deficient, ob/ob mice have increased susceptibility to immune-mediated liver injury in a model of Concanavalin-A or LPS-induced hepatitis. We found that in contrast to lean mice, ob/ob mice have over-activation of the NF- B signaling pathway in the liver, a mechanisms likely to contribute to increased susceptibility to liver injury. Results from these experiments have direct clinical relevance to mechanisms of liver injury in non-alcoholic steatohepatitis in human.

Clinical Research:

  1. Immune mechanisms of increased liver injury in HCV plus alcohol: overlap with bench research project #3.
  2. Therapeutic studies in chronic hepatitis C: I am an investigator at the UMass Memorial site of the national HALT-C trial supported by NIH.
  3. Therapeutic approaches in non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). A clinical trial to investigate the potential therapeutic benefit of an insulin sensitizing agent in NASH is being initiated. Additional therapeutic approaches in patients with NAFLD are under development. NAFLD /NASH have recently been recognized as one of the most prevalent liver diseases in the USA, and the most common cause of cryptogenic cirrhosis.

Research Figure

Research Figure


One or more keywords matched the following items that are connected to Szabo, Gyongyi

Item TypeName
Academic Article Pathogenic interactions between alcohol and hepatitis C.
Academic Article Toll-like receptor 2 mediates inflammatory cytokine induction but not sensitization for liver injury by Propioni- bacterium acnes.
Academic Article RSA 2004: combined basic research satellite symposium - session four: hepatitis virus and alcohol interactions in immunity and liver disease.
Academic Article The emerging role of toll-like receptor pathways in surgical diseases.
Academic Article Critical role of toll-like receptors and the common TLR adaptor, MyD88, in induction of granulomas and liver injury.
Academic Article Innate immune response and hepatic inflammation.
Academic Article The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88.
Academic Article Myeloid dendritic cells of patients with chronic HCV infection induce proliferation of regulatory T lymphocytes.
Academic Article Alcohol-induced modulation of signaling pathways in liver parenchymal and nonparenchymal cells: implications for immunity.
Academic Article Emerging role of microRNAs in liver diseases.
Academic Article Toll-like receptors in the pathogenesis of alcoholic liver disease.
Academic Article Up-regulation of microRNA-155 in macrophages contributes to increased tumor necrosis factor {alpha} (TNF{alpha}) production via increased mRNA half-life in alcoholic liver disease.
Academic Article Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice.
Academic Article Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells.
Academic Article A prospective study of the rate of progression in compensated, histologically advanced chronic hepatitis C.
Academic Article Gut-liver axis and sensing microbes.
Academic Article Toll-like receptor signaling in liver diseases.
Academic Article MicroRNA Signature in Alcoholic Liver Disease.
Academic Article Inflammasomes in liver diseases.
Academic Article Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases.
Academic Article Plasma microRNA profiles distinguish lethal injury in acetaminophen toxicity: a research study.
Academic Article Human monoclonal antibody HCV1 effectively prevents and treats HCV infection in chimpanzees.
Academic Article Innate immunity and alcoholic liver disease.
Academic Article Reply: To PMID 22684891.
Academic Article Modulation of immunity and viral-host interactions by alcohol.
Academic Article Liver in sepsis and systemic inflammatory response syndrome.
Academic Article Toll-like receptors in liver disease.
Academic Article MicroRNAs in liver disease.
Academic Article Differences in innate immune signaling between alcoholic and non-alcoholic steatohepatitis.
Academic Article Chronic alcohol-induced microRNA-155 contributes to neuroinflammation in a TLR4-dependent manner in mice.
Academic Article Increased lipopolysaccharide sensitivity in alcoholic fatty livers is independent of leptin deficiency and toll-like receptor 4 (TLR4) or TLR2 mRNA expression.
Academic Article RSA 2004: combined basic research satellite symposium - session two: toll-like receptors and organ damage.
Academic Article Hepatitis C infection and alcohol use: A dangerous mix for the liver and antiviral immunity.
Academic Article Cytokines and alcohol.
Academic Article Pattern recognition receptors: a contemporary view on liver diseases.
Academic Article Bone marrow-derived immune cells mediate sensitization to liver injury in a myeloid differentiation factor 88-dependent fashion.
Academic Article VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet-induced nonalcoholic steatohepatitis model in mice.
Academic Article The opposite effects of acute and chronic alcohol on lipopolysaccharide-induced inflammation are linked to IRAK-M in human monocytes.
Academic Article Factors that determine the development and progression of gastroesophageal varices in patients with chronic hepatitis C.
Academic Article Alcoholic liver disease and the gut-liver axis.
Academic Article The 40th anniversary of the National Institute on Alcoholism and Alcohol Abuse: the impact on liver disease.
Academic Article Innate immunity in alcoholic liver disease.
Academic Article Dendritic cells in hepatitis C infection: can they (help) win the battle?
Academic Article Mitochondrial antiviral signaling protein defect links impaired antiviral response and liver injury in steatohepatitis in mice.
Academic Article Mechanisms of alcohol-mediated hepatotoxicity in human-immunodeficiency-virus-infected patients.
Academic Article An essential role for monocyte chemoattractant protein-1 in alcoholic liver injury: regulation of proinflammatory cytokines and hepatic steatosis in mice.
Academic Article Advanced molecular biologic techniques in toxicologic disease.
Academic Article Hypoxia and hypoxia inducible factors: diverse roles in liver diseases.
Academic Article MicroRNA silencing and the development of novel therapies for liver disease.
Academic Article Binge ethanol and liver: new molecular developments.
Academic Article Focus on: Alcohol and the liver.
Concept Disease Models, Animal
Concept Virus Diseases
Concept Disease Progression
Concept Liver Diseases
Concept Chronic Disease
Concept Acute Disease
Concept Genetic Predisposition to Disease
Concept Cardiovascular Diseases
Concept Lung Diseases
Concept Liver Diseases, Alcoholic
Concept Disease
Concept Inflammatory Bowel Diseases
Concept Gastrointestinal Diseases
Academic Article STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease.
Academic Article High fat diet feeding results in gender specific steatohepatitis and inflammasome activation.
Academic Article Micro-RNA-155 deficiency prevents alcohol-induced serum endotoxin increase and small bowel inflammation in mice.
Academic Article Both bone marrow-derived and non-bone marrow-derived cells contribute to AIM2 and NLRP3 inflammasome activation in a MyD88-dependent manner in dietary steatohepatitis.
Academic Article Gut-liver axis in alcoholic liver disease.
Academic Article MicroRNAs in alcoholic liver disease.
Academic Article microRNA-122 regulates hypoxia-inducible factor-1 and vimentin in hepatocytes and correlates with fibrosis in diet-induced steatohepatitis.
Academic Article MicroRNA-155 Deficiency Attenuates Liver Steatosis and Fibrosis without Reducing Inflammation in a Mouse Model of Steatohepatitis.
Academic Article Progression of non-alcoholic steatosis to steatohepatitis and fibrosis parallels cumulative accumulation of danger signals that promote inflammation and liver tumors in a high fat-cholesterol-sugar diet model in mice.
Academic Article Inflammasome activation and function in liver disease.
Academic Article Metabolic danger signals, uric acid and ATP, mediate inflammatory cross-talk between hepatocytes and immune cells in alcoholic liver disease.
Academic Article Inflammasome activation in the liver: Focus on alcoholic and non-alcoholic steatohepatitis.
Academic Article Inhibition of sterile danger signals, uric acid and ATP, prevents inflammasome activation and protects from alcoholic steatohepatitis in mice.
Academic Article Alcohol's Effect on Host Defense.
Academic Article Reduction in Hepatic Inflammation Is Associated With Less Fibrosis Progression and Fewer Clinical Outcomes in Advanced Hepatitis C.
Academic Article Role of MicroRNAs in NAFLD/NASH.
Academic Article Adult mouse model of early hepatocellular carcinoma promoted by alcoholic liver disease.
Academic Article Interleukin-1 and inflammasomes in alcoholic liver disease/acute alcoholic hepatitis and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.
Academic Article Inhibition of spleen tyrosine kinase activation ameliorates inflammation, cell death, and steatosis in alcoholic liver disease.
Academic Article Krüppel-like factor 4 is a transcriptional regulator of M1/M2 macrophage polarization in alcoholic liver disease.
Academic Article Gut-liver axis and sterile signals in the development of alcoholic liver disease.
Academic Article Recovery of ethanol-induced Akkermansia muciniphila depletion ameliorates alcoholic liver disease.
Academic Article Alcohol-induced miR-155 and HDAC11 inhibit negative regulators of the TLR4 pathway and lead to increased LPS responsiveness of Kupffer cells in alcoholic liver disease.
Academic Article Extracellular vesicles in liver disease and potential as biomarkers and therapeutic targets.
Academic Article Sepsis in Alcohol-related Liver Disease.
Academic Article Extracellular vesicles from mice with alcoholic liver disease carry a distinct protein cargo and induce macrophage activation via Hsp90.
Academic Article MicroRNA 122, Regulated by GRLH2, Protects Livers of Mice and Patients From Ethanol-Induced Liver Disease.
Academic Article Women and alcoholic liver disease - warning of a silent danger.
Academic Article Alcoholic liver disease.
Academic Article Publisher Correction: Alcoholic liver disease.
Academic Article Commentary on "Intestinal fungi contribute to development of alcoholic liver disease" Yang et al, J Clin Invest 127:2829-2841 (2017).
Academic Article Alcoholic Liver Disease Accelerates Early Hepatocellular Cancer in a Mouse Model.
Academic Article TFEB, a master regulator of lysosome biogenesis and autophagy, is a new player in alcoholic liver disease.
Academic Article Inhibition of Triggering Receptor Expressed on Myeloid Cells 1 Ameliorates Inflammation and Macrophage and Neutrophil Activation in Alcoholic Liver Disease in Mice.
Academic Article Alcohol-Related Liver Disease: Areas of Consensus, Unmet Needs and Opportunities for Further Study.
Academic Article Alcohol-related Liver Disease: Areas of Consensus, Unmet Needs and Opportunities for Further Study.
Academic Article Non-invasive diagnosis and biomarkers in alcohol-related liver disease.
Academic Article Extracellular Vesicles in Liver Diseases: Meeting Report from the International Liver Congress 2018.
Academic Article Dysregulated autophagy and lysosome function are linked to exosome production via miR-155 in alcoholic liver disease.
Academic Article Diagnosis and Treatment of Alcohol-Related Liver Diseases: 2019 Practice Guidance from the American Association for the Study of Liver Diseases.
Academic Article Introducing the 2019 American Association for the Study of Liver Diseases Guidance on Alcohol-Related Liver Disease.
Academic Article Recent advances in alcohol-related liver disease (ALD): summary of a Gut round table meeting.
Academic Article Provider Attitudes and Practices for Alcohol Screening, Treatment and Education in Patients with Liver Disease: a Survey from the AASLD ALD SIG.
Academic Article Immunopathobiology and therapeutic targets related to cytokines in liver diseases.
Academic Article Two faces of neutrophils in liver disease development and progression.

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