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Search Results to Gyongyi Szabo MD, PhD

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One or more keywords matched the following properties of Szabo, Gyongyi

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Background

Education:

MD, University Medical School Debrecen, Hungary
PhD, Hungarian Academy of Sciences (Immunology/Medicine)

Post-Graduate Training:

Internal Medicine Residency, University of Massachusetts Medical Center Worcester, MA

Gastroenterology and Hepatology Fellowship, Division of Gastroenterology, University of Massachusetts Medical Center, Worcester, MA

Current Research Activities

Bench Research:

Photo: Gyongyi Szabo
  1. Immune alterations induced by acute alcohol consumption: My laboratory is one of the few focusing on immunomodulation by moderate alcohol use in humans. In addition to understanding mechanisms for the increased susceptibility to infections after alcohol use, results from our investigations have relevance to decreased cardiovascular morbidity after moderate alcohol use as well as to accelerated liver disease in chronic hepatitis C virus infection. My laboratory studies changes in the interaction between accessory cells (monocytes and dendritic cells) and T lymphocytes after moderate alcohol use. The overall aim of our studies is to delineate the effect of alcohol on antigen presenting cell function and determine role of cytokine and co-stimulatory molecules leading to decreased antigen-specific T cell proliferation and impaired antimicrobial defense after alcohol use.
  2. Intracellular signaling pathways in leukocytes mediating altered cytokine production after alcohol use. We are studying intracellular signaling mechanisms leading to decreased NF- B activation in monocytic and immune cells after acute alcohol treatment in relation to signals mediated by toll-like receptors. Recent interest is to define the NF-kB-mediated intracellular mechanisms that lead to the opposite effects of acute and chronic alcohol use on pro-inflammatory cytokine production.
  3. Immune mechanisms leading to increased liver injury in HCV plus alcohol. The hypothesis is that impaired dendritic cell costimulatory activity is a pivotal defect of host response to hepatitis C infection and alcohol further reduces immunity by inhibiting maturation and functions of myeloid dendritic cells in HCV.
  4. Immunopathogenesis of liver injury in obese mice: This is a developing project to investigate the hypothesis that leptin deficient, ob/ob mice have increased susceptibility to immune-mediated liver injury in a model of Concanavalin-A or LPS-induced hepatitis. We found that in contrast to lean mice, ob/ob mice have over-activation of the NF- B signaling pathway in the liver, a mechanisms likely to contribute to increased susceptibility to liver injury. Results from these experiments have direct clinical relevance to mechanisms of liver injury in non-alcoholic steatohepatitis in human.

Clinical Research:

  1. Immune mechanisms of increased liver injury in HCV plus alcohol: overlap with bench research project #3.
  2. Therapeutic studies in chronic hepatitis C: I am an investigator at the UMass Memorial site of the national HALT-C trial supported by NIH.
  3. Therapeutic approaches in non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). A clinical trial to investigate the potential therapeutic benefit of an insulin sensitizing agent in NASH is being initiated. Additional therapeutic approaches in patients with NAFLD are under development. NAFLD /NASH have recently been recognized as one of the most prevalent liver diseases in the USA, and the most common cause of cryptogenic cirrhosis.

Research Figure

Research Figure

Post Docs

Immediate opening!

Two postdoctoral positions are available immediately to study cellular andmolecular mechanisms resulting in immunosuppression after alcohol use. Thefocus of this research is the role of monocytes and dendritic cells indecreased antigen-specific T cell activation after alcohol use.Intracellular signalling mechanisms resulting in decreased NF-kBactivation and inflammatory cytokine induction after acute alcoholconsumption are being investigated.

Please contact Dr. Szabo for details.


One or more keywords matched the following items that are connected to Szabo, Gyongyi

Item TypeName
Academic Article FcgammaR cross-linking mediates NF-kappaB activation, reduced antigen presentation capacity, and decreased IL-12 production in monocytes without modulation of myeloid dendritic cell development.
Academic Article Acute alcohol consumption inhibits accessory cell function of monocytes and dendritic cells.
Academic Article Inhibition of myeloid dendritic cell accessory cell function and induction of T cell anergy by alcohol correlates with decreased IL-12 production.
Academic Article Diverse regulation of NF-kappaB and peroxisome proliferator-activated receptors in murine nonalcoholic fatty liver.
Academic Article Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation.
Academic Article Inhibition of antigen-presenting cell functions by alcohol: implications for hepatitis C virus infection.
Academic Article Subversion of plasmacytoid and myeloid dendritic cell functions in chronic HCV infection.
Academic Article Toll-like receptor 2 mediates inflammatory cytokine induction but not sensitization for liver injury by Propioni- bacterium acnes.
Academic Article Acute ethanol treatment modulates Toll-like receptor-4 association with lipid rafts.
Academic Article Hepatitis C virus NS5A protein--a master regulator?
Academic Article Distinct Toll-like receptor expression in monocytes and T cells in chronic HCV infection.
Academic Article TLR2- and TLR4-mediated signals determine attenuation or augmentation of inflammation by acute alcohol in monocytes.
Academic Article Viral and host factors induce macrophage activation and loss of toll-like receptor tolerance in chronic HCV infection.
Academic Article T cells with regulatory activity in hepatitis C virus infection: what we know and what we don't.
Academic Article Myeloid dendritic cells of patients with chronic HCV infection induce proliferation of regulatory T lymphocytes.
Academic Article Antigen-presenting cells under the influence of alcohol.
Academic Article Alcohol-induced modulation of signaling pathways in liver parenchymal and nonparenchymal cells: implications for immunity.
Academic Article Signalling pathways in alcohol-induced liver inflammation.
Academic Article Type I interferons protect from Toll-like receptor 9-associated liver injury and regulate IL-1 receptor antagonist in mice.
Academic Article Up-regulation of microRNA-155 in macrophages contributes to increased tumor necrosis factor {alpha} (TNF{alpha}) production via increased mRNA half-life in alcoholic liver disease.
Academic Article Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells.
Academic Article Ethanol-mediated regulation of transcription factors in immunocompetent cells.
Academic Article Inhibition of TLR8- and TLR4-induced Type I IFN induction by alcohol is different from its effects on inflammatory cytokine production in monocytes.
Academic Article Novel developmental biology-based protocol of embryonic stem cell differentiation to morphologically sound and functional yet immature hepatocytes.
Academic Article The presence of p47phox in liver parenchymal cells is a key mediator in the pathogenesis of alcoholic liver steatosis.
Academic Article CD81/CD9 tetraspanins aid plasmacytoid dendritic cells in recognition of hepatitis C virus-infected cells and induction of interferon-alpha.
Academic Article Molecular hepatic carcinogenesis: impact of inflammation.
Academic Article Ethanol facilitates hepatitis C virus replication via up-regulation of GW182 and heat shock protein 90 in human hepatoma cells.
Academic Article IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice.
Academic Article Human monoclonal antibody HCV1 effectively prevents and treats HCV infection in chimpanzees.
Academic Article Type III interferons, IL-28 and IL-29, are increased in chronic HCV infection and induce myeloid dendritic cell-mediated FoxP3+ regulatory T cells.
Academic Article Innate immunity and alcoholic liver disease.
Academic Article Acute alcohol inhibits the induction of nuclear regulatory factor kappa B activation through CD14/toll-like receptor 4, interleukin-1, and tumor necrosis factor receptors: a common mechanism independent of inhibitory kappa B alpha degradation?
Academic Article MicroRNAs in liver disease.
Academic Article Chronic alcohol-induced microRNA-155 contributes to neuroinflammation in a TLR4-dependent manner in mice.
Academic Article Hepatitis C virus core and nonstructural protein 3 proteins induce pro- and anti-inflammatory cytokines and inhibit dendritic cell differentiation.
Academic Article Additive inhibition of dendritic cell allostimulatory capacity by alcohol and hepatitis C is not restored by DC maturation and involves abnormal IL-10 and IL-2 induction.
Academic Article Selective priming to Toll-like receptor 4 (TLR4), not TLR2, ligands by P. acnes involves up-regulation of MD-2 in mice.
Academic Article Increased lipopolysaccharide sensitivity in alcoholic fatty livers is independent of leptin deficiency and toll-like receptor 4 (TLR4) or TLR2 mRNA expression.
Academic Article Hepatitis C infection and alcohol use: A dangerous mix for the liver and antiviral immunity.
Academic Article Cytokines and alcohol.
Academic Article Intervention at the level of the neuroendocrine-immune axis and postoperative pneumonia rate in long-term alcoholics.
Academic Article Heme oxygenase-1 mediates the anti-inflammatory effects of acute alcohol on IL-10 induction involving p38 MAPK activation in monocytes.
Academic Article Hepatitis C virus (HCV) core protein-induced, monocyte-mediated mechanisms of reduced IFN-alpha and plasmacytoid dendritic cell loss in chronic HCV infection.
Academic Article Acute alcohol exposure exerts anti-inflammatory effects by inhibiting IkappaB kinase activity and p65 phosphorylation in human monocytes.
Academic Article Acute alcohol activates STAT3, AP-1, and Sp-1 transcription factors via the family of Src kinases to promote IL-10 production in human monocytes.
Academic Article Effect of ethanol on inflammatory responses. Implications for pancreatitis.
Academic Article Altered innate immunity in chronic hepatitis C infection: cause or effect?
Academic Article Hepatitis C core protein - the "core" of immune deception?
Academic Article The role of plasmacytoid dendritic cell-derived IFN alpha in antiviral immunity.
Academic Article Human monocytes, macrophages, and dendritic cells: alcohol treatment methods.
Academic Article Bone marrow-derived immune cells mediate sensitization to liver injury in a myeloid differentiation factor 88-dependent fashion.
Academic Article Impaired expression and function of toll-like receptor 7 in hepatitis C virus infection in human hepatoma cells.
Academic Article Innate immunity in alcoholic liver disease.
Academic Article Interferon regulatory factor 3 and type I interferons are protective in alcoholic liver injury in mice by way of crosstalk of parenchymal and myeloid cells.
Academic Article Dendritic cells in hepatitis C infection: can they (help) win the battle?
Academic Article An essential role for monocyte chemoattractant protein-1 in alcoholic liver injury: regulation of proinflammatory cytokines and hepatic steatosis in mice.
Academic Article Human type 2 myeloid dendritic cells produce interferon-? and amplify interferon-a in response to hepatitis C virus infection.
Academic Article Alcohol facilitates HCV RNA replication via up-regulation of miR-122 expression and inhibition of cyclin G1 in human hepatoma cells.
Academic Article Another armed CD4(+) T cell ready to battle hepatocellular carcinoma.
Academic Article IFN-? production by human natural killer cells in response to HCV-infected hepatoma cells is dependent on accessory cells.
Concept Cell Nucleus
Concept Cell Division
Concept Cell Communication
Concept Cell Survival
Concept Receptors, Cell Surface
Concept Kupffer Cells
Concept Jurkat Cells
Concept Dendritic Cells
Concept CHO Cells
Concept Cell Differentiation
Concept Bone Marrow Cells
Concept Hep G2 Cells
Concept Cell Polarity
Concept Cell Movement
Concept Cells, Cultured
Concept Cell Separation
Concept Cell Proliferation
Concept Cell Death
Concept Cell Culture Techniques
Concept Th1 Cells
Concept Cell Transformation, Neoplastic
Concept Antigen-Presenting Cells
Concept Th2 Cells
Concept Embryonic Stem Cells
Concept Cell Line
Concept Myeloid Cells
Concept Killer Cells, Natural
Concept Cell Line, Tumor
Academic Article Human ezrin-moesin-radixin proteins modulate hepatitis C virus infection.
Academic Article Both bone marrow-derived and non-bone marrow-derived cells contribute to AIM2 and NLRP3 inflammasome activation in a MyD88-dependent manner in dietary steatohepatitis.
Academic Article Exosome-mediated delivery of functionally active miRNA-155 inhibitor to macrophages.
Academic Article Innate immune cell networking in hepatitis C virus infection.
Academic Article Exosomes from hepatitis C infected patients transmit HCV infection and contain replication competent viral RNA in complex with Ago2-miR122-HSP90.
Academic Article Alcohol and HCV: implications for liver cancer.
Academic Article MicroRNAs in alcoholic liver disease.
Academic Article Alcohol-induced miR-27a regulates differentiation and M2 macrophage polarization of normal human monocytes.
Academic Article Exosomes derived from alcohol-treated hepatocytes horizontally transfer liver specific miRNA-122 and sensitize monocytes to LPS.
Academic Article Biodistribution and function of extracellular miRNA-155 in mice.
Academic Article MicroRNA-155 Deficiency Attenuates Liver Steatosis and Fibrosis without Reducing Inflammation in a Mouse Model of Steatohepatitis.
Academic Article Progression of non-alcoholic steatosis to steatohepatitis and fibrosis parallels cumulative accumulation of danger signals that promote inflammation and liver tumors in a high fat-cholesterol-sugar diet model in mice.
Academic Article Metabolic danger signals, uric acid and ATP, mediate inflammatory cross-talk between hepatocytes and immune cells in alcoholic liver disease.
Academic Article Inhibition of sterile danger signals, uric acid and ATP, prevents inflammasome activation and protects from alcoholic steatohepatitis in mice.
Academic Article MicroRNA Cargo of Extracellular Vesicles from Alcohol-exposed Monocytes Signals Naive Monocytes to Differentiate into M2 Macrophages.
Academic Article Inhibition of spleen tyrosine kinase activation ameliorates inflammation, cell death, and steatosis in alcoholic liver disease.
Academic Article A Novel Human Radixin Peptide Inhibits Hepatitis C Virus Infection at the Level of Cell Entry.
Academic Article Hepatitis C Virus-Induced Monocyte Differentiation Into Polarized M2 Macrophages Promotes Stellate Cell Activation via TGF-ß.
Academic Article Alcohol-induced miR-155 and HDAC11 inhibit negative regulators of the TLR4 pathway and lead to increased LPS responsiveness of Kupffer cells in alcoholic liver disease.
Academic Article IL-1a in acetaminophen toxicity: a sterile danger signal.
Academic Article Inhibition of Triggering Receptor Expressed on Myeloid Cells 1 Ameliorates Inflammation and Macrophage and Neutrophil Activation in Alcoholic Liver Disease in Mice.

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