Header Logo

Search Result Details

This page shows the details of why an item matched the keywords from your search.
One or more keywords matched the following properties of Szabo, Gyongyi
PropertyValue
overview

Background

Education:

MD, University Medical School Debrecen, Hungary
PhD, Hungarian Academy of Sciences (Immunology/Medicine)

Post-Graduate Training:

Internal Medicine Residency, University of Massachusetts Medical Center Worcester, MA

Gastroenterology and Hepatology Fellowship, Division of Gastroenterology, University of Massachusetts Medical Center, Worcester, MA

Current Research Activities

Bench Research:

Photo: Gyongyi Szabo
  1. Immune alterations induced by acute alcohol consumption: My laboratory is one of the few focusing on immunomodulation by moderate alcohol use in humans. In addition to understanding mechanisms for the increased susceptibility to infections after alcohol use, results from our investigations have relevance to decreased cardiovascular morbidity after moderate alcohol use as well as to accelerated liver disease in chronic hepatitis C virus infection. My laboratory studies changes in the interaction between accessory cells (monocytes and dendritic cells) and T lymphocytes after moderate alcohol use. The overall aim of our studies is to delineate the effect of alcohol on antigen presenting cell function and determine role of cytokine and co-stimulatory molecules leading to decreased antigen-specific T cell proliferation and impaired antimicrobial defense after alcohol use.
  2. Intracellular signaling pathways in leukocytes mediating altered cytokine production after alcohol use. We are studying intracellular signaling mechanisms leading to decreased NF- B activation in monocytic and immune cells after acute alcohol treatment in relation to signals mediated by toll-like receptors. Recent interest is to define the NF-kB-mediated intracellular mechanisms that lead to the opposite effects of acute and chronic alcohol use on pro-inflammatory cytokine production.
  3. Immune mechanisms leading to increased liver injury in HCV plus alcohol. The hypothesis is that impaired dendritic cell costimulatory activity is a pivotal defect of host response to hepatitis C infection and alcohol further reduces immunity by inhibiting maturation and functions of myeloid dendritic cells in HCV.
  4. Immunopathogenesis of liver injury in obese mice: This is a developing project to investigate the hypothesis that leptin deficient, ob/ob mice have increased susceptibility to immune-mediated liver injury in a model of Concanavalin-A or LPS-induced hepatitis. We found that in contrast to lean mice, ob/ob mice have over-activation of the NF- B signaling pathway in the liver, a mechanisms likely to contribute to increased susceptibility to liver injury. Results from these experiments have direct clinical relevance to mechanisms of liver injury in non-alcoholic steatohepatitis in human.

Clinical Research:

  1. Immune mechanisms of increased liver injury in HCV plus alcohol: overlap with bench research project #3.
  2. Therapeutic studies in chronic hepatitis C: I am an investigator at the UMass Memorial site of the national HALT-C trial supported by NIH.
  3. Therapeutic approaches in non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). A clinical trial to investigate the potential therapeutic benefit of an insulin sensitizing agent in NASH is being initiated. Additional therapeutic approaches in patients with NAFLD are under development. NAFLD /NASH have recently been recognized as one of the most prevalent liver diseases in the USA, and the most common cause of cryptogenic cirrhosis.

Research Figure

Research Figure

One or more keywords matched the following items that are connected to Szabo, Gyongyi
Item TypeName
Academic Article Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation.
Academic Article Subversion of plasmacytoid and myeloid dendritic cell functions in chronic HCV infection.
Academic Article Toll-like receptor 2 mediates inflammatory cytokine induction but not sensitization for liver injury by Propioni- bacterium acnes.
Academic Article Acute ethanol treatment modulates Toll-like receptor-4 association with lipid rafts.
Academic Article Distinct Toll-like receptor expression in monocytes and T cells in chronic HCV infection.
Academic Article TLR2- and TLR4-mediated signals determine attenuation or augmentation of inflammation by acute alcohol in monocytes.
Academic Article The emerging role of toll-like receptor pathways in surgical diseases.
Academic Article Critical role of toll-like receptors and the common TLR adaptor, MyD88, in induction of granulomas and liver injury.
Academic Article Viral and host factors induce macrophage activation and loss of toll-like receptor tolerance in chronic HCV infection.
Academic Article The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88.
Academic Article Alcohol-induced modulation of signaling pathways in liver parenchymal and nonparenchymal cells: implications for immunity.
Academic Article Signalling pathways in alcohol-induced liver inflammation.
Academic Article Type I interferons protect from Toll-like receptor 9-associated liver injury and regulate IL-1 receptor antagonist in mice.
Academic Article Toll-like receptors in the pathogenesis of alcoholic liver disease.
Academic Article Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice.
Academic Article Toll-like receptor signaling in liver diseases.
Academic Article Inhibition of TLR8- and TLR4-induced Type I IFN induction by alcohol is different from its effects on inflammatory cytokine production in monocytes.
Academic Article Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases.
Academic Article IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice.
Academic Article Acute alcohol inhibits the induction of nuclear regulatory factor kappa B activation through CD14/toll-like receptor 4, interleukin-1, and tumor necrosis factor receptors: a common mechanism independent of inhibitory kappa B alpha degradation?
Academic Article Toll-like receptors in liver disease.
Academic Article Differences in innate immune signaling between alcoholic and non-alcoholic steatohepatitis.
Academic Article Chronic alcohol-induced microRNA-155 contributes to neuroinflammation in a TLR4-dependent manner in mice.
Academic Article Selective priming to Toll-like receptor 4 (TLR4), not TLR2, ligands by P. acnes involves up-regulation of MD-2 in mice.
Academic Article Increased lipopolysaccharide sensitivity in alcoholic fatty livers is independent of leptin deficiency and toll-like receptor 4 (TLR4) or TLR2 mRNA expression.
Academic Article RSA 2004: combined basic research satellite symposium - session two: toll-like receptors and organ damage.
Academic Article Modulation of non-alcoholic steatohepatitis by pattern recognition receptors in mice: the role of toll-like receptors 2 and 4.
Academic Article TLR4, ethanol, and lipid rafts: a new mechanism of ethanol action with implications for other receptor-mediated effects.
Academic Article Effect of ethanol on inflammatory responses. Implications for pancreatitis.
Academic Article Toll-like receptors 1 and 6 are involved in TLR2-mediated macrophage activation by hepatitis C virus core and NS3 proteins.
Academic Article The role of plasmacytoid dendritic cell-derived IFN alpha in antiviral immunity.
Academic Article Bone marrow-derived immune cells mediate sensitization to liver injury in a myeloid differentiation factor 88-dependent fashion.
Academic Article Impaired expression and function of toll-like receptor 7 in hepatitis C virus infection in human hepatoma cells.
Academic Article Alcoholic liver disease and the gut-liver axis.
Academic Article Innate immunity in alcoholic liver disease.
Academic Article Interferon regulatory factor 3 and type I interferons are protective in alcoholic liver injury in mice by way of crosstalk of parenchymal and myeloid cells.
Academic Article Induction of Bcl-3 by acute binge alcohol results in toll-like receptor 4/LPS tolerance.
Academic Article Increased microRNA-155 expression in the serum and peripheral monocytes in chronic HCV infection.
Academic Article Alcohol-induced IL-1? in the brain is mediated by NLRP3/ASC inflammasome activation that amplifies neuroinflammation.
Concept Toll-Like Receptors
Concept Toll-Like Receptor 6
Concept Toll-Like Receptor 4
Concept Toll-Like Receptor 9
Concept Toll-Like Receptor 2
Concept Toll-Like Receptor 7
Concept Toll-Like Receptor 1
Concept Toll-Like Receptor 8
Academic Article Both bone marrow-derived and non-bone marrow-derived cells contribute to AIM2 and NLRP3 inflammasome activation in a MyD88-dependent manner in dietary steatohepatitis.
Academic Article The pro-inflammatory effects of miR-155 promote liver fibrosis and alcohol-induced steatohepatitis.
Academic Article Endoplasmic Reticulum Stress-induced Hepatocellular Death Pathways Mediate Liver Injury and Fibrosis via Stimulator of Interferon Genes.
Academic Article Circulating and Exosome-Packaged Hepatitis C Single-Stranded RNA Induce Monocyte Differentiation via TLR7/8 to Polarized Macrophages and Fibrocytes.
Academic Article Alcohol-induced miR-155 and HDAC11 inhibit negative regulators of the TLR4 pathway and lead to increased LPS responsiveness of Kupffer cells in alcoholic liver disease.
Search Criteria
  • Toll Like Receptors