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Search Results to John P Haran MD

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BS: Rensselaer Polytechnic Institute                                                                    
MD: University of Massachusetts Medical School                                                
Residency Training: Alpert Medical School of Brown University                                
PhD: University of Massachusetts Medical School Millennium PhD Program


Associate Professor of Emergency Medicine                                                   
Associate Professor in the Department of Microbiology & Physiological Systems 
Associate Clinical Director of the Center for Microbiome Research

Research Overview:

 Dr. Haran is an NIH funded investigator who’s research interests include: 1) stemming the spread of Clostridium difficile infection and colonization among nursing home residents and hospitalized elders; 2) preventing the transmission of multi-drug resistant organisms within the hospital setting; and 3) implementing novel treatment guidelines to reduce unnecessary antibiotic usage.

 Dr. Haran’s current research is supported by internal grant funding through UMMS and an R03 GEMSSTAR award through NIA which focuses on the complex interplay between medication use and Clostridium difficile (C. difficile) colonization/infection in both community-dwelling elders and those residing in nursing homes. We have built a large research network of nursing home facilities within central Massachusetts where we collect longitudinal samples and monitor for colonization with C. difficile and other drug resistant organisms. This investigates both: 1) the nursing home microbiome and its association with these organisms; and 2) clinical and nutritional factors that influence the microbiome. The ultimate goal of this work is to identify microbiome changes that occur as an elder transitions to nursing home care which leads to a bacterial carrier state. This will lay the foundation for targeted interventions to prevent the spread of C. difficile and other drug resistant organisms in the elderly nursing home community.

 We are not only working to understand and prevent the spread of these organisms within the nursing home but also within the hospital setting. We are working to combine machine-learning approaches and novel numerical integrators for the prediction of changing dynamics of complex systems that will allow for a personalized evaluation of C. difficile risk in real-time among hospitalized patients undergoing antibiotic treatment. We are working towards establishing a model that will lay the foundation for the future use of rapid point-of-care testing to stratify at-risk patients.

 Finally as a member of the hospital Antimicrobial Stewardship Taskforce, Dr. Haran has worked with other committee members to implement novel antimicrobial treatment algorithms to reduce the unnecessary use of antibiotics within the Emergency Department and the hospital wards. Our current project had dramatically reduced Vancomycin use as a treatment for non-purulent skin infections and helped the hospital to align with the IDSA treatment guidelines for skin and soft tissue infections.

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