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Haran, John

One or more keywords matched the following properties of Haran, John

Property	Value
overview	Education: BS: Rensselaer Polytechnic Institute MD: University of Massachusetts Medical School Residency Training: Alpert Medical School of Brown University PhD: University of Massachusetts Medical School Millennium PhD Program Appointments: Associate Professor of Emergency Medicine Associate Professor in the Department of Microbiology & Physiological Systems Associate Clinical Director of the Center for Microbiome Research Research Overview: Please see Dr. Haran's Research Group Website for more details: https://www.umassmed.edu/haranresearchgroup/ Dr. Haran is an NIH funded investigator whose research background is anchored with a focus on investigations into the link between gut microbiome composition and older adult health outcomes. Specifically, his research interests span 2 domains that include the “microbiota-gut-brain” axis and drug resistant pathogens. Within the microbiota-gut-brain axis, Dr. Haran’s current NIH funding focuses on how dysbiosis in the intestinal microbiome of elders with Alzheimer’s disease associates with immune system dysregulation and cognitive impairment. He is currently enrolling and following older adults, collecting longitudinal cognitive, immune system functioning, and microbiome data. Through funding from the Alzheimer’s Association and the National Institute on Aging, we have built a large cohort of community-dwelling and nursing home older adults with and without Alzheimer’s disease that we are following for cognitive changes. We run a research clinic here at UMass Chan Medical School for older adults with cognitive issues and are leveraging data from these patients to design and test novel microbiome therapies to improve cognition and prevent Alzheimer’s disease progression. Under the microbiota-gut-brain axis domain, Dr. Haran also runs investigations into the relationship between pro-inflammatory type oral microbiome composition and the risk of developing long-COVID. Finally, leveraging patients he treats in the ED from minor accidents, Dr. Haran studies the relationship between the gut microbiome composition and development of post-traumatic neurological disorders. Dr. Haran’s focus on drug resistant pathogens includes: 1) stemming the spread of Clostridium difficile infection and colonization among nursing home residents and hospitalized elders; 2) preventing the transmission of multi-drug resistant organisms within the hospital setting; and 3) implementing novel treatment guidelines to reduce unnecessary antibiotic usage. Dr. Haran’s current research is supported by internal grant funding through UMMS and NIA which focuses on the complex interplay between medication use and Clostridium difficile (C. difficile) colonization/infection in both community-dwelling elders and those residing in nursing homes. We have built a large research network of nursing home facilities within central Massachusetts where we collect longitudinal samples and monitor for colonization with C. difficile and other drug resistant organisms. This investigates both: 1) the nursing home microbiome and its association with these organisms; and 2) clinical and nutritional factors that influence the microbiome. The ultimate goal of this work is to identify microbiome changes that occur as an elder transitions to nursing home care which leads to a bacterial carrier state. This will lay the foundation for targeted interventions to prevent the spread of C. difficile and other drug resistant organisms in the elderly nursing home community.Additionally, as a member of the hospital Antimicrobial Stewardship Taskforce, Dr. Haran has worked with other committee members to implement novel antimicrobial treatment algorithms to reduce the unnecessary use of antibiotics within the Emergency Department and the hospital wards. Our current project had dramatically reduced Vancomycin use as a treatment for non-purulent skin infections and helped the hospital to align with the IDSA treatment guidelines for skin and soft tissue infections. Finally in response to the COVID-19 pandemic, Dr. Haran has been working with the CDC in several surveillance projects that aim to understand the risk healthcare workers have to contracting COVID-19 from the workplace and the benefits of vaccination in preventing the spread of COVID-19.

Property

Value

overview

Education:

BS: Rensselaer Polytechnic Institute
MD: University of Massachusetts Medical School
Residency Training: Alpert Medical School of Brown University
PhD: University of Massachusetts Medical School Millennium PhD Program

Appointments:

Associate Professor of Emergency Medicine
Associate Professor in the Department of Microbiology & Physiological Systems
Associate Clinical Director of the Center for Microbiome Research

Research Overview:

Please see Dr. Haran's Research Group Website for more details: https://www.umassmed.edu/haranresearchgroup/

Dr. Haran is an NIH funded investigator whose research background is anchored with a focus on investigations into the link between gut microbiome composition and older adult health outcomes. Specifically, his research interests span 2 domains that include the “microbiota-gut-brain” axis and drug resistant pathogens.

Within the microbiota-gut-brain axis, Dr. Haran’s current NIH funding focuses on how dysbiosis in the intestinal microbiome of elders with Alzheimer’s disease associates with immune system dysregulation and cognitive impairment. He is currently enrolling and following older adults, collecting longitudinal cognitive, immune system functioning, and microbiome data. Through funding from the Alzheimer’s Association and the National Institute on Aging, we have built a large cohort of community-dwelling and nursing home older adults with and without Alzheimer’s disease that we are following for cognitive changes. We run a research clinic here at UMass Chan Medical School for older adults with cognitive issues and are leveraging data from these patients to design and test novel microbiome therapies to improve cognition and prevent Alzheimer’s disease progression.

Under the microbiota-gut-brain axis domain, Dr. Haran also runs investigations into the relationship between pro-inflammatory type oral microbiome composition and the risk of developing long-COVID. Finally, leveraging patients he treats in the ED from minor accidents, Dr. Haran studies the relationship between the gut microbiome composition and development of post-traumatic neurological disorders.

Dr. Haran’s focus on drug resistant pathogens includes: 1) stemming the spread of Clostridium difficile infection and colonization among nursing home residents and hospitalized elders; 2) preventing the transmission of multi-drug resistant organisms within the hospital setting; and 3) implementing novel treatment guidelines to reduce unnecessary antibiotic usage.

Dr. Haran’s current research is supported by internal grant funding through UMMS and NIA which focuses on the complex interplay between medication use and Clostridium difficile (C. difficile) colonization/infection in both community-dwelling elders and those residing in nursing homes. We have built a large research network of nursing home facilities within central Massachusetts where we collect longitudinal samples and monitor for colonization with C. difficile and other drug resistant organisms. This investigates both: 1) the nursing home microbiome and its association with these organisms; and 2) clinical and nutritional factors that influence the microbiome. The ultimate goal of this work is to identify microbiome changes that occur as an elder transitions to nursing home care which leads to a bacterial carrier state. This will lay the foundation for targeted interventions to prevent the spread of C. difficile and other drug resistant organisms in the elderly nursing home community.Additionally, as a member of the hospital Antimicrobial Stewardship Taskforce, Dr. Haran has worked with other committee members to implement novel antimicrobial treatment algorithms to reduce the unnecessary use of antibiotics within the Emergency Department and the hospital wards. Our current project had dramatically reduced Vancomycin use as a treatment for non-purulent skin infections and helped the hospital to align with the IDSA treatment guidelines for skin and soft tissue infections.

Finally in response to the COVID-19 pandemic, Dr. Haran has been working with the CDC in several surveillance projects that aim to understand the risk healthcare workers have to contracting COVID-19 from the workplace and the benefits of vaccination in preventing the spread of COVID-19.

One or more keywords matched the following items that are connected to Haran, John

Item Type	Name
Academic Article	A comparison of ultrasound-guided three-in-one femoral nerve block versus parenteral opioids alone for analgesia in emergency department patients with hip fractures: a randomized controlled trial.
Concept	Emergency Service, Hospital
Academic Article	All purulence is local - epidemiology and management of skin and soft tissue infections in three urban emergency departments.
Academic Article	Factors influencing the development of antibiotic associated diarrhea in ED patients discharged home: risk of administering IV antibiotics.
Academic Article	Treatment of bacterial skin infections in ED observation units: factors influencing prescribing practice.
Academic Article	Antibiotic-associated diarrhoea in emergency department observation unit patients.
Academic Article	Elderly patients are at increased risk for treatment failure in outpatient management of purulent skin infections.
Academic Article	Macrolide Resistance in Cases of Community-Acquired Bacterial Pneumonia in the Emergency Department.
Academic Article	Reduction of Inappropriate Antibiotic Use and Improved Outcomes by Implementation of an Algorithm-Based Clinical Guideline for Nonpurulent Skin and Soft Tissue Infections.
Academic Article	Development and Validation of a Model to Predict Posttraumatic Stress Disorder and Major Depression After a Motor Vehicle Collision.
Academic Article	Clinical failure in abscess treatment: the role of ultrasound and incision and drainage.
Academic Article	Brain-Based Biotypes of Psychiatric Vulnerability in the Acute Aftermath of Trauma.
Academic Article	Derivation and Validation of a Brief Emergency Department-Based Prediction Tool for Posttraumatic Stress After Motor Vehicle Collision.
Academic Article	Predicting at-risk opioid use three months after ed visit for trauma: Results from the AURORA study.
Academic Article	Deviating from IDSA treatment guidelines for non-purulent skin infections increases the risk of treatment failure in emergency department patients.
Academic Article	Sex-dependent differences in vulnerability to early risk factors for posttraumatic stress disorder: results from the AURORA study.
Academic Article	Multi-level socioeconomic modifiers of the comorbidity of post-traumatic stress and tobacco, alcohol, and cannabis use: the importance of income.
Academic Article	Longitudinal Associations Between Peritraumatic Oestradiol and Fear Responding in Women and Men.

Search Criteria

Emergency Service Hospital