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Haran, John
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overview

Education:

BS: Rensselaer Polytechnic Institute                                                                    
MD: University of Massachusetts Medical School                                                
Residency Training: Alpert Medical School of Brown University                                
PhD: University of Massachusetts Medical School Millennium PhD Program

Appointments:

Associate Professor of Emergency Medicine                                                   
Associate Professor in the Department of Microbiology & Physiological Systems 
Associate Clinical Director of the Center for Microbiome Research

Research Overview:

Please see Dr. Haran's Research Group Website for more details: https://www.umassmed.edu/haranresearchgroup/

Dr. Haran is an NIH funded investigator whose research background is anchored with a focus on investigations into the link between gut microbiome composition and older adult health outcomes. Specifically, his research interests span 2 domains that include the “microbiota-gut-brain” axis and drug resistant pathogens.

Within the microbiota-gut-brain axis, Dr. Haran’s current NIH funding focuses on how dysbiosis in the intestinal microbiome of elders with Alzheimer’s disease associates with immune system dysregulation and cognitive impairment. He is currently enrolling and following older adults, collecting longitudinal cognitive, immune system functioning, and microbiome data. Through funding from the Alzheimer’s Association and the National Institute on Aging, we have built a large cohort of community-dwelling and nursing home older adults with and without Alzheimer’s disease that we are following for cognitive changes. We run a research clinic here at UMass Chan Medical School for older adults with cognitive issues and are leveraging data from these patients to design and test novel microbiome therapies to improve cognition and prevent Alzheimer’s disease progression.

Under the microbiota-gut-brain axis domain, Dr. Haran also runs investigations into the relationship between pro-inflammatory type oral microbiome composition and the risk of developing long-COVID. Finally, leveraging patients he treats in the ED from minor accidents, Dr. Haran studies the relationship between the gut microbiome composition and development of post-traumatic neurological disorders.

Dr. Haran’s focus on drug resistant pathogens includes: 1) stemming the spread of Clostridium difficile infection and colonization among nursing home residents and hospitalized elders; 2) preventing the transmission of multi-drug resistant organisms within the hospital setting; and 3) implementing novel treatment guidelines to reduce unnecessary antibiotic usage.

Dr. Haran’s current research is supported by internal grant funding through UMMS and NIA which focuses on the complex interplay between medication use and Clostridium difficile (C. difficile) colonization/infection in both community-dwelling elders and those residing in nursing homes. We have built a large research network of nursing home facilities within central Massachusetts where we collect longitudinal samples and monitor for colonization with C. difficile and other drug resistant organisms. This investigates both: 1) the nursing home microbiome and its association with these organisms; and 2) clinical and nutritional factors that influence the microbiome. The ultimate goal of this work is to identify microbiome changes that occur as an elder transitions to nursing home care which leads to a bacterial carrier state. This will lay the foundation for targeted interventions to prevent the spread of C. difficile and other drug resistant organisms in the elderly nursing home community.Additionally, as a member of the hospital Antimicrobial Stewardship Taskforce, Dr. Haran has worked with other committee members to implement novel antimicrobial treatment algorithms to reduce the unnecessary use of antibiotics within the Emergency Department and the hospital wards. Our current project had dramatically reduced Vancomycin use as a treatment for non-purulent skin infections and helped the hospital to align with the IDSA treatment guidelines for skin and soft tissue infections.

Finally in response to the COVID-19 pandemic, Dr. Haran has been working with the CDC in several surveillance projects that aim to understand the risk healthcare workers have to contracting COVID-19 from the workplace and the benefits of vaccination in preventing the spread of COVID-19.
Rotation Projects

Rotation projects are available related to microbiota-gut brain axis and antibiotic usage and the sequelae of antibiotic use in hospitalized patients which include Clostridium difficile and multi-drug resistant organism infection and colonization.
One or more keywords matched the following items that are connected to Haran, John
Item TypeName
Academic Article Enhanced culture method for detection of replication-competent virus in peripheral blood mononuclear cells of HIV type 1-infected individuals.
Academic Article A comparison of ultrasound-guided three-in-one femoral nerve block versus parenteral opioids alone for analgesia in emergency department patients with hip fractures: a randomized controlled trial.
Academic Article Correlation of C-reactive protein to severity of symptoms in acute influenza A infection.
Academic Article C-reactive protein as predictor of bacterial infection among patients with an influenza-like illness.
Academic Article Cytokine markers as predictors of type of respiratory infection in patients during the influenza season.
Concept Substance-Related Disorders
Concept Staphylococcus aureus
Concept Trauma Severity Indices
Concept Symbiosis
Concept Seroepidemiologic Studies
Concept Social Support
Concept Influenza A Virus, H1N1 Subtype
Concept Sensitivity and Specificity
Concept Chi-Square Distribution
Concept Disease Susceptibility
Concept Stress Disorders, Post-Traumatic
Concept Cohort Studies
Concept Galvanic Skin Response
Concept Emergency Service, Hospital
Concept Statistics, Nonparametric
Concept Soft Tissue Infections
Concept Sex Offenses
Concept Retrospective Studies
Concept Multicenter Studies as Topic
Concept Immunization Schedule
Concept Urinalysis
Concept Urinary Tract Infections
Concept Severity of Illness Index
Concept Urine
Concept Reflex, Startle
Concept Longitudinal Studies
Concept Fatty Acids, Unsaturated
Concept Psychiatric Status Rating Scales
Concept Sex Factors
Concept Sleep
Concept Skin Diseases, Infectious
Concept Survivors
Concept Case-Control Studies
Concept Adult Survivors of Child Abuse
Concept Prospective Studies
Concept Cross-Sectional Studies
Concept Socioeconomic Factors
Concept Hospitals, Urban
Concept Sleep Wake Disorders
Concept Surveys and Questionnaires
Concept Autonomic Nervous System
Concept Emergency Medical Services
Concept Oligonucleotide Array Sequence Analysis
Concept Stress Disorders, Traumatic
Concept Rats, Sprague-Dawley
Concept United States
Concept Sex Characteristics
Concept Ultrasonography
Concept Immunization, Secondary
Concept Self Care
Concept Sleep Initiation and Maintenance Disorders
Concept Skin Diseases, Bacterial
Concept Nutritional Status
Academic Article A case of neck pain: The presentation of Chairi 1 malformations in children.
Academic Article All purulence is local - epidemiology and management of skin and soft tissue infections in three urban emergency departments.
Academic Article Immunization with cross-conserved H1N1 influenza CD4+ T-cell epitopes lowers viral burden in HLA DR3 transgenic mice.
Academic Article Antigen-specific H1N1 influenza antibody responses in acute respiratory tract infections and their relation to influenza infection and disease course.
Academic Article Factors influencing the development of antibiotic associated diarrhea in ED patients discharged home: risk of administering IV antibiotics.
Academic Article Treatment of bacterial skin infections in ED observation units: factors influencing prescribing practice.
Academic Article Antibiotic-associated diarrhoea in emergency department observation unit patients.
Academic Article Elderly patients are at increased risk for treatment failure in outpatient management of purulent skin infections.
Academic Article The nursing home elder microbiome stability and associations with age, frailty, nutrition and physical location.
Academic Article Medication Exposure and Risk of Recurrent Clostridium difficile Infection in Community-Dwelling Older People and Nursing Home Residents.
Academic Article Macrolide Resistance in Cases of Community-Acquired Bacterial Pneumonia in the Emergency Department.
Academic Article Alzheimer's Disease Microbiome Is Associated with Dysregulation of the Anti-Inflammatory P-Glycoprotein Pathway.
Academic Article The AURORA Study: a longitudinal, multimodal library of brain biology and function after traumatic stress exposure.
Academic Article Reduction of Inappropriate Antibiotic Use and Improved Outcomes by Implementation of an Algorithm-Based Clinical Guideline for Nonpurulent Skin and Soft Tissue Infections.
Academic Article Prior sleep problems and adverse post-traumatic neuropsychiatric sequelae of motor vehicle collision in the AURORA study.
Academic Article Correction: The AURORA Study: a longitudinal, multimodal library of brain biology and function after traumatic stress exposure.
Academic Article Socio-demographic and trauma-related predictors of PTSD within 8 weeks of a motor vehicle collision in the AURORA study.
Academic Article Socio-demographic and trauma-related predictors of depression within eight weeks of motor vehicle collision in the AURORA study.
Academic Article Prognostic neuroimaging biomarkers of trauma-related psychopathology: resting-state fMRI shortly after trauma predicts future PTSD and depression symptoms in the AURORA study.
Academic Article Classification and Prediction of Post-Trauma Outcomes Related to PTSD Using Circadian Rhythm Changes Measured via Wrist-Worn Research Watch in a Large Longitudinal Cohort.
Academic Article The high prevalence of Clostridioides difficile among nursing home elders associates with a dysbiotic microbiome.
Academic Article Virtualized clinical studies to assess the natural history and impact of gut microbiome modulation in non-hospitalized patients with mild to moderate COVID-19 a randomized, open-label, prospective study with a parallel group study evaluating the physiologic effects of KB109 on gut microbiota structure and function: a structured summary of a study protocol for a randomized controlled study.
Academic Article Interim Estimates of Vaccine Effectiveness of Pfizer-BioNTech and Moderna COVID-19 Vaccines Among Health Care Personnel - 33 U.S. Sites, January-March 2021.
Academic Article The Nursing Home Older Adult Gut Microbiome Composition Shows Time-dependent Dysbiosis and Is Influenced by Medication Exposures, Age, Environment, and Frailty.
Academic Article Inflammation-type dysbiosis of the oral microbiome associates with the duration of COVID-19 symptoms and long COVID.
Academic Article Development and Validation of a Model to Predict Posttraumatic Stress Disorder and Major Depression After a Motor Vehicle Collision.
Academic Article A prospective examination of sex differences in posttraumatic autonomic functioning.
Academic Article Effectiveness of mRNA Covid-19 Vaccine among U.S. Health Care Personnel.
Academic Article Clinical failure in abscess treatment: the role of ultrasound and incision and drainage.
Academic Article Brain-Based Biotypes of Psychiatric Vulnerability in the Acute Aftermath of Trauma.
Academic Article The Urinary Microbiome of Older Adults Residing in a Nursing Home Varies With Duration of Residence and Shows Increases in Potential Pathogens.
Academic Article Prior histories of posttraumatic stress disorder and major depression and their onset and course in the three months after a motor vehicle collision in the AURORA study.
Academic Article Gut microbiota regulate Alzheimer's disease pathologies and cognitive disorders via PUFA-associated neuroinflammation.
Concept Smartphone
Concept Self Report
Concept Spike Glycoprotein, Coronavirus
Academic Article Prior differences in previous trauma exposure primarily drive the observed racial/ethnic differences in posttrauma depression and anxiety following a recent trauma.
Academic Article Oropharyngeal Microbiome Profiled at Admission is Predictive of the Need for Respiratory Support Among COVID-19 Patients.
Academic Article Persistent Dissociation and Its Neural Correlates in Predicting Outcomes After Trauma Exposure.
Academic Article Hippocampal Threat Reactivity Interacts with Physiological Arousal to Predict PTSD Symptoms.
Academic Article SARS-CoV-2 Serosurveys: How Antigen, Isotype and Threshold Choices Affect the Outcome.
Academic Article Anxiety sensitivity as a transdiagnostic risk factor for trajectories of adverse posttraumatic neuropsychiatric sequelae in the AURORA study.
Academic Article Structural covariance of the ventral visual stream predicts posttraumatic intrusion and nightmare symptoms: a multivariate data fusion analysis.
Academic Article Oropharyngeal microbiome profiled at admission is predictive of the need for respiratory support among COVID-19 patients.
Academic Article Derivation and Validation of a Brief Emergency Department-Based Prediction Tool for Posttraumatic Stress After Motor Vehicle Collision.
Academic Article Use of serial smartphone-based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohort.
Academic Article Childhood adversities and risk of posttraumatic stress disorder and major depression following a motor vehicle collision in adulthood.
Academic Article Utility of Wrist-Wearable Data for Assessing Pain, Sleep, and Anxiety Outcomes After Traumatic Stress Exposure.
Academic Article Telomeric ORFs (TLOs) in Candida spp. Encode mediator subunits that regulate distinct virulence traits.
Academic Article Predicting at-risk opioid use three months after ed visit for trauma: Results from the AURORA study.
Academic Article Structural inequities contribute to racial/ethnic differences in neurophysiological tone, but not threat reactivity, after trauma exposure.
Academic Article Presence of symptoms 6 weeks after COVID-19 among vaccinated and unvaccinated US healthcare personnel: a prospective cohort study.
Academic Article Internal capsule microstructure mediates the relationship between childhood maltreatment and PTSD following adulthood trauma exposure.
Academic Article Deviating from IDSA treatment guidelines for non-purulent skin infections increases the risk of treatment failure in emergency department patients.
Academic Article Associations of alcohol and cannabis use with change in posttraumatic stress disorder and depression symptoms over time in recently trauma-exposed individuals.
Academic Article Neighborhood Disadvantage and Neural Correlates of Threat and Reward Processing in Survivors of Recent Trauma.
Academic Article Bacteroides Fragilis in the gut microbiomes of Alzheimer's disease activates microglia and triggers pathogenesis in neuronal C/EBP? transgenic mice.
Academic Article Effectiveness of a Messenger RNA Vaccine Booster Dose Against Coronavirus Disease 2019 Among US Healthcare Personnel, October 2021-July 2022.
Academic Article Prior Sexual Trauma Exposure Impacts Posttraumatic Dysfunction and Neural Circuitry Following a Recent Traumatic Event in the AURORA Study.
Academic Article Effectiveness of a bivalent mRNA vaccine dose against symptomatic SARS-CoV-2 infection among U.S. Healthcare personnel, September 2022-May 2023.
Academic Article Association between microbiome and the development of adverse posttraumatic neuropsychiatric sequelae after traumatic stress exposure.
Academic Article Brain dynamics reflecting an intra-network brain state is associated with increased posttraumatic stress symptoms in the early aftermath of trauma.
Academic Article Sex Differences in Response Inhibition-Related Neural Predictors of Posttraumatic Stress Disorder in Civilians With Recent Trauma.
Academic Article Post-traumatic stress and future substance use outcomes: leveraging antecedent factors to stratify risk.
Academic Article Probing the neurocardiac circuit in trauma and posttraumatic stress.
Academic Article Intensive longitudinal assessment following index trauma to predict development of PTSD using machine learning.
Academic Article Sex-dependent differences in vulnerability to early risk factors for posttraumatic stress disorder: results from the AURORA study.
Academic Article Neighborhood Resources Associated With Psychological Trajectories and Neural Reactivity to Reward After Trauma.
Academic Article Reward Neurocircuitry Predicts Longitudinal Changes in Alcohol Use Following Trauma Exposure.
Academic Article Symptoms Six Weeks After COVID-19 Are Reduced Among US Health Care Personnel Receiving Additional Vaccine Doses During the Omicron Period, December 2021-April 2022.
Academic Article Disentangling sex differences in PTSD risk factors.
Academic Article Heart rate variability wrist-wearable biomarkers identify adverse posttraumatic neuropsychiatric sequelae after traumatic stress exposure.
Academic Article Executive Functioning and Processing Speed as Predictors of Global Cognitive Decline in Alzheimer Disease.
Academic Article Social Buffering of Posttraumatic Stress Disorder: Longitudinal Effects and Neural Mediators.
Academic Article Peritraumatic C-reactive protein levels predict pain outcomes following traumatic stress exposure in a sex-dependent manner.
Academic Article Basic Science and Pathogenesis.
Academic Article Basic Science and Pathogenesis.
Academic Article Basic Science and Pathogenesis.
Academic Article Clinical Manifestations.
Academic Article Multi-level socioeconomic modifiers of the comorbidity of post-traumatic stress and tobacco, alcohol, and cannabis use: the importance of income.
Academic Article Longitudinal Associations Between Peritraumatic Oestradiol and Fear Responding in Women and Men.
Academic Article Childhood adversity is associated with longitudinal white matter changes after adulthood trauma.
Academic Article Associations between residential segregation, ambient air pollution, and hippocampal features in recent trauma survivors.
Academic Article Understanding Onset, Dynamic Transitions, and Associated Inequality Risk Factors for Adverse Posttraumatic Neuropsychiatric Sequelae After Trauma Exposure.
Academic Article Sequential decreases in basolateral amygdala response to threat predict failure to recover from PTSD.
Academic Article Microbiome functional gene pathways predict cognitive performance in older adults with Alzheimer's disease.
Academic Article Smartphone language features may help identify adverse post-traumatic neuropsychiatric sequelae and their trajectories.
Academic Article Brain dynamics reflecting an intra-network brain state is associated with increased posttraumatic stress symptoms in the early aftermath of trauma.
Academic Article Associations between residential segregation, ambient air pollution, and hippocampal features in recent trauma survivors.
Academic Article Peritraumatic C-reactive protein levels predict pain outcomes following traumatic stress exposure in a sex-dependent manner.
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