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Gierasch, Lila

One or more keywords matched the following items that are connected to Gierasch, Lila

Item Type	Name
Academic Article	Molecular chaperones: clamps for the Clps?
Academic Article	Constrained peptides: models of bioactive peptides and protein substructures.
Academic Article	Renaturation of citrate synthase: influence of denaturant and folding assistants.
Academic Article	Dynamics of cellular retinoic acid binding protein I on multiple time scales with implications for ligand binding.
Academic Article	Mutating the charged residues in the binding pocket of cellular retinoic acid-binding protein simultaneously reduces its binding affinity to retinoic acid and increases its thermostability.
Academic Article	Keeping it in the family: folding studies of related proteins.
Academic Article	The cost of exposing a hydrophobic loop and implications for the functional role of 4.5 S RNA in the Escherichia coli signal recognition particle.
Academic Article	Caught in the act: how ATP binding triggers cooperative conformational changes in a molecular machine.
Academic Article	The LDL receptor clustering motif interacts with the clathrin terminal domain in a reverse turn conformation.
Academic Article	Solution conformations of two flexible cyclic pentapeptides: cyclo(Gly-Pro-D-Phe-Gly-Ala) and cyclo(Gly-Pro-D-Phe-Gly-Val).
Academic Article	Mutations in the substrate binding domain of the Escherichia coli 70 kDa molecular chaperone, DnaK, which alter substrate affinity or interdomain coupling.
Academic Article	Sequence and structural analysis of cellular retinoic acid-binding proteins reveals a network of conserved hydrophobic interactions.
Academic Article	Local sequence information in cellular retinoic acid-binding protein I: specific residue roles in beta-turns.
Academic Article	Unfolding dynamics of a beta-sheet protein studied by mass spectrometry.
Academic Article	Direct comparison of a stable isolated Hsp70 substrate-binding domain in the empty and substrate-bound states.
Academic Article	Evolutionary coupling of structural and functional sequence information in the intracellular lipid-binding protein family.
Academic Article	Structural insights into substrate binding by the molecular chaperone DnaK.
Academic Article	Design of biologically active, conformationally constrained GnRH antagonists.
Academic Article	Disorder breathes life into a DEAD motor.
Academic Article	The structure of Escherichia coli signal recognition particle revealed by scanning transmission electron microscopy.
Academic Article	From the test tube to the cell: exploring the folding and aggregation of a beta-clam protein.
Academic Article	Use of synthetic signal sequences to explore the protein export machinery.
Academic Article	Cyclic pentapeptides as models for reverse turns: determination of the equilibrium distribution between type I and type II conformations of Pro-Asn and Pro-Ala beta-turns.
Academic Article	Cross-strand split tetra-Cys motifs as structure sensors in a beta-sheet protein.
Academic Article	Sending signals dynamically.
Academic Article	Native structural propensity in cellular retinoic acid-binding protein I 64-88: the role of locally encoded structure in the folding of a beta-barrel protein.
Academic Article	Nuclear magnetic resonance analysis and conformational characterization of a cyclic decapeptide antagonist of gonadotropin-releasing hormone.
Academic Article	The NPXY internalization signal of the LDL receptor adopts a reverse-turn conformation.
Academic Article	Roles of beta-turns in protein folding: from peptide models to protein engineering.
Academic Article	Rett syndrome-causing mutations in human MeCP2 result in diverse structural changes that impact folding and DNA interactions.
Academic Article	The molecular dating game: an antibody heavy chain hangs loose with a chaperone while waiting for its life partner.
Academic Article	Unique physical properties and interactions of the domains of methylated DNA binding protein 2.
Academic Article	Dynamic local unfolding in the serpin a-1 antitrypsin provides a mechanism for loop insertion and polymerization.
Academic Article	Turns in peptides and proteins.
Academic Article	An interdomain energetic tug-of-war creates the allosterically active state in Hsp70 molecular chaperones.
Academic Article	How bacteria survive an acid trip.
Academic Article	The Role of Aromatic-Aromatic Interactions in Strand-Strand Stabilization of ?-Sheets.
Academic Article	Conformations of (X-L-Pro-Y)2 cyclic hexapeptides. Preferred beta-turn conformers and implications for beta turns in proteins.
Academic Article	Polypeptide interactions with molecular chaperones and their relationship to in vivo protein folding.
Academic Article	Conformational analysis of a highly potent dicyclic gonadotropin-releasing hormone antagonist by nuclear magnetic resonance and molecular dynamics.
Academic Article	Conformation of a heptapeptide substrate bound to protein farnesyltransferase.
Academic Article	The structure of Escherichia coli heat-stable enterotoxin b by nuclear magnetic resonance and circular dichroism.
Concept	Models, Molecular
Academic Article	Delicate balance between functionally required flexibility and aggregation risk in a ?-rich protein.
Academic Article	Comparing protein folding in vitro and in vivo: foldability meets the fitness challenge.
Academic Article	ATPase subdomain IA is a mediator of interdomain allostery in Hsp70 molecular chaperones.
Academic Article	Energy landscapes of functional proteins are inherently risky.
Academic Article	How hsp70 molecular machines interact with their substrates to mediate diverse physiological functions.
Academic Article	Substrate-binding domain conformational dynamics mediate Hsp70 allostery.
Academic Article	Ligand-promoted protein folding by biased kinetic partitioning.
Academic Article	Key features of an Hsp70 chaperone allosteric landscape revealed by ion-mobility native mass spectrometry and double electron-electron resonance.
Academic Article	Allosteric landscapes of eukaryotic cytoplasmic Hsp70s are shaped by evolutionary tuning of key interfaces.
Academic Article	Local and non-local topological information in the denatured state ensemble of a ?-barrel protein.
Academic Article	The Hsp70 interdomain linker is a dynamic switch that enables allosteric communication between two structured domains.
Academic Article	Kinetic versus thermodynamic control of mutational effects on protein homeostasis: A perspective from computational modeling and experiment.
Academic Article	Hsp70 molecular chaperones: multifunctional allosteric holding and unfolding machines.
Academic Article	Selective promiscuity in the binding of E. coli Hsp70 to an unfolded protein.
Academic Article	Computationally-Aided Modeling of Hsp70-Client Interactions: Past, Present, and Future.

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