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Gierasch, Lila

One or more keywords matched the following items that are connected to Gierasch, Lila

Item Type	Name
Academic Article	The crystal structure of the GroES co-chaperonin at 2.8 A resolution.
Academic Article	Intrinsic tryptophans of CRABPI as probes of structure and folding.
Academic Article	Orientations of helical peptides in membrane bilayers by solid state NMR spectroscopy.
Academic Article	Local interactions in a Schellman motif dictate interhelical arrangement in a protein fragment.
Academic Article	Cavity formation before stable hydrogen bonding in the folding of a beta-clam protein.
Academic Article	Molecular chaperones: clamps for the Clps?
Academic Article	Different conformations for the same polypeptide bound to chaperones DnaK and GroEL.
Academic Article	Biophysical studies of recognition sequences for targeting and folding.
Academic Article	Probing the folding pathway of a beta-clam protein with single-tryptophan constructs.
Academic Article	Combined use of molecular dynamics simulations and NMR to explore peptide bond isomerization and multiple intramolecular hydrogen-bonding possibilities in a cyclic pentapeptide, cyclo(Gly-Pro-D-Phe-Gly-Val).
Academic Article	Constrained peptides: models of bioactive peptides and protein substructures.
Academic Article	Basis of substrate binding by the chaperonin GroEL.
Academic Article	Renaturation of citrate synthase: influence of denaturant and folding assistants.
Academic Article	Dynamics of cellular retinoic acid binding protein I on multiple time scales with implications for ligand binding.
Academic Article	Mutating the charged residues in the binding pocket of cellular retinoic acid-binding protein simultaneously reduces its binding affinity to retinoic acid and increases its thermostability.
Academic Article	Signal peptides bind and aggregate RNA. An alternative explanation for GTPase inhibition in the signal recognition particle.
Academic Article	Keeping it in the family: folding studies of related proteins.
Academic Article	The cost of exposing a hydrophobic loop and implications for the functional role of 4.5 S RNA in the Escherichia coli signal recognition particle.
Academic Article	Caught in the act: how ATP binding triggers cooperative conformational changes in a molecular machine.
Academic Article	Domain interactions in E. coli SRP: stabilization of M domain by RNA is required for effective signal sequence modulation of NG domain.
Academic Article	The LDL receptor clustering motif interacts with the clathrin terminal domain in a reverse turn conformation.
Academic Article	Solution conformations of two flexible cyclic pentapeptides: cyclo(Gly-Pro-D-Phe-Gly-Ala) and cyclo(Gly-Pro-D-Phe-Gly-Val).
Academic Article	Impact of a micellar environment on the conformations of two cyclic pentapeptides.
Academic Article	Functionally significant mobile regions of Escherichia coli SecA ATPase identified by NMR.
Academic Article	Role of local sequence in the folding of cellular retinoic abinding protein I: structural propensities of reverse turns.
Academic Article	Dependence of endoplasmic reticulum-associated degradation on the peptide binding domain and concentration of BiP.
Academic Article	Mutations in the substrate binding domain of the Escherichia coli 70 kDa molecular chaperone, DnaK, which alter substrate affinity or interdomain coupling.
Academic Article	Sequence and structural analysis of cellular retinoic acid-binding proteins reveals a network of conserved hydrophobic interactions.
Academic Article	A peptide corresponding to an export-defective mutant OmpA signal sequence with asparagine in the hydrophobic core is unable to insert into model membranes.
Academic Article	Local sequence information in cellular retinoic acid-binding protein I: specific residue roles in beta-turns.
Academic Article	Recognition of nascent polypeptides for targeting and folding.
Academic Article	Nucleotide exchange from the high-affinity ATP-binding site in SecA is the rate-limiting step in the ATPase cycle of the soluble enzyme and occurs through a specialized conformational state.
Academic Article	Unfolding dynamics of a beta-sheet protein studied by mass spectrometry.
Academic Article	Sequence requirement for peptide recognition by rat brain p21ras protein farnesyltransferase.
Academic Article	First glimpses of a chaperonin-bound folding intermediate.
Academic Article	GroEL-substrate interactions: molding the fold, or folding the mold?
Academic Article	Direct comparison of a stable isolated Hsp70 substrate-binding domain in the empty and substrate-bound states.
Academic Article	Evolutionary coupling of structural and functional sequence information in the intracellular lipid-binding protein family.
Academic Article	Extended polyglutamine tracts cause aggregation and structural perturbation of an adjacent beta barrel protein.
Academic Article	Structural insights into substrate binding by the molecular chaperone DnaK.
Academic Article	Design of biologically active, conformationally constrained GnRH antagonists.
Academic Article	Disorder breathes life into a DEAD motor.
Academic Article	Multiple roles of prolyl residues in structure and folding.
Academic Article	The structure of Escherichia coli signal recognition particle revealed by scanning transmission electron microscopy.
Academic Article	From the test tube to the cell: exploring the folding and aggregation of a beta-clam protein.
Academic Article	Functional signal peptides bind a soluble N-terminal fragment of SecA and inhibit its ATPase activity.
Academic Article	Biophysical studies of signal peptides: implications for signal sequence functions and the involvement of lipid in protein export.
Academic Article	Use of synthetic signal sequences to explore the protein export machinery.
Academic Article	Cyclic pentapeptides as models for reverse turns: determination of the equilibrium distribution between type I and type II conformations of Pro-Asn and Pro-Ala beta-turns.
Academic Article	Cross-strand split tetra-Cys motifs as structure sensors in a beta-sheet protein.
Academic Article	Comparison of helix stability in wild-type and mutant LamB signal sequences.
Academic Article	Defining the structure of the substrate-free state of the DnaK molecular chaperone.
Academic Article	Exploring the interactions between signal sequences and E. coli SRP by two distinct and complementary crosslinking methods.
Academic Article	Sending signals dynamically.
Academic Article	Nature's molecular sponges: small heat shock proteins grow into their chaperone roles.
Academic Article	T-cell antigenic peptides from sperm whale myoglobin fold as amphipathic helices: a possible determinant for immunodominance?
Academic Article	The chaperonin GroEL binds a polypeptide in an alpha-helical conformation.
Academic Article	Segmental isotopic labeling of the Hsp70 molecular chaperone DnaK using expressed protein ligation.
Academic Article	Protein folding in the cell: challenges and progress.
Academic Article	Signal sequences.
Academic Article	A career pathway in protein folding: from model peptides to postreductionist protein science.
Academic Article	Allosteric signal transmission in the nucleotide-binding domain of 70-kDa heat shock protein (Hsp70) molecular chaperones.
Academic Article	FoldEco: a model for proteostasis in E. coli.
Academic Article	A new twist for an Hsp70 chaperone.
Academic Article	Mapping the signal sequence-binding site on SRP reveals a significant role for the NG domain.
Academic Article	Phospholipid-induced monomerization and signal-peptide-induced oligomerization of SecA.
Academic Article	Native structural propensity in cellular retinoic acid-binding protein I 64-88: the role of locally encoded structure in the folding of a beta-barrel protein.
Academic Article	Nuclear magnetic resonance analysis and conformational characterization of a cyclic decapeptide antagonist of gonadotropin-releasing hormone.
Academic Article	The NPXY internalization signal of the LDL receptor adopts a reverse-turn conformation.
Academic Article	Molecular mechanisms of protein secretion: the role of the signal sequence.
Academic Article	Dynamics of a hydrophobic peptide in membrane bilayers by solid-state nuclear magnetic resonance.
Academic Article	Dehydrophenylalanine can occur in various reverse-turn sites: conformational analysis of delta Phe-containing model peptides.
Academic Article	Conformation-function relationships in hydrophobic peptides: interior turns and signal sequences.
Academic Article	Interaction of peptides corresponding to mitochondrial presequences with membranes.
Academic Article	Exploring the conformational roles of signal sequences: synthesis and conformational analysis of lambda receptor protein wild-type and mutant signal peptides.
Academic Article	Monitoring protein stability and aggregation in vivo by real-time fluorescent labeling.
Academic Article	Conformations of model peptides in membrane-mimetic environments.
Academic Article	Nonfarnesylated tetrapeptide inhibitors of protein farnesyltransferase.
Academic Article	1H and 15N resonance assignments and secondary structure of cellular retinoic acid-binding protein with and without bound ligand.
Academic Article	Effect of charged residue substitutions on the membrane-interactive properties of signal sequences of the Escherichia coli LamB protein.
Academic Article	Effect of charged residue substitutions on the thermodynamics of signal peptide-lipid interactions for the Escherichia coli LamB signal sequence.
Academic Article	Reorganization of lipid domain structure in membranes by a transmembrane peptide: an ESR spin label study on the effect of the Escherichia coli outer membrane protein A signal peptide on the fluid lipid domain connectivity in binary mixtures of dimyristoyl phosphatidylcholine and distearoyl phosphatidylcholine.
Academic Article	GTP binding and hydrolysis by the signal recognition particle during initiation of protein translocation.
Academic Article	Membrane-bound conformation of a signal peptide: a transferred nuclear Overhauser effect analysis.
Academic Article	Equilibrium folding studies of cellular retinoic acid binding protein, a predominantly beta-sheet protein.
Academic Article	Conformational behavior of Escherichia coli OmpA signal peptides in membrane mimetic environments.
Academic Article	Side chain-backbone hydrogen bonding contributes to helix stability in peptides derived from an alpha-helical region of carboxypeptidase A.
Academic Article	Hydrophobic content and lipid interactions of wild-type and mutant OmpA signal peptides correlate with their in vivo function.
Academic Article	A well-defined amphipathic conformation for the calcium-free cyclic lipopeptide antibiotic, daptomycin, in aqueous solution.
Academic Article	Aggregation of a slow-folding mutant of a beta-clam protein proceeds through a monomeric nucleus.
Academic Article	The conformation of a signal peptide bound by Escherichia coli preprotein translocase SecA.
Academic Article	Finding the fittest fold: using the evolutionary record to design new proteins.
Academic Article	Natural polypeptide scaffolds: beta-sheets, beta-turns, and beta-hairpins.
Academic Article	The changing landscape of protein allostery.
Academic Article	Fluorescence analysis of tryptophan-containing variants of the LamB signal sequence upon insertion into a lipid bilayer.
Academic Article	Conformational and membrane-binding properties of a signal sequence are largely unaltered by its adjacent mature region.
Academic Article	Synthesis and crystal structures of Boc-L-Asn-L-Pro-OBzl.CH3OH and dehydration side product, Boc-beta-cyano-L-alanine-L-Pro-OBzl.
Academic Article	Inhibition of protein aggregation in vitro and in vivo by a natural osmoprotectant.
Academic Article	Reduced tendency to form a beta turn in peptides from the P22 tailspike protein correlates with a temperature-sensitive folding defect.
Academic Article	Hsp70 chaperone ligands control domain association via an allosteric mechanism mediated by the interdomain linker.
Academic Article	Electrophysiological studies in Xenopus oocytes for the opening of Escherichia coli SecA-dependent protein-conducting channels.
Academic Article	Effects of osmolytes on protein folding and aggregation in cells.
Academic Article	In-cell aggregation of a polyglutamine-containing chimera is a multistep process initiated by the flanking sequence.
Academic Article	Roles of beta-turns in protein folding: from peptide models to protein engineering.
Academic Article	Orthogonal cross-seeding: an approach to explore protein aggregates in living cells.
Academic Article	Rett syndrome-causing mutations in human MeCP2 result in diverse structural changes that impact folding and DNA interactions.
Academic Article	Chapter 3: A fluorescent window into protein folding and aggregation in cells.
Academic Article	A method for direct measurement of protein stability in vivo.
Academic Article	The molecular dating game: an antibody heavy chain hangs loose with a chaperone while waiting for its life partner.
Academic Article	Post-reductionist protein science, or putting Humpty Dumpty back together again.
Academic Article	Conformations and orientations of a signal peptide interacting with phospholipid monolayers.
Academic Article	Unique physical properties and interactions of the domains of methylated DNA binding protein 2.
Academic Article	Macromolecular crowding remodels the energy landscape of a protein by favoring a more compact unfolded state.
Academic Article	Role of Hsp70 ATPase domain intrinsic dynamics and sequence evolution in enabling its functional interactions with NEFs.
Academic Article	An interdomain sector mediating allostery in Hsp70 molecular chaperones.
Academic Article	Helix formation and stability in a signal sequence.
Academic Article	How one bad protein spoils the barrel: structural details of ?2-microglobulin amyloidogenicity.
Academic Article	Dynamic local unfolding in the serpin a-1 antitrypsin provides a mechanism for loop insertion and polymerization.
Academic Article	Functional and nonfunctional LamB signal sequences can be distinguished by their biophysical properties.
Academic Article	Conserved, disordered C terminus of DnaK enhances cellular survival upon stress and DnaK in vitro chaperone activity.
Academic Article	Exploring weak, transient protein--protein interactions in crowded in vivo environments by in-cell nuclear magnetic resonance spectroscopy.
Academic Article	Using a low denaturant model to explore the conformational features of translocation-active SecA.
Academic Article	Turns in peptides and proteins.
Academic Article	An interdomain energetic tug-of-war creates the allosterically active state in Hsp70 molecular chaperones.
Academic Article	Conformations of signal peptides induced by lipids suggest initial steps in protein export.
Academic Article	Early folding events protect aggregation-prone regions of a ?-rich protein.
Academic Article	How bacteria survive an acid trip.
Academic Article	The Role of Aromatic-Aromatic Interactions in Strand-Strand Stabilization of ?-Sheets.
Academic Article	In vivo function and membrane binding properties are correlated for Escherichia coli lamB signal peptides.
Academic Article	Protein translocation into Escherichia coli membrane vesicles is inhibited by functional synthetic signal peptides.
Academic Article	Conformations of (X-L-Pro-Y)2 cyclic hexapeptides. Preferred beta-turn conformers and implications for beta turns in proteins.
Academic Article	Polypeptide interactions with molecular chaperones and their relationship to in vivo protein folding.
Academic Article	Molecular chaperones. Panning for chaperone-binding peptides.
Academic Article	Characterization of a functionally important mobile domain of GroES.
Academic Article	Conformational analysis of a highly potent dicyclic gonadotropin-releasing hormone antagonist by nuclear magnetic resonance and molecular dynamics.
Academic Article	Conformation of a heptapeptide substrate bound to protein farnesyltransferase.
Academic Article	The structure of Escherichia coli heat-stable enterotoxin b by nuclear magnetic resonance and circular dichroism.
Concept	Protein Binding
Concept	Protein Subunits
Concept	Protein Transport
Concept	Protein Folding
Concept	Protein Processing, Post-Translational
Concept	Adaptor Protein Complex alpha Subunits
Concept	Adaptor Protein Complex 2
Concept	Protein Biosynthesis
Concept	Methyl-CpG-Binding Protein 2
Concept	Protein Precursors
Concept	Protein Interaction Domains and Motifs
Concept	Protein Denaturation
Concept	Protein Structure, Secondary
Concept	Protein Structure, Tertiary
Concept	Protein Multimerization
Concept	Protein Stability
Concept	Protein Structure, Quaternary
Concept	Myelin Basic Protein
Concept	Protein Sorting Signals
Concept	Myelin P2 Protein
Concept	Protein Conformation
Concept	Databases, Protein
Concept	Sequence Analysis, Protein
Concept	Protein Engineering
Academic Article	Delicate balance between functionally required flexibility and aggregation risk in a ?-rich protein.
Academic Article	Comparing protein folding in vitro and in vivo: foldability meets the fitness challenge.
Academic Article	ATPase subdomain IA is a mediator of interdomain allostery in Hsp70 molecular chaperones.
Academic Article	Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs).
Academic Article	Energy landscapes of functional proteins are inherently risky.
Academic Article	Challenges and dreams: physics of weak interactions essential to life.
Academic Article	How hsp70 molecular machines interact with their substrates to mediate diverse physiological functions.
Academic Article	Individual and collective contributions of chaperoning and degradation to protein homeostasis in E. coli.
Academic Article	Substrate-binding domain conformational dynamics mediate Hsp70 allostery.
Academic Article	Its preferential interactions with biopolymers account for diverse observed effects of trehalose.
Academic Article	Cellular folding pathway of a metastable serpin.
Academic Article	Ligand-promoted protein folding by biased kinetic partitioning.
Academic Article	Key features of an Hsp70 chaperone allosteric landscape revealed by ion-mobility native mass spectrometry and double electron-electron resonance.
Academic Article	Recent advances in the structural and mechanistic aspects of Hsp70 molecular chaperones.
Academic Article	Allosteric landscapes of eukaryotic cytoplasmic Hsp70s are shaped by evolutionary tuning of key interfaces.
Academic Article	Local and non-local topological information in the denatured state ensemble of a ?-barrel protein.
Academic Article	The Hsp70 interdomain linker is a dynamic switch that enables allosteric communication between two structured domains.
Academic Article	Kinetic versus thermodynamic control of mutational effects on protein homeostasis: A perspective from computational modeling and experiment.
Academic Article	Hsp70 molecular chaperones: multifunctional allosteric holding and unfolding machines.
Academic Article	Erratum to "Kinetic versus thermodynamic control of mutational effects on protein homeostasis: A perspective from computational modeling and experiment".
Academic Article	How the Protein Data Bank changed biology: An introduction to the JBC Reviews thematic series, part 1.
Academic Article	How the Protein Data Bank changed biology: An introduction to the JBC Reviews thematic series, part 2.
Academic Article	The Proteome Folding Problem and Cellular Proteostasis.
Academic Article	Selective promiscuity in the binding of E. coli Hsp70 to an unfolded protein.
Academic Article	Physics-based modeling provides predictive understanding of selectively promiscuous substrate binding by Hsp70 chaperones.
Concept	Huntingtin Protein
Concept	Protein Domains
Concept	Protein Unfolding
Concept	Protein Interaction Maps
Concept	Protein Aggregation, Pathological
Concept	Protein Aggregates
Academic Article	There are more Hsp90 chaperone mechanisms in heaven and earth, dear reader, than are dreamt of in your philosophy.
Academic Article	Computationally-Aided Modeling of Hsp70-Client Interactions: Past, Present, and Future.
Academic Article	ER chaperones use a protein folding and quality control glyco-code.
Academic Article	New insights into the structure and function of the complex?between the Escherichia coli Hsp70, DnaK, and its nucleotide-exchange factor, GrpE.
Academic Article	Insights into the interaction between UGGT, the gatekeeper of folding in the ER, and its partner, the selenoprotein SEP15.
Academic Article	The Hsc70 system maintains the synaptic SNARE protein SNAP-25 in an assembly-competent state and delays its aggregation.

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