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Search Results to Lila M Gierasch Ph.D.

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One or more keywords matched the following items that are connected to Gierasch, Lila

Item TypeName
Academic Article The crystal structure of the GroES co-chaperonin at 2.8 A resolution.
Academic Article Intrinsic tryptophans of CRABPI as probes of structure and folding.
Academic Article Orientations of helical peptides in membrane bilayers by solid state NMR spectroscopy.
Academic Article Local interactions in a Schellman motif dictate interhelical arrangement in a protein fragment.
Academic Article Cavity formation before stable hydrogen bonding in the folding of a beta-clam protein.
Academic Article Molecular chaperones: clamps for the Clps?
Academic Article Different conformations for the same polypeptide bound to chaperones DnaK and GroEL.
Academic Article Biophysical studies of recognition sequences for targeting and folding.
Academic Article Probing the folding pathway of a beta-clam protein with single-tryptophan constructs.
Academic Article Combined use of molecular dynamics simulations and NMR to explore peptide bond isomerization and multiple intramolecular hydrogen-bonding possibilities in a cyclic pentapeptide, cyclo(Gly-Pro-D-Phe-Gly-Val).
Academic Article Constrained peptides: models of bioactive peptides and protein substructures.
Academic Article Basis of substrate binding by the chaperonin GroEL.
Academic Article Renaturation of citrate synthase: influence of denaturant and folding assistants.
Academic Article Dynamics of cellular retinoic acid binding protein I on multiple time scales with implications for ligand binding.
Academic Article Mutating the charged residues in the binding pocket of cellular retinoic acid-binding protein simultaneously reduces its binding affinity to retinoic acid and increases its thermostability.
Academic Article Signal peptides bind and aggregate RNA. An alternative explanation for GTPase inhibition in the signal recognition particle.
Academic Article Keeping it in the family: folding studies of related proteins.
Academic Article The cost of exposing a hydrophobic loop and implications for the functional role of 4.5 S RNA in the Escherichia coli signal recognition particle.
Academic Article Caught in the act: how ATP binding triggers cooperative conformational changes in a molecular machine.
Academic Article Domain interactions in E. coli SRP: stabilization of M domain by RNA is required for effective signal sequence modulation of NG domain.
Academic Article The LDL receptor clustering motif interacts with the clathrin terminal domain in a reverse turn conformation.
Academic Article Solution conformations of two flexible cyclic pentapeptides: cyclo(Gly-Pro-D-Phe-Gly-Ala) and cyclo(Gly-Pro-D-Phe-Gly-Val).
Academic Article Impact of a micellar environment on the conformations of two cyclic pentapeptides.
Academic Article Functionally significant mobile regions of Escherichia coli SecA ATPase identified by NMR.
Academic Article Role of local sequence in the folding of cellular retinoic abinding protein I: structural propensities of reverse turns.
Academic Article Dependence of endoplasmic reticulum-associated degradation on the peptide binding domain and concentration of BiP.
Academic Article Mutations in the substrate binding domain of the Escherichia coli 70 kDa molecular chaperone, DnaK, which alter substrate affinity or interdomain coupling.
Academic Article Sequence and structural analysis of cellular retinoic acid-binding proteins reveals a network of conserved hydrophobic interactions.
Academic Article A peptide corresponding to an export-defective mutant OmpA signal sequence with asparagine in the hydrophobic core is unable to insert into model membranes.
Academic Article Local sequence information in cellular retinoic acid-binding protein I: specific residue roles in beta-turns.
Academic Article Recognition of nascent polypeptides for targeting and folding.
Academic Article Nucleotide exchange from the high-affinity ATP-binding site in SecA is the rate-limiting step in the ATPase cycle of the soluble enzyme and occurs through a specialized conformational state.
Academic Article Unfolding dynamics of a beta-sheet protein studied by mass spectrometry.
Academic Article Sequence requirement for peptide recognition by rat brain p21ras protein farnesyltransferase.
Academic Article First glimpses of a chaperonin-bound folding intermediate.
Academic Article GroEL-substrate interactions: molding the fold, or folding the mold?
Academic Article Direct comparison of a stable isolated Hsp70 substrate-binding domain in the empty and substrate-bound states.
Academic Article Evolutionary coupling of structural and functional sequence information in the intracellular lipid-binding protein family.
Academic Article Extended polyglutamine tracts cause aggregation and structural perturbation of an adjacent beta barrel protein.
Academic Article Structural insights into substrate binding by the molecular chaperone DnaK.
Academic Article Design of biologically active, conformationally constrained GnRH antagonists.
Academic Article Disorder breathes life into a DEAD motor.
Academic Article Multiple roles of prolyl residues in structure and folding.
Academic Article The structure of Escherichia coli signal recognition particle revealed by scanning transmission electron microscopy.
Academic Article From the test tube to the cell: exploring the folding and aggregation of a beta-clam protein.
Academic Article Functional signal peptides bind a soluble N-terminal fragment of SecA and inhibit its ATPase activity.
Academic Article Biophysical studies of signal peptides: implications for signal sequence functions and the involvement of lipid in protein export.
Academic Article Use of synthetic signal sequences to explore the protein export machinery.
Academic Article Cyclic pentapeptides as models for reverse turns: determination of the equilibrium distribution between type I and type II conformations of Pro-Asn and Pro-Ala beta-turns.
Academic Article Cross-strand split tetra-Cys motifs as structure sensors in a beta-sheet protein.
Academic Article Comparison of helix stability in wild-type and mutant LamB signal sequences.
Academic Article Defining the structure of the substrate-free state of the DnaK molecular chaperone.
Academic Article Exploring the interactions between signal sequences and E. coli SRP by two distinct and complementary crosslinking methods.
Academic Article Sending signals dynamically.
Academic Article Nature's molecular sponges: small heat shock proteins grow into their chaperone roles.
Academic Article T-cell antigenic peptides from sperm whale myoglobin fold as amphipathic helices: a possible determinant for immunodominance?
Academic Article The chaperonin GroEL binds a polypeptide in an alpha-helical conformation.
Academic Article Segmental isotopic labeling of the Hsp70 molecular chaperone DnaK using expressed protein ligation.
Academic Article Protein folding in the cell: challenges and progress.
Academic Article Signal sequences.
Academic Article A career pathway in protein folding: from model peptides to postreductionist protein science.
Academic Article Allosteric signal transmission in the nucleotide-binding domain of 70-kDa heat shock protein (Hsp70) molecular chaperones.
Academic Article FoldEco: a model for proteostasis in E. coli.
Academic Article A new twist for an Hsp70 chaperone.
Academic Article Mapping the signal sequence-binding site on SRP reveals a significant role for the NG domain.
Academic Article Phospholipid-induced monomerization and signal-peptide-induced oligomerization of SecA.
Academic Article Native structural propensity in cellular retinoic acid-binding protein I 64-88: the role of locally encoded structure in the folding of a beta-barrel protein.
Academic Article Nuclear magnetic resonance analysis and conformational characterization of a cyclic decapeptide antagonist of gonadotropin-releasing hormone.
Academic Article The NPXY internalization signal of the LDL receptor adopts a reverse-turn conformation.
Academic Article Molecular mechanisms of protein secretion: the role of the signal sequence.
Academic Article Dynamics of a hydrophobic peptide in membrane bilayers by solid-state nuclear magnetic resonance.
Academic Article Dehydrophenylalanine can occur in various reverse-turn sites: conformational analysis of delta Phe-containing model peptides.
Academic Article Conformation-function relationships in hydrophobic peptides: interior turns and signal sequences.
Academic Article Interaction of peptides corresponding to mitochondrial presequences with membranes.
Academic Article Exploring the conformational roles of signal sequences: synthesis and conformational analysis of lambda receptor protein wild-type and mutant signal peptides.
Academic Article Monitoring protein stability and aggregation in vivo by real-time fluorescent labeling.
Academic Article Conformations of model peptides in membrane-mimetic environments.
Academic Article Nonfarnesylated tetrapeptide inhibitors of protein farnesyltransferase.
Academic Article 1H and 15N resonance assignments and secondary structure of cellular retinoic acid-binding protein with and without bound ligand.
Academic Article Effect of charged residue substitutions on the membrane-interactive properties of signal sequences of the Escherichia coli LamB protein.
Academic Article Effect of charged residue substitutions on the thermodynamics of signal peptide-lipid interactions for the Escherichia coli LamB signal sequence.
Academic Article Reorganization of lipid domain structure in membranes by a transmembrane peptide: an ESR spin label study on the effect of the Escherichia coli outer membrane protein A signal peptide on the fluid lipid domain connectivity in binary mixtures of dimyristoyl phosphatidylcholine and distearoyl phosphatidylcholine.
Academic Article GTP binding and hydrolysis by the signal recognition particle during initiation of protein translocation.
Academic Article Membrane-bound conformation of a signal peptide: a transferred nuclear Overhauser effect analysis.
Academic Article Equilibrium folding studies of cellular retinoic acid binding protein, a predominantly beta-sheet protein.
Academic Article Conformational behavior of Escherichia coli OmpA signal peptides in membrane mimetic environments.
Academic Article Side chain-backbone hydrogen bonding contributes to helix stability in peptides derived from an alpha-helical region of carboxypeptidase A.
Academic Article Hydrophobic content and lipid interactions of wild-type and mutant OmpA signal peptides correlate with their in vivo function.
Academic Article A well-defined amphipathic conformation for the calcium-free cyclic lipopeptide antibiotic, daptomycin, in aqueous solution.
Academic Article Aggregation of a slow-folding mutant of a beta-clam protein proceeds through a monomeric nucleus.
Academic Article The conformation of a signal peptide bound by Escherichia coli preprotein translocase SecA.
Academic Article Finding the fittest fold: using the evolutionary record to design new proteins.
Academic Article Natural polypeptide scaffolds: beta-sheets, beta-turns, and beta-hairpins.
Academic Article The changing landscape of protein allostery.
Academic Article Fluorescence analysis of tryptophan-containing variants of the LamB signal sequence upon insertion into a lipid bilayer.
Academic Article Conformational and membrane-binding properties of a signal sequence are largely unaltered by its adjacent mature region.
Academic Article Synthesis and crystal structures of Boc-L-Asn-L-Pro-OBzl.CH3OH and dehydration side product, Boc-beta-cyano-L-alanine-L-Pro-OBzl.
Academic Article Inhibition of protein aggregation in vitro and in vivo by a natural osmoprotectant.
Academic Article Reduced tendency to form a beta turn in peptides from the P22 tailspike protein correlates with a temperature-sensitive folding defect.
Academic Article Hsp70 chaperone ligands control domain association via an allosteric mechanism mediated by the interdomain linker.
Academic Article Electrophysiological studies in Xenopus oocytes for the opening of Escherichia coli SecA-dependent protein-conducting channels.
Academic Article Effects of osmolytes on protein folding and aggregation in cells.
Academic Article In-cell aggregation of a polyglutamine-containing chimera is a multistep process initiated by the flanking sequence.
Academic Article Roles of beta-turns in protein folding: from peptide models to protein engineering.
Academic Article Orthogonal cross-seeding: an approach to explore protein aggregates in living cells.
Academic Article Rett syndrome-causing mutations in human MeCP2 result in diverse structural changes that impact folding and DNA interactions.
Academic Article Chapter 3: A fluorescent window into protein folding and aggregation in cells.
Academic Article A method for direct measurement of protein stability in vivo.
Academic Article The molecular dating game: an antibody heavy chain hangs loose with a chaperone while waiting for its life partner.
Academic Article Post-reductionist protein science, or putting Humpty Dumpty back together again.
Academic Article Conformations and orientations of a signal peptide interacting with phospholipid monolayers.
Academic Article Unique physical properties and interactions of the domains of methylated DNA binding protein 2.
Academic Article Macromolecular crowding remodels the energy landscape of a protein by favoring a more compact unfolded state.
Academic Article Role of Hsp70 ATPase domain intrinsic dynamics and sequence evolution in enabling its functional interactions with NEFs.
Academic Article An interdomain sector mediating allostery in Hsp70 molecular chaperones.
Academic Article Helix formation and stability in a signal sequence.
Academic Article How one bad protein spoils the barrel: structural details of ß2-microglobulin amyloidogenicity.
Academic Article Dynamic local unfolding in the serpin a-1 antitrypsin provides a mechanism for loop insertion and polymerization.
Academic Article Functional and nonfunctional LamB signal sequences can be distinguished by their biophysical properties.
Academic Article Conserved, disordered C terminus of DnaK enhances cellular survival upon stress and DnaK in vitro chaperone activity.
Academic Article Exploring weak, transient protein--protein interactions in crowded in vivo environments by in-cell nuclear magnetic resonance spectroscopy.
Academic Article Using a low denaturant model to explore the conformational features of translocation-active SecA.
Academic Article Turns in peptides and proteins.
Academic Article An interdomain energetic tug-of-war creates the allosterically active state in Hsp70 molecular chaperones.
Academic Article Conformations of signal peptides induced by lipids suggest initial steps in protein export.
Academic Article Early folding events protect aggregation-prone regions of a ß-rich protein.
Academic Article How bacteria survive an acid trip.
Academic Article The Role of Aromatic-Aromatic Interactions in Strand-Strand Stabilization of ß-Sheets.
Academic Article In vivo function and membrane binding properties are correlated for Escherichia coli lamB signal peptides.
Academic Article Protein translocation into Escherichia coli membrane vesicles is inhibited by functional synthetic signal peptides.
Academic Article Conformations of (X-L-Pro-Y)2 cyclic hexapeptides. Preferred beta-turn conformers and implications for beta turns in proteins.
Academic Article Polypeptide interactions with molecular chaperones and their relationship to in vivo protein folding.
Academic Article Molecular chaperones. Panning for chaperone-binding peptides.
Academic Article Characterization of a functionally important mobile domain of GroES.
Academic Article Conformational analysis of a highly potent dicyclic gonadotropin-releasing hormone antagonist by nuclear magnetic resonance and molecular dynamics.
Academic Article Conformation of a heptapeptide substrate bound to protein farnesyltransferase.
Academic Article The structure of Escherichia coli heat-stable enterotoxin b by nuclear magnetic resonance and circular dichroism.
Concept Protein Binding
Concept Protein Subunits
Concept Protein Transport
Concept Protein Folding
Concept Protein Processing, Post-Translational
Concept Adaptor Protein Complex alpha Subunits
Concept Adaptor Protein Complex 2
Concept Protein Biosynthesis
Concept Methyl-CpG-Binding Protein 2
Concept Protein Precursors
Concept Protein Interaction Domains and Motifs
Concept Protein Denaturation
Concept Protein Structure, Secondary
Concept Protein Structure, Tertiary
Concept Protein Multimerization
Concept Protein Stability
Concept Protein Structure, Quaternary
Concept Protein Sorting Signals
Concept Myelin P2 Protein
Concept Protein Conformation
Concept Sequence Analysis, Protein
Concept Protein Engineering
Academic Article Delicate balance between functionally required flexibility and aggregation risk in a ß-rich protein.
Academic Article Comparing protein folding in vitro and in vivo: foldability meets the fitness challenge.
Academic Article ATPase subdomain IA is a mediator of interdomain allostery in Hsp70 molecular chaperones.
Academic Article Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs).
Academic Article Energy landscapes of functional proteins are inherently risky.
Academic Article Challenges and dreams: physics of weak interactions essential to life.
Academic Article How hsp70 molecular machines interact with their substrates to mediate diverse physiological functions.
Academic Article Individual and collective contributions of chaperoning and degradation to protein homeostasis in E. coli.
Academic Article Substrate-binding domain conformational dynamics mediate Hsp70 allostery.
Academic Article Its preferential interactions with biopolymers account for diverse observed effects of trehalose.
Academic Article Ligand-promoted protein folding by biased kinetic partitioning.
Academic Article Local and non-local topological information in the denatured state ensemble of a ß-barrel protein.
Academic Article The Hsp70 interdomain linker is a dynamic switch that enables allosteric communication between two structured domains.
Academic Article Kinetic vs. Thermodynamic Control of Mutational Effects on Protein Homeostasis: A Perspective from Computational Modeling and Experiment.

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