| Item Type | Name |
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Academic Article
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Intrinsic tryptophans of CRABPI as probes of structure and folding.
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Academic Article
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Orientations of helical peptides in membrane bilayers by solid state NMR spectroscopy.
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Academic Article
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Molecular chaperones: clamps for the Clps?
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Academic Article
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Different conformations for the same polypeptide bound to chaperones DnaK and GroEL.
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Academic Article
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Biophysical studies of recognition sequences for targeting and folding.
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Academic Article
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Constrained peptides: models of bioactive peptides and protein substructures.
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Academic Article
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Basis of substrate binding by the chaperonin GroEL.
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Academic Article
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Renaturation of citrate synthase: influence of denaturant and folding assistants.
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Academic Article
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Mutating the charged residues in the binding pocket of cellular retinoic acid-binding protein simultaneously reduces its binding affinity to retinoic acid and increases its thermostability.
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Academic Article
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Keeping it in the family: folding studies of related proteins.
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Academic Article
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The cost of exposing a hydrophobic loop and implications for the functional role of 4.5 S RNA in the Escherichia coli signal recognition particle.
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Academic Article
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Caught in the act: how ATP binding triggers cooperative conformational changes in a molecular machine.
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Academic Article
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Domain interactions in E. coli SRP: stabilization of M domain by RNA is required for effective signal sequence modulation of NG domain.
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Academic Article
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The LDL receptor clustering motif interacts with the clathrin terminal domain in a reverse turn conformation.
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Academic Article
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Dependence of endoplasmic reticulum-associated degradation on the peptide binding domain and concentration of BiP.
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Academic Article
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Mutations in the substrate binding domain of the Escherichia coli 70 kDa molecular chaperone, DnaK, which alter substrate affinity or interdomain coupling.
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Academic Article
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Sequence and structural analysis of cellular retinoic acid-binding proteins reveals a network of conserved hydrophobic interactions.
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Academic Article
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A peptide corresponding to an export-defective mutant OmpA signal sequence with asparagine in the hydrophobic core is unable to insert into model membranes.
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Academic Article
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Recognition of nascent polypeptides for targeting and folding.
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Academic Article
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Nucleotide exchange from the high-affinity ATP-binding site in SecA is the rate-limiting step in the ATPase cycle of the soluble enzyme and occurs through a specialized conformational state.
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Academic Article
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First glimpses of a chaperonin-bound folding intermediate.
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Academic Article
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Direct comparison of a stable isolated Hsp70 substrate-binding domain in the empty and substrate-bound states.
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Academic Article
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Evolutionary coupling of structural and functional sequence information in the intracellular lipid-binding protein family.
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Academic Article
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Extended polyglutamine tracts cause aggregation and structural perturbation of an adjacent beta barrel protein.
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Academic Article
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Structural insights into substrate binding by the molecular chaperone DnaK.
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Academic Article
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Design of biologically active, conformationally constrained GnRH antagonists.
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Academic Article
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Disorder breathes life into a DEAD motor.
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Academic Article
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From the test tube to the cell: exploring the folding and aggregation of a beta-clam protein.
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Academic Article
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Functional signal peptides bind a soluble N-terminal fragment of SecA and inhibit its ATPase activity.
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Academic Article
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Biophysical studies of signal peptides: implications for signal sequence functions and the involvement of lipid in protein export.
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Academic Article
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Use of synthetic signal sequences to explore the protein export machinery.
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Academic Article
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Comparison of helix stability in wild-type and mutant LamB signal sequences.
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Academic Article
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Exploring the interactions between signal sequences and E. coli SRP by two distinct and complementary crosslinking methods.
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Academic Article
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Sending signals dynamically.
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Academic Article
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Nature's molecular sponges: small heat shock proteins grow into their chaperone roles.
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Academic Article
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The chaperonin GroEL binds a polypeptide in an alpha-helical conformation.
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Academic Article
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Segmental isotopic labeling of the Hsp70 molecular chaperone DnaK using expressed protein ligation.
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Academic Article
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Protein folding in the cell: challenges and progress.
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Academic Article
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A career pathway in protein folding: from model peptides to postreductionist protein science.
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Academic Article
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Allosteric signal transmission in the nucleotide-binding domain of 70-kDa heat shock protein (Hsp70) molecular chaperones.
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Academic Article
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FoldEco: a model for proteostasis in E. coli.
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Academic Article
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A new twist for an Hsp70 chaperone.
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Academic Article
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The NPXY internalization signal of the LDL receptor adopts a reverse-turn conformation.
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Academic Article
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Molecular mechanisms of protein secretion: the role of the signal sequence.
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Academic Article
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Exploring the conformational roles of signal sequences: synthesis and conformational analysis of lambda receptor protein wild-type and mutant signal peptides.
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Academic Article
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Interior turns in globular proteins.
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Academic Article
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Monitoring protein stability and aggregation in vivo by real-time fluorescent labeling.
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Academic Article
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Effect of charged residue substitutions on the membrane-interactive properties of signal sequences of the Escherichia coli LamB protein.
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Academic Article
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Effect of charged residue substitutions on the thermodynamics of signal peptide-lipid interactions for the Escherichia coli LamB signal sequence.
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Academic Article
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Reorganization of lipid domain structure in membranes by a transmembrane peptide: an ESR spin label study on the effect of the Escherichia coli outer membrane protein A signal peptide on the fluid lipid domain connectivity in binary mixtures of dimyristoyl phosphatidylcholine and distearoyl phosphatidylcholine.
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Academic Article
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GTP binding and hydrolysis by the signal recognition particle during initiation of protein translocation.
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Academic Article
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Membrane-bound conformation of a signal peptide: a transferred nuclear Overhauser effect analysis.
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Academic Article
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Equilibrium folding studies of cellular retinoic acid binding protein, a predominantly beta-sheet protein.
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Academic Article
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Conformational behavior of Escherichia coli OmpA signal peptides in membrane mimetic environments.
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Academic Article
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Side chain-backbone hydrogen bonding contributes to helix stability in peptides derived from an alpha-helical region of carboxypeptidase A.
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Academic Article
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Hydrophobic content and lipid interactions of wild-type and mutant OmpA signal peptides correlate with their in vivo function.
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Academic Article
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The conformation of a signal peptide bound by Escherichia coli preprotein translocase SecA.
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Academic Article
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Finding the fittest fold: using the evolutionary record to design new proteins.
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Academic Article
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The changing landscape of protein allostery.
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Academic Article
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Fluorescence analysis of tryptophan-containing variants of the LamB signal sequence upon insertion into a lipid bilayer.
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Academic Article
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Conformational and membrane-binding properties of a signal sequence are largely unaltered by its adjacent mature region.
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Academic Article
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Inhibition of protein aggregation in vitro and in vivo by a natural osmoprotectant.
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Academic Article
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Reduced tendency to form a beta turn in peptides from the P22 tailspike protein correlates with a temperature-sensitive folding defect.
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Academic Article
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Hsp70 chaperone ligands control domain association via an allosteric mechanism mediated by the interdomain linker.
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Academic Article
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Electrophysiological studies in Xenopus oocytes for the opening of Escherichia coli SecA-dependent protein-conducting channels.
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Academic Article
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Effects of osmolytes on protein folding and aggregation in cells.
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Academic Article
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In-cell aggregation of a polyglutamine-containing chimera is a multistep process initiated by the flanking sequence.
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Academic Article
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Roles of beta-turns in protein folding: from peptide models to protein engineering.
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Academic Article
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Orthogonal cross-seeding: an approach to explore protein aggregates in living cells.
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Academic Article
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Chapter 3: A fluorescent window into protein folding and aggregation in cells.
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Academic Article
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A method for direct measurement of protein stability in vivo.
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Academic Article
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The molecular dating game: an antibody heavy chain hangs loose with a chaperone while waiting for its life partner.
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Academic Article
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Post-reductionist protein science, or putting Humpty Dumpty back together again.
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Academic Article
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Conformations and orientations of a signal peptide interacting with phospholipid monolayers.
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Academic Article
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Role of Hsp70 ATPase domain intrinsic dynamics and sequence evolution in enabling its functional interactions with NEFs.
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Academic Article
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An interdomain sector mediating allostery in Hsp70 molecular chaperones.
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Academic Article
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Helix formation and stability in a signal sequence.
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Academic Article
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Functional and nonfunctional LamB signal sequences can be distinguished by their biophysical properties.
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Academic Article
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Conserved, disordered C terminus of DnaK enhances cellular survival upon stress and DnaK in vitro chaperone activity.
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Academic Article
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Exploring weak, transient protein--protein interactions in crowded in vivo environments by in-cell nuclear magnetic resonance spectroscopy.
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Academic Article
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Using a low denaturant model to explore the conformational features of translocation-active SecA.
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Academic Article
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Turns in peptides and proteins.
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Academic Article
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An interdomain energetic tug-of-war creates the allosterically active state in Hsp70 molecular chaperones.
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Academic Article
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Conformations of signal peptides induced by lipids suggest initial steps in protein export.
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Academic Article
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Early folding events protect aggregation-prone regions of a ?-rich protein.
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Academic Article
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How bacteria survive an acid trip.
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Academic Article
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The Role of Aromatic-Aromatic Interactions in Strand-Strand Stabilization of ?-Sheets.
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Academic Article
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In vivo function and membrane binding properties are correlated for Escherichia coli lamB signal peptides.
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Academic Article
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Protein translocation into Escherichia coli membrane vesicles is inhibited by functional synthetic signal peptides.
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Academic Article
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Conformations of (X-L-Pro-Y)2 cyclic hexapeptides. Preferred beta-turn conformers and implications for beta turns in proteins.
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Academic Article
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Polypeptide interactions with molecular chaperones and their relationship to in vivo protein folding.
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Academic Article
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Molecular chaperones. Panning for chaperone-binding peptides.
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Academic Article
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Characterization of a functionally important mobile domain of GroES.
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Academic Article
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Conformation of a heptapeptide substrate bound to protein farnesyltransferase.
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Academic Article
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The structure of Escherichia coli heat-stable enterotoxin b by nuclear magnetic resonance and circular dichroism.
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Concept
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Viral Tail Proteins
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Concept
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Membrane Proteins
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Concept
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Heat-Shock Proteins
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Concept
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HSC70 Heat-Shock Proteins
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Concept
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Fatty Acid-Binding Proteins
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Concept
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HSP70 Heat-Shock Proteins
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Concept
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GTP-Binding Proteins
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Concept
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Heat-Shock Proteins, Small
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Concept
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Carrier Proteins
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Concept
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Nuclear Proteins
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Concept
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Recombinant Proteins
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Concept
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Intracellular Signaling Peptides and Proteins
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Concept
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Viral Proteins
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Concept
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Intercellular Signaling Peptides and Proteins
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Concept
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Xenopus Proteins
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Concept
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HSP90 Heat-Shock Proteins
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Concept
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Proteins
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Concept
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Serotonin Plasma Membrane Transport Proteins
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Concept
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Membrane Transport Proteins
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Concept
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Escherichia coli Proteins
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Concept
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Bacterial Proteins
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Concept
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Recombinant Fusion Proteins
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Concept
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Bacterial Outer Membrane Proteins
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Concept
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Fungal Proteins
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Concept
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Neoplasm Proteins
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Concept
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Proto-Oncogene Proteins p21(ras)
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Concept
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Adaptor Proteins, Vesicular Transport
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Concept
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Molecular Motor Proteins
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Concept
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Protozoan Proteins
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Concept
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Nerve Tissue Proteins
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Academic Article
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Comparing protein folding in vitro and in vivo: foldability meets the fitness challenge.
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Academic Article
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ATPase subdomain IA is a mediator of interdomain allostery in Hsp70 molecular chaperones.
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Academic Article
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Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs).
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Academic Article
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Energy landscapes of functional proteins are inherently risky.
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Academic Article
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Challenges and dreams: physics of weak interactions essential to life.
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Academic Article
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How hsp70 molecular machines interact with their substrates to mediate diverse physiological functions.
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Academic Article
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Individual and collective contributions of chaperoning and degradation to protein homeostasis in E. coli.
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Academic Article
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Substrate-binding domain conformational dynamics mediate Hsp70 allostery.
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Academic Article
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Division of Labor: ER-Resident BiP Co-Chaperones Match Substrates to Fates Based on Specific Binding Sequences.
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Academic Article
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Key features of an Hsp70 chaperone allosteric landscape revealed by ion-mobility native mass spectrometry and double electron-electron resonance.
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Academic Article
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Recent advances in the structural and mechanistic aspects of Hsp70 molecular chaperones.
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Academic Article
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Allosteric landscapes of eukaryotic cytoplasmic Hsp70s are shaped by evolutionary tuning of key interfaces.
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Academic Article
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Expression and Purification of Active Recombinant Human Alpha-1 Antitrypsin (AAT) from Escherichia coli.
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Academic Article
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The Hsp70 interdomain linker is a dynamic switch that enables allosteric communication between two structured domains.
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Academic Article
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Kinetic versus thermodynamic control of mutational effects on protein homeostasis: A perspective from computational modeling and experiment.
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Academic Article
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Hsp70 molecular chaperones: multifunctional allosteric holding and unfolding machines.
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Academic Article
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How the Protein Data Bank changed biology: An introduction to the JBC Reviews thematic series, part 1.
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Academic Article
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How the Protein Data Bank changed biology: An introduction to the JBC Reviews thematic series, part 2.
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Academic Article
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Selective promiscuity in the binding of E. coli Hsp70 to an unfolded protein.
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Academic Article
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Physics-based modeling provides predictive understanding of selectively promiscuous substrate binding by Hsp70 chaperones.
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Concept
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Intrinsically Disordered Proteins
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Academic Article
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There are more Hsp90 chaperone mechanisms in heaven and earth, dear reader, than are dreamt of in your philosophy.
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Academic Article
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Computationally-Aided Modeling of Hsp70-Client Interactions: Past, Present, and Future.
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