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Kaltashov, Igor

One or more keywords matched the following items that are connected to Kaltashov, Igor

Item Type	Name
Academic Article	Stability of secondary structural elements in a solvent-free environment: the alpha helix.
Academic Article	Detection of multiple protein conformational ensembles in solution via deconvolution of charge-state distributions in ESI MS.
Academic Article	Expression cloning of a Pseudomonas gene encoding a hydroxydecanoyl-acyl carrier protein-dependent UDP-GlcNAc acyltransferase.
Academic Article	Indirect assessment of small hydrophobic ligand binding to a model protein using a combination of ESI MS and HDX/ESI MS.
Academic Article	Highly asymmetric interactions between globin chains during hemoglobin assembly revealed by electrospray ionization mass spectrometry.
Academic Article	Is there hydrogen scrambling in the gas phase? Energetic and structural determinants of proton mobility within protein ions.
Academic Article	Indirect detection of protein-metal binding: interaction of serum transferrin with In3+ and Bi3+.
Academic Article	Mapping protein energy landscapes with amide hydrogen exchange and mass spectrometry: I. A generalized model for a two-state protein and comparison with experiment.
Academic Article	Unfolding dynamics of a beta-sheet protein studied by mass spectrometry.
Academic Article	Effect of glycosylation on the function of a soluble, recombinant form of the transferrin receptor.
Academic Article	Mapping of protein disulfide bonds using negative ion fragmentation with a broadband precursor selection.
Academic Article	Secondary structure of peptide ions in the gas phase evaluated by MIKE spectrometry. Relevance to native conformations.
Academic Article	Transporter-to-trap conversion: a disulfide bond formation in cellular retinoic acid binding protein I mutant triggered by retinoic acid binding irreversibly locks the ligand inside the protein.
Academic Article	Detection and characterization of altered conformations of protein pharmaceuticals using complementary mass spectrometry-based approaches.
Academic Article	Expression, purification, and characterization of recombinant nonglycosylated human serum transferrin containing a C-terminal hexahistidine tag.
Academic Article	Protein conformations can be probed in top-down HDX MS experiments utilizing electron transfer dissociation of protein ions without hydrogen scrambling.
Academic Article	Characterization of intrinsically disordered proteins with electrospray ionization mass spectrometry: conformational heterogeneity of alpha-synuclein.
Academic Article	Conformation and dynamics of biopharmaceuticals: transition of mass spectrometry-based tools from academe to industry.
Academic Article	Controlling hydrogen scrambling in multiply charged protein ions during collisional activation: implications for top-down hydrogen/deuterium exchange MS utilizing collisional activation in the gas phase.
Academic Article	Properties of a homogeneous C-lobe prepared by introduction of a TEV cleavage site between the lobes of human transferrin.
Academic Article	Noncanonical interactions between serum transferrin and transferrin receptor evaluated with electrospray ionization mass spectrometry.
Academic Article	Electrospray ionization mass spectrometry of highly heterogeneous protein systems: protein ion charge state assignment via incomplete charge reduction.
Academic Article	Direct monitoring of heat-stressed biopolymers with temperature-controlled electrospray ionization mass spectrometry.
Academic Article	Evaluation of electrospray ionization mass spectrometry as a tool for characterization of small soluble protein aggregates.
Academic Article	Detection and characterization of large-scale protein conformational transitions in solution using charge-state distribution analysis in ESI-MS.
Academic Article	Localizing flexible regions in proteins using hydrogen-deuterium exchange mass spectrometry.
Academic Article	Crossing the phase boundary to study protein dynamics and function: combination of amide hydrogen exchange in solution and ion fragmentation in the gas phase.
Academic Article	Studies of biomolecular conformations and conformational dynamics by mass spectrometry.
Academic Article	Mass spectrometry-based methods to study protein architecture and dynamics.
Academic Article	Emerging mass spectrometry-based approaches to probe protein-receptor interactions: focus on overcoming physiological barriers.
Academic Article	Interlobe communication in human serum transferrin: metal binding and conformational dynamics investigated by electrospray ionization mass spectrometry.
Academic Article	A chemometric approach to detection and characterization of multiple protein conformers in solution using electrospray ionization mass spectrometry.
Academic Article	Methods to study protein dynamics and folding by mass spectrometry.
Academic Article	Transient structural disorder as a facilitator of protein-ligand binding: native H/D exchange-mass spectrometry study of cellular retinoic acid binding protein I.
Academic Article	Estimates of protein surface areas in solution by electrospray ionization mass spectrometry.
Academic Article	Structural and dynamic characteristics of a partially folded state of ubiquitin revealed by hydrogen exchange mass spectrometry.
Academic Article	Extraction of local hydrogen exchange data from HDX CAD MS measurements by deconvolution of isotopic distributions of fragment ions.
Academic Article	Protein conformational heterogeneity as a binding catalyst: ESI-MS study of hemoglobin H formation.
Academic Article	Gas-phase interference-free analysis of protein ion charge-state distributions: detection of small-scale conformational transitions accompanying pepsin inactivation.
Academic Article	A novel murine protein with no effect on iron homoeostasis is homologous with transferrin and is the putative inhibitor of carbonic anhydrase.
Academic Article	Do ionic charges in ESI MS provide useful information on macromolecular structure?
Academic Article	Structural and functional consequences of the substitution of glycine 65 with arginine in the N-lobe of human transferrin.
Academic Article	Existence of a noncanonical state of iron-bound transferrin at endosomal pH revealed by hydrogen exchange and mass spectrometry.
Academic Article	H/D exchange and mass spectrometry in the studies of protein conformation and dynamics: is there a need for a top-down approach?
Academic Article	Impact of oxidation on protein therapeutics: conformational dynamics of intact and oxidized acid-?-glucocerebrosidase at near-physiological pH.
Academic Article	Advanced mass spectrometry-based methods for the analysis of conformational integrity of biopharmaceutical products.
Academic Article	Advances and challenges in analytical characterization of biotechnology products: mass spectrometry-based approaches to study properties and behavior of protein therapeutics.
Academic Article	Transferrin as a model system for method development to study structure, dynamics and interactions of metalloproteins using mass spectrometry.
Academic Article	Pitfalls in protein quantitation using acid-catalyzed O18 labeling: hydrolysis-driven deamidation.
Academic Article	Modification of the zonal elution method for detection of transient protein-protein interactions involving ligand exchange.
Academic Article	A new strategy of using O18-labeled iodoacetic acid for mass spectrometry-based protein quantitation.
Academic Article	Mass spectrometry study of a transferrin-based protein drug reveals the key role of protein aggregation for successful oral delivery.
Academic Article	Mass spectrometry-guided optimization and characterization of a biologically active transferrin-lysozyme model drug conjugate.
Concept	Protein Binding
Concept	Protein Subunits
Concept	Protein Folding
Concept	Protein Processing, Post-Translational
Concept	Protein Interaction Mapping
Concept	Protein Interaction Domains and Motifs
Concept	Protein Denaturation
Concept	Protein Structure, Secondary
Concept	Protein Structure, Tertiary
Concept	Protein Multimerization
Concept	Protein Stability
Concept	Protein Isoforms
Concept	Protein Conformation
Concept	Sequence Analysis, Protein
Academic Article	A new approach to measuring protein backbone protection with high spatial resolution using H/D exchange and electron capture dissociation.
Academic Article	Conformer-specific characterization of nonnative protein states using hydrogen exchange and top-down mass spectrometry.
Academic Article	Enhancing the quality of H/D exchange measurements with mass spectrometry detection in disulfide-rich proteins using electron capture dissociation.
Academic Article	Characterization of small protein aggregates and oligomers using size exclusion chromatography with online detection by native electrospray ionization mass spectrometry.
Academic Article	Identification of reduction-susceptible disulfide bonds in transferrin by differential alkylation using O(16)/O(18) labeled iodoacetic acid.
Academic Article	Characterization of intact protein conjugates and biopharmaceuticals using ion-exchange chromatography with online detection by native electrospray ionization mass spectrometry and top-down tandem mass spectrometry.
Academic Article	Interactions of Haptoglobin with Monomeric Globin Species: Insights from Molecular Modeling and Native Electrospray Ionization Mass Spectrometry.
Academic Article	Characterization of a PEGylated protein therapeutic by ion exchange chromatography with on-line detection by native ESI MS and MS/MS.
Academic Article	Electrostatic Forces as Dominant Interactions Between Proteins and Polyanions: an ESI MS Study of Fibroblast Growth Factor Binding to Heparin Oligomers.
Academic Article	Multi-step conformational transitions in heat-treated protein therapeutics can be monitored in real time with temperature-controlled electrospray ionization mass spectrometry.
Academic Article	Integration of On-Column Chemical Reactions in Protein Characterization by Liquid Chromatography/Mass Spectrometry: Cross-Path Reactive Chromatography.
Academic Article	Influence of glycan modification on IgG1 biochemical and biophysical properties.
Academic Article	LC/MS at the whole protein level: Studies of biomolecular structure and interactions using native LC/MS and cross-path reactive chromatography (XP-RC) MS.
Academic Article	Overcoming the Hydrolytic Lability of a Reaction Intermediate in Production of Protein/Drug Conjugates: Conjugation of an Acyclic Nucleoside Phosphonate to a Model Carrier Protein.
Academic Article	Mechanism of Reduction in IgG and IgE Binding of ?-Lactoglobulin Induced by Ultrasound Pretreatment Combined with Dry-State Glycation: A Study Using Conventional Spectrometry and High-Resolution Mass Spectrometry.
Academic Article	Exploiting His-Tags for Absolute Quantitation of Exogenous Recombinant Proteins in Biological Matrices: Ruthenium as a Protein Tracer.
Academic Article	Mass spectrometry-based methods in characterization of the higher order structure of protein therapeutics.
Academic Article	Evaluation of top-down mass spectrometry and ion-mobility spectroscopy as a means of mapping protein-binding motifs within heparin chains.
Academic Article	Identification of Protein Recognition Elements within Heparin Chains Using Enzymatic Foot-Printing in Solution and Online SEC/MS.
Academic Article	The Utility of Native MS for Understanding the Mechanism of Action of Repurposed Therapeutics in COVID-19: Heparin as a Disruptor of the SARS-CoV-2 Interaction with Its Host Cell Receptor.
Academic Article	Charge Manipulation Using Solution and Gas-Phase Chemistry to Facilitate Analysis of Highly Heterogeneous Protein Complexes in Native Mass Spectrometry.
Academic Article	Simultaneous Evaluation of a Vaccine Component Microheterogeneity and Conformational Integrity Using Native Mass Spectrometry and Limited Charge Reduction.
Academic Article	The challenge of structural heterogeneity in the native mass spectrometry studies of the SARS-CoV-2 spike protein interactions with its host cell-surface receptor.
Academic Article	A systematic assessment of structural heterogeneity and IgG/IgE-binding of ovalbumin.
Academic Article	The challenge of structural heterogeneity in the native mass spectrometry studies of the SARS-CoV-2 spike protein interactions with its host cell-surface receptor.
Concept	Protein Domains
Concept	Protein Unfolding
Concept	Protein Interaction Maps
Concept	Protein Aggregates
Academic Article	Characterizing Soluble Protein Aggregates Using Native Mass Spectrometry Coupled with Temperature-Controlled Electrospray Ionization and Size-Excl usion Chromatography.
Academic Article	Decavanadate interactions with the elements of the SARS-CoV-2 spike protein highlight the potential role of electrostatics in disrupting the infectivity cycle.
Academic Article	Genetically detoxified tetanus toxin as a vaccine and conjugate carrier protein.
Academic Article	Probing the Architecture of Multisubunit Protein Complexes with In-line Disulfide Reduction and Native MS Analysis.

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