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A multipurpose microfluidic device designed to mimic microenvironment gradients and develop targeted cancer therapeutics.
Motility is critical for effective distribution and accumulation of bacteria in tumor tissue.
Identification of Staphylococcus aureus a-hemolysin as a protein drug that is secreted by anticancer bacteria and rapidly kills cancer cells.
Genetically modified bacteria as a tool to detect microscopic solid tumor masses with triggered release of a recombinant biomarker.
Potent and tumor specific: arming bacteria with therapeutic proteins.
Microfluidic Device to Quantify the Behavior of Therapeutic Bacteria in Three-Dimensional Tumor Tissue.
Engineered bacteria detect spatial profiles in glucose concentration within solid tumor cell masses.
White paper on microbial anti-cancer therapy and prevention.
Detection of tumors with fluoromarker-releasing bacteria.
Mucus blocks probiotics but increases penetration of motile pathogens and induces TNF-a and IL-8 secretion.
Bacteria-based immune therapies for cancer treatment.
Microbial Imbalance Induces Inflammation by Promoting Salmonella Penetration through the Mucosal Barrier.