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Construction of an inducible cell-communication system that amplifies Salmonella gene expression in tumor tissue.
Salmonella typhimurium lacking ribose chemoreceptors localize in tumor quiescence and induce apoptosis.
Trg-deficient Salmonella colonize quiescent tumor regions by exclusively penetrating or proliferating.
Potent and tumor specific: arming bacteria with therapeutic proteins.
The motility regulator flhDC drives intracellular accumulation and tumor colonization of Salmonella.