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One or more keywords matched the following items that are connected to Hardy, Jeanne
Item TypeName
Academic Article Substrate-induced conformational changes occur in all cleaved forms of caspase-6.
Academic Article Caspase-6 latent state stability relies on helical propensity.
Academic Article Phosphorylation regulates assembly of the caspase-6 substrate-binding groove.
Academic Article Zinc-mediated allosteric inhibition of caspase-6.
Academic Article Identification of protease exosite-interacting peptides that enhance substrate cleavage kinetics.
Academic Article Discovery of an allosteric site in the caspases.
Academic Article L2' loop is critical for caspase-7 active site formation.
Academic Article Dissecting an allosteric switch in caspase-7 using chemical and mutational probes.
Academic Article Mechanism of a genetically encoded dark-to-bright reporter for caspase activity.
Academic Article A designed redox-controlled caspase.
Academic Article Mechanism of zinc-mediated inhibition of caspase-9.
Academic Article Structural basis of fluorescence quenching in caspase activatable-GFP.
Academic Article Inhibition of caspase-9 by stabilized peptides targeting the dimerization interface.
Academic Article Direct delivery of functional proteins and enzymes to the cytosol using nanoparticle-stabilized nanocapsules.
Concept Caspase 8
Concept Caspase 9
Concept Caspase 3
Concept Caspase 7
Concept Caspase 6
Academic Article A multipronged approach for compiling a global map of allosteric regulation in the apoptotic caspases.
Academic Article Co-delivery of protein and small molecule therapeutics using nanoparticle-stabilized nanocapsules.
Academic Article Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition.
Academic Article Dual Site Phosphorylation of Caspase-7 by PAK2 Blocks Apoptotic Activity by Two Distinct Mechanisms.
Academic Article Caspase-6 Undergoes a Distinct Helix-Strand Interconversion upon Substrate Binding.
Academic Article Active site-adjacent phosphorylation at Tyr-397 by c-Abl kinase inactivates caspase-9.
Academic Article Phosphorylation by protein kinase A disassembles the caspase-9 core.
Academic Article Rare human Caspase-6-R65W and Caspase-6-G66R variants identify a novel regulatory region of Caspase-6 activity.
Academic Article Caspase-9 CARD?:?core domain interactions require a properly formed active site.
Academic Article Fighting Kinase Drug Resistance with Caspase Activators.
Academic Article Tri-arginine exosite patch of caspase-6 recruits substrates for hydrolysis.
Academic Article Tumor-Associated Mutations in Caspase-6 Negatively Impact Catalytic Efficiency.
Academic Article Multiple proteolytic events in caspase-6 self-activation impact conformations of discrete structural regions.
Academic Article Utilizing Inverse Emulsion Polymerization To Generate Responsive Nanogels for Cytosolic Protein Delivery.
Academic Article Chemoproteomics Using Nucleotide Acyl Phosphates Reveals an ATP Binding Site at the Dimer Interface of Procaspase-6.
Academic Article A Nanopore Approach for Analysis of Caspase-7 Activity in Cell Lysates.
Academic Article Tracking exogenous intracellular casp-3 using split GFP.
Academic Article Evaluating Endosomal Escape of Caspase-3-Containing Nanomaterials Using Split GFP.
Academic Article Caspase-9 Activation of Procaspase-3 but Not Procaspase-6 Is Based on the Local Context of Cleavage Site Motifs and on Sequence.
Academic Article Deorphanizing Caspase-3 and Caspase-9 Substrates In and Out of Apoptosis with Deep Substrate Profiling.
Academic Article Intracellular delivery of protein drugs with an autonomously lysing bacterial system reduces tumor growth and metastases.
Concept Caspase Activation and Recruitment Domain
Concept Caspase Inhibitors
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  • Caspase 6