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Hardy, Jeanne

One or more keywords matched the following items that are connected to Hardy, Jeanne

Item Type	Name
Academic Article	Substrate-induced conformational changes occur in all cleaved forms of caspase-6.
Academic Article	Caspase-6 latent state stability relies on helical propensity.
Academic Article	Phosphorylation regulates assembly of the caspase-6 substrate-binding groove.
Academic Article	Zinc-mediated allosteric inhibition of caspase-6.
Academic Article	Identification of protease exosite-interacting peptides that enhance substrate cleavage kinetics.
Academic Article	Discovery of an allosteric site in the caspases.
Academic Article	L2' loop is critical for caspase-7 active site formation.
Academic Article	Dissecting an allosteric switch in caspase-7 using chemical and mutational probes.
Academic Article	Mechanism of a genetically encoded dark-to-bright reporter for caspase activity.
Academic Article	A designed redox-controlled caspase.
Academic Article	Mechanism of zinc-mediated inhibition of caspase-9.
Academic Article	Structural basis of fluorescence quenching in caspase activatable-GFP.
Academic Article	Inhibition of caspase-9 by stabilized peptides targeting the dimerization interface.
Academic Article	Direct delivery of functional proteins and enzymes to the cytosol using nanoparticle-stabilized nanocapsules.
Concept	Caspase 8
Concept	Caspase 9
Concept	Caspase 3
Concept	Caspase 7
Concept	Caspase 6
Academic Article	A multipronged approach for compiling a global map of allosteric regulation in the apoptotic caspases.
Academic Article	Co-delivery of protein and small molecule therapeutics using nanoparticle-stabilized nanocapsules.
Academic Article	Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition.
Academic Article	Dual Site Phosphorylation of Caspase-7 by PAK2 Blocks Apoptotic Activity by Two Distinct Mechanisms.
Academic Article	Caspase-6 Undergoes a Distinct Helix-Strand Interconversion upon Substrate Binding.
Academic Article	Active site-adjacent phosphorylation at Tyr-397 by c-Abl kinase inactivates caspase-9.
Academic Article	Phosphorylation by protein kinase A disassembles the caspase-9 core.
Academic Article	Rare human Caspase-6-R65W and Caspase-6-G66R variants identify a novel regulatory region of Caspase-6 activity.
Academic Article	Caspase-9 CARD?:?core domain interactions require a properly formed active site.
Academic Article	Fighting Kinase Drug Resistance with Caspase Activators.
Academic Article	Tri-arginine exosite patch of caspase-6 recruits substrates for hydrolysis.
Academic Article	Tumor-Associated Mutations in Caspase-6 Negatively Impact Catalytic Efficiency.
Academic Article	Multiple proteolytic events in caspase-6 self-activation impact conformations of discrete structural regions.
Academic Article	Utilizing Inverse Emulsion Polymerization To Generate Responsive Nanogels for Cytosolic Protein Delivery.
Academic Article	Chemoproteomics Using Nucleotide Acyl Phosphates Reveals an ATP Binding Site at the Dimer Interface of Procaspase-6.
Academic Article	A Nanopore Approach for Analysis of Caspase-7 Activity in Cell Lysates.
Academic Article	Tracking exogenous intracellular casp-3 using split GFP.
Academic Article	Evaluating Endosomal Escape of Caspase-3-Containing Nanomaterials Using Split GFP.
Academic Article	Caspase-9 Activation of Procaspase-3 but Not Procaspase-6 Is Based on the Local Context of Cleavage Site Motifs and on Sequence.
Academic Article	Deorphanizing Caspase-3 and Caspase-9 Substrates In and Out of Apoptosis with Deep Substrate Profiling.
Academic Article	Intracellular delivery of protein drugs with an autonomously lysing bacterial system reduces tumor growth and metastases.
Concept	Caspase Activation and Recruitment Domain
Concept	Caspase Inhibitors

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Caspase 6