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Pederson, Thoru

One or more keywords matched the following properties of Pederson, Thoru

Property	Value
overview	Academic Background Thoru Pederson received his Ph.D. in Zoology from Syracuse University and was a NIH postdoctoral fellow in the Department of Cell Biology at Albert Einstein College of Medicine.He then joined the Worcester Foundation as a Staff Scientist in Cell Biology and was promoted to President of the institute in 1985. In 1997 the Worcester Foundation merged with UMass Medical School. Dr. Pederson holds the Vitold Arnett Professorship, an endowed position, and is also Associate Vice Provost for Research. He has held a Scholar Award from the Leukemia & Lymphoma Society of America and has served on the N.I.H. Cell Biology Study Section, the N.I.H. Molecular Biology Study Section, and the Editorial Board of the Journal of Cell Biology.He currently serves on the editorial board of Molecular Biology of the Cell.He is an Elected Fellow of the American Association for the Advancement of Science and of the American Academy of Microbiology.He has been awarded the Wilhelm Bernhard Medal and also the Medal of Charles University, Prague, for his research in the cell nucleus.He has served as the Chair of the Keith Porter Endowment Fund in Cell Biology, which supports the career development of young cell biologists, and also serves as Chair of the Research Awards Review Committee at the Marine Biological Laboratory, Woods Hole, MA, which evaluates proposals for summer research grants -- again emphasizing young scientists. Track record of most recent graduate student: Qian Huang was the most recent graduate student to finish in the Pederson laboratory.She post-doc’d in the laboratory of Richard Young at the Whitehead Institute, MIT, and is now a Staff Scientist at the Novartis Research Institute, Cambridge, MA Vitold Arnett Professor of Cell Biology RNA traffic in eukaryotic cells, RNA processing, RNA-protein interactions, microRNAs We are investigating the functional significance of specific protein-RNA interactions in eukaryotic gene expression, with particular emphasis on RNA traffic and processing as well as domains in the cell nucleus where these events are set in motion. One axis of this program combines in situ RNA detection methods with novel approaches we have developed for following fluorescent RNA molecules in living mammalian cells. A recent focus has been the assembly of the signal recognition particle, which we have discovered occurs in an unanticipated place in the cell: the nucleolus. This has led us to look into the possibility that this special domain of the nucleus may be doing yet other things, beyond its long-known role in making ribosomes. We have found that the nucleolus harbors numerous proteins involved in cell cycle progression as well as a specific set of microRNAs. We are now trying to sort out the meaning of both of these unexpected discoveries. My laboratory follows the doctrine uttered by a famous biochemist when asked by a reporter how he planned his work, who replied “I follow my nose.” Research Funding National Science Foundation grant MCB-1051398, “Probing New Dimensions of the Nucleolus”; April 1, 2011-March 31, 2014

Property

Value

overview

Academic Background

Thoru Pederson received his Ph.D. in Zoology from Syracuse University and was a NIH postdoctoral fellow in the Department of Cell Biology at Albert Einstein College of Medicine.He then joined the Worcester Foundation as a Staff Scientist in Cell Biology and was promoted to President of the institute in 1985. In 1997 the Worcester Foundation merged with UMass Medical School. Dr. Pederson holds the Vitold Arnett Professorship, an endowed position, and is also Associate Vice Provost for Research.

He has held a Scholar Award from the Leukemia & Lymphoma Society of America and has served on the N.I.H. Cell Biology Study Section, the N.I.H. Molecular Biology Study Section, and the Editorial Board of the Journal of Cell Biology.He currently serves on the editorial board of Molecular Biology of the Cell.He is an Elected Fellow of the American Association for the Advancement of Science and of the American Academy of Microbiology.He has been awarded the Wilhelm Bernhard Medal and also the Medal of Charles University, Prague, for his research in the cell nucleus.He has served as the Chair of the Keith Porter Endowment Fund in Cell Biology, which supports the career development of young cell biologists, and also serves as Chair of the Research Awards Review Committee at the Marine Biological Laboratory, Woods Hole, MA, which evaluates proposals for summer research grants -- again emphasizing young scientists.

Track record of most recent graduate student:

Qian Huang was the most recent graduate student to finish in the Pederson laboratory.She post-doc’d in the laboratory of Richard Young at the Whitehead Institute, MIT, and is now a Staff Scientist at the Novartis Research Institute, Cambridge, MA

Vitold Arnett Professor of Cell Biology

RNA traffic in eukaryotic cells, RNA processing, RNA-protein interactions, microRNAs

We are investigating the functional significance of specific protein-RNA interactions in eukaryotic gene expression, with particular emphasis on RNA traffic and processing as well as domains in the cell nucleus where these events are set in motion. One axis of this program combines in situ RNA detection methods with novel approaches we have developed for following fluorescent RNA molecules in living mammalian cells. A recent focus has been the assembly of the signal recognition particle, which we have discovered occurs in an unanticipated place in the cell: the nucleolus. This has led us to look into the possibility that this special domain of the nucleus may be doing yet other things, beyond its long-known role in making ribosomes. We have found that the nucleolus harbors numerous proteins involved in cell cycle progression as well as a specific set of microRNAs. We are now trying to sort out the meaning of both of these unexpected discoveries. My laboratory follows the doctrine uttered by a famous biochemist when asked by a reporter how he planned his work, who replied “I follow my nose.”

Research Funding

National Science Foundation grant MCB-1051398, “Probing New Dimensions of the Nucleolus”; April 1, 2011-March 31, 2014

One or more keywords matched the following items that are connected to Pederson, Thoru

Item Type	Name
Academic Article	Movement and localization of RNA in the cell nucleus.
Academic Article	Intranuclear diffusion and hybridization state of oligonucleotides measured by fluorescence correlation spectroscopy in living cells.
Academic Article	Actin in the nucleus: what form and what for?
Academic Article	RNA polymerase III transcripts and the PTB protein are essential for the integrity of the perinucleolar compartment.
Academic Article	A human U2 RNA mutant stalled in 3' end processing is impaired in nuclear import.
Academic Article	Movement of nuclear poly(A) RNA throughout the interchromatin space in living cells.
Academic Article	The molecular cytology of gene expression: fluorescent RNA as both a stain and tracer in vivo.
Academic Article	A nonribosomal landscape in the nucleolus revealed by the stem cell protein nucleostemin.
Academic Article	Nuclear actin extends, with no contraction in sight.
Academic Article	Rapid, diffusional shuttling of poly(A) RNA between nuclear speckles and the nucleoplasm.
Academic Article	Half a century of "the nuclear matrix".
Academic Article	Protein mobility within the nucleus--what are the right moves?
Academic Article	Nucleophosmin is a binding partner of nucleostemin in human osteosarcoma cells.
Academic Article	Human cell lines expressing hormone regulated T7 RNA polymerase localized at distinct intranuclear sites.
Academic Article	An Olympian protozoan.
Academic Article	Dynamics and genome-centricity of interchromatin domains in the nucleus.
Academic Article	The persistent plausibility of protein synthesis in the nucleus: process, palimpsest or pitfall?
Academic Article	Genome function and nuclear architecture: from gene expression to nanoscience.
Academic Article	Nuclear export of signal recognition particle RNA in mammalian cells.
Academic Article	Can telomerase be put in its place?
Academic Article	The spatial organization of the genome in mammalian cells.
Academic Article	Signal recognition particle assembly in relation to the function of amplified nucleoli of Xenopus oocytes.
Academic Article	As functional nuclear actin comes into view, is it globular, filamentous, or both?
Academic Article	The nucleus introduced.
Academic Article	Nuclear export, enlightened.
Academic Article	Tracking nuclear poly(A) RNA movement within and among speckle nuclear bodies and the surrounding nucleoplasm.
Concept	Cell Nucleus
Concept	Cell Nucleus Structures
Concept	Active Transport, Cell Nucleus
Concept	Cell Nucleus Division
Academic Article	The nuclear physique.
Academic Article	Repeated TALEs: visualizing DNA sequence localization and chromosome dynamics in live cells.
Academic Article	Nuclear physics (of the cell, not the atom).
Academic Article	Forces, fluctuations, and self-organization in the nucleus.
Academic Article	Nucleus and gene regulation.
Academic Article	CRISPR-Cas9 nuclear dynamics and target recognition in living cells.
Academic Article	PML-like subnuclear bodies, containing XRCC1, juxtaposed to DNA replication-based single-strand breaks.
Academic Article	Cell cycle- and genomic distance-dependent dynamics of a discrete chromosomal region.
Academic Article	A conundrum in 3-D genome organization and expression?
Academic Article	Nucleolar structure connects with global nuclear organization.

Search Criteria

Cell Nucleus