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One or more keywords matched the following properties of Pederson, Thoru
Endowed Chair Honorary Title Vitold Arnett Professor in Cell Biology

Academic Background

Thoru Pederson received his Ph.D. in Zoology from Syracuse University and was a NIH postdoctoral fellow in the Department of Cell Biology at Albert Einstein College of Medicine.He then joined the Worcester Foundation as a Staff Scientist in Cell Biology and was promoted to President of the institute in 1985. In 1997 the Worcester Foundation merged with UMass Medical School. Dr. Pederson holds the Vitold Arnett Professorship, an endowed position, and is also Associate Vice Provost for Research.

He has held a Scholar Award from the Leukemia & Lymphoma Society of America and has served on the N.I.H. Cell Biology Study Section, the N.I.H. Molecular Biology Study Section, and the Editorial Board of the Journal of Cell Biology.He currently serves on the editorial board of Molecular Biology of the Cell.He is an Elected Fellow of the American Association for the Advancement of Science and of the American Academy of Microbiology.He has been awarded the Wilhelm Bernhard Medal and also the Medal of Charles University, Prague, for his research in the cell nucleus.He has served as the Chair of the Keith Porter Endowment Fund in Cell Biology, which supports the career development of young cell biologists, and also serves as Chair of the Research Awards Review Committee at the Marine Biological Laboratory, Woods Hole, MA, which evaluates proposals for summer research grants -- again emphasizing young scientists.

Track record of most recent graduate student:

Qian Huang was the most recent graduate student to finish in the Pederson laboratory.She post-doc’d in the laboratory of Richard Young at the Whitehead Institute, MIT, and is now a Staff Scientist at the Novartis Research Institute, Cambridge, MA

Vitold Arnett Professor of Cell Biology

RNA traffic in eukaryotic cells, RNA processing, RNA-protein interactions, microRNAs

Dr.  Thoru Pederson, Ph.D.

We are investigating the functional significance of specific protein-RNA interactions in eukaryotic gene expression, with particular emphasis on RNA traffic and processing as well as domains in the cell nucleus where these events are set in motion. One axis of this program combines in situ RNA detection methods with novel approaches we have developed for following fluorescent RNA molecules in living mammalian cells. A recent focus has been the assembly of the signal recognition particle, which we have discovered occurs in an unanticipated place in the cell: the nucleolus. This has led us to look into the possibility that this special domain of the nucleus may be doing yet other things, beyond its long-known role in making ribosomes. We have found that the nucleolus harbors numerous proteins involved in cell cycle progression as well as a specific set of microRNAs. We are now trying to sort out the meaning of both of these unexpected discoveries. My laboratory follows the doctrine uttered by a famous biochemist when asked by a reporter how he planned his work, who replied “I follow my nose.”

Research Funding

National Science Foundation grant MCB-1051398, “Probing New Dimensions of the Nucleolus”; April 1, 2011-March 31, 2014

Rotation Projects

Background for Student Rotation Projects

See Politz, Hogan and Pederson (2009) and Politz et al. (2005) in the above list. The novel microRNA work may be the most suitable for student rotations.

Potential Rotation Projects

Are the nucleolar microRNAs pri-, pre- or mature?

Are they complexed with other nucleolar RNAs?

Do the cell cycle related proteins in the nucleolus exist as heterotypic complexes?

Does the nucleolus of human embryonic stem cells also share these features (which we have so far looked for, and found, only in transformed human cell lines)?

Can vanadium tagging be used to detect specific proteins by electron microscopy, perhaps exceeding the limitations of immuno-EM?

One or more keywords matched the following items that are connected to Pederson, Thoru
Item TypeName
Academic Article Growth factors in the nucleolus?
Academic Article Movement and localization of RNA in the cell nucleus.
Academic Article The nucleolus and the four ribonucleoproteins of translation.
Academic Article Viewing the ribosome and visiting the nucleolus at Lake Tahoe.
Academic Article Intranuclear diffusion and hybridization state of oligonucleotides measured by fluorescence correlation spectroscopy in living cells.
Academic Article Localization of signal recognition particle RNA in the nucleolus of mammalian cells.
Academic Article The plurifunctional nucleolus.
Academic Article Signal recognition particle RNA localization within the nucleolus differs from the classical sites of ribosome synthesis.
Academic Article Actin in the nucleus: what form and what for?
Academic Article Historical review: an energy reservoir for mitosis, and its productive wake.
Academic Article RNA polymerase III transcripts and the PTB protein are essential for the integrity of the perinucleolar compartment.
Academic Article A human U2 RNA mutant stalled in 3' end processing is impaired in nuclear import.
Academic Article Diffusion-based transport of nascent ribosomes in the nucleus.
Academic Article Movement of nuclear poly(A) RNA throughout the interchromatin space in living cells.
Academic Article The molecular cytology of gene expression: fluorescent RNA as both a stain and tracer in vivo.
Academic Article A nonribosomal landscape in the nucleolus revealed by the stem cell protein nucleostemin.
Academic Article Signal recognition particle components in the nucleolus.
Academic Article Nuclear actin extends, with no contraction in sight.
Academic Article Rapid, diffusional shuttling of poly(A) RNA between nuclear speckles and the nucleoplasm.
Academic Article Half a century of "the nuclear matrix".
Academic Article The centrosome: built on an mRNA?
Academic Article Fluorescent RNA cytochemistry: tracking gene transcripts in living cells.
Academic Article Protein mobility within the nucleus--what are the right moves?
Academic Article Depletion of the nucleolar protein nucleostemin causes G1 cell cycle arrest via the p53 pathway.
Academic Article Nucleophosmin is a binding partner of nucleostemin in human osteosarcoma cells.
Academic Article Nucleostemin: a multiplex regulator of cell-cycle progression.
Academic Article Human cell lines expressing hormone regulated T7 RNA polymerase localized at distinct intranuclear sites.
Academic Article Proteomics of the nucleolus: more proteins, more functions?
Academic Article The nucleolus.
Academic Article An Olympian protozoan.
Academic Article Is chromatin helical?
Academic Article Dynamics and genome-centricity of interchromatin domains in the nucleus.
Academic Article The nucleolus stress response is coupled to an ATR-Chk1-mediated G2 arrest.
Academic Article The persistent plausibility of protein synthesis in the nucleus: process, palimpsest or pitfall?
Academic Article Genome function and nuclear architecture: from gene expression to nanoscience.
Academic Article RNA interference and mRNA silencing, 2004: how far will they reach?
Academic Article Nuclear export of signal recognition particle RNA in mammalian cells.
Academic Article Can telomerase be put in its place?
Academic Article The spatial organization of the genome in mammalian cells.
Academic Article Signal recognition particle assembly in relation to the function of amplified nucleoli of Xenopus oocytes.
Academic Article Author, author burning bright; author, author are you right?
Academic Article MicroRNA-206 colocalizes with ribosome-rich regions in both the nucleolus and cytoplasm of rat myogenic cells.
Academic Article As functional nuclear actin comes into view, is it globular, filamentous, or both?
Academic Article In search of nonribosomal nucleolar protein function and regulation.
Academic Article The discovery of eukaryotic genome design and its forgotten corollary--the postulate of gene regulation by nuclear RNA.
Academic Article MicroRNAs with a nucleolar location.
Academic Article Obituary: Paul C. Zamecnik (1912-2009).
Academic Article The nucleus introduced.
Academic Article "Tall oaks fallen": three pioneers of chromosome science.
Academic Article Nuclear export, enlightened.
Academic Article The "study" role of past National Institutes of Health study sections.
Academic Article Tracking nuclear poly(A) RNA movement within and among speckle nuclear bodies and the surrounding nucleoplasm.
Concept Epithelial Cells
Concept Cell Physiological Phenomena
Concept HeLa Cells
Concept Cell Nucleus
Concept Cell Division
Concept Cell Survival
Concept Cell Cycle Proteins
Concept Cell Biology
Concept Blood Cells
Concept 3T3 Cells
Concept Tumor Cells, Cultured
Concept Cell Differentiation
Concept Cell-Free System
Concept Cell Line, Transformed
Concept Cells, Cultured
Concept Stem Cells
Concept Cell Nucleus Structures
Concept Cell Proliferation
Concept Cell Nucleolus
Concept Active Transport, Cell Nucleus
Concept Cell Cycle
Concept Eukaryotic Cells
Concept Cell Line
Concept Cells
Concept Cell Nucleus Division
Concept Cell Line, Tumor
Academic Article The nuclear physique.
Academic Article Nucleostemin and GNL3L exercise distinct functions in genome protection and ribosome synthesis, respectively.
Academic Article Repeated TALEs: visualizing DNA sequence localization and chromosome dynamics in live cells.
Academic Article Connecting the nucleolus to the cell cycle and human disease.
Academic Article Nuclear physics (of the cell, not the atom).
Academic Article A mRNA and cognate microRNAs localize in the nucleolus.
Academic Article Multicolor CRISPR labeling of chromosomal loci in human cells.
Academic Article Forces, fluctuations, and self-organization in the nucleus.
Academic Article Thoru Pederson: Spotting novel roles for the nucleolus.
Academic Article Nucleus and gene regulation.
Academic Article CRISPR-Cas9 nuclear dynamics and target recognition in living cells.
Academic Article Macromolecular synthesis in dogfish peripheral blood cells.
Academic Article PML-like subnuclear bodies, containing XRCC1, juxtaposed to DNA replication-based single-strand breaks.
Academic Article CRISPR-Sirius: RNA scaffolds for signal amplification in genome imaging.
Academic Article G√ľnter Blobel: a voyager of the cell.
Academic Article Cell cycle- and genomic distance-dependent dynamics of a discrete chromosomal region.
Academic Article Arthur B. Pardee (1921-2019).
Academic Article Physics and the Cell.
Academic Article Perennial Prescience.
Academic Article Ein Kleiner Kern: A Century and a Half of the Nucleolus.
Academic Article Half a century of locating DNA and RNA in cells.
Academic Article The Wilhelm Bernhard workshop: half a century of collegiality.
Academic Article STRIDE-a fluorescence method for direct, specific in situ detection of individual single- or double-strand DNA breaks in fixed cells.
Academic Article The Centriole Mystique.
Academic Article A 20-year encounter with the imposter syndrome.
Academic Article Simultaneous epigenetic perturbation and genome imaging reveal distinct roles of H3K9me3 in chromatin architecture and transcription.
Academic Article The epistemological wheel turns: AI's tipping point is here.
Concept A549 Cells
Concept HEK293 Cells
Concept Single-Cell Analysis
Concept Cell Cycle Checkpoints
Concept G2 Phase Cell Cycle Checkpoints
Academic Article The UVSSA protein is part of a genome integrity homeostasis network with links to transcription-coupled DNA repair and ATM signaling.
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