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MPZP: a novel small molecule corticotropin-releasing factor type 1 receptor (CRF1) antagonist.
Effects of naltrexone, duloxetine, and a corticotropin-releasing factor type 1 receptor antagonist on binge-like alcohol drinking in rats.
Corticotropin-releasing factor-1 receptor antagonists decrease heroin self-administration in long- but not short-access rats.
Protracted withdrawal from alcohol and drugs of abuse impairs long-term potentiation of intrinsic excitability in the juxtacapsular bed nucleus of the stria terminalis.
Permanent impairment of birth and survival of cortical and hippocampal proliferating cells following excessive drinking during alcohol dependence.
Operant behavior and alcohol levels in blood and brain of alcohol-dependent rats.
CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats.
Methamphetamine self-administration and voluntary exercise have opposing effects on medial prefrontal cortex gliogenesis.
Varied access to intravenous methamphetamine self-administration differentially alters adult hippocampal neurogenesis.
Vapor inhalation of alcohol in rats.
Alcohol self-administration acutely stimulates the hypothalamic-pituitary-adrenal axis, but alcohol dependence leads to a dampened neuroendocrine state.
Drug Administration Schedule
Alcohol drinking during early adolescence activates microglial cells and increases frontolimbic Interleukin-1 beta and Toll-like receptor 4 gene expression, with heightened sensitivity in male rats compared to females.
Shortening time for access to alcohol drives up front-loading behavior, bringing consumption in male rats to the level of females.
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