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One or more keywords matched the following properties of Donahue, J.

Dr. Donahue completed undergraduate and medical education at Washington University in St. Louis, followed by an internal medicine residency at the Hospital of the University of Pennsylvania and fellowships in cardiology and cardiac electrophysiology at the Johns Hopkins University.  After completion of his medical training in 1999, Dr. Donahue served on the medical faculty at Johns Hopkins, where he attained the rank of Associate Professor prior to his 2005 relocation to Case Western Reserve University-MetroHealth Campus.  He was promoted to Professor at Case Western in 2011.  In 2013, Dr. Donahue relocated to the University of Massachusetts Medical School to start a position as Director of Electrophysiology Research. 

Dr. Donahue’s primary research interests are the elucidation of mechanisms, and from that, the development of therapies for cardiac arrhythmias.  As a means to that end, the Donahue lab has developed several gene therapy methods and created novel animal models of cardiac arrhythmias.  The Donahue lab was first to show efficacy of gene therapy for a cardiac arrhythmia in a 12/2000 Nature Medicine publication documenting heart rate control in atrial fibrillation after atrioventricular nodal gene transfer of Gαi2.  More recently, the lab demonstrated complete elimination of post-myocardial infarction ventricular arrhythmias(Nature Medicine 12/2006) and reduction in atrial fibrillation vulnerability in porcine disease models after potassium channel and connexin gene transfer.  Ongoing interests include the investigation of mechanisms for ischemic and post-infarct ventricular arrhythmias and chronic atrial fibrillation, the development of improved gene delivery methods, and the use of these methods for arrhythmia gene therapy.

One or more keywords matched the following items that are connected to Donahue, J.
Item TypeName
Academic Article Focal modification of electrical conduction in the heart by viral gene transfer.
Academic Article Inhibitory G protein overexpression provides physiologically relevant heart rate control in persistent atrial fibrillation.
Concept Atrial Fibrillation
Academic Article Connexin gene transfer preserves conduction velocity and prevents atrial fibrillation.
Academic Article Selective molecular potassium channel blockade prevents atrial fibrillation.
Academic Article Creation of a genetic calcium channel blocker by targeted gem gene transfer in the heart.
Academic Article Pathophysiological findings in a model of persistent atrial fibrillation and severe congestive heart failure.
Academic Article Gene therapy strategies for cardiac electrical dysfunction.
Academic Article Biological therapies for atrial fibrillation.
Academic Article Information learned from animal models of atrial fibrillation.
Academic Article Plasma microRNAs are associated with atrial fibrillation and change after catheter ablation (the miRhythm study).
Academic Article Addition of B-Type Natriuretic Peptide to Existing Clinical Risk Scores Enhances Identification of Patients at Risk for Atrial Fibrillation Recurrence After Pulmonary Vein Isolation.
Academic Article Biological Therapies for Atrial Fibrillation: Ready for Prime Time?
Academic Article The Use of Gene Therapy for Ablation of Atrial Fibrillation.
Academic Article Association of Left Atrial Function Index With Late Atrial Fibrillation Recurrence after Catheter Ablation.
Academic Article Connexin Remodeling Contributes to Atrial Fibrillation.
Academic Article Preclinical efficacy and safety of KCNH2-G628S gene therapy for postoperative atrial fibrillation.
Academic Article Calcium/calmodulin-dependent protein kinase II causes atrial structural remodeling associated with atrial fibrillation and heart failure.
Academic Article Relations between plasma microRNAs, echocardiographic markers of atrial remodeling, and atrial fibrillation: Data from the Framingham Offspring study.
Academic Article Atrial Gene Painting in Large Animal Model of Atrial Fibrillation.
Academic Article Preclinical safety and biodistribution assessment of Ad-KCNH2-G628S administered via atrial painting in New Zealand white rabbits.
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  • Atrial Fibrillation