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Dr. Donahue completed undergraduate and medical education at Washington University in St. Louis, followed by an internal medicine residency at the Hospital of the University of Pennsylvania and fellowships in cardiology and cardiac electrophysiology at the Johns Hopkins University.  After completion of his medical training in 1999, Dr. Donahue served on the medical faculty at Johns Hopkins, where he attained the rank of Associate Professor prior to his 2005 relocation to Case Western Reserve University-MetroHealth Campus.  He was promoted to Professor at Case Western in 2011.  In 2013, Dr. Donahue relocated to the University of Massachusetts Medical School to start a position as Director of Electrophysiology Research. 

Dr. Donahue’s primary research interests are the elucidation of mechanisms, and from that, the development of therapies for cardiac arrhythmias.  As a means to that end, the Donahue lab has developed several gene therapy methods and created novel animal models of cardiac arrhythmias.  The Donahue lab was first to show efficacy of gene therapy for a cardiac arrhythmia in a 12/2000 Nature Medicine publication documenting heart rate control in atrial fibrillation after atrioventricular nodal gene transfer of Gαi2.  More recently, the lab demonstrated complete elimination of post-myocardial infarction ventricular arrhythmias(Nature Medicine 12/2006) and reduction in atrial fibrillation vulnerability in porcine disease models after potassium channel and connexin gene transfer.  Ongoing interests include the investigation of mechanisms for ischemic and post-infarct ventricular arrhythmias and chronic atrial fibrillation, the development of improved gene delivery methods, and the use of these methods for arrhythmia gene therapy.

One or more keywords matched the following items that are connected to Donahue, J.
Item TypeName
Academic Article Focal modification of electrical conduction in the heart by viral gene transfer.
Academic Article Hemodynamic modulation of endocardial thromboresistance.
Academic Article Inhibitory G protein overexpression provides physiologically relevant heart rate control in persistent atrial fibrillation.
Concept Heart Arrest
Concept Heart Block
Concept Heart
Concept Heart Transplantation
Concept Heart Failure
Concept National Heart, Lung, and Blood Institute (U.S.)
Concept Heart Conduction System
Concept Heart Rate
Concept Heart Atria
Concept Heart Ventricles
Concept Heart Diseases
Academic Article Connexin43 gene transfer reduces ventricular tachycardia susceptibility after myocardial infarction.
Academic Article Connexin gene transfer preserves conduction velocity and prevents atrial fibrillation.
Academic Article Selective molecular potassium channel blockade prevents atrial fibrillation.
Academic Article Ventricular tachycardia from the healed myocardial infarction scar: validation of an animal model and utility of gene therapy.
Academic Article Inherited arrhythmias: a National Heart, Lung, and Blood Institute and Office of Rare Diseases workshop consensus report about the diagnosis, phenotyping, molecular mechanisms, and therapeutic approaches for primary cardiomyopathies of gene mutations affecting ion channel function.
Academic Article Clinical course and long-term follow-up of patients receiving implantable cardioverter-defibrillators.
Academic Article Temporary placement of a defibrillating lead in the treatment of infection and ventricular tachycardia.
Academic Article Targeted modification of atrial electrophysiology by homogeneous transmural atrial gene transfer.
Academic Article Creation of a genetic calcium channel blocker by targeted gem gene transfer in the heart.
Academic Article Successful implantable cardioverter defibrillator placement in an ambulatory patient without thoracic venous access.
Academic Article Pathophysiological findings in a model of persistent atrial fibrillation and severe congestive heart failure.
Academic Article Phosphodiesterase inhibitor-mediated potentiation of adenovirus delivery to myocardium.
Academic Article Acceleration of widespread adenoviral gene transfer to intact rabbit hearts by coronary perfusion with low calcium and serotonin.
Academic Article Ultrarapid, highly efficient viral gene transfer to the heart.
Academic Article Advice for management of the long-QT patient.
Academic Article Gender and the heart.
Academic Article Biological therapies for atrial fibrillation.
Academic Article Information learned from animal models of atrial fibrillation.
Academic Article Coronary perfusion cocktails for in vivo gene transfer.
Academic Article Gene therapy to treat cardiovascular disease.
Academic Article Highlights of Heart Rhythm 2005, the Annual Scientific Sessions of the Heart Rhythm Society, May 4-7, 2005, New Orleans, Louisiana.
Academic Article The future of fellowship training in clinical cardiac electrophysiology: Program directors' perspective 2008.
Academic Article Pro- and antiarrhythmic effects of fast cardiac pacing in a canine model of acquired long QT syndrome.
Academic Article Improved conduction and increased cell retention in healed MI using mesenchymal stem cells suspended in alginate hydrogel.
Academic Article Plasma microRNAs are associated with atrial fibrillation and change after catheter ablation (the miRhythm study).
Academic Article Cardiac gene therapy: a call for basic methods development.
Academic Article Association of Left Atrial Function Index With Late Atrial Fibrillation Recurrence after Catheter Ablation.
Academic Article Preclinical efficacy and safety of KCNH2-G628S gene therapy for postoperative atrial fibrillation.
Academic Article Calcium/calmodulin-dependent protein kinase II causes atrial structural remodeling associated with atrial fibrillation and heart failure.
Academic Article Heterogeneous repolarization creates ventricular tachycardia circuits in healed myocardial infarction scar.
Academic Article Repolarization Heterogeneity in Human Post-Infarct Ventricular Tachycardia.
Academic Article Atrial Gene Painting in Large Animal Model of Atrial Fibrillation.
Academic Article Preclinical safety and biodistribution assessment of Ad-KCNH2-G628S administered via atrial painting in New Zealand white rabbits.
Academic Article Mechanism of Ventricular Tachycardia Occurring in Chronic Myocardial Infarction Scar.
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