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Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways.
Sequential rounds of RNA-dependent RNA transcription drive endogenous small-RNA biogenesis in the ERGO-1/Argonaute pathway.
Tudor domain ERI-5 tethers an RNA-dependent RNA polymerase to DCR-1 to potentiate endo-RNAi.
A ribonuclease coordinates siRNA amplification and mRNA cleavage during RNAi.
The RNA phosphatase PIR-1 regulates endogenous small RNA pathways in C. elegans.