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Phillip D. Zamore, Ph.D., the Gretchen Stone Cook Professor of Biomedical Sciences, Professor of Biochemistry and Molecular Pharmacology, and Investigator of the Howard Hughes Medical Institute, is Chair of the RNA Therapeutics Institute, which was established at the University of Massachusetts Medical School in 2009. Zamore received his A.B. and Ph.D. degrees in Biochemistry and Molecular Biology from Harvard University. He then pursued postdoctoral studies at MIT and the Whitehead Institute for Biomedical Research.

The Zamore laboratory studies small RNA silencing pathways in eukaryotes and prokaryotes, including the RNA interference (RNAi), microRNA, and PIWI-interacting RNA pathways. Zamore and his collaborators seek to use the fundamental insights gained from studies in model and non-model bacteria, insects, and mammals to design therapies for human diseases, including Huntington’s disease. 

In 2015, Zamore was awarded the Chancellor’s Medal for Excellence in Scholarship at the University of Massachusetts Medical School. To date, Zamore has more than 125 publications and has been among the most highly cited researchers for more than a decade. 

Zamore was elected a Fellow of the National Academy of Inventors in 2014 and was selected in 2015 by Nature Biotechnology as one of the Top 20 Translational Researchers of 2014. In 2002, Zamore co-founded Alnylam Pharmaceuticals, a publicly traded biotech company which now has more than 200 employees and currently has more than six drugs in clinical trials. In 2014, he co-founded Voyager Therapeutics. He serves on the scientific advisory boards of Alnylam, Voyager, and RaNA Therapeutics.

Understanding the molecular mechanisms of post-transcriptional gene regulation.
 
How do animal embryos regulate the localization, translation, and stability of mRNAs?
In Drosophila, mRNA encoding the transcription factor, hunchback, is present throughout the embryo, but is translated into protein only in the anterior half of the cell. Two proteins, NANOS and PUMILIO. are required to repress hunchback translation in the posterior half of the fly embryo. PUMILIO binds RNA through a novel RNA-binding motif found in proteins that control developmental decisions in yeast, slime mold, and worms, and is more than 80% identical to a protein of unknown function in humans. A major goal of our laboratory is to learn how PUMILIO and NANOS control hunchback mRNA translation and to determine the biological role of the human PUMILIO protein.
 
For more information, please visit our lab website and our Howard Hughes Medical Institute web page. 
 
 

 

overview

Phillip D. Zamore, Ph.D., the Gretchen Stone Cook Professor of Biomedical Sciences, Professor of Biochemistry and Molecular Pharmacology, and Investigator of the Howard Hughes Medical Institute, is Chair of the RNA Therapeutics Institute, which was established at the University of Massachusetts Medical School in 2009. Zamore received his A.B. and Ph.D. degrees in Biochemistry and Molecular Biology from Harvard University. He then pursued postdoctoral studies at MIT and the Whitehead Institute for Biomedical Research.

The Zamore laboratory studies small RNA silencing pathways in eukaryotes and prokaryotes, including the RNA interference (RNAi), microRNA, and PIWI-interacting RNA pathways. Zamore and his collaborators seek to use the fundamental insights gained from studies in model and non-model bacteria, insects, and mammals to design therapies for human diseases, including Huntington’s disease. 

In 2015, Zamore was awarded the Chancellor’s Medal for Excellence in Scholarship at the University of Massachusetts Medical School. To date, Zamore has more than 125 publications and has been among the most highly cited researchers for more than a decade. 

Zamore was elected a Fellow of the National Academy of Inventors in 2014 and was selected in 2015 by Nature Biotechnology as one of the Top 20 Translational Researchers of 2014. In 2002, Zamore co-founded Alnylam Pharmaceuticals, a publicly traded biotech company which now has more than 200 employees and currently has more than six drugs in clinical trials. In 2014, he co-founded Voyager Therapeutics. He serves on the scientific advisory boards of Alnylam, Voyager, and RaNA Therapeutics.

Understanding the molecular mechanisms of post-transcriptional gene regulation.
 
How do animal embryos regulate the localization, translation, and stability of mRNAs?
In Drosophila, mRNA encoding the transcription factor, hunchback, is present throughout the embryo, but is translated into protein only in the anterior half of the cell. Two proteins, NANOS and PUMILIO. are required to repress hunchback translation in the posterior half of the fly embryo. PUMILIO binds RNA through a novel RNA-binding motif found in proteins that control developmental decisions in yeast, slime mold, and worms, and is more than 80% identical to a protein of unknown function in humans. A major goal of our laboratory is to learn how PUMILIO and NANOS control hunchback mRNA translation and to determine the biological role of the human PUMILIO protein.
 
For more information, please visit our lab website and our Howard Hughes Medical Institute web page. 
 
 

 

One or more keywords matched the following items that are connected to Zamore, Phillip
Item TypeName
Academic Article A CCHC metal-binding domain in Nanos is essential for translational regulation.
Academic Article The Pumilio protein binds RNA through a conserved domain that defines a new class of RNA-binding proteins.
Academic Article Drosophila development: homeodomains and translational control.
Academic Article RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals.
Academic Article Crystal structure of a Pumilio homology domain.
Academic Article A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA.
Academic Article ATP requirements and small interfering RNA structure in the RNA interference pathway.
Academic Article The PUMILIO-RNA interaction: a single RNA-binding domain monomer recognizes a bipartite target sequence.
Academic Article Asymmetry in the assembly of the RNAi enzyme complex.
Academic Article Sequence-specific inhibition of small RNA function.
Academic Article Kinetic analysis of the RNAi enzyme complex.
Academic Article Targeted mRNA degradation by double-stranded RNA in vitro.
Academic Article Plant RNA interference in vitro.
Academic Article Designing siRNA that distinguish between genes that differ by a single nucleotide.
Academic Article Measuring the rates of transcriptional elongation in the female Drosophila melanogaster germ line by nuclear run-on.
Academic Article The Drosophila RNA methyltransferase, DmHen1, modifies germline piRNAs and single-stranded siRNAs in RISC.
Academic Article Drosophila microRNAs are sorted into functionally distinct argonaute complexes after production by dicer-1.
Academic Article Argonaute loading improves the 5' precision of both MicroRNAs and their miRNA* strands in flies.
Academic Article Endogenous siRNAs derived from transposons and mRNAs in Drosophila somatic cells.
Academic Article Design and delivery of antisense oligonucleotides to block microRNA function in cultured Drosophila and human cells.
Academic Article Collapse of germline piRNAs in the absence of Argonaute3 reveals somatic piRNAs in flies.
Academic Article The Drosophila HP1 homolog Rhino is required for transposon silencing and piRNA production by dual-strand clusters.
Academic Article Target RNA-directed trimming and tailing of small silencing RNAs.
Academic Article Somatic piRNA biogenesis.
Academic Article Target RNA-directed tailing and trimming purifies the sorting of endo-siRNAs between the two Drosophila Argonaute proteins.
Academic Article Deep annotation of Drosophila melanogaster microRNAs yields insights into their processing, modification, and emergence.
Academic Article A 5'-uridine amplifies miRNA/miRNA* asymmetry in Drosophila by promoting RNA-induced silencing complex formation.
Academic Article Why do miRNAs live in the miRNP?
Academic Article The 3'-to-5' exoribonuclease Nibbler shapes the 3' ends of microRNAs bound to Drosophila Argonaute1.
Academic Article A microRNA in a multiple-turnover RNAi enzyme complex.
Academic Article Modular recognition of RNA by a human pumilio-homology domain.
Academic Article Argonaute divides its RNA guide into domains with distinct functions and RNA-binding properties.
Academic Article Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways.
Academic Article Rapid and specific purification of Argonaute-small RNA complexes from crude cell lysates.
Academic Article In vitro analysis of RNA interference in Drosophila melanogaster.
Academic Article Selective silencing by RNAi of a dominant allele that causes amyotrophic lateral sclerosis.
Academic Article Biochemical dissection of RNA silencing in plants.
Academic Article RISC assembly defects in the Drosophila RNAi mutant armitage.
Academic Article The protein Sex-lethal antagonizes the splicing factor U2AF to regulate alternative splicing of transformer pre-mRNA.
Academic Article The RNA-induced silencing complex is a Mg2+-dependent endonuclease.
Academic Article A protein sensor for siRNA asymmetry.
Academic Article Normal microRNA maturation and germ-line stem cell maintenance requires Loquacious, a double-stranded RNA-binding domain protein.
Academic Article Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes.
Academic Article A distinct small RNA pathway silences selfish genetic elements in the germline.
Academic Article RNA silencing: genomic defence with a slice of pi.
Academic Article Sorting of Drosophila small silencing RNAs.
Academic Article A role for microRNAs in the Drosophila circadian clock.
Academic Article SnapShot: Fly piRNAs, PIWI proteins, and the ping-pong cycle.
Academic Article Sorting of Drosophila small silencing RNAs partitions microRNA* strands into the RNA interference pathway.
Academic Article Phosphate and R2D2 restrict the substrate specificity of Dicer-2, an ATP-driven ribonuclease.
Academic Article Isolation of Drosophila melanogaster testes.
Academic Article Heterotypic piRNA Ping-Pong requires qin, a protein with both E3 ligase and Tudor domains.
Academic Article Adaptation to P element transposon invasion in Drosophila melanogaster.
Academic Article Dicer partner proteins tune the length of mature miRNAs in flies and mammals.
Academic Article UAP56 couples piRNA clusters to the perinuclear transposon silencing machinery.
Academic Article Small RNA-directed silencing: the fly finds its inner fission yeast?
Academic Article Translational regulation in development.
Concept Drosophila melanogaster
Concept Drosophila
Concept Drosophila Proteins
Academic Article Inorganic phosphate blocks binding of pre-miRNA to Dicer-2 via its PAZ domain.
Academic Article Antisense piRNA amplification, but not piRNA production or nuage assembly, requires the Tudor-domain protein Qin.
Academic Article A universal small molecule, inorganic phosphate, restricts the substrate specificity of Dicer-2 in small RNA biogenesis.
Academic Article The HP1 homolog rhino anchors a nuclear complex that suppresses piRNA precursor splicing.
Academic Article The initial uridine of primary piRNAs does not create the tenth adenine that Is the hallmark of secondary piRNAs.
Academic Article piPipes: a set of pipelines for piRNA and transposon analysis via small RNA-seq, RNA-seq, degradome- and CAGE-seq, ChIP-seq and genomic DNA sequencing.
Academic Article Pitfalls of mapping high-throughput sequencing data to repetitive sequences: Piwi's genomic targets still not identified.
Academic Article Noncoding RNA. piRNA-guided transposon cleavage initiates Zucchini-dependent, phased piRNA production.
Academic Article Assessing long-distance RNA sequence connectivity via RNA-templated DNA-DNA ligation.
Academic Article Slicing and Binding by Ago3 or Aub Trigger Piwi-Bound piRNA Production by Distinct Mechanisms.
Academic Article Tailor: a computational framework for detecting non-templated tailing of small silencing RNAs.
Academic Article Rapid Screening for CRISPR-Directed Editing of the Drosophila Genome Using white Coconversion.
Academic Article A Single Mechanism of Biogenesis, Initiated and Directed by PIWI Proteins, Explains piRNA Production in Most Animals.
Academic Article Inhibiting miRNA Function by Antisense Oligonucleotides in Drosophila S2 Cells.
Academic Article Maelstrom Represses Canonical Polymerase II Transcription within Bi-directional piRNA Clusters in Drosophila melanogaster.
Academic Article RNAi in Drosophila S2 Cells by dsRNA Soaking.
Academic Article RNAi in Drosophila S2 Cells by siRNA Duplex or dsRNA Transfection.
Academic Article The RNA-Binding ATPase, Armitage, Couples piRNA Amplification in Nuage to Phased piRNA Production on Mitochondria.
Academic Article Terminal modification, sequence, length, and PIWI-protein identity determine piRNA stability.
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  • Drosophila