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Academic Article
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T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens.
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Academic Article
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Dynamics of memory T cell proliferation under conditions of heterologous immunity and bystander stimulation.
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Academic Article
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A molecular basis for how a single TCR interfaces multiple ligands.
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Academic Article
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Direct visualization of cross-reactive effector and memory allo-specific CD8 T cells generated in response to viral infections.
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Academic Article
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Immunogenicity of herpes simplex virus type 1 mutants containing deletions in one or more alpha-genes: ICP4, ICP27, ICP22, and ICP0.
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Academic Article
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Narrowed TCR repertoire and viral escape as a consequence of heterologous immunity.
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Academic Article
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Partial versus full allogeneic hemopoietic chimerization is a preferential means to inhibit type 1 diabetes as the latter induces generalized immunosuppression.
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Academic Article
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Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice.
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Academic Article
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Cutting edge: Dab2 is a FOXP3 target gene required for regulatory T cell function.
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Academic Article
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Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation.
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Academic Article
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Engraftment of human HSCs in nonirradiated newborn NOD-scid IL2r? null mice is enhanced by transgenic expression of membrane-bound human SCF.
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Academic Article
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Enhanced humoral and HLA-A2-restricted dengue virus-specific T-cell responses in humanized BLT NSG mice.
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Academic Article
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The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells.
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Academic Article
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Durable knockdown and protection from HIV transmission in humanized mice treated with gel-formulated CD4 aptamer-siRNA chimeras.
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Academic Article
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Preapoptotic phenotype of viral epitope-specific CD8 T cells precludes memory development and is an intrinsic property of the epitope.
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Academic Article
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Rapid conversion of effector mechanisms from NK to T cells during virus-induced lysis of allogeneic implants in vivo.
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Academic Article
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Rapid production of TNF-alpha following TCR engagement of naive CD8 T cells.
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Academic Article
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TLR agonists abrogate costimulation blockade-induced prolongation of skin allografts.
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Academic Article
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Tec kinases Itk and Rlk are required for CD8+ T cell responses to virus infection independent of their role in CD4+ T cell help.
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Academic Article
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Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims MHC class I-presented peptides in vivo and plays an important role in immunodominance.
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Academic Article
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Transgenic expression of the viral FLIP MC159 causes lpr/gld-like lymphoproliferation and autoimmunity.
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Academic Article
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Rapid quantification of naive alloreactive T cells by TNF-alpha production and correlation with allograft rejection in mice.
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Academic Article
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Protection against vaccinia virus challenge by CD8 memory T cells resolved by molecular mimicry.
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Academic Article
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TLR agonists prevent the establishment of allogeneic hematopoietic chimerism in mice treated with costimulation blockade.
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Academic Article
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Development of novel major histocompatibility complex class I and class II-deficient NOD-SCID IL2R gamma chain knockout mice for modeling human xenogeneic graft-versus-host disease.
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Academic Article
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NOD-scid IL2rgamma(null) mouse model of human skin transplantation and allograft rejection.
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Academic Article
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CD8 T cell cross-reactivity networks mediate heterologous immunity in human EBV and murine vaccinia virus infections.
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Academic Article
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Human immune system development and rejection of human islet allografts in spontaneously diabetic NOD-Rag1null IL2rgammanull Ins2Akita mice.
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Academic Article
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Humanized nonobese diabetic-scid IL2rgammanull mice are susceptible to lethal Salmonella Typhi infection.
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Academic Article
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Dynamic glucoregulation and mammalian-like responses to metabolic and developmental disruption in zebrafish.
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Academic Article
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Maturation-dependent licensing of naive T cells for rapid TNF production.
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Academic Article
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Hyperglycemia-induced proliferation of adult human beta cells engrafted into spontaneously diabetic immunodeficient NOD-Rag1null IL2r?null Ins2Akita mice.
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Academic Article
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Humanized mice as a preclinical tool for infectious disease and biomedical research.
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Academic Article
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Humanized mice for the study of type 1 and type 2 diabetes.
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Academic Article
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Advancing animal models of human type 1 diabetes by engraftment of functional human tissues in immunodeficient mice.
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Academic Article
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Alloreactive CD8 T cells rescued from apoptosis during co-stimulation blockade by Toll-like receptor stimulation remain susceptible to Fas-induced cell death.
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Academic Article
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Generation of islet-like cells from mouse gall bladder by direct ex vivo reprogramming.
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Concept
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Mice, Inbred CBA
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Concept
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Mice, Inbred BALB C
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Concept
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Mice, Inbred MRL lpr
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Concept
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Mice, Inbred C3H
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Concept
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Mice, Inbred C57BL
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Concept
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Mice, Inbred NOD
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Concept
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Mice, Inbred DBA
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Academic Article
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Engrafted human cells generate adaptive immune responses to Mycobacterium bovis BCG infection in humanized mice.
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Academic Article
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MHC basis of T cell-dependent heterologous immunity to arenaviruses.
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Academic Article
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The Presence and Preferential Activation of Regulatory T Cells Diminish Adoptive Transfer of Autoimmune Diabetes by Polyclonal Nonobese Diabetic (NOD) T Cell Effectors into NSG versus NOD-scid Mice.
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Academic Article
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Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection.
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Academic Article
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Inflammation Mediated by JNK in Myeloid Cells Promotes the Development of Hepatitis and Hepatocellular Carcinoma.
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Academic Article
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Generation of Immunodeficient Mice Bearing Human Immune Systems by the Engraftment of Hematopoietic Stem Cells.
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Academic Article
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Genetically modified human CD4(+) T cells can be evaluated in?vivo without lethal graft-versus-host disease.
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Academic Article
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Improved B cell development in humanized NOD-scid IL2R?null mice transgenically expressing human stem cell factor, granulocyte-macrophage colony-stimulating factor and interleukin-3.
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Academic Article
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A novel hemolytic complement-sufficient NSG mouse model supports studies of complement-mediated antitumor activity in vivo.
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Academic Article
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mRNA-mediated glycoengineering ameliorates deficient homing of human stem cell-derived hematopoietic progenitors.
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Academic Article
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Gene Therapy with an Adeno-Associated Viral Vector Expressing Human Interleukin-2 Alters Immune System Homeostasis in Humanized Mice.
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Academic Article
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Lack of acute xenogeneic graft- versus-host disease, but retention of T-cell function following engraftment of human peripheral blood mononuclear cells in NSG mice deficient in MHC class I and II expression.
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Academic Article
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Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunotherapy.
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Academic Article
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Survival Advantage of Both Human Hepatocyte Xenografts and Genome-Edited Hepatocytes for Treatment of a-1 Antitrypsin Deficiency.
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Academic Article
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Human Anti-HIV-1 gp120 Monoclonal Antibodies with Neutralizing Activity Cloned from Humanized Mice Infected with HIV-1.
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Academic Article
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Cutting Edge: Early Attrition of Memory T Cells during Inflammation and Costimulation Blockade Is Regulated Concurrently by Proapoptotic Proteins Fas and Bim.
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Academic Article
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Creation of PDX-Bearing Humanized Mice to Study Immuno-oncology.
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Academic Article
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Genome-wide Analysis of Salmonella enterica serovar Typhi in Humanized Mice Reveals Key Virulence Features.
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Academic Article
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Role of Interferon-?-Producing Th1 Cells in a Murine Model of Type I Interferon-Independent Autoinflammation Resulting From DNase II Deficiency.
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Academic Article
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A rapid, sensitive, and reproducible in vivo PBMC humanized murine model for determining therapeutic-related cytokine release syndrome.
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Academic Article
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An RNAi therapeutic targeting hepatic DGAT2 in a genetically obese mouse model of nonalcoholic steatohepatitis.
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Academic Article
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Enhanced development of functional human NK cells in NOD-scid-IL2rgnull mice expressing human IL15.
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Academic Article
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I-Ag7 ?56/57 polymorphisms regulate non-cognate negative selection to CD4+ T cell orchestrators of type 1 diabetes.
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Academic Article
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NOD-scid IL2r?null mice lacking TLR4 support human immune system development and the study of human-specific innate immunity.
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Academic Article
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Simultaneous evaluation of treatment efficacy and toxicity for bispecific T-cell engager therapeutics in a humanized mouse model.
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