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Brehm, Michael
One or more keywords matched the following properties of Brehm, Michael
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Endowed Chair Honorary Title Harvey A. Shultz Chair in Diabetes
One or more keywords matched the following items that are connected to Brehm, Michael
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Academic Article Virus-induced abrogation of transplantation tolerance induced by donor-specific transfusion and anti-CD154 antibody.
Academic Article Immunization with a replication-deficient mutant of herpes simplex virus type 1 (HSV-1) induces a CD8+ cytotoxic T-lymphocyte response and confers a level of protection comparable to that of wild-type HSV-1.
Academic Article The impact of psychological stress on the efficacy of anti-viral adoptive immunotherapy in an immunocompromised host.
Academic Article T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens.
Academic Article Dynamics of memory T cell proliferation under conditions of heterologous immunity and bystander stimulation.
Academic Article A molecular basis for how a single TCR interfaces multiple ligands.
Academic Article Immunization with a single major histocompatibility complex class I-restricted cytotoxic T-lymphocyte recognition epitope of herpes simplex virus type 2 confers protective immunity.
Academic Article Heterologous immunity and the CD8 T cell network.
Academic Article Direct visualization of cross-reactive effector and memory allo-specific CD8 T cells generated in response to viral infections.
Academic Article Virus-specific CD8 T cells in peripheral tissues are more resistant to apoptosis than those in lymphoid organs.
Academic Article Immunogenicity of herpes simplex virus type 1 mutants containing deletions in one or more alpha-genes: ICP4, ICP27, ICP22, and ICP0.
Academic Article CD8 T cell responses to viral infections in sequence.
Academic Article CD8 memory T cells: cross-reactivity and heterologous immunity.
Academic Article Narrowed TCR repertoire and viral escape as a consequence of heterologous immunity.
Academic Article Consequences of cross-reactive and bystander CTL responses during viral infections.
Academic Article Partial versus full allogeneic hemopoietic chimerization is a preferential means to inhibit type 1 diabetes as the latter induces generalized immunosuppression.
Academic Article Different mechanisms control peripheral and central tolerance in hematopoietic chimeric mice.
Academic Article Frontiers in nephrology: heterologous immunity, T cell cross-reactivity, and alloreactivity.
Academic Article Type 1 IFN mediates cross-talk between innate and adaptive immunity that abrogates transplantation tolerance.
Academic Article Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice.
Academic Article TLR agonists abrogate co-stimulation blockade-induced mixed chimerism and transplantation tolerance.
Academic Article Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex.
Academic Article Memory CD8+ T cells in heterologous antiviral immunity and immunopathology in the lung.
Academic Article Cutting edge: Dab2 is a FOXP3 target gene required for regulatory T cell function.
Academic Article Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation.
Academic Article Humanized mouse models to study human diseases.
Academic Article Heterologous immunity between viruses.
Academic Article Allografts stimulate cross-reactive virus-specific memory CD8 T cells with private specificity.
Academic Article Engraftment of human HSCs in nonirradiated newborn NOD-scid IL2r? null mice is enhanced by transgenic expression of membrane-bound human SCF.
Academic Article Human allograft rejection in humanized mice: a historical perspective.
Academic Article Enhanced humoral and HLA-A2-restricted dengue virus-specific T-cell responses in humanized BLT NSG mice.
Academic Article The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells.
Academic Article Humanized mice for immune system investigation: progress, promise and challenges.
Academic Article Durable knockdown and protection from HIV transmission in humanized mice treated with gel-formulated CD4 aptamer-siRNA chimeras.
Academic Article Preapoptotic phenotype of viral epitope-specific CD8 T cells precludes memory development and is an intrinsic property of the epitope.
Academic Article Rapid conversion of effector mechanisms from NK to T cells during virus-induced lysis of allogeneic implants in vivo.
Academic Article Rapid production of TNF-alpha following TCR engagement of naive CD8 T cells.
Academic Article TLR agonists abrogate costimulation blockade-induced prolongation of skin allografts.
Academic Article Stem cell therapy in postinfarction chronic coronary heart disease.
Academic Article Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims MHC class I-presented peptides in vivo and plays an important role in immunodominance.
Academic Article Memory of mice and men: CD8+ T-cell cross-reactivity and heterologous immunity.
Academic Article Transgenic expression of the viral FLIP MC159 causes lpr/gld-like lymphoproliferation and autoimmunity.
Academic Article Rapid quantification of naive alloreactive T cells by TNF-alpha production and correlation with allograft rejection in mice.
Academic Article Protection against vaccinia virus challenge by CD8 memory T cells resolved by molecular mimicry.
Academic Article TLR agonists prevent the establishment of allogeneic hematopoietic chimerism in mice treated with costimulation blockade.
Academic Article CHOP mediates endoplasmic reticulum stress-induced apoptosis in Gimap5-deficient T cells.
Academic Article Development of novel major histocompatibility complex class I and class II-deficient NOD-SCID IL2R gamma chain knockout mice for modeling human xenogeneic graft-versus-host disease.
Academic Article NOD-scid IL2rgamma(null) mouse model of human skin transplantation and allograft rejection.
Academic Article CD8 T cell cross-reactivity networks mediate heterologous immunity in human EBV and murine vaccinia virus infections.
Academic Article Human immune system development and rejection of human islet allografts in spontaneously diabetic NOD-Rag1null IL2rgammanull Ins2Akita mice.
Academic Article Humanized nonobese diabetic-scid IL2rgammanull mice are susceptible to lethal Salmonella Typhi infection.
Academic Article Bi-specific MHC heterodimers for characterization of cross-reactive T cells.
Academic Article Dynamic glucoregulation and mammalian-like responses to metabolic and developmental disruption in zebrafish.
Academic Article Maturation-dependent licensing of naive T cells for rapid TNF production.
Academic Article Hyperglycemia-induced proliferation of adult human beta cells engrafted into spontaneously diabetic immunodeficient NOD-Rag1null IL2r?null Ins2Akita mice.
Academic Article Human peripheral blood CD4 T cell-engrafted non-obese diabetic-scid IL2r?(null) H2-Ab1 (tm1Gru) Tg (human leucocyte antigen D-related 4) mice: a mouse model of human allogeneic graft-versus-host disease.
Academic Article T-cell activation and transplantation tolerance.
Academic Article Humanized mice as a preclinical tool for infectious disease and biomedical research.
Academic Article Humanized mice for the study of type 1 and type 2 diabetes.
Academic Article Advancing animal models of human type 1 diabetes by engraftment of functional human tissues in immunodeficient mice.
Academic Article Alloreactive CD8 T cells rescued from apoptosis during co-stimulation blockade by Toll-like receptor stimulation remain susceptible to Fas-induced cell death.
Academic Article Generation of islet-like cells from mouse gall bladder by direct ex vivo reprogramming.
Academic Article Humanized mice for the study of infectious diseases.
Concept SOXB1 Transcription Factors
Concept Central Nervous System
Concept RNA, Small Interfering
Concept Heat-Shock Proteins
Concept Interleukin-2 Receptor alpha Subunit
Concept Neoplastic Stem Cells
Concept Ubiquitin-Protein Ligases
Concept Hematopoietic Stem Cell Transplantation
Concept Oxidative Stress
Concept Genes, MHC Class II
Concept Immune System Diseases
Concept Cell Survival
Concept Glucagon-Secreting Cells
Concept National Institute of Diabetes and Digestive and Kidney Diseases (U.S.)
Concept Genes, Dominant
Concept Genes, Viral
Concept Succinimides
Concept Amino Acid Sequence
Concept Stress, Physiological
Concept src-Family Kinases
Concept Salmonella
Concept Specific Pathogen-Free Organisms
Concept Salicylates
Concept E-Selectin
Concept Tumor Stem Cell Assay
Concept T-Lymphocyte Subsets
Concept Herpes Simplex
Concept GTP-Binding Protein alpha Subunits, Gs
Concept Up-Regulation
Concept Small Molecule Libraries
Concept Acquired Immunodeficiency Syndrome
Concept Salmonella typhi
Concept Statistics, Nonparametric
Concept Simplexvirus
Concept Serum Albumin
Concept Transgenes
Concept STAT Transcription Factors
Concept Organ Specificity
Concept Complement System Proteins
Concept Retrospective Studies
Concept Insulin-Secreting Cells
Concept Cell Separation
Concept Granulocyte-Macrophage Colony-Stimulating Factor
Concept Skin Transplantation
Concept Signal Transduction
Concept Hematopoietic Stem Cells
Concept Drug Screening Assays, Antitumor
Concept Adaptor Proteins, Signal Transducing
Concept Major Histocompatibility Complex
Concept Severe Combined Immunodeficiency
Concept Stem Cell Factor
Concept Second Messenger Systems
Concept Protein Structure, Quaternary
Concept Salmonella Infections
Concept Amyloid Precursor Protein Secretases
Concept Mice, SCID
Concept Digestive System
Concept Induced Pluripotent Stem Cells
Concept Genes, abl
Concept Interleukin Receptor Common gamma Subunit
Concept Antibody Specificity
Concept Stem Cell Transplantation
Concept Immune System
Concept Spleen
Concept Stress, Psychological
Concept In Situ Hybridization
Concept Genome-Wide Association Study
Concept Embryonic Stem Cells
Concept Nitric Oxide Synthase Type II
Concept Graft Survival
Concept Pluripotent Stem Cells
Concept Rats, Sprague-Dawley
Concept Siderophores
Concept United States
Concept Structure-Activity Relationship
Concept Gene Silencing
Concept Base Sequence
Concept Genes, Recessive
Concept Muscle, Skeletal
Concept Mice, Mutant Strains
Concept Molecular Sequence Data
Concept Tumor Suppressor Proteins
Concept Lymphocyte Subsets
Concept Genes, MHC Class I
Academic Article Generation of organized anterior foregut epithelia from pluripotent stem cells using small molecules.
Academic Article Salicylate prevents virus-induced type 1 diabetes in the BBDR rat.
Academic Article Overcoming current limitations in humanized mouse research.
Academic Article Site-specific Genome Editing in PBMCs With PLGA Nanoparticle-delivered PNAs Confers HIV-1 Resistance in Humanized Mice.
Academic Article Engrafted human cells generate adaptive immune responses to Mycobacterium bovis BCG infection in humanized mice.
Academic Article c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells.
Academic Article An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia.
Academic Article Graded levels of IRF4 regulate CD8+ T cell differentiation and expansion, but not attrition, in response to acute virus infection.
Academic Article Immunodeficient mouse model for human hematopoietic stem cell engraftment and immune system development.
Academic Article Viral infection of engrafted human islets leads to diabetes.
Academic Article Generation of improved humanized mouse models for human infectious diseases.
Academic Article MHC basis of T cell-dependent heterologous immunity to arenaviruses.
Academic Article Dengue virus infection induces broadly cross-reactive human IgM antibodies that recognize intact virions in humanized BLT-NSG mice.
Academic Article Extensive double humanization of both liver and hematopoiesis in FRGN mice.
Academic Article The Presence and Preferential Activation of Regulatory T Cells Diminish Adoptive Transfer of Autoimmune Diabetes by Polyclonal Nonobese Diabetic (NOD) T Cell Effectors into NSG versus NOD-scid Mice.
Academic Article Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection.
Academic Article Animal Models for Alopecia Areata: What and Where?
Academic Article Efficient and Targeted Transduction of Nonhuman Primate Liver With Systemically Delivered Optimized AAV3B Vectors.
Academic Article IRF4 Regulates the Ratio of T-Bet to Eomesodermin in CD8+ T Cells Responding to Persistent LCMV Infection.
Academic Article Humanized Mouse Models for Transplant Immunology.
Academic Article Human 'brite/beige' adipocytes develop from capillary networks, and their implantation improves metabolic homeostasis in mice.
Academic Article Generation of Immunodeficient Mice Bearing Human Immune Systems by the Engraftment of Hematopoietic Stem Cells.
Academic Article Genetically modified human CD4(+) T cells can be evaluated in?vivo without lethal graft-versus-host disease.
Academic Article Humanized mouse model of mast cell-mediated passive cutaneous anaphylaxis and passive systemic anaphylaxis.
Academic Article In vivo correction of anaemia in ?-thalassemic mice by ?PNA-mediated gene editing with nanoparticle delivery.
Academic Article Humanized Mouse Models of Clinical Disease.
Academic Article Improved B cell development in humanized NOD-scid IL2R?null mice transgenically expressing human stem cell factor, granulocyte-macrophage colony-stimulating factor and interleukin-3.
Academic Article A novel hemolytic complement-sufficient NSG mouse model supports studies of complement-mediated antitumor activity in vivo.
Academic Article mRNA-mediated glycoengineering ameliorates deficient homing of human stem cell-derived hematopoietic progenitors.
Academic Article Gene Therapy with an Adeno-Associated Viral Vector Expressing Human Interleukin-2 Alters Immune System Homeostasis in Humanized Mice.
Academic Article Lack of acute xenogeneic graft- versus-host disease, but retention of T-cell function following engraftment of human peripheral blood mononuclear cells in NSG mice deficient in MHC class I and II expression.
Academic Article Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunotherapy.
Academic Article Human immune system development and survival of non-obese diabetic (NOD)-scid IL2r?(null) (NSG) mice engrafted with human thymus and autologous haematopoietic stem cells.
Academic Article Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics.
Academic Article Survival Advantage of Both Human Hepatocyte Xenografts and Genome-Edited Hepatocytes for Treatment of a-1 Antitrypsin Deficiency.
Academic Article Human Anti-HIV-1 gp120 Monoclonal Antibodies with Neutralizing Activity Cloned from Humanized Mice Infected with HIV-1.
Academic Article Cutting Edge: Early Attrition of Memory T Cells during Inflammation and Costimulation Blockade Is Regulated Concurrently by Proapoptotic Proteins Fas and Bim.
Academic Article Humanized mouse models of immunological diseases and precision medicine.
Academic Article Creation of PDX-Bearing Humanized Mice to Study Immuno-oncology.
Academic Article Prosurvival kinase PIM2 is a therapeutic target for eradication of chronic myeloid leukemia stem cells.
Academic Article Humanized immune system mouse models: progress, challenges and opportunities.
Academic Article AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast Cell-Mediated Anaphylaxis in Mice.
Academic Article Genome-wide Analysis of Salmonella enterica serovar Typhi in Humanized Mice Reveals Key Virulence Features.
Academic Article Role of Interferon-?-Producing Th1 Cells in a Murine Model of Type I Interferon-Independent Autoinflammation Resulting From DNase II Deficiency.
Academic Article Proteomic and Transcriptional Profiles of Human Stem Cell-Derived ? Cells Following Enteroviral Challenge.
Academic Article Modeling Type 1 Diabetes In?Vitro Using Human Pluripotent Stem Cells.
Academic Article A rapid, sensitive, and reproducible in vivo PBMC humanized murine model for determining therapeutic-related cytokine release syndrome.
Academic Article Prostaglandin E2 stimulates cAMP signaling and resensitizes human leukemia cells to glucocorticoid-induced cell death.
Academic Article An RNAi therapeutic targeting hepatic DGAT2 in a genetically obese mouse model of nonalcoholic steatohepatitis.
Academic Article Modeling human T1D-associated autoimmune processes.
Concept Uncoupling Protein 1
Concept Walking Speed
Concept Transcriptome
Concept Receptors, Prostaglandin E, EP4 Subtype
Concept Endoplasmic Reticulum Stress
Concept Sialic Acid Binding Immunoglobulin-like Lectins
Concept Sialic Acid Binding Ig-like Lectin 1
Academic Article Analysis of Salmonella Typhi Pathogenesis in a Humanized Mouse Model.
Academic Article Discovery of an agonistic Siglec-6 antibody that inhibits and reduces human mast cells.
Academic Article Enhanced development of functional human NK cells in NOD-scid-IL2rgnull mice expressing human IL15.
Academic Article Humanized mouse models for immuno-oncology research.
Academic Article I-Ag7 ?56/57 polymorphisms regulate non-cognate negative selection to CD4+ T cell orchestrators of type 1 diabetes.
Academic Article NOD-scid IL2r?null mice lacking TLR4 support human immune system development and the study of human-specific innate immunity.
Academic Article Endemic Burkitt lymphoma avatar mouse models for exploring inter-patient tumor variation and testing targeted therapies.
Academic Article Therapeutic blocking of VEGF binding to neuropilin-2 diminishes PD-L1 expression to activate antitumor immunity in prostate cancer.
Academic Article Transcriptional and chromatin profiling of human blood innate lymphoid cell subsets sheds light on HIV-1 pathogenesis.
Academic Article Generation of the NeoThy mouse model for human immune system studies.
Academic Article Simultaneous evaluation of treatment efficacy and toxicity for bispecific T-cell engager therapeutics in a humanized mouse model.
Academic Article Identification of a humanized mouse model for functional testing of immune-mediated biomaterial foreign body response.
Academic Article ?d T cell dichotomy with opposing cytotoxic and wound healing functions in human solid tumors.
Academic Article CDK4/6 Inhibition Sensitizes Intracranial Tumors to PD-1 Blockade in Preclinical Models of Brain Metastasis.
Academic Article Generation and molecular characterization of human pluripotent stem cell-derived pharyngeal foregut endoderm.
Academic Article The calcium channel TRPC6 promotes chemotherapy-induced persistence by regulating integrin a6 mRNA splicing.
Academic Article Physical activity regulates the immune response to breast cancer by a hematopoietic stem cell-autonomous mechanism.
Academic Article A human immune/muscle xenograft model of FSHD muscle pathology.
Academic Article Nuclear factor kappa B-dependent persistence of Salmonella Typhi and Paratyphi in human macrophages.
Academic Article The role of quiescent thymic progenitors in TAL/LMO2-induced T-ALL chemotolerance.
Academic Article Preclinical Efficacy of VTX-0811: A Humanized First-in-Class PSGL-1 mAb Targeting TAMs to Suppress Tumor Growth.
Academic Article Neuropilin-2-expressing breast cancer cells mitigate radiation-induced oxidative stress through nitric oxide signaling.
Academic Article IRF2 loss is associated with reduced MHC I pathway transcripts in subsets of most human cancers and causes resistance to checkpoint immunotherapy in human and mouse melanomas.
Academic Article IRF2 loss is associated with reduced MHC I pathway transcripts in subsets of most human cancers and causes resistance to checkpoint immunotherapy in human and mouse melanomas.
Academic Article The co-receptor Neuropilin-1 enhances proliferation in inv(16) acute myeloid leukemia via VEGF signaling.
Academic Article Closing the Gap Between Vision and Victory in Type 1 Diabetes: The NIDDK Human Islet Research Network (HIRN) Initiative.
Academic Article Transplantation of human kidney organoids elicited a robust allogeneic response in a humanized mouse model.
Academic Article Reliability of the walking energy cost test and the six-minute walk test in boys with Duchenne muscular dystrophy.
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