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Calcium Channels and Neuronal Plasticity

My laboratory is interested in understanding the role that voltage-gated Ca2+ channel (VGCC) subunits play in both health and disease. In neurons, influx of Ca2+ through these channels serves the critical function of interfacing electrical signals with biochemical and transcriptional changes. Variability in their level of expression, cell-surface location and activity has profound effects on how much and where Ca2+ enters a nerve cell. This in turn influences neurotransmitter release, the strength of synaptic contacts as well as cellular and transcriptional processes, which ultimately affect learning and behavior. At the cellular level, my lab has focused on understanding how neuro­trans­mitters, small lipid molecules, and cytoplasmic proteins modulate postsynaptic neuronal VGCC activity and also VGCC activity in pancreatic beta cells that regulates insulin secretion. These basic questions about VGCC function overlap with our interest in understanding the cellular basis of schizophrenia. Explore the lab webpage to learn more about the lab’s research interests. 



Summary Focus: Voltage-Gated Calcium channels and neuronal plasticity
One or more keywords matched the following items that are connected to Rittenhouse, Ann
Item TypeName
Academic Article Phospholipid metabolism is required for M1 muscarinic inhibition of N-type calcium current in sympathetic neurons.
Academic Article Role of PIP2 in regulating versus modulating Ca2+ channel activity.
Academic Article Arachidonic acid inhibition of L-type calcium (CaV1.3b) channels varies with accessory CaVbeta subunits.
Academic Article Orientation of palmitoylated CaVbeta2a relative to CaV2.2 is critical for slow pathway modulation of N-type Ca2+ current by tachykinin receptor activation.
Academic Article Arachidonic acid mediates muscarinic inhibition and enhancement of N-type Ca2+ current in sympathetic neurons.
Academic Article Pharmacological discrimination between muscarinic receptor signal transduction cascades with bethanechol chloride.
Academic Article The calcium channel ligand FPL 64176 enhances L-type but inhibits N-type neuronal calcium currents.
Academic Article M1 muscarinic receptors inhibit L-type Ca2+ current and M-current by divergent signal transduction cascades.
Academic Article Ca2+ influx through both L- and N-type Ca2+ channels increases c-fos expression by electrical stimulation of sympathetic neurons.
Academic Article L- and N-current but not M-current inhibition by M1 muscarinic receptors requires DAG lipase activity.
Academic Article PIP2 PIP2 hooray for maxi K+.
Academic Article Regulation of voltage-gated Ca2+ channels by lipids.
Academic Article The Ca2+ channel beta subunit determines whether stimulation of Gq-coupled receptors enhances or inhibits N current.
Academic Article The acid-sensitive, anesthetic-activated potassium leak channel, KCNK3, is regulated by 14-3-3?-dependent, protein kinase C (PKC)-mediated endocytic trafficking.
Concept Calcium Channels, N-Type
Concept Potassium Channels, Tandem Pore Domain
Concept Large-Conductance Calcium-Activated Potassium Channels
Concept Calcium Channels
Concept Calcium Channels, R-Type
Concept Potassium Channels, Voltage-Gated
Concept Calcium Channels, L-Type
Concept Potassium Channels
Academic Article Novel coupling is painless.
Academic Article Role of cilia in normal pancreas function and in diseased states.
Academic Article Characterization of ST14A Cells for Studying Modulation of Voltage-Gated Calcium Channels.
Academic Article A novel transgenic mouse model of lysosomal storage disorder.
Academic Article Modulation of CaV1.3b L-type calcium channels by M1 muscarinic receptors varies with CaV? subunit expression.
Academic Article cPLA2a-/- sympathetic neurons exhibit increased membrane excitability and loss of N-Type Ca2+ current inhibition by M1 muscarinic receptor signaling.
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  • Hyperpolarization Activated Cyclic Nucleotide Gated Channels