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One or more keywords matched the following properties of Baker, Richard

Academic Background

Ph. D. (1980) Pennsylvania State University

Molecular Mechanisms of Chromosome Segregation

For over 20 years, my lab studied centromere function and chromosome segregation using the model organism S. cerevisiae. In collaboration with Dr. Molly Fitzgerald-Hayes (UMass Amherst), we carried out groundbreaking work on the structure and function of the yeast centromeric H3 variant Cse4 and discovered the key CenH3 chaperone Scm3/HJURP. The research took full advantage of the combined genetic and biochemical methods available with this model organism and its sequenced genome, and the research increasingly included genomic and computational components. Currently I devote most of my time to bioinformatics and computational biology while pursuing my interest in yeast centromeres via ongoing collaborations. Presently, I serve as the de facto departmental bioinformatician, assisting our "wet lab" scientists to assemble and analyze data, and navigate the numerous assets of the Institution's Bioinformatics Core. I am actively engaged in several collaborative projects, including genome-wide analysis of double-strand breaks in activated B cells, high density transposon mutagenesis studies in both Yersinia and M. tuberculosis, ribosome profiling in yeast, and combined RNA-seq/ChIP-seq analysis of developmental gene regulation in the mouse cerebellum.


One or more keywords matched the following items that are connected to Baker, Richard
Item TypeName
Academic Article Genetic and genomic analysis of the AT-rich centromere DNA element II of Saccharomyces cerevisiae.
Academic Article Phylogenetic analysis of fungal centromere H3 proteins.
Academic Article CENP-A targeting moves a step back.
Academic Article Misregulation of Scm3p/HJURP causes chromosome instability in Saccharomyces cerevisiae and human cells.
Academic Article Phosphorylation of centromeric histone H3 variant regulates chromosome segregation in Saccharomyces cerevisiae.
Academic Article The histone fold domain of Cse4 is sufficient for CEN targeting and propagation of active centromeres in budding yeast.
Academic Article Scm3, an essential Saccharomyces cerevisiae centromere protein required for G2/M progression and Cse4 localization.
Concept Centromere
Academic Article Polo kinase Cdc5 associates with centromeres to facilitate the removal of centromeric cohesin during mitosis.
Academic Article N-terminal Sumoylation of Centromeric Histone H3 Variant Cse4 Regulates Its Proteolysis To Prevent Mislocalization to Non-centromeric Chromatin.
Academic Article A Genome-Wide Screen Reveals a Role for the HIR Histone Chaperone Complex in Preventing Mislocalization of Budding Yeast CENP-A.
Academic Article Cell cycle-dependent association of polo kinase Cdc5 with CENP-A contributes to faithful chromosome segregation in budding yeast.
Academic Article Skp, Cullin, F-box (SCF)-Met30 and SCF-Cdc4-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A for Chromosomal Stability in Budding Yeast.
Concept Centromere Protein A
Search Criteria
  • Centromere