Header Logo

Search Result Details

This page shows the details of why an item matched the keywords from your search.
One or more keywords matched the following properties of Baker, Richard
PropertyValue
overview

Academic Background

Ph. D. (1980) Pennsylvania State University

Molecular Mechanisms of Chromosome Segregation

For over 20 years, my lab studied centromere function and chromosome segregation using the model organism S. cerevisiae. In collaboration with Dr. Molly Fitzgerald-Hayes (UMass Amherst), we carried out groundbreaking work on the structure and function of the yeast centromeric H3 variant Cse4 and discovered the key CenH3 chaperone Scm3/HJURP. The research took full advantage of the combined genetic and biochemical methods available with this model organism and its sequenced genome, and the research increasingly included genomic and computational components. Currently I devote most of my time to bioinformatics and computational biology while pursuing my interest in yeast centromeres via ongoing collaborations. Presently, I serve as the de facto departmental bioinformatician, assisting our "wet lab" scientists to assemble and analyze data, and navigate the numerous assets of the Institution's Bioinformatics Core. I am actively engaged in several collaborative projects, including genome-wide analysis of double-strand breaks in activated B cells, high density transposon mutagenesis studies in both Yersinia and M. tuberculosis, ribosome profiling in yeast, and combined RNA-seq/ChIP-seq analysis of developmental gene regulation in the mouse cerebellum.

 

One or more keywords matched the following items that are connected to Baker, Richard
Item TypeName
Concept Mycobacterium tuberculosis
Concept Tuberculosis
Concept Tuberculosis Vaccines
Academic Article Identifying essential genes in Mycobacterium tuberculosis by global phenotypic profiling.
Academic Article Tuberculosis Susceptibility and Vaccine Protection Are Independently Controlled by Host Genotype.
Academic Article Statistical analysis of genetic interactions in Tn-Seq data.
Academic Article Nitric oxide prevents a pathogen-permissive granulocytic inflammation during tuberculosis.
Academic Article A Lysine Acetyltransferase Contributes to the Metabolic Adaptation to Hypoxia in Mycobacterium tuberculosis.
Academic Article Common Variants in the Glycerol Kinase Gene Reduce Tuberculosis Drug Efficacy.
Academic Article Statistical analysis of variability in TnSeq data across conditions using zero-inflated negative binomial regression.
Academic Article Functionally Overlapping Variants Control Tuberculosis Susceptibility in Collaborative Cross Mice.
Academic Article Distinct Bacterial Pathways Influence the Efficacy of Antibiotics against Mycobacterium tuberculosis.
Academic Article Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice.
Academic Article Chemical-genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy.
Academic Article Multiple genetic loci influence vaccine-induced protection against Mycobacterium tuberculosis in genetically diverse mice.
Search Criteria
  • Tuberculosis