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Axonal transport of N-terminal huntingtin suggests early pathology of corticostriatal projections in Huntington disease.
Changes in cortical and striatal neurons predict behavioral and electrophysiological abnormalities in a transgenic murine model of Huntington's disease.
Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain.
Huntingtin localization in brains of normal and Huntington's disease patients.
Huntingtin is degraded to small fragments by calpain after ischemic injury.
Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits.
Mutant huntingtin and glycogen synthase kinase 3-beta accumulate in neuronal lipid rafts of a presymptomatic knock-in mouse model of Huntington's disease.
Aberrant Rab11-dependent trafficking of the neuronal glutamate transporter EAAC1 causes oxidative stress and cell death in Huntington's disease.
Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction.
CAG expansion affects the expression of mutant Huntingtin in the Huntington's disease brain.
Mass Spectrometry Analysis of Wild-Type and Knock-in Q140/Q140 Huntington's Disease Mouse Brains Reveals Changes in Glycerophospholipids Including Alterations in Phosphatidic Acid and Lyso-Phosphatidic Acid.