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Academic Article
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Expression of normal and mutant huntingtin in the developing brain.
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Academic Article
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Fast transport and retrograde movement of huntingtin and HAP 1 in axons.
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Academic Article
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Are neuronal intranuclear inclusions the common neuropathology of triplet-repeat disorders with polyglutamine-repeat expansions?
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Academic Article
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Wild-type and mutant huntingtins function in vesicle trafficking in the secretory and endocytic pathways.
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Academic Article
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Axonal transport of N-terminal huntingtin suggests early pathology of corticostriatal projections in Huntington disease.
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Academic Article
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Forskolin and dopamine D1 receptor activation increase huntingtin's association with endosomes in immortalized neuronal cells of striatal origin.
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Academic Article
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Are there multiple pathways in the pathogenesis of Huntington's disease?
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Academic Article
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Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy.
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Academic Article
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Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis.
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Academic Article
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Changes in cortical and striatal neurons predict behavioral and electrophysiological abnormalities in a transgenic murine model of Huntington's disease.
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Academic Article
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Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain.
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Academic Article
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Huntingtin localization in brains of normal and Huntington's disease patients.
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Academic Article
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Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcription.
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Academic Article
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Mutant huntingtin expression in clonal striatal cells: dissociation of inclusion formation and neuronal survival by caspase inhibition.
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Academic Article
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Huntingtin is degraded to small fragments by calpain after ischemic injury.
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Academic Article
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Lysosomal proteases are involved in generation of N-terminal huntingtin fragments.
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Academic Article
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Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits.
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Academic Article
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Five siRNAs targeting three SNPs may provide therapy for three-quarters of Huntington's disease patients.
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Academic Article
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Polyglutamine expansion in huntingtin alters its interaction with phospholipids.
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Academic Article
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Mutant huntingtin and glycogen synthase kinase 3-beta accumulate in neuronal lipid rafts of a presymptomatic knock-in mouse model of Huntington's disease.
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Academic Article
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Mutant huntingtin impairs vesicle formation from recycling endosomes by interfering with Rab11 activity.
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Academic Article
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Aberrant Rab11-dependent trafficking of the neuronal glutamate transporter EAAC1 causes oxidative stress and cell death in Huntington's disease.
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Academic Article
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Oligonucleotide therapeutic approaches for Huntington disease.
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Academic Article
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Native mutant huntingtin in human brain: evidence for prevalence of full-length monomer.
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Academic Article
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Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease.
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Academic Article
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Hunting down huntingtin.
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Academic Article
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Autophagy regulates the processing of amino terminal huntingtin fragments.
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Academic Article
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Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction.
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Academic Article
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Huntingtin associates with acidic phospholipids at the plasma membrane.
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Academic Article
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CAG expansion affects the expression of mutant Huntingtin in the Huntington's disease brain.
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Academic Article
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Striatal synaptosomes from Hdh140Q/140Q knock-in mice have altered protein levels, novel sites of methionine oxidation, and excess glutamate release after stimulation.
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Academic Article
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HTT-lowering reverses Huntington's disease immune dysfunction caused by NF?B pathway dysregulation.
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Academic Article
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Increased Steady-State Mutant Huntingtin mRNA in Huntington's Disease Brain.
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Academic Article
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Assessment of chloroquine treatment for modulating autophagy flux in brain of WT and HD mice.
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Academic Article
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CRISPRseek: a bioconductor package to identify target-specific guide RNAs for CRISPR-Cas9 genome-editing systems.
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Academic Article
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Huntingtin-lowering strategies in Huntington's disease: antisense oligonucleotides, small RNAs, and gene editing.
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Academic Article
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Mass Spectrometry Analysis of Wild-Type and Knock-in Q140/Q140 Huntington's Disease Mouse Brains Reveals Changes in Glycerophospholipids Including Alterations in Phosphatidic Acid and Lyso-Phosphatidic Acid.
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Academic Article
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Does the Mutant CAG Expansion in Huntingtin mRNA Interfere with Exonucleolytic Cleavage of its First Exon?
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Academic Article
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Widespread Central Nervous System Gene Transfer and Silencing After Systemic Delivery of Novel AAV-AS Vector.
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Academic Article
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Effects of Exogenous NUB1 Expression in the Striatum of HDQ175/Q7 Mice.
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Academic Article
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Autophagy Activation by Transcription Factor EB (TFEB) in Striatum of HDQ175/Q7 Mice.
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Academic Article
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Cellular Analysis of Silencing the?Huntington's Disease Gene Using AAV9?Mediated Delivery of Artificial Micro?RNA into the Striatum of?Q140/Q140?Mice.
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Academic Article
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Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing.
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Academic Article
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Allele-Selective Suppression of Mutant Huntingtin in Primary Human Blood Cells.
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Academic Article
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Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable O-Phosphocholine-N-docosahexaenoyl-l-serine siRNA Conjugate in Mouse Brain.
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Academic Article
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A Fresh Look at Huntingtin mRNA Processing in Huntington's Disease.
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Academic Article
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Optimized Cholesterol-siRNA Chemistry Improves Productive Loading onto Extracellular Vesicles.
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Academic Article
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Artificial miRNAs Reduce Human Mutant Huntingtin Throughout the Striatum in a Transgenic Sheep Model of Huntington's Disease.
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Academic Article
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Transvascular Delivery of Hydrophobically Modified siRNAs: Gene Silencing in the Rat Brain upon Disruption of the Blood-Brain Barrier.
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Academic Article
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Selective Neuronal Uptake and Distribution of AAVrh8, AAV9, and AAVrh10 in Sheep After Intra-Striatal Administration.
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Academic Article
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Rac1 Activity Is Modulated by Huntingtin and Dysregulated in Models of Huntington's Disease.
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Academic Article
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Huntingtin associates with the actin cytoskeleton and a-actinin isoforms to influence stimulus dependent morphology changes.
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Academic Article
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A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system.
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Academic Article
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Allele-Specific Knockdown of Mutant Huntingtin Protein via Editing at Coding Region Single Nucleotide Polymorphism Heterozygosities.
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Concept
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Huntingtin Protein
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Academic Article
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Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in Huntington's disease models.
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Academic Article
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Di-valent siRNA-mediated silencing of MSH3 blocks somatic repeat expansion in mouse models of Huntington's disease.
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Academic Article
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A programmable dual-targeting siRNA scaffold supports potent two-gene modulation in the central nervous system.
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Academic Article
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mRNA Nuclear Clustering Leads to a Difference in Mutant Huntingtin mRNA and Protein Silencing by siRNAs In Vivo.
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