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One or more keywords matched the following items that are connected to Aronin, Neil
Item TypeName
Academic Article Expression of normal and mutant huntingtin in the developing brain.
Academic Article Fast transport and retrograde movement of huntingtin and HAP 1 in axons.
Academic Article Are neuronal intranuclear inclusions the common neuropathology of triplet-repeat disorders with polyglutamine-repeat expansions?
Academic Article Wild-type and mutant huntingtins function in vesicle trafficking in the secretory and endocytic pathways.
Academic Article Axonal transport of N-terminal huntingtin suggests early pathology of corticostriatal projections in Huntington disease.
Academic Article Forskolin and dopamine D1 receptor activation increase huntingtin's association with endosomes in immortalized neuronal cells of striatal origin.
Academic Article Are there multiple pathways in the pathogenesis of Huntington's disease?
Academic Article Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy.
Academic Article Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis.
Academic Article Changes in cortical and striatal neurons predict behavioral and electrophysiological abnormalities in a transgenic murine model of Huntington's disease.
Academic Article Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain.
Academic Article Huntingtin localization in brains of normal and Huntington's disease patients.
Academic Article Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcription.
Academic Article Mutant huntingtin expression in clonal striatal cells: dissociation of inclusion formation and neuronal survival by caspase inhibition.
Academic Article Huntingtin is degraded to small fragments by calpain after ischemic injury.
Academic Article Lysosomal proteases are involved in generation of N-terminal huntingtin fragments.
Academic Article Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits.
Academic Article Five siRNAs targeting three SNPs may provide therapy for three-quarters of Huntington's disease patients.
Academic Article Polyglutamine expansion in huntingtin alters its interaction with phospholipids.
Academic Article Mutant huntingtin and glycogen synthase kinase 3-beta accumulate in neuronal lipid rafts of a presymptomatic knock-in mouse model of Huntington's disease.
Academic Article Mutant huntingtin impairs vesicle formation from recycling endosomes by interfering with Rab11 activity.
Academic Article Aberrant Rab11-dependent trafficking of the neuronal glutamate transporter EAAC1 causes oxidative stress and cell death in Huntington's disease.
Academic Article Oligonucleotide therapeutic approaches for Huntington disease.
Academic Article Native mutant huntingtin in human brain: evidence for prevalence of full-length monomer.
Academic Article Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease.
Academic Article Hunting down huntingtin.
Academic Article Autophagy regulates the processing of amino terminal huntingtin fragments.
Academic Article Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction.
Academic Article Huntingtin associates with acidic phospholipids at the plasma membrane.
Academic Article CAG expansion affects the expression of mutant Huntingtin in the Huntington's disease brain.
Academic Article Striatal synaptosomes from Hdh140Q/140Q knock-in mice have altered protein levels, novel sites of methionine oxidation, and excess glutamate release after stimulation.
Academic Article HTT-lowering reverses Huntington's disease immune dysfunction caused by NF?B pathway dysregulation.
Academic Article Increased Steady-State Mutant Huntingtin mRNA in Huntington's Disease Brain.
Academic Article Assessment of chloroquine treatment for modulating autophagy flux in brain of WT and HD mice.
Academic Article CRISPRseek: a bioconductor package to identify target-specific guide RNAs for CRISPR-Cas9 genome-editing systems.
Academic Article Huntingtin-lowering strategies in Huntington's disease: antisense oligonucleotides, small RNAs, and gene editing.
Academic Article Mass Spectrometry Analysis of Wild-Type and Knock-in Q140/Q140 Huntington's Disease Mouse Brains Reveals Changes in Glycerophospholipids Including Alterations in Phosphatidic Acid and Lyso-Phosphatidic Acid.
Academic Article Does the Mutant CAG Expansion in Huntingtin mRNA Interfere with Exonucleolytic Cleavage of its First Exon?
Academic Article Widespread Central Nervous System Gene Transfer and Silencing After Systemic Delivery of Novel AAV-AS Vector.
Academic Article Effects of Exogenous NUB1 Expression in the Striatum of HDQ175/Q7 Mice.
Academic Article Autophagy Activation by Transcription Factor EB (TFEB) in Striatum of HDQ175/Q7 Mice.
Academic Article Cellular Analysis of Silencing the?Huntington's Disease Gene Using AAV9?Mediated Delivery of Artificial Micro?RNA into the Striatum of?Q140/Q140?Mice.
Academic Article Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing.
Academic Article Allele-Selective Suppression of Mutant Huntingtin in Primary Human Blood Cells.
Academic Article Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable O-Phosphocholine-N-docosahexaenoyl-l-serine siRNA Conjugate in Mouse Brain.
Academic Article A Fresh Look at Huntingtin mRNA Processing in Huntington's Disease.
Academic Article Optimized Cholesterol-siRNA Chemistry Improves Productive Loading onto Extracellular Vesicles.
Academic Article Artificial miRNAs Reduce Human Mutant Huntingtin Throughout the Striatum in a Transgenic Sheep Model of Huntington's Disease.
Academic Article Transvascular Delivery of Hydrophobically Modified siRNAs: Gene Silencing in the Rat Brain upon Disruption of the Blood-Brain Barrier.
Academic Article Selective Neuronal Uptake and Distribution of AAVrh8, AAV9, and AAVrh10 in Sheep After Intra-Striatal Administration.
Academic Article Rac1 Activity Is Modulated by Huntingtin and Dysregulated in Models of Huntington's Disease.
Academic Article Huntingtin associates with the actin cytoskeleton and a-actinin isoforms to influence stimulus dependent morphology changes.
Academic Article A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system.
Academic Article Allele-Specific Knockdown of Mutant Huntingtin Protein via Editing at Coding Region Single Nucleotide Polymorphism Heterozygosities.
Concept Huntingtin Protein
Academic Article Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in Huntington's disease models.
Academic Article Di-valent siRNA-mediated silencing of MSH3 blocks somatic repeat expansion in mouse models of Huntington's disease.
Academic Article A programmable dual-targeting siRNA scaffold supports potent two-gene modulation in the central nervous system.
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