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Aronin, Neil

One or more keywords matched the following properties of Aronin, Neil

Property	Value
overview	Background Undergraduate: Duke University, 1966-1970 Medical School: University of Pennsylvania, 1970-1974 Internship and Residency: Duke University Medical Center, 1974-1977 Research Fellowship: Massachusetts General Hospital and Harvard MedicalSchool, 1979-1981 Positions University of Massachusetts Medical School, 1981 - present, Professor of Medicine and Cell Biology, Director of Endocrinology and Metabolism Board Certifications Internal Medicine, Endocrinology and Metabolism Huntington's Disease My clinical interests focus on neuroendocrinology (pituitary and hypothalamic diseases), inherited endocrine diseases, and adrenal problems. We are currently conducting research in the treatment of patients with impaired pituitary function. My basic research centers on the pathogensis of neurodegenerative diseases, especially Parkinson's disease and Huntington's disease. Dr. Aronin's Clinical Site

Property

Value

overview

Background

Undergraduate: Duke University, 1966-1970
Medical School: University of Pennsylvania, 1970-1974
Internship and Residency: Duke University Medical Center, 1974-1977
Research Fellowship: Massachusetts General Hospital and Harvard MedicalSchool, 1979-1981

Positions

University of Massachusetts Medical School, 1981 - present,
Professor of Medicine and Cell Biology,
Director of Endocrinology and Metabolism

Board Certifications

Internal Medicine, Endocrinology and Metabolism

Huntington's Disease

My clinical interests focus on neuroendocrinology (pituitary and hypothalamic diseases), inherited endocrine diseases, and adrenal problems. We are currently conducting research in the treatment of patients with impaired pituitary function. My basic research centers on the pathogensis of neurodegenerative diseases, especially Parkinson's disease and Huntington's disease.

Dr. Aronin's Clinical Site

One or more keywords matched the following items that are connected to Aronin, Neil

Item Type	Name
Academic Article	Expression of normal and mutant huntingtin in the developing brain.
Academic Article	Are neuronal intranuclear inclusions the common neuropathology of triplet-repeat disorders with polyglutamine-repeat expansions?
Academic Article	Axonal transport of N-terminal huntingtin suggests early pathology of corticostriatal projections in Huntington disease.
Academic Article	Forskolin and dopamine D1 receptor activation increase huntingtin's association with endosomes in immortalized neuronal cells of striatal origin.
Academic Article	Are there multiple pathways in the pathogenesis of Huntington's disease?
Academic Article	Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy.
Academic Article	Early and progressive accumulation of reactive microglia in the Huntington disease brain.
Academic Article	Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis.
Academic Article	Changes in cortical and striatal neurons predict behavioral and electrophysiological abnormalities in a transgenic murine model of Huntington's disease.
Academic Article	Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain.
Academic Article	Huntingtin localization in brains of normal and Huntington's disease patients.
Academic Article	Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcription.
Academic Article	Maintenance of susceptibility to neurodegeneration following intrastriatal injections of quinolinic acid in a new transgenic mouse model of Huntington's disease.
Academic Article	Analysis of Huntingtin-associated protein 1 in mouse brain and immortalized striatal neurons.
Academic Article	Striatal potassium channel dysfunction in Huntington's disease transgenic mice.
Academic Article	Lysosomal proteases are involved in generation of N-terminal huntingtin fragments.
Academic Article	Target selectivity in mRNA silencing.
Academic Article	Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits.
Academic Article	Five siRNAs targeting three SNPs may provide therapy for three-quarters of Huntington's disease patients.
Academic Article	Expanded CAG repeats in the crosshairs.
Academic Article	Polyglutamine expansion in huntingtin alters its interaction with phospholipids.
Academic Article	Mutant huntingtin and glycogen synthase kinase 3-beta accumulate in neuronal lipid rafts of a presymptomatic knock-in mouse model of Huntington's disease.
Academic Article	Aberrant Rab11-dependent trafficking of the neuronal glutamate transporter EAAC1 causes oxidative stress and cell death in Huntington's disease.
Academic Article	Oligonucleotide therapeutic approaches for Huntington disease.
Academic Article	Native mutant huntingtin in human brain: evidence for prevalence of full-length monomer.
Academic Article	Striatal neurochemical changes in transgenic models of Huntington's disease.
Academic Article	Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease.
Academic Article	Hunting down huntingtin.
Academic Article	Autophagy regulates the processing of amino terminal huntingtin fragments.
Academic Article	Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction.
Academic Article	Linking SNPs to CAG repeat length in Huntington's disease patients.
Academic Article	Disruption of Rab11 activity in a knock-in mouse model of Huntington's disease.
Academic Article	Somatostatin is increased in the basal ganglia in Huntington disease.
Academic Article	CAG expansion affects the expression of mutant Huntingtin in the Huntington's disease brain.
Concept	Huntington Disease
Academic Article	Striatal synaptosomes from Hdh140Q/140Q knock-in mice have altered protein levels, novel sites of methionine oxidation, and excess glutamate release after stimulation.
Academic Article	HTT-lowering reverses Huntington's disease immune dysfunction caused by NF?B pathway dysregulation.
Academic Article	Increased Steady-State Mutant Huntingtin mRNA in Huntington's Disease Brain.
Academic Article	Assessment of chloroquine treatment for modulating autophagy flux in brain of WT and HD mice.
Academic Article	Finding the striatum in sheep: use of a multi-modal guided approach for convection enhanced delivery.
Academic Article	Huntingtin-lowering strategies in Huntington's disease: antisense oligonucleotides, small RNAs, and gene editing.
Academic Article	Mass Spectrometry Analysis of Wild-Type and Knock-in Q140/Q140 Huntington's Disease Mouse Brains Reveals Changes in Glycerophospholipids Including Alterations in Phosphatidic Acid and Lyso-Phosphatidic Acid.
Academic Article	Safety of Striatal Infusion of siRNA in a Transgenic Huntington's Disease Mouse Model.
Academic Article	Does the Mutant CAG Expansion in Huntingtin mRNA Interfere with Exonucleolytic Cleavage of its First Exon?
Academic Article	Effects of Exogenous NUB1 Expression in the Striatum of HDQ175/Q7 Mice.
Academic Article	Autophagy Activation by Transcription Factor EB (TFEB) in Striatum of HDQ175/Q7 Mice.
Academic Article	Cellular Analysis of Silencing the?Huntington's Disease Gene Using AAV9?Mediated Delivery of Artificial Micro?RNA into the Striatum of?Q140/Q140?Mice.
Academic Article	Allele-Selective Suppression of Mutant Huntingtin in Primary Human Blood Cells.
Academic Article	Nuclear Localization of Huntingtin mRNA Is Specific to Cells of Neuronal Origin.
Academic Article	Alterations in mRNA 3' UTR Isoform Abundance Accompany Gene Expression Changes in Human Huntington's Disease Brains.
Academic Article	A Fresh Look at Huntingtin mRNA Processing in Huntington's Disease.
Academic Article	Artificial miRNAs Reduce Human Mutant Huntingtin Throughout the Striatum in a Transgenic Sheep Model of Huntington's Disease.
Academic Article	Rac1 Activity Is Modulated by Huntingtin and Dysregulated in Models of Huntington's Disease.
Academic Article	Huntingtin associates with the actin cytoskeleton and a-actinin isoforms to influence stimulus dependent morphology changes.
Academic Article	Huntington's Disease: Les Jeux Sont Faits?
Academic Article	Large Animal Models of Huntington's Disease: What We Have Learned and Where We Need to Go Next.
Academic Article	Structurally constrained phosphonate internucleotide linkage impacts oligonucleotide-enzyme interaction, and modulates siRNA activity and allele specificity.
Academic Article	Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in Huntington's disease models.
Academic Article	Di-valent siRNA-mediated silencing of MSH3 blocks somatic repeat expansion in mouse models of Huntington's disease.
Academic Article	Di-valent siRNA-mediated silencing of MSH3 blocks somatic repeat expansion in mouse models of Huntington's disease.
Academic Article	A programmable dual-targeting siRNA scaffold supports potent two-gene modulation in the central nervous system.
Academic Article	mRNA Nuclear Clustering Leads to a Difference in Mutant Huntingtin mRNA and Protein Silencing by siRNAs In Vivo.

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Huntington Disease