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One or more keywords matched the following properties of Aronin, Neil


  • Undergraduate: Duke University, 1966-1970
  • Medical School: University of Pennsylvania, 1970-1974
  • Internship and Residency: Duke University Medical Center, 1974-1977
  • Research Fellowship: Massachusetts General Hospital and Harvard MedicalSchool, 1979-1981


  • University of Massachusetts Medical School, 1981 - present,
  • Professor of Medicine and Cell Biology,
  • Director of Endocrinology and Metabolism

Board Certifications

  • Internal Medicine, Endocrinology and Metabolism

Huntington's Disease

Photo: Neil AroninMy clinical interests focus on neuroendocrinology (pituitary and hypothalamic diseases), inherited endocrine diseases, and adrenal problems. We are currently conducting research in the treatment of patients with impaired pituitary function. My basic research centers on the pathogensis of neurodegenerative diseases, especially Parkinson's disease and Huntington's disease.

Dr. Aronin's Clinical Site This link goes 
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One or more keywords matched the following items that are connected to Aronin, Neil
Item TypeName
Academic Article Expression of normal and mutant huntingtin in the developing brain.
Academic Article Are neuronal intranuclear inclusions the common neuropathology of triplet-repeat disorders with polyglutamine-repeat expansions?
Academic Article Axonal transport of N-terminal huntingtin suggests early pathology of corticostriatal projections in Huntington disease.
Academic Article Forskolin and dopamine D1 receptor activation increase huntingtin's association with endosomes in immortalized neuronal cells of striatal origin.
Academic Article Are there multiple pathways in the pathogenesis of Huntington's disease?
Academic Article Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy.
Academic Article Early and progressive accumulation of reactive microglia in the Huntington disease brain.
Academic Article Changes in cortical and striatal neurons predict behavioral and electrophysiological abnormalities in a transgenic murine model of Huntington's disease.
Academic Article Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain.
Academic Article Huntingtin localization in brains of normal and Huntington's disease patients.
Academic Article Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcription.
Academic Article Maintenance of susceptibility to neurodegeneration following intrastriatal injections of quinolinic acid in a new transgenic mouse model of Huntington's disease.
Academic Article Analysis of Huntingtin-associated protein 1 in mouse brain and immortalized striatal neurons.
Academic Article Striatal potassium channel dysfunction in Huntington's disease transgenic mice.
Academic Article Lysosomal proteases are involved in generation of N-terminal huntingtin fragments.
Academic Article Target selectivity in mRNA silencing.
Academic Article Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits.
Academic Article Five siRNAs targeting three SNPs may provide therapy for three-quarters of Huntington's disease patients.
Academic Article Expanded CAG repeats in the crosshairs.
Academic Article Polyglutamine expansion in huntingtin alters its interaction with phospholipids.
Academic Article Mutant huntingtin and glycogen synthase kinase 3-beta accumulate in neuronal lipid rafts of a presymptomatic knock-in mouse model of Huntington's disease.
Academic Article Aberrant Rab11-dependent trafficking of the neuronal glutamate transporter EAAC1 causes oxidative stress and cell death in Huntington's disease.
Academic Article Oligonucleotide therapeutic approaches for Huntington disease.
Academic Article Native mutant huntingtin in human brain: evidence for prevalence of full-length monomer.
Academic Article Striatal neurochemical changes in transgenic models of Huntington's disease.
Academic Article Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease.
Academic Article Hunting down huntingtin.
Academic Article Autophagy regulates the processing of amino terminal huntingtin fragments.
Academic Article Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction.
Academic Article Linking SNPs to CAG repeat length in Huntington's disease patients.
Academic Article Disruption of Rab11 activity in a knock-in mouse model of Huntington's disease.
Academic Article Somatostatin is increased in the basal ganglia in Huntington disease.
Academic Article CAG expansion affects the expression of mutant Huntingtin in the Huntington's disease brain.
Concept Huntington Disease
Academic Article Striatal synaptosomes from Hdh140Q/140Q knock-in mice have altered protein levels, novel sites of methionine oxidation, and excess glutamate release after stimulation.
Academic Article HTT-lowering reverses Huntington's disease immune dysfunction caused by NF?B pathway dysregulation.
Academic Article Increased Steady-State Mutant Huntingtin mRNA in Huntington's Disease Brain.
Academic Article Assessment of chloroquine treatment for modulating autophagy flux in brain of WT and HD mice.
Academic Article Finding the striatum in sheep: use of a multi-modal guided approach for convection enhanced delivery.
Academic Article Huntingtin-lowering strategies in Huntington's disease: antisense oligonucleotides, small RNAs, and gene editing.
Academic Article Mass Spectrometry Analysis of Wild-Type and Knock-in Q140/Q140 Huntington's Disease Mouse Brains Reveals Changes in Glycerophospholipids Including Alterations in Phosphatidic Acid and Lyso-Phosphatidic Acid.
Academic Article Safety of Striatal Infusion of siRNA in a Transgenic Huntington's Disease Mouse Model.
Academic Article Does the Mutant CAG Expansion in Huntingtin mRNA Interfere with Exonucleolytic Cleavage of its First Exon?
Academic Article Effects of Exogenous NUB1 Expression in the Striatum of HDQ175/Q7 Mice.
Academic Article Autophagy Activation by Transcription Factor EB (TFEB) in Striatum of HDQ175/Q7 Mice.
Academic Article Cellular Analysis of Silencing the?Huntington's Disease Gene Using AAV9?Mediated Delivery of Artificial Micro?RNA into the Striatum of?Q140/Q140?Mice.
Academic Article Allele-Selective Suppression of Mutant Huntingtin in Primary Human Blood Cells.
Academic Article Nuclear Localization of Huntingtin mRNA Is Specific to Cells of Neuronal Origin.
Academic Article Alterations in mRNA 3' UTR Isoform Abundance Accompany Gene Expression Changes in Human Huntington's Disease Brains.
Academic Article A Fresh Look at Huntingtin mRNA Processing in Huntington's Disease.
Academic Article Artificial miRNAs Reduce Human Mutant Huntingtin Throughout the Striatum in a Transgenic Sheep Model of Huntington's Disease.
Academic Article Rac1 Activity Is Modulated by Huntingtin and Dysregulated in Models of Huntington's Disease.
Academic Article Huntingtin associates with the actin cytoskeleton and a-actinin isoforms to influence stimulus dependent morphology changes.
Academic Article Huntington's Disease: Les Jeux Sont Faits?
Academic Article Large Animal Models of Huntington's Disease: What We Have Learned and Where We Need to Go Next.
Academic Article Structurally constrained phosphonate internucleotide linkage impacts oligonucleotide-enzyme interaction, and modulates siRNA activity and allele specificity.
Academic Article Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in Huntington's disease models.
Academic Article Di-valent siRNA-mediated silencing of MSH3 blocks somatic repeat expansion in mouse models of Huntington's disease.
Search Criteria
  • Huntington Disease