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Schiffer, Celia

One or more keywords matched the following items that are connected to Schiffer, Celia

Item Type	Name
Academic Article	Cooperative fluctuations of unliganded and substrate-bound HIV-1 protease: a structure-based analysis on a variety of conformations from crystallography and molecular dynamics simulations.
Academic Article	Competition between Ski and CREB-binding protein for binding to Smad proteins in transforming growth factor-beta signaling.
Academic Article	Contribution of Ser386 and Ser396 to activation of interferon regulatory factor 3.
Academic Article	Toward the design of mutation-resistant enzyme inhibitors: further evaluation of the substrate envelope hypothesis.
Academic Article	Molecular mechanisms of viral and host cell substrate recognition by hepatitis C virus NS3/4A protease.
Academic Article	Extreme entropy-enthalpy compensation in a drug-resistant variant of HIV-1 protease.
Academic Article	Point mutants of EHEC intimin that diminish Tir recognition and actin pedestal formation highlight a putative Tir binding pocket.
Academic Article	Nitric oxide-mediated inhibition of Hdm2-p53 binding.
Academic Article	Structure-based prediction of potential binding and nonbinding peptides to HIV-1 protease.
Academic Article	Mass spectrometry analysis of HIV-1 Vif reveals an increase in ordered structure upon oligomerization in regions necessary for viral infectivity.
Academic Article	Evaluating the substrate-envelope hypothesis: structural analysis of novel HIV-1 protease inhibitors designed to be robust against drug resistance.
Academic Article	Therapeutic targeting of C-terminal binding protein in human cancer.
Academic Article	Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding.
Academic Article	Mass spectrometry tools for analysis of intermolecular interactions.
Academic Article	Structural insights into neuronal K+ channel-calmodulin complexes.
Academic Article	Structural and thermodynamic basis of amprenavir/darunavir and atazanavir resistance in HIV-1 protease with mutations at residue 50.
Concept	Protein Binding
Concept	DNA-Binding Proteins
Concept	Carrier Proteins
Concept	CREB-Binding Protein
Academic Article	Evaluating the role of macrocycles in the susceptibility of hepatitis C virus NS3/4A protease inhibitors to drug resistance.
Academic Article	Substrate envelope-designed potent HIV-1 protease inhibitors to avoid drug resistance.
Academic Article	The interdomain interface in bifunctional enzyme protein 3/4A (NS3/4A) regulates protease and helicase activities.
Academic Article	Crystal structures of human CtBP in complex with substrate MTOB reveal active site features useful for inhibitor design.
Academic Article	Drug resistance conferred by mutations outside the active site through alterations in the dynamic and structural ensemble of HIV-1 protease.
Academic Article	A computational analysis of the structural determinants of APOBEC3's catalytic activity and vulnerability to HIV-1 Vif.
Academic Article	Structural analysis of asunaprevir resistance in HCV NS3/4A protease.
Academic Article	The ssDNA Mutator APOBEC3A Is Regulated by Cooperative Dimerization.
Academic Article	Structure-guided design of a high affinity inhibitor to human CtBP.
Academic Article	Structure of the Vif-binding domain of the antiviral enzyme APOBEC3G.
Academic Article	A Direct Interaction with RNA Dramatically Enhances the Catalytic Activity of the HIV-1 Protease In Vitro.
Academic Article	Structural and molecular analysis of a protective epitope of Lyme disease antigen OspA and antibody interactions.
Academic Article	Molecular Basis for Differential Patterns of Drug Resistance in Influenza N1 and N2 Neuraminidase.
Academic Article	Dengue Virus NS2B/NS3 Protease Inhibitors Exploiting the Prime Side.
Academic Article	Structural Determination of the Broadly Reactive Anti-IGHV1-69 Anti-idiotypic Antibody G6 and Its Idiotope.
Academic Article	Substrate sequence selectivity of APOBEC3A implicates intra-DNA interactions.
Academic Article	Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity.
Academic Article	Assembly of human C-terminal binding protein (CtBP) into tetramers.
Academic Article	Structural Analysis of the Active Site and DNA Binding of Human Cytidine Deaminase APOBEC3B.
Academic Article	APOBEC3s: DNA-editing human cytidine deaminases.
Academic Article	NMR and MD studies combined to elucidate inhibitor and water interactions of HIV-1 protease and their modulations with resistance mutations.
Academic Article	Picomolar to Micromolar: Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance.
Academic Article	Target-Specific Prediction of Ligand Affinity with Structure-Based Interaction Fingerprints.
Academic Article	Molecular Determinants of Epistasis in HIV-1 Protease: Elucidating the Interdependence of L89V and L90M Mutations in Resistance.
Academic Article	Mechanism for APOBEC3G catalytic exclusion of RNA and non-substrate DNA.
Academic Article	Molecular and Structural Mechanism of Pan-Genotypic HCV NS3/4A Protease Inhibition by Glecaprevir.
Academic Article	Characterizing Protein-Ligand Binding Using Atomistic Simulation and Machine Learning: Application to Drug Resistance in HIV-1 Protease.
Academic Article	A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction.
Academic Article	Crystal Structure of a Soluble APOBEC3G Variant Suggests ssDNA to Bind in a Channel that Extends between the Two Domains.
Academic Article	Cryo-EM structure of CtBP2 confirms tetrameric architecture.
Academic Article	Drug Design Strategies to Avoid Resistance in Direct-Acting Antivirals and Beyond.
Academic Article	Crystal Structure of SARS-CoV-2 Main Protease in Complex with the Non-Covalent Inhibitor ML188.
Academic Article	NAD(H) phosphates mediate tetramer assembly of human C-terminal binding protein (CtBP).
Academic Article	Inhibiting HTLV-1 Protease: A Viable Antiviral Target.
Academic Article	Introduction: Drug Resistance.
Academic Article	Structural basis of substrate specificity in human cytidine deaminase family APOBEC3s.
Academic Article	Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations.
Academic Article	Discovery of Quinoxaline-Based P1-P3 Macrocyclic NS3/4A Protease Inhibitors with Potent Activity against Drug-Resistant Hepatitis C Virus Variants.
Academic Article	Pan-3C Protease Inhibitor Rupintrivir Binds SARS-CoV-2 Main Protease in a Unique Binding Mode.

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Carrier Proteins