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Schiffer, Celia
One or more keywords matched the following items that are connected to
Schiffer, Celia
Item Type
Name
Academic Article
Co-evolution of nelfinavir-resistant HIV-1 protease and the p1-p6 substrate.
Academic Article
Substrate envelope and drug resistance: crystal structure of RO1 in complex with wild-type human immunodeficiency virus type 1 protease.
Academic Article
Viral protease inhibitors.
Academic Article
Toward the design of mutation-resistant enzyme inhibitors: further evaluation of the substrate envelope hypothesis.
Academic Article
The effect of clade-specific sequence polymorphisms on HIV-1 protease activity and inhibitor resistance pathways.
Academic Article
Dynamics of preferential substrate recognition in HIV-1 protease: redefining the substrate envelope.
Academic Article
Design, synthesis, and biological and structural evaluations of novel HIV-1 protease inhibitors to combat drug resistance.
Academic Article
Extreme entropy-enthalpy compensation in a drug-resistant variant of HIV-1 protease.
Academic Article
The molecular basis of drug resistance against hepatitis C virus NS3/4A protease inhibitors.
Academic Article
Cooperative effects of drug-resistance mutations in the flap region of HIV-1 protease.
Academic Article
Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments.
Academic Article
Covariation of amino acid positions in HIV-1 protease.
Academic Article
Combating susceptibility to drug resistance: lessons from HIV-1 protease.
Academic Article
Structural basis for coevolution of a human immunodeficiency virus type 1 nucleocapsid-p1 cleavage site with a V82A drug-resistant mutation in viral protease.
Academic Article
Association of a novel human immunodeficiency virus type 1 protease substrate cleft mutation, L23I, with protease inhibitor therapy and in vitro drug resistance.
Academic Article
Mechanism of substrate recognition by drug-resistant human immunodeficiency virus type 1 protease variants revealed by a novel structural intermediate.
Academic Article
Hydrophobic sliding: a possible mechanism for drug resistance in human immunodeficiency virus type 1 protease.
Academic Article
HIV-1 protease inhibitors from inverse design in the substrate envelope exhibit subnanomolar binding to drug-resistant variants.
Academic Article
Resilience to resistance of HIV-1 protease inhibitors: profile of darunavir.
Academic Article
Human immunodeficiency virus type 1 protease-correlated cleavage site mutations enhance inhibitor resistance.
Academic Article
Evaluating the substrate-envelope hypothesis: structural analysis of novel HIV-1 protease inhibitors designed to be robust against drug resistance.
Academic Article
Rationale for more diverse inhibitors in competition with substrates in HIV-1 protease.
Academic Article
Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding.
Academic Article
Three residues in HIV-1 matrix contribute to protease inhibitor susceptibility and replication capacity.
Academic Article
TMC310911, a novel human immunodeficiency virus type 1 protease inhibitor, shows in vitro an improved resistance profile and higher genetic barrier to resistance compared with current protease inhibitors.
Academic Article
Decomposing the energetic impact of drug-resistant mutations: the example of HIV-1 protease-DRV binding.
Academic Article
Collinearity of protease mutations in HIV-1 samples with high-level protease inhibitor class resistance.
Academic Article
Structural and thermodynamic basis of amprenavir/darunavir and atazanavir resistance in HIV-1 protease with mutations at residue 50.
Academic Article
Interview with Celia Schiffer.
Academic Article
Evolution of the influenza A virus genome during development of oseltamivir resistance in vitro.
Concept
Drug Resistance, Viral
Academic Article
Influenza virus drug resistance: a time-sampled population genetics perspective.
Academic Article
Evaluating the role of macrocycles in the susceptibility of hepatitis C virus NS3/4A protease inhibitors to drug resistance.
Academic Article
Testing the substrate-envelope hypothesis with designed pairs of compounds.
Academic Article
Substrate envelope-designed potent HIV-1 protease inhibitors to avoid drug resistance.
Academic Article
HIV-1 protease-substrate coevolution in nelfinavir resistance.
Academic Article
Drug resistance conferred by mutations outside the active site through alterations in the dynamic and structural ensemble of HIV-1 protease.
Academic Article
Structural basis and distal effects of Gag substrate coevolution in drug resistance to HIV-1 protease.
Academic Article
Structural analysis of asunaprevir resistance in HCV NS3/4A protease.
Academic Article
A Balance between Inhibitor Binding and Substrate Processing Confers Influenza Drug Resistance.
Academic Article
Improving Viral Protease Inhibitors to Counter Drug Resistance.
Academic Article
Molecular and Dynamic Mechanism Underlying Drug Resistance in Genotype 3 Hepatitis C NS3/4A Protease.
Academic Article
Molecular Basis for Differential Patterns of Drug Resistance in Influenza N1 and N2 Neuraminidase.
Academic Article
Hepatitis C Virus NS3/4A Protease Inhibitors Incorporating Flexible P2 Quinoxalines Target Drug Resistant Viral Variants.
Academic Article
Hydration Structure and Dynamics of Inhibitor-Bound HIV-1 Protease.
Academic Article
Probing Structural Changes among Analogous Inhibitor-Bound Forms of HIV-1 Protease and a Drug-Resistant Mutant in Solution by Nuclear Magnetic Resonance.
Academic Article
Mutations in Influenza A Virus Neuraminidase and Hemagglutinin Confer Resistance against a Broadly Neutralizing Hemagglutinin Stem Antibody.
Academic Article
Resistance outside the substrate envelope: hepatitis C NS3/4A protease inhibitors.
Academic Article
NMR and MD studies combined to elucidate inhibitor and water interactions of HIV-1 protease and their modulations with resistance mutations.
Academic Article
Picomolar to Micromolar: Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance.
Academic Article
Molecular Determinants of Epistasis in HIV-1 Protease: Elucidating the Interdependence of L89V and L90M Mutations in Resistance.
Academic Article
Characterizing Protein-Ligand Binding Using Atomistic Simulation and Machine Learning: Application to Drug Resistance in HIV-1 Protease.
Academic Article
Avoiding Drug Resistance by Substrate Envelope-Guided Design: Toward Potent and Robust HCV NS3/4A Protease Inhibitors.
Academic Article
Drug Design Strategies to Avoid Resistance in Direct-Acting Antivirals and Beyond.
Academic Article
Deciphering Complex Mechanisms of Resistance and Loss of Potency through Coupled Molecular Dynamics and Machine Learning.
Academic Article
Discovery of Quinoxaline-Based P1-P3 Macrocyclic NS3/4A Protease Inhibitors with Potent Activity against Drug-Resistant Hepatitis C Virus Variants.
Academic Article
Identification of a Permissive Secondary Mutation That Restores the Enzymatic Activity of Oseltamivir Resistance Mutation H275Y.
Academic Article
Deciphering the Molecular Mechanism of HCV Protease Inhibitor Fluorination as a General Approach to Avoid Drug Resistance.
Academic Article
Selection of HIV-1 for resistance to fifth-generation protease inhibitors reveals two independent pathways to high-level resistance.
Academic Article
Elucidating the Substrate Envelope of Enterovirus 68-3C Protease: Structural Basis of Specificity and Potential Resistance.
Search Criteria
Drug Resistance Viral