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Schiffer, Celia

One or more keywords matched the following items that are connected to Schiffer, Celia

Item Type	Name
Academic Article	Co-evolution of nelfinavir-resistant HIV-1 protease and the p1-p6 substrate.
Academic Article	Substrate envelope and drug resistance: crystal structure of RO1 in complex with wild-type human immunodeficiency virus type 1 protease.
Academic Article	Viral protease inhibitors.
Academic Article	Toward the design of mutation-resistant enzyme inhibitors: further evaluation of the substrate envelope hypothesis.
Academic Article	The effect of clade-specific sequence polymorphisms on HIV-1 protease activity and inhibitor resistance pathways.
Academic Article	Dynamics of preferential substrate recognition in HIV-1 protease: redefining the substrate envelope.
Academic Article	Design, synthesis, and biological and structural evaluations of novel HIV-1 protease inhibitors to combat drug resistance.
Academic Article	Extreme entropy-enthalpy compensation in a drug-resistant variant of HIV-1 protease.
Academic Article	The molecular basis of drug resistance against hepatitis C virus NS3/4A protease inhibitors.
Academic Article	Cooperative effects of drug-resistance mutations in the flap region of HIV-1 protease.
Academic Article	Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments.
Academic Article	Covariation of amino acid positions in HIV-1 protease.
Academic Article	Combating susceptibility to drug resistance: lessons from HIV-1 protease.
Academic Article	Structural basis for coevolution of a human immunodeficiency virus type 1 nucleocapsid-p1 cleavage site with a V82A drug-resistant mutation in viral protease.
Academic Article	Association of a novel human immunodeficiency virus type 1 protease substrate cleft mutation, L23I, with protease inhibitor therapy and in vitro drug resistance.
Academic Article	Mechanism of substrate recognition by drug-resistant human immunodeficiency virus type 1 protease variants revealed by a novel structural intermediate.
Academic Article	Hydrophobic sliding: a possible mechanism for drug resistance in human immunodeficiency virus type 1 protease.
Academic Article	HIV-1 protease inhibitors from inverse design in the substrate envelope exhibit subnanomolar binding to drug-resistant variants.
Academic Article	Resilience to resistance of HIV-1 protease inhibitors: profile of darunavir.
Academic Article	Human immunodeficiency virus type 1 protease-correlated cleavage site mutations enhance inhibitor resistance.
Academic Article	Evaluating the substrate-envelope hypothesis: structural analysis of novel HIV-1 protease inhibitors designed to be robust against drug resistance.
Academic Article	Rationale for more diverse inhibitors in competition with substrates in HIV-1 protease.
Academic Article	Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding.
Academic Article	Three residues in HIV-1 matrix contribute to protease inhibitor susceptibility and replication capacity.
Academic Article	TMC310911, a novel human immunodeficiency virus type 1 protease inhibitor, shows in vitro an improved resistance profile and higher genetic barrier to resistance compared with current protease inhibitors.
Academic Article	Decomposing the energetic impact of drug-resistant mutations: the example of HIV-1 protease-DRV binding.
Academic Article	Collinearity of protease mutations in HIV-1 samples with high-level protease inhibitor class resistance.
Academic Article	Structural and thermodynamic basis of amprenavir/darunavir and atazanavir resistance in HIV-1 protease with mutations at residue 50.
Academic Article	Interview with Celia Schiffer.
Academic Article	Evolution of the influenza A virus genome during development of oseltamivir resistance in vitro.
Concept	Drug Resistance, Viral
Academic Article	Influenza virus drug resistance: a time-sampled population genetics perspective.
Academic Article	Evaluating the role of macrocycles in the susceptibility of hepatitis C virus NS3/4A protease inhibitors to drug resistance.
Academic Article	Testing the substrate-envelope hypothesis with designed pairs of compounds.
Academic Article	Substrate envelope-designed potent HIV-1 protease inhibitors to avoid drug resistance.
Academic Article	HIV-1 protease-substrate coevolution in nelfinavir resistance.
Academic Article	Drug resistance conferred by mutations outside the active site through alterations in the dynamic and structural ensemble of HIV-1 protease.
Academic Article	Structural basis and distal effects of Gag substrate coevolution in drug resistance to HIV-1 protease.
Academic Article	Structural analysis of asunaprevir resistance in HCV NS3/4A protease.
Academic Article	A Balance between Inhibitor Binding and Substrate Processing Confers Influenza Drug Resistance.
Academic Article	Improving Viral Protease Inhibitors to Counter Drug Resistance.
Academic Article	Molecular and Dynamic Mechanism Underlying Drug Resistance in Genotype 3 Hepatitis C NS3/4A Protease.
Academic Article	Molecular Basis for Differential Patterns of Drug Resistance in Influenza N1 and N2 Neuraminidase.
Academic Article	Hepatitis C Virus NS3/4A Protease Inhibitors Incorporating Flexible P2 Quinoxalines Target Drug Resistant Viral Variants.
Academic Article	Hydration Structure and Dynamics of Inhibitor-Bound HIV-1 Protease.
Academic Article	Probing Structural Changes among Analogous Inhibitor-Bound Forms of HIV-1 Protease and a Drug-Resistant Mutant in Solution by Nuclear Magnetic Resonance.
Academic Article	Mutations in Influenza A Virus Neuraminidase and Hemagglutinin Confer Resistance against a Broadly Neutralizing Hemagglutinin Stem Antibody.
Academic Article	Resistance outside the substrate envelope: hepatitis C NS3/4A protease inhibitors.
Academic Article	NMR and MD studies combined to elucidate inhibitor and water interactions of HIV-1 protease and their modulations with resistance mutations.
Academic Article	Picomolar to Micromolar: Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance.
Academic Article	Molecular Determinants of Epistasis in HIV-1 Protease: Elucidating the Interdependence of L89V and L90M Mutations in Resistance.
Academic Article	Characterizing Protein-Ligand Binding Using Atomistic Simulation and Machine Learning: Application to Drug Resistance in HIV-1 Protease.
Academic Article	Avoiding Drug Resistance by Substrate Envelope-Guided Design: Toward Potent and Robust HCV NS3/4A Protease Inhibitors.
Academic Article	Drug Design Strategies to Avoid Resistance in Direct-Acting Antivirals and Beyond.
Academic Article	Deciphering Complex Mechanisms of Resistance and Loss of Potency through Coupled Molecular Dynamics and Machine Learning.
Academic Article	Discovery of Quinoxaline-Based P1-P3 Macrocyclic NS3/4A Protease Inhibitors with Potent Activity against Drug-Resistant Hepatitis C Virus Variants.
Academic Article	Identification of a Permissive Secondary Mutation That Restores the Enzymatic Activity of Oseltamivir Resistance Mutation H275Y.
Academic Article	Deciphering the Molecular Mechanism of HCV Protease Inhibitor Fluorination as a General Approach to Avoid Drug Resistance.
Academic Article	Selection of HIV-1 for resistance to fifth-generation protease inhibitors reveals two independent pathways to high-level resistance.
Academic Article	Elucidating the Substrate Envelope of Enterovirus 68-3C Protease: Structural Basis of Specificity and Potential Resistance.

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Drug Resistance Viral