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Schiffer, Celia

One or more keywords matched the following items that are connected to Schiffer, Celia

Item Type	Name
Academic Article	Structural stability of disulfide mutants of basic pancreatic trypsin inhibitor: a molecular dynamics study.
Academic Article	The role of protein-solvent interactions in protein unfolding.
Academic Article	Accessibility and order of water sites in and around proteins: A crystallographic time-averaging study.
Academic Article	Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site.
Academic Article	Curling of flap tips in HIV-1 protease as a mechanism for substrate entry and tolerance of drug resistance.
Academic Article	Cooperative fluctuations of unliganded and substrate-bound HIV-1 protease: a structure-based analysis on a variety of conformations from crystallography and molecular dynamics simulations.
Academic Article	Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor.
Academic Article	Design of HIV-1 protease inhibitors active on multidrug-resistant virus.
Academic Article	How does a symmetric dimer recognize an asymmetric substrate? A substrate complex of HIV-1 protease.
Academic Article	Competition between Ski and CREB-binding protein for binding to Smad proteins in transforming growth factor-beta signaling.
Academic Article	Evaluation of the substrate envelope hypothesis for inhibitors of HIV-1 protease.
Academic Article	Design and synthesis of HIV-1 protease inhibitors incorporating oxazolidinones as P2/P2' ligands in pseudosymmetric dipeptide isosteres.
Academic Article	Contribution of Ser386 and Ser396 to activation of interferon regulatory factor 3.
Academic Article	Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5.
Academic Article	Viral protease inhibitors.
Academic Article	Additivity in the analysis and design of HIV protease inhibitors.
Academic Article	Crystal structure of the APOBEC3G catalytic domain reveals potential oligomerization interfaces.
Academic Article	Structure of a phage display-derived variant of human growth hormone complexed to two copies of the extracellular domain of its receptor: evidence for strong structural coupling between receptor binding sites.
Academic Article	The effect of clade-specific sequence polymorphisms on HIV-1 protease activity and inhibitor resistance pathways.
Academic Article	Structure-based design, synthesis, and structure-activity relationship studies of HIV-1 protease inhibitors incorporating phenyloxazolidinones.
Academic Article	Molecular mechanisms of viral and host cell substrate recognition by hepatitis C virus NS3/4A protease.
Academic Article	Substrate shape determines specificity of recognition for HIV-1 protease: analysis of crystal structures of six substrate complexes.
Academic Article	First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G.
Academic Article	Hydrophobic core flexibility modulates enzyme activity in HIV-1 protease.
Academic Article	Design, synthesis, and biological and structural evaluations of novel HIV-1 protease inhibitors to combat drug resistance.
Academic Article	Extreme entropy-enthalpy compensation in a drug-resistant variant of HIV-1 protease.
Academic Article	The molecular basis of drug resistance against hepatitis C virus NS3/4A protease inhibitors.
Academic Article	Point mutants of EHEC intimin that diminish Tir recognition and actin pedestal formation highlight a putative Tir binding pocket.
Academic Article	Cooperative effects of drug-resistance mutations in the flap region of HIV-1 protease.
Academic Article	Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments.
Academic Article	Structure-based prediction of potential binding and nonbinding peptides to HIV-1 protease.
Academic Article	Covariation of amino acid positions in HIV-1 protease.
Academic Article	Promise of advances in simulation methods for protein crystallography: implicit solvent models, time-averaging refinement, and quantum mechanical modeling.
Academic Article	Exploring the role of the solvent in the denaturation of a protein: a molecular dynamics study of the DNA binding domain of the 434 repressor.
Academic Article	Expression, purification, and characterization of thymidylate synthase from Lactococcus lactis.
Academic Article	Association of a novel human immunodeficiency virus type 1 protease substrate cleft mutation, L23I, with protease inhibitor therapy and in vitro drug resistance.
Academic Article	Mechanism of substrate recognition by drug-resistant human immunodeficiency virus type 1 protease variants revealed by a novel structural intermediate.
Academic Article	Role of invariant Thr80 in human immunodeficiency virus type 1 protease structure, function, and viral infectivity.
Academic Article	Crystal structure of lysine sulfonamide inhibitor reveals the displacement of the conserved flap water molecule in human immunodeficiency virus type 1 protease.
Academic Article	HIV-1 protease inhibitors from inverse design in the substrate envelope exhibit subnanomolar binding to drug-resistant variants.
Academic Article	Structural analysis of human immunodeficiency virus type 1 CRF01_AE protease in complex with the substrate p1-p6.
Academic Article	Resilience to resistance of HIV-1 protease inhibitors: profile of darunavir.
Academic Article	Human immunodeficiency virus type 1 protease-correlated cleavage site mutations enhance inhibitor resistance.
Academic Article	Evaluating the substrate-envelope hypothesis: structural analysis of novel HIV-1 protease inhibitors designed to be robust against drug resistance.
Academic Article	Rationale for more diverse inhibitors in competition with substrates in HIV-1 protease.
Academic Article	Structural, kinetic, and thermodynamic studies of specificity designed HIV-1 protease.
Academic Article	Structural insights into neuronal K+ channel-calmodulin complexes.
Academic Article	Structural and thermodynamic basis of amprenavir/darunavir and atazanavir resistance in HIV-1 protease with mutations at residue 50.
Academic Article	Crystal structure of the DNA cytosine deaminase APOBEC3F: the catalytically active and HIV-1 Vif-binding domain.
Concept	Models, Molecular
Academic Article	Testing the substrate-envelope hypothesis with designed pairs of compounds.
Academic Article	Crystal structures of human CtBP in complex with substrate MTOB reveal active site features useful for inhibitor design.
Academic Article	HIV-1 protease-substrate coevolution in nelfinavir resistance.
Academic Article	Drug resistance conferred by mutations outside the active site through alterations in the dynamic and structural ensemble of HIV-1 protease.
Academic Article	The ssDNA Mutator APOBEC3A Is Regulated by Cooperative Dimerization.
Academic Article	Structure-guided design of a high affinity inhibitor to human CtBP.
Academic Article	REdiii: a pipeline for automated structure solution.
Academic Article	Structure of the Vif-binding domain of the antiviral enzyme APOBEC3G.
Academic Article	A Direct Interaction with RNA Dramatically Enhances the Catalytic Activity of the HIV-1 Protease In Vitro.
Academic Article	Simultaneously Targeting the NS3 Protease and Helicase Activities for More Effective Hepatitis C Virus Therapy.
Academic Article	A Balance between Inhibitor Binding and Substrate Processing Confers Influenza Drug Resistance.
Academic Article	Structural and molecular analysis of a protective epitope of Lyme disease antigen OspA and antibody interactions.
Academic Article	Structural Determination of the Broadly Reactive Anti-IGHV1-69 Anti-idiotypic Antibody G6 and Its Idiotope.
Academic Article	Synonymous Mutations at the Beginning of the Influenza A Virus Hemagglutinin Gene Impact Experimental Fitness.
Academic Article	Substrate sequence selectivity of APOBEC3A implicates intra-DNA interactions.
Academic Article	Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity.
Academic Article	Molecular Mechanism of Resistance in a Clinically Significant Double-Mutant Variant of HCV NS3/4A Protease.
Academic Article	T cell epitope engineering: an avian H7N9 influenza vaccine strategy for pandemic preparedness and response.
Academic Article	Mutations in Influenza A Virus Neuraminidase and Hemagglutinin Confer Resistance against a Broadly Neutralizing Hemagglutinin Stem Antibody.
Academic Article	Assembly of human C-terminal binding protein (CtBP) into tetramers.
Academic Article	HIV-1 Protease Uses Bi-Specific S2/S2' Subsites to Optimize Cleavage of Two Classes of Target Sites.
Academic Article	Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with ssDNA.
Academic Article	Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease.
Academic Article	HIV-1 Protease Inhibitors Incorporating Stereochemically Defined P2' Ligands To Optimize Hydrogen Bonding in the Substrate Envelope.
Academic Article	Molecular Determinants of Epistasis in HIV-1 Protease: Elucidating the Interdependence of L89V and L90M Mutations in Resistance.
Academic Article	Optimizing the refinement of merohedrally twinned P61 HIV-1 protease-inhibitor cocrystal structures.
Academic Article	Structural Analysis of Potent Hybrid HIV-1 Protease Inhibitors Containing Bis-tetrahydrofuran in a Pseudosymmetric Dipeptide Isostere.
Academic Article	A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction.
Academic Article	Crystal Structure of SARS-CoV-2 Main Protease in Complex with the Non-Covalent Inhibitor ML188.
Academic Article	NAD(H) phosphates mediate tetramer assembly of human C-terminal binding protein (CtBP).
Academic Article	Structural basis of substrate specificity in human cytidine deaminase family APOBEC3s.
Academic Article	Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations.
Academic Article	Elucidating the Substrate Envelope of Enterovirus 68-3C Protease: Structural Basis of Specificity and Potential Resistance.

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