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Schiffer, Celia
One or more keywords matched the following properties of Schiffer, Celia
PropertyValue
keywords Protein Crystallography
One or more keywords matched the following items that are connected to Schiffer, Celia
Item TypeName
Academic Article Structural stability of disulfide mutants of basic pancreatic trypsin inhibitor: a molecular dynamics study.
Academic Article The role of protein-solvent interactions in protein unfolding.
Academic Article Accessibility and order of water sites in and around proteins: A crystallographic time-averaging study.
Academic Article Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site.
Academic Article Curling of flap tips in HIV-1 protease as a mechanism for substrate entry and tolerance of drug resistance.
Academic Article Replacement of the P1 amino acid of human immunodeficiency virus type 1 Gag processing sites can inhibit or enhance the rate of cleavage by the viral protease.
Academic Article Cooperative fluctuations of unliganded and substrate-bound HIV-1 protease: a structure-based analysis on a variety of conformations from crystallography and molecular dynamics simulations.
Academic Article PTEN enters the nucleus by diffusion.
Academic Article Crystallization of human thymidylate synthase.
Academic Article How does a symmetric dimer recognize an asymmetric substrate? A substrate complex of HIV-1 protease.
Academic Article Competition between Ski and CREB-binding protein for binding to Smad proteins in transforming growth factor-beta signaling.
Academic Article Contribution of Ser386 and Ser396 to activation of interferon regulatory factor 3.
Academic Article Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5.
Academic Article Toward the design of mutation-resistant enzyme inhibitors: further evaluation of the substrate envelope hypothesis.
Academic Article Crystal structure of the APOBEC3G catalytic domain reveals potential oligomerization interfaces.
Academic Article Lack of synergy for inhibitors targeting a multi-drug-resistant HIV-1 protease.
Academic Article Structure of a phage display-derived variant of human growth hormone complexed to two copies of the extracellular domain of its receptor: evidence for strong structural coupling between receptor binding sites.
Academic Article The effect of clade-specific sequence polymorphisms on HIV-1 protease activity and inhibitor resistance pathways.
Academic Article Molecular mechanisms of viral and host cell substrate recognition by hepatitis C virus NS3/4A protease.
Academic Article Substrate shape determines specificity of recognition for HIV-1 protease: analysis of crystal structures of six substrate complexes.
Academic Article Hydrophobic core flexibility modulates enzyme activity in HIV-1 protease.
Academic Article Design, synthesis, and biological and structural evaluations of novel HIV-1 protease inhibitors to combat drug resistance.
Academic Article Extreme entropy-enthalpy compensation in a drug-resistant variant of HIV-1 protease.
Academic Article The molecular basis of drug resistance against hepatitis C virus NS3/4A protease inhibitors.
Academic Article Nitric oxide-mediated inhibition of Hdm2-p53 binding.
Academic Article Viability of a drug-resistant human immunodeficiency virus type 1 protease variant: structural insights for better antiviral therapy.
Academic Article Structure-based prediction of potential binding and nonbinding peptides to HIV-1 protease.
Academic Article Promise of advances in simulation methods for protein crystallography: implicit solvent models, time-averaging refinement, and quantum mechanical modeling.
Academic Article Simultaneous refinement of the structure of BPTI against NMR data measured in solution and X-ray diffraction data measured in single crystals.
Academic Article Exploring the role of the solvent in the denaturation of a protein: a molecular dynamics study of the DNA binding domain of the 434 repressor.
Academic Article Expression, purification, and characterization of thymidylate synthase from Lactococcus lactis.
Academic Article Inclusion of solvation free energy with molecular mechanics energy: alanyl dipeptide as a test case.
Academic Article Structural basis for coevolution of a human immunodeficiency virus type 1 nucleocapsid-p1 cleavage site with a V82A drug-resistant mutation in viral protease.
Academic Article Association of a novel human immunodeficiency virus type 1 protease substrate cleft mutation, L23I, with protease inhibitor therapy and in vitro drug resistance.
Academic Article Mechanism of substrate recognition by drug-resistant human immunodeficiency virus type 1 protease variants revealed by a novel structural intermediate.
Academic Article Substrate specificity in HIV-1 protease by a biased sequence search method.
Academic Article Role of invariant Thr80 in human immunodeficiency virus type 1 protease structure, function, and viral infectivity.
Academic Article Hydrophobic sliding: a possible mechanism for drug resistance in human immunodeficiency virus type 1 protease.
Academic Article Prediction of homologous protein structures based on conformational searches and energetics.
Academic Article Crystal structure of lysine sulfonamide inhibitor reveals the displacement of the conserved flap water molecule in human immunodeficiency virus type 1 protease.
Academic Article Mass spectrometry analysis of HIV-1 Vif reveals an increase in ordered structure upon oligomerization in regions necessary for viral infectivity.
Academic Article Structural analysis of human immunodeficiency virus type 1 CRF01_AE protease in complex with the substrate p1-p6.
Academic Article Human immunodeficiency virus type 1 protease-correlated cleavage site mutations enhance inhibitor resistance.
Academic Article Evaluating the substrate-envelope hypothesis: structural analysis of novel HIV-1 protease inhibitors designed to be robust against drug resistance.
Academic Article Rationale for more diverse inhibitors in competition with substrates in HIV-1 protease.
Academic Article Therapeutic targeting of C-terminal binding protein in human cancer.
Academic Article Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding.
Academic Article Structural, kinetic, and thermodynamic studies of specificity designed HIV-1 protease.
Academic Article Mass spectrometry tools for analysis of intermolecular interactions.
Academic Article Structural insights into neuronal K+ channel-calmodulin complexes.
Academic Article Structural and thermodynamic basis of amprenavir/darunavir and atazanavir resistance in HIV-1 protease with mutations at residue 50.
Academic Article Crystal structure of the DNA cytosine deaminase APOBEC3F: the catalytically active and HIV-1 Vif-binding domain.
Concept Protein Binding
Concept Protein Transport
Concept Protein Folding
Concept Protein Processing, Post-Translational
Concept Tumor Suppressor Protein p53
Concept Protein Interaction Mapping
Concept Protein Interaction Domains and Motifs
Concept Protein Denaturation
Concept CREB-Binding Protein
Concept Protein Structure, Secondary
Concept Protein Structure, Tertiary
Concept Protein Multimerization
Concept Protein Structure, Quaternary
Concept Structural Homology, Protein
Concept Protein Conformation
Concept Protein Engineering
Academic Article A sensitive assay using a native protein substrate for screening HIV-1 maturation inhibitors targeting the protease cleavage site between the matrix and capsid.
Academic Article Substrate envelope-designed potent HIV-1 protease inhibitors to avoid drug resistance.
Academic Article The interdomain interface in bifunctional enzyme protein 3/4A (NS3/4A) regulates protease and helicase activities.
Academic Article Crystal structures of human CtBP in complex with substrate MTOB reveal active site features useful for inhibitor design.
Academic Article HIV-1 protease-substrate coevolution in nelfinavir resistance.
Academic Article Drug resistance conferred by mutations outside the active site through alterations in the dynamic and structural ensemble of HIV-1 protease.
Academic Article A computational analysis of the structural determinants of APOBEC3's catalytic activity and vulnerability to HIV-1 Vif.
Academic Article A novel Geobacteraceae-specific outer membrane protein J (OmpJ) is essential for electron transport to Fe(III) and Mn(IV) oxides in Geobacter sulfurreducens.
Academic Article Investigation of protein unfolding and stability by computer simulation.
Academic Article The ssDNA Mutator APOBEC3A Is Regulated by Cooperative Dimerization.
Academic Article Structure-guided design of a high affinity inhibitor to human CtBP.
Academic Article Structure of the Vif-binding domain of the antiviral enzyme APOBEC3G.
Academic Article A Direct Interaction with RNA Dramatically Enhances the Catalytic Activity of the HIV-1 Protease In Vitro.
Academic Article Structural basis for mutation-induced destabilization of profilin 1 in ALS.
Academic Article Structural and molecular analysis of a protective epitope of Lyme disease antigen OspA and antibody interactions.
Academic Article Molecular Basis for Differential Patterns of Drug Resistance in Influenza N1 and N2 Neuraminidase.
Academic Article Dengue Virus NS2B/NS3 Protease Inhibitors Exploiting the Prime Side.
Academic Article Interdependence of Inhibitor Recognition in HIV-1 Protease.
Academic Article Structural Determination of the Broadly Reactive Anti-IGHV1-69 Anti-idiotypic Antibody G6 and Its Idiotope.
Academic Article Substrate sequence selectivity of APOBEC3A implicates intra-DNA interactions.
Academic Article Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity.
Academic Article Molecular Mechanism of Resistance in a Clinically Significant Double-Mutant Variant of HCV NS3/4A Protease.
Academic Article Probing Structural Changes among Analogous Inhibitor-Bound Forms of HIV-1 Protease and a Drug-Resistant Mutant in Solution by Nuclear Magnetic Resonance.
Academic Article Assembly of human C-terminal binding protein (CtBP) into tetramers.
Academic Article Structural Analysis of the Active Site and DNA Binding of Human Cytidine Deaminase APOBEC3B.
Academic Article HIV-1 Protease Uses Bi-Specific S2/S2' Subsites to Optimize Cleavage of Two Classes of Target Sites.
Academic Article Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with ssDNA.
Academic Article Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease.
Academic Article Resistance outside the substrate envelope: hepatitis C NS3/4A protease inhibitors.
Academic Article APOBEC3s: DNA-editing human cytidine deaminases.
Academic Article NMR and MD studies combined to elucidate inhibitor and water interactions of HIV-1 protease and their modulations with resistance mutations.
Academic Article Picomolar to Micromolar: Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance.
Academic Article Target-Specific Prediction of Ligand Affinity with Structure-Based Interaction Fingerprints.
Academic Article Molecular Determinants of Epistasis in HIV-1 Protease: Elucidating the Interdependence of L89V and L90M Mutations in Resistance.
Academic Article Mechanism for APOBEC3G catalytic exclusion of RNA and non-substrate DNA.
Academic Article Molecular and Structural Mechanism of Pan-Genotypic HCV NS3/4A Protease Inhibition by Glecaprevir.
Academic Article Characterizing Protein-Ligand Binding Using Atomistic Simulation and Machine Learning: Application to Drug Resistance in HIV-1 Protease.
Academic Article A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction.
Academic Article Crystal Structure of a Soluble APOBEC3G Variant Suggests ssDNA to Bind in a Channel that Extends between the Two Domains.
Academic Article Cryo-EM structure of CtBP2 confirms tetrameric architecture.
Academic Article Drug Design Strategies to Avoid Resistance in Direct-Acting Antivirals and Beyond.
Academic Article Crystal Structure of SARS-CoV-2 Main Protease in Complex with the Non-Covalent Inhibitor ML188.
Academic Article NAD(H) phosphates mediate tetramer assembly of human C-terminal binding protein (CtBP).
Academic Article Inhibiting HTLV-1 Protease: A Viable Antiviral Target.
Academic Article Introduction: Drug Resistance.
Academic Article Structural basis of substrate specificity in human cytidine deaminase family APOBEC3s.
Academic Article Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations.
Academic Article Discovery of Quinoxaline-Based P1-P3 Macrocyclic NS3/4A Protease Inhibitors with Potent Activity against Drug-Resistant Hepatitis C Virus Variants.
Academic Article Pan-3C Protease Inhibitor Rupintrivir Binds SARS-CoV-2 Main Protease in a Unique Binding Mode.
Concept Protein Domains
Concept T-Lymphoma Invasion and Metastasis-inducing Protein 1
Academic Article Elucidating the Substrate Envelope of Enterovirus 68-3C Protease: Structural Basis of Specificity and Potential Resistance.
Academic Article Direct delivery of Cas-embedded cytosine base editors as ribonucleoprotein complexes for efficient and accurate editing of clinically relevant targets.
Academic Article Structural Analysis of Inhibitor Binding to Enterovirus-D68 3C Protease.
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  • Protein S