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Search Results to David R Weaver PhD

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Academic Background

B.S., Michigan State University1981
Ph.D., Michigan State University1985
Postdoctoral Research Fellow, Mass. General Hospital1985-1987
Postdoctoral Research Fellow, Harvard Medical School1985-1987
Assistant in Neurobiology, Massachusetts General Hospital1987-1992
Instructor, Harvard Medical School1987-1989
Assistant Professor, Harvard Medical School1989-1994
Associate Neurobiologist, Massachusetts General Hospital1993-2001
Associate Professor, Harvard Medical School1994-2001
Associate Professor, UMass Medical School2001-2006
Director, Graduate Program in Neuroscience, UMass Medical School2005-
Professor, UMass Medical School2006-

Research Program Description: Molecular Physiology of Circadian Rhythms

The major objective of our research program is to understand the molecular mechanisms for circadian rhythmicity, and the impact of circadian rhythms on physiology and behavior.

Molecular mechanisms of circadian rhythmicity.

Daily rhythms in activity levels, alertness/sleep, body temperature, and hormonal profiles will persist in constant conditions, with a cycle length of about 24 hours, demonstrating the presence of an internal time-keeping system. When exposed to a daily light-dark cycle, these rhythms are synchronized (entrained) to a 24-hour period. In mammals, a small area of the anterior hypothalamus called the suprachiasmatic nucleus (SCN) is the principal circadian pacemaker (for review see Weaver, 1998; Reppert & Weaver 2001).

How do SCN neurons measure out 24 hours? Work on the circadian clocks of species ranging from bacteria to fungi to fruit flies has revealed a common thread, that the molecular basis for circadian rhythmicity is the rhythmic synthesis of "clock" molecules. In each of these species, and in mammals, molecules are synthesized rhythmically, and these molecules then feed back to turn off their own synthesis. This forms what is called a "transcriptional-translational feedback loop." Mutations of specific genes within the feedback loop result in altered or disrupted rhythmicity. Recently, great advances have been made in identifying the components of the circadian feedback loop in mammals, and in defining the specific roles of individual gene products in the circadian clock (reviewed in Reppert & Weaver 2002). The aim of this research is to understand the molecular mechanisms underlying generation and entrainment of circadian rhythms in mammals.

Current Research Projects:

We are studying behavioral and molecular phenotypes of mice with genetic defects altering circadian behavior. We continue to generate line of mice with targeted disruption of genes relevant to circadian rhythms. Other areas of interest are to identify the effects of clock gene mutations on other behavioral and physiological processes, including sleep, and to understand the importance of local oscillators in tissues outside the brain.

Please use the Publications Tab at the top of this page for the most up-to-date description of this research program and my collaborators.


One or more keywords matched the following items that are connected to Weaver, David

Item TypeName
Academic Article Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei.
Academic Article Interacting molecular loops in the mammalian circadian clock.
Academic Article Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock.
Academic Article Postmortem stability of melatonin receptor binding and clock-relevant mRNAs in mouse suprachiasmatic nucleus.
Academic Article Cellular construction of a circadian clock: period determination in the suprachiasmatic nuclei.
Academic Article Three period homologs in mammals: differential light responses in the suprachiasmatic circadian clock and oscillating transcripts outside of brain.
Academic Article Molecular analysis of mammalian timeless.
Academic Article Expression and regulation of mPer1 in immortalized GnRH neurons.
Academic Article Light-induced phase shifts in mice lacking mPER1 or mPER2.
Academic Article A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock.
Academic Article Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock.
Academic Article Photic induction of Period gene expression is reduced in Clock mutant mice.
Academic Article Differential regulation of mPER1 and mTIM proteins in the mouse suprachiasmatic nuclei: new insights into a core clock mechanism.
Academic Article mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop.
Academic Article Peripheral gene expression rhythms in a diurnal rodent.
Academic Article Analysis of clock proteins in mouse SCN demonstrates phylogenetic divergence of the circadian clockwork and resetting mechanisms.
Academic Article Targeted disruption of the mPer3 gene: subtle effects on circadian clock function.
Academic Article Molecular analysis of mammalian circadian rhythms.
Academic Article Rhythmic gene expression in pituitary depends on heterologous sensitization by the neurohormone melatonin.
Academic Article Casein kinase 1 delta (CK1delta) regulates period length of the mouse suprachiasmatic circadian clock in vitro.
Academic Article The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1.
Academic Article Distinct patterns of Period gene expression in the suprachiasmatic nucleus underlie circadian clock photoentrainment by advances or delays.
Academic Article Integrative gene regulatory network analysis reveals light-induced regional gene expression phase shift programs in the mouse suprachiasmatic nucleus.
Academic Article Maternal communication of circadian phase to the developing mammal.
Academic Article Definition of a prenatal sensitive period for maternal-fetal communication of day length.
Academic Article Maternal-fetal communication of circadian phase in a precocious rodent, the spiny mouse.
Academic Article Sleep rhythmicity and homeostasis in mice with targeted disruption of mPeriod genes.
Academic Article PER1-like immunoreactivity in oxytocin cells of the hamster hypothalamo-neurohypophyseal system.
Academic Article Transient, light-induced rhythmicity in mPer-deficient mice.
Academic Article Rhythmic expression of clock genes in the ependymal cell layer of the third ventricle of rodents is independent of melatonin signaling.
Academic Article Casein kinase 1 delta regulates the pace of the mammalian circadian clock.
Academic Article The circadian clock protein Period 1 regulates expression of the renal epithelial sodium channel in mice.
Academic Article Altered body mass regulation in male mPeriod mutant mice on high-fat diet.
Concept Period Circadian Proteins
Academic Article Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration.

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