| Item Type | Name |
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Academic Article
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Antibody class switching.
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Academic Article
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The ability of CD40L, but not lipopolysaccharide, to initiate immunoglobulin switching to immunoglobulin G1 is explained by differential induction of NF-kappaB/Rel proteins.
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Academic Article
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Activation of NF-kappaB/Rel by CD40 engagement induces the mouse germ line immunoglobulin Cgamma1 promoter.
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Academic Article
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Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes.
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Academic Article
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The mu switch region tandem repeats are important, but not required, for antibody class switch recombination.
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Academic Article
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Immunoglobulin genes: generating diversity with AID and UNG.
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Academic Article
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Ialpha exon-replacement mice synthesize a spliced HPRT-C(alpha) transcript which may explain their ability to switch to IgA. Inhibition of switching to IgG in these mice.
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Academic Article
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Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions.
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Academic Article
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Inducible DNA breaks in Ig S regions are dependent on AID and UNG.
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Academic Article
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Copy choice mechanism of immunoglobulin heavy-chain switch recombination.
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Academic Article
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The histone methyltransferase Suv39h1 increases class switch recombination specifically to IgA.
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Academic Article
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Stimuli that enhance IgA class switching increase histone 3 acetylation at S alpha, but poorly stimulate sequential switching from IgG2b.
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Academic Article
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Activation-induced cytidine deaminase-dependent DNA breaks in class switch recombination occur during G1 phase of the cell cycle and depend upon mismatch repair.
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Academic Article
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APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination.
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Academic Article
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The roles of APE1, APE2, DNA polymerase beta and mismatch repair in creating S region DNA breaks during antibody class switch.
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Academic Article
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Reassessment of the role of Mut S homolog 5 in Ig class switch recombination shows lack of involvement in cis- and trans-switching.
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Academic Article
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Class switch recombination efficiency and junction microhomology patterns in Msh2-, Mlh1-, and Exo1-deficient mice depend on the presence of mu switch region tandem repeats.
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Academic Article
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Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes.
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Academic Article
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A B-cell-specific nuclear protein that binds to DNA sites 5' to immunoglobulin S alpha tandem repeats is regulated during differentiation.
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Academic Article
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Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions.
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Academic Article
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Induction of immunoglobulin isotype switching in cultured I.29 B lymphoma cells. Characterization of the accompanying rearrangements of heavy chain genes.
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Academic Article
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Complex regulation and function of activation-induced cytidine deaminase.
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Academic Article
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AID recruits UNG and Msh2 to Ig switch regions dependent upon the AID C terminus [corrected].
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Academic Article
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The DNA glycosylases Ogg1 and Nth1 do not contribute to Ig class switching in activated mouse splenic B cells.
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Academic Article
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Activation-induced cytidine deaminase-initiated off-target DNA breaks are detected and resolved during S phase.
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Academic Article
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Regulation of transcription of immunoglobulin germ-line gamma 1 RNA: analysis of the promoter/enhancer.
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Academic Article
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Mlh1 can function in antibody class switch recombination independently of Msh2.
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Academic Article
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The Smu tandem repeat region is critical for Ig isotype switching in the absence of Msh2.
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Academic Article
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Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination.
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Academic Article
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Regulation of antibody production and class switching by TGF-beta.
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Academic Article
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Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50.
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Academic Article
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Inhibitors of poly(ADP-ribose) polymerase increase antibody class switching.
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Academic Article
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Antibody class switching: uncoupling S region accessibility from transcription.
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Academic Article
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Evolution of isotype switching.
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Academic Article
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Induction of germ-line immunoglobulin heavy chain transcripts by mitogens and interleukins prior to switch recombination.
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Academic Article
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Shifts in targeting of class switch recombination sites in mice that lack mu switch region tandem repeats or Msh2.
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Academic Article
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Mismatch repair converts AID-instigated nicks to double-strand breaks for antibody class-switch recombination.
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Academic Article
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Enhanced IgA class switching in marginal zone and B1 B cells relative to follicular/B2 B cells.
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Academic Article
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DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination.
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Academic Article
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Mechanism and regulation of class switch recombination.
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Academic Article
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The surprising discovery that TGF beta specifically induces the IgA class switch.
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Academic Article
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p53 represses class switch recombination to IgG2a through its antioxidant function.
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Academic Article
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Mapping of switch recombination junctions, a tool for studying DNA repair pathways during immunoglobulin class switching.
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Academic Article
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Activation-induced cytidine deaminase induces reproducible DNA breaks at many non-Ig Loci in activated B cells.
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Academic Article
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Mutations, duplication, and deletion of recombined switch regions suggest a role for DNA replication in the immunoglobulin heavy-chain switch.
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Concept
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Immunoglobulin Allotypes
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Concept
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Immunoglobulin epsilon-Chains
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Concept
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Immunoglobulin Variable Region
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Concept
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Somatic Hypermutation, Immunoglobulin
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Concept
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Immunoglobulin alpha-Chains
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Concept
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Genes, Immunoglobulin
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Concept
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Immunoglobulin gamma-Chains
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Concept
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Immunoglobulin M
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Concept
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Immunoglobulin G
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Concept
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Immunoglobulin A
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Concept
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Immunoglobulin Switch Region
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Concept
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Immunoglobulin E
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Concept
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Immunoglobulin Heavy Chains
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Concept
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Immunoglobulin Isotypes
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Concept
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Immunoglobulin Idiotypes
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Concept
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Immunoglobulin Constant Regions
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Concept
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Immunoglobulin Class Switching
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Concept
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Immunoglobulin mu-Chains
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Academic Article
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DNA polymerases ? and ? do not directly affect Ig variable region somatic hypermutation although their absence reduces the frequency of mutations.
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Academic Article
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A DNA break- and phosphorylation-dependent positive feedback loop promotes immunoglobulin class-switch recombination.
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Academic Article
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Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation.
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Academic Article
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IgH chain class switch recombination: mechanism and regulation.
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Academic Article
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Response to comment on "IgH chain class switch recombination: mechanism and regulation".
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Academic Article
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Individual substitution mutations in the AID C terminus that ablate IgH class switch recombination.
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