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Trans-synaptic transmission of vesicular Wnt signals through Evi/Wntless.
The Drosophila Wnt, wingless, provides an essential signal for pre- and postsynaptic differentiation.
Wingless signaling at synapses is through cleavage and nuclear import of receptor DFrizzled2.
Nuclear trafficking of Drosophila Frizzled-2 during synapse development requires the PDZ protein dGRIP.