Item Type | Name |
Academic Article
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Cytokine gene expression in islets and thyroids of BB rats. IFN-gamma and IL-12p40 mRNA increase with age in both diabetic and insulin-treated nondiabetic BB rats.
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Academic Article
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Oral insulin does not prevent insulin-dependent diabetes mellitus in BB rats.
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Academic Article
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Ontogeny and immunohistochemical localization of thymus-dependent and thymus-independent RT6+ cells in the rat.
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Academic Article
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Lack of peripherally induced tolerance to established skin allografts in immunologically reconstituted scid mice.
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Academic Article
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Role of natural killer cells on engraftment of human lymphoid cells and on metastasis of human T-lymphoblastoid leukemia cells in C57BL/6J-scid mice and in C57BL/6J-scid bg mice.
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Academic Article
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Thymus atrophy and changes in thymocyte subpopulations of BN rats with mercury-induced renal autoimmune disease.
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Academic Article
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Tolerance to islet xenografts induced by dual manipulation of antigen presentation and co-stimulation.
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Academic Article
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Improved engraftment of human cord blood stem cells in NOD/LtSz-scid/scid mice after irradiation or multiple-day injections into unirradiated recipients.
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Academic Article
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Enhanced human CD4+ T cell engraftment in beta2-microglobulin-deficient NOD-scid mice.
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Academic Article
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CD8+ T lymphocytes are not required for murine resistance to human filarial parasites.
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Academic Article
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Induction of insulin-dependent diabetes mellitus in PVG.RT1u rats.
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Academic Article
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The T cell marker RT6 in a rat model of autoimmune diabetes.
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Academic Article
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Severe defects in immunity and hematopoiesis caused by SHP-1 protein-tyrosine-phosphatase deficiency.
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Academic Article
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Effects of HgCl2 on the expression of autoimmune responses and disease in diabetes-prone (DP) BB rats.
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Academic Article
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Diethylcarbamazine (DEC) does not induce nitric oxide (NO) synthesis.
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Academic Article
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Mercury-induced autoimmunity in Brown Norway rats: kinetics of changes in RT6+ T lymphocytes correlated with IgG isotypes of circulating autoantibodies to laminin 1.
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Academic Article
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SCID mouse models of human stem cell engraftment.
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Academic Article
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High frequency apoptosis of recent thymic emigrants in the liver of lymphopenic diabetes-prone BioBreeding rats.
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Academic Article
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Induction of immunological tolerance to islet allografts.
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Academic Article
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Rat RT6.2 and mouse Rt6 locus 1 are NAD+: arginine ADP ribosyltransferases with auto-ADP ribosylation activity.
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Academic Article
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HIV-1 infectivity of human T cells in a human/murine chimeric fetal thymic organ culture system.
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Academic Article
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Animal models for immunodeficiency diseases.
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Academic Article
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Induction of islet transplantation tolerance using donor specific transfusion and anti-CD154 monoclonal antibody.
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Academic Article
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Prolonged skin allograft survival in mice treated with Flt3-ligand-induced dendritic cells and anti-CD154 monoclonal antibody.
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Academic Article
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Recapitulation of normal and abnormal BioBreeding rat T cell development in adult thymus organ culture.
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Academic Article
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Cutting edge: sustained expansion of CD8+ T cells requires CD154 expression by Th cells in acute graft versus host disease.
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Academic Article
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NOD mice have a generalized defect in their response to transplantation tolerance induction.
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Academic Article
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Diabetes-prone and diabetes-resistant BB rats share a common major diabetes susceptibility locus, iddm4: additional evidence for a "universal autoimmunity locus" on rat chromosome 4.
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Academic Article
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Treatment of allograft recipients with donor-specific transfusion and anti-CD154 antibody leads to deletion of alloreactive CD8+ T cells and prolonged graft survival in a CTLA4-dependent manner.
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Academic Article
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Virus-induced abrogation of transplantation tolerance induced by donor-specific transfusion and anti-CD154 antibody.
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Academic Article
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Growth of the human filarial parasite Brugia malayi in mice lacking major histocompatibility complex class II antigen expression.
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Academic Article
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The rat T-cell surface protein RT6 is associated with src family tyrosine kinases and generates an activation signal.
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Academic Article
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The BB/Wor rat and the balance hypothesis of autoimmunity.
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Academic Article
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Abnormalities in the export and fate of recent thymic emigrants in diabetes-prone BB/W rats.
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Academic Article
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Regulation of human cell engraftment and development of EBV-related lymphoproliferative disorders in Hu-PBL-scid mice.
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Academic Article
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Viral infection abrogates CD8(+) T-cell deletion induced by costimulation blockade.
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Academic Article
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Characterization of mouse Rt6.1 NAD:arginine ADP-ribosyltransferase.
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Academic Article
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Thymic expression of insulin-related genes in an animal model of autoimmune type 1 diabetes.
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Academic Article
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Thymic involution in viable motheaten (me(v)) mice is associated with a loss of intrathymic precursor activity.
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Academic Article
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Variables to predict engraftment of umbilical cord blood into immunodeficient mice: usefulness of the non-obese diabetic--severe combined immunodeficient assay.
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Academic Article
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Nicotinamide adenine dinucleotide (NAD) and its metabolites inhibit T lymphocyte proliferation: role of cell surface NAD glycohydrolase and pyrophosphatase activities.
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Academic Article
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Mouse RT6 locus 1 and rat RT6.2 are NAD+. Arginine ADP-ribosyltransferases with auto-ADP-ribosylation activity.
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Academic Article
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Dietary cow's milk protein does not alter the frequency of diabetes in the BB rat.
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Academic Article
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Prolonged survival of mouse skin allografts in recipients treated with donor splenocytes and antibody to CD40 ligand.
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Academic Article
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Expression in BALB/c and C57BL/6 mice of Rt6-1 and Rt6-2 ADP-ribosyltransferases that differ in enzymatic activity: C57BL/6 Rt6-1 is a natural transferase knockout.
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Academic Article
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Blockade of CD40-CD154 interferes with human T cell engraftment in scid mice.
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Academic Article
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Long-term survival of skin allografts induced by donor splenocytes and anti-CD154 antibody in thymectomized mice requires CD4(+) T cells, interferon-gamma, and CTLA4.
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Academic Article
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Altered expression of diabetes in BB/Wor rats by exposure to viral pathogens.
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Academic Article
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Characterization of high density lipoprotein-bound and soluble RT6 released following administration of anti-RT6.1 monoclonal antibody.
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Academic Article
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Prolonged survival of rat islet and skin xenografts in mice treated with donor splenocytes and anti-CD154 monoclonal antibody.
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Academic Article
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Improved skin allograft tolerance induced by treatment with donor splenocytes and an extended course of anti-CD154 monoclonal antibody.
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Academic Article
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NOD congenic mice genetically protected from autoimmune diabetes remain resistant to transplantation tolerance induction.
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Academic Article
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Blockade of CD40-mediated signaling is sufficient for inducing islet but not skin transplantation tolerance.
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Academic Article
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Direct visualization of cross-reactive effector and memory allo-specific CD8 T cells generated in response to viral infections.
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Academic Article
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Induction of tolerance for islet transplantation for type 1 diabetes.
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Academic Article
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Islet cells but not thyrocytes are susceptible to lysis by NK cells.
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Academic Article
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Ian4 is required for mitochondrial integrity and T cell survival.
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Academic Article
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Non-major histocompatibility complex-linked diabetes susceptibility loci on chromosomes 4 and 13 in a backcross of the DP-BB/Wor rat to the WF rat.
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Academic Article
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Induction of immunologic tolerance for transplantation.
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Academic Article
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Mechanisms of allograft prolongation in RT6 T cell-depleted rats.
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Academic Article
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Genetic separation of the transplantation tolerance and autoimmune phenotypes in NOD mice.
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Academic Article
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Islet cell autoimmunity and transplantation tolerance: two distinct mechanisms?
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Academic Article
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Comparative mapping of rat Iddm4 to segments on HSA7 and MMU6.
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Academic Article
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CTLA4 signals are required to optimally induce allograft tolerance with combined donor-specific transfusion and anti-CD154 monoclonal antibody treatment.
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Academic Article
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Intravital dye-labeled diabetogenic rat T cells retain dye, home to the pancreas, and induce diabetes.
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Academic Article
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The RT6 (Art2) family of ADP-ribosyltransferases in rat and mouse.
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Academic Article
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A new isolation method for rat intraepithelial lymphocytes.
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Academic Article
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Islet allograft survival induced by costimulation blockade in NOD mice is controlled by allelic variants of Idd3.
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Academic Article
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Regulation of skin and islet allograft survival in mice treated with costimulation blockade is mediated by different CD4+ cell subsets and different mechanisms.
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Academic Article
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Insulin dependent diabetes mellitus hypothesis of autoimmunity.
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Academic Article
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Early growth response gene-2, a zinc-finger transcription factor, is required for full induction of clonal anergy in CD4+ T cells.
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Academic Article
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Evaluation of donor-specific transfusion sources: unique failure of bone marrow cells to induce prolonged skin allograft survival with anti-CD154 monoclonal antibody.
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Academic Article
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TLR activation synergizes with Kilham rat virus infection to induce diabetes in BBDR rats.
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Academic Article
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The rat diabetes susceptibility locus Iddm4 and at least one additional gene are required for autoimmune diabetes induced by viral infection.
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Academic Article
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Autoimmune destruction of islets transplanted into RT6-depleted diabetes-resistant BB/Wor rats.
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Academic Article
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Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes.
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Academic Article
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Diabetes prone BB rats are severely deficient in natural killer T cells.
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Academic Article
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Reduction of the RT6.2+ subset of T lymphocytes in brown Norway rats with mercury-induced renal autoimmunity.
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Academic Article
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NOD/LtSz-Rag1null mice: an immunodeficient and radioresistant model for engraftment of human hematolymphoid cells, HIV infection, and adoptive transfer of NOD mouse diabetogenic T cells.
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Academic Article
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Experimental autoallergic sialadenitis in the LEW rat. I. Parameters of disease induction.
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Academic Article
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Allogeneic hematopoietic chimerism in mice treated with sublethal myeloablation and anti-CD154 antibody: absence of graft-versus-host disease, induction of skin allograft tolerance, and prevention of recurrent autoimmunity in islet-allografted NOD/Lt mice.
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Academic Article
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Costimulation and autoimmune diabetes in BB rats.
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Academic Article
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Effect of ex vivo cytokine treatment on human cord blood engraftment in NOD-scid mice.
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Academic Article
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beta2 microglobulin-deficient (B2m(null)) NOD/SCID mice are excellent recipients for studying human stem cell function.
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Academic Article
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Evidence for elevated prothymocyte activity in the bone marrow of New Zealand Black (NZB) mice. Elevated prothymocyte activity in NZB mice.
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Academic Article
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Rat xenograft survival in mice treated with donor-specific transfusion and anti-CD154 antibody is enhanced by elimination of host CD4+ cells.
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Academic Article
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Costimulatory blockade induces hyporesponsiveness in T cells that recognize alloantigen via indirect antigen presentation.
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Academic Article
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Partial versus full allogeneic hemopoietic chimerization is a preferential means to inhibit type 1 diabetes as the latter induces generalized immunosuppression.
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Academic Article
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TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant rat.
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Academic Article
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Humanized NOD/LtSz-scid IL2 receptor common gamma chain knockout mice in diabetes research.
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Academic Article
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Fetal thymi from diabetes-prone but not diabetes-resistant BB/Wor rats fail to generate mature ART2+ T-cells in organ culture.
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Academic Article
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Intrinsic cytotoxicity of natural killer cells to pancreatic islets in vitro.
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Academic Article
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BB rat thymocytes cultured in the presence of islets lose their ability to transfer autoimmune diabetes.
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Academic Article
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Different mechanisms control peripheral and central tolerance in hematopoietic chimeric mice.
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Academic Article
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Tuberculosis susceptibility of diabetic mice.
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Academic Article
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A novel alloantigen-specific CD8+PD1+ regulatory T cell induced by ICOS-B7h blockade in vivo.
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Academic Article
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Type 1 IFN mediates cross-talk between innate and adaptive immunity that abrogates transplantation tolerance.
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Academic Article
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Translating data from animal models into methods for preventing human autoimmune diabetes mellitus: caveat emptor and primum non nocere.
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Academic Article
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Creation of "humanized" mice to study human immunity.
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Academic Article
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Non-obese diabetic-recombination activating gene-1 (NOD-Rag1 null) interleukin (IL)-2 receptor common gamma chain (IL2r gamma null) null mice: a radioresistant model for human lymphohaematopoietic engraftment.
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Academic Article
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Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice.
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Academic Article
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Closing the circle between the bedside and the bench: Toll-like receptors in models of virally induced diabetes.
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Academic Article
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TLR agonists abrogate co-stimulation blockade-induced mixed chimerism and transplantation tolerance.
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Academic Article
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An atypical population of NK cells that spontaneously secrete IFN-gamma and IL-4 is present in the intraepithelial lymphoid compartment of the rat.
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Academic Article
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Depletion of the programmed death-1 receptor completely reverses established clonal anergy in CD4(+) T lymphocytes via an interleukin-2-dependent mechanism.
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Academic Article
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Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex.
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Academic Article
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Virus-induced autoimmune diabetes in the LEW.1WR1 rat requires Iddm14 and a genetic locus proximal to the major histocompatibility complex.
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Academic Article
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Levels of Art2+ cells but not soluble Art2 protein correlate with expression of autoimmune diabetes in the BB rat.
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Academic Article
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Infection with viruses from several families triggers autoimmune diabetes in LEW*1WR1 rats: prevention of diabetes by maternal immunization.
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Academic Article
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Dengue virus infection and virus-specific HLA-A2 restricted immune responses in humanized NOD-scid IL2rgammanull mice.
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Academic Article
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AATF mediates an antiapoptotic effect of the unfolded protein response through transcriptional regulation of AKT1.
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Academic Article
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Skin allograft maintenance in a new synchimeric model system of tolerance.
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Academic Article
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Effects of irradiation on diabetes in the BB/Wor rat.
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Academic Article
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Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation.
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Academic Article
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Humanized mouse models to study human diseases.
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Academic Article
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Islet cell transplantation tolerance.
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Academic Article
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T cell developmental defects in 'viable motheaten' mice deficient in SHP-1 protein-tyrosine phosphatase. Developmental defects are corrected in vitro in the presence of normal hematopoietic-origin stromal cells and in vivo by exogenous IL-7.
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Academic Article
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Cardioprotection with postconditioning: loss of efficacy in murine models of type-2 and type-1 diabetes.
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Academic Article
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Allografts stimulate cross-reactive virus-specific memory CD8 T cells with private specificity.
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Academic Article
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Defects in the thymic epithelial stroma of diabetes prone BB rats.
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Academic Article
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Prevention of "Humanized" diabetogenic CD8 T-cell responses in HLA-transgenic NOD mice by a multipeptide coupled-cell approach.
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Academic Article
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Rapid recruitment and activation of macrophages by anti-Gal/a-Gal liposome interaction accelerates wound healing.
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Academic Article
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Human islet cell MORF/cMORF pretargeting in a xenogeneic murine transplant model.
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Academic Article
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The pathogenesis of autoimmune diabetes mellitus.
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Academic Article
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Isolation of mouse pancreatic alpha, beta, duct and acinar populations with cell surface markers.
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Academic Article
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Imaging the pancreatic vasculature in diabetes models.
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Academic Article
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Engraftment of human HSCs in nonirradiated newborn NOD-scid IL2r? null mice is enhanced by transgenic expression of membrane-bound human SCF.
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Academic Article
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Pretargeting vs. direct targeting of human betalox5 islet cells subcutaneously implanted in mice using an anti-human islet cell antibody.
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Academic Article
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Prevention of type 1 diabetes in the rat with an allele-specific anti-T-cell receptor antibody: V?13 as a therapeutic target and biomarker.
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Academic Article
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Enhanced humoral and HLA-A2-restricted dengue virus-specific T-cell responses in humanized BLT NSG mice.
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Academic Article
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JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate.
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Academic Article
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Thioredoxin-interacting protein mediates ER stress-induced ? cell death through initiation of the inflammasome.
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Academic Article
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Viral abrogation of stem cell transplantation tolerance causes graft rejection and host death by different mechanisms.
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Academic Article
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T-lymphocyte requirement for diabetes in RT6-depleted diabetes-resistant BB rats.
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Academic Article
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A420983, a novel, small molecule inhibitor of LCK prevents allograft rejection.
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Academic Article
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Humanized mice for immune system investigation: progress, promise and challenges.
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Academic Article
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The iddm4 locus segregates with diabetes susceptibility in congenic WF.iddm4 rats.
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Academic Article
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Survival of Onchocerca volvulus in nodules implanted in immunodeficient rodents.
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Academic Article
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GLI1 regulates a novel neuropilin-2/a6?1 integrin based autocrine pathway that contributes to breast cancer initiation.
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Academic Article
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Type 1 cytokines polarize thymocytes during T cell development in adult thymus organ cultures.
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Academic Article
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Durable knockdown and protection from HIV transmission in humanized mice treated with gel-formulated CD4 aptamer-siRNA chimeras.
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Academic Article
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Infections that induce autoimmune diabetes in BBDR rats modulate CD4+CD25+ T cell populations.
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Academic Article
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Absence of RT6+ T cells in diabetes-prone biobreeding/Worcester rats is due to genetic and cell developmental defects.
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Academic Article
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Absence of the RT-6 T cell subset in diabetes-prone BB/W rats.
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Academic Article
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Characterization of RT6 bearing rat lymphocytes. I. Ontogeny of the RT6+ subset.
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Academic Article
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Prothymocyte development in diabetes-prone BB rats: description of a defect that predisposes to immune abnormalities.
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Academic Article
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Animal models of Sj?gren's syndrome.
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Academic Article
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Studies of thymocytopoiesis in rats and mice. I. Kinetics of appearance of thymocytes using a direct intrathymic adoptive transfer assay for thymocyte precursors.
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Academic Article
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Defective lymphopoiesis in bone marrow of motheaten (me/me) and viable motheaten (mev/mev) mutant mice. I. Analysis of development of prothymocytes, early B lineage cells, and terminal deoxynucleotidyl transferase-positive cells.
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Academic Article
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Characterization of rat prothymocyte with monoclonal antibodies recognizing rat lymphocyte membrane antigenic determinants.
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Academic Article
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Defective lymphopoiesis in the bone marrow of motheaten (me/me) and viable motheaten (mev/mev) mutant mice. II. Description of a microenvironmental defect for the generation of terminal deoxynucleotidyltransferase-positive bone marrow cells in vitro.
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Academic Article
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Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice.
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Academic Article
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Regulation of human short-term repopulating cell (STRC) engraftment in NOD/SCID mice by host CD122+ cells.
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Academic Article
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Spleen cell transfusion in the Bio-Breeding/Worcester rat. Prevention of diabetes, major histocompatibility complex restriction, and long-term persistence of transfused cells.
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Academic Article
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Hematopoietic chimerism and central tolerance created by peripheral-tolerance induction without myeloablative conditioning.
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Academic Article
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Characterization of RT6-bearing rat lymphocytes. II. Developmental relationships of RT6- and RT6+ T cells.
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Academic Article
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Experimental autoallergic sialadenitis in the LEW rat. III. Role of CD4+ T cells in EAS induction.
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Academic Article
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Alloimmune injury and rejection of human skin grafts on human peripheral blood lymphocyte-reconstituted non-obese diabetic severe combined immunodeficient beta2-microglobulin-null mice.
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Academic Article
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NOD/LtSz-Rag1nullPfpnull mice: a new model system with increased levels of human peripheral leukocyte and hematopoietic stem-cell engraftment.
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Academic Article
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Lack of graft-versus-host-like pathology in mercury-induced autoimmunity of Brown Norway rats.
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Academic Article
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Identification of thymocyte progenitors in hemopoietic tissues of the rat. II. Enrichment of functional prothymocytes on the fluorescence-activated cell sorter.
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Academic Article
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A quantitative assay system for thymocyte regeneration in the rat.
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Academic Article
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Characterization of monoclonal antibodies that define rat T cell alloantigens.
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Academic Article
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Maturation of functional T-lymphocyte subpopulations in the rat.
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Academic Article
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Growth and reproduction complex in the rat. Genes linked to the major histocompatibility complex that affect development.
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Academic Article
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Insulin treatment prevents diabetes mellitus but not thyroiditis in RT6-depleted diabetes resistant BB/Wor rats.
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Academic Article
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Recapitulation of normal and abnormal BB rat immune system development in scid mouse/rat lymphohemopoietic chimeras.
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Academic Article
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High levels of human peripheral blood mononuclear cell engraftment and enhanced susceptibility to human immunodeficiency virus type 1 infection in NOD/LtSz-scid/scid mice.
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Academic Article
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Emv30null NOD-scid mice. An improved host for adoptive transfer of autoimmune diabetes and growth of human lymphohematopoietic cells.
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Academic Article
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Maternal influence on susceptibility of offspring to Brugia malayi infection in a murine model of filariasis.
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Academic Article
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Adoptive transfer of autoimmune diabetes mellitus to athymic rats: synergy of CD4+ and CD8+ T cells and prevention by RT6+ T cells.
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Academic Article
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CD4+ T-lymphocytes are not required for murine resistance to the human filarial parasite, Brugia malayi.
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Academic Article
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Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice.
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Academic Article
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Role of RT6+ T lymphocytes in mercury-induced renal autoimmunity: experimental manipulations of "susceptible" and "resistant" rats.
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Academic Article
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Influence of gonadal steroids on susceptibility to Brugia malayi in scid mice.
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Academic Article
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Relative susceptibility of SJL/J and B10.S mice to experimental allergic encephalomyelitis (EAE) is determined by the ability of prethymic cells in bone marrow to develop into EAE effector T cells.
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Academic Article
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Evidence that intrathymic islet transplantation does not prevent diabetes or subsequent islet graft destruction in RT6-depleted, diabetes-resistant BioBreeding/Worcester rats.
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Academic Article
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Rat stem-cell factor induces splenocytes capable of regenerating the thymus.
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Academic Article
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Deficiencies in gut NK cell number and function precede diabetes onset in BB rats.
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Academic Article
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Prolonged survival of neonatal porcine islet xenografts in mice treated with a donor-specific transfusion and anti-CD154 antibody.
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Academic Article
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Rat models of type 1 diabetes: genetics, environment, and autoimmunity.
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Academic Article
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Rejection of human islets and human HLA-A2.1 transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD-scid and NOD-Rag1(null)Prf1(null) mice.
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Academic Article
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Autoimmune diabetes and resistance to xenograft transplantation tolerance in NOD mice.
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Academic Article
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Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells.
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Academic Article
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The immunodeficient scid mouse as a model for human lymphatic filariasis.
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Academic Article
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LEW.1WR1 rats develop autoimmune diabetes spontaneously and in response to environmental perturbation.
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Academic Article
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Experimental autoallergic sialadenitis in the LEW rat. II. Target antigens are associated with cell surface and intracellular particulate fractions derived from the submandibular gland.
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Academic Article
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TLR agonists abrogate costimulation blockade-induced prolongation of skin allografts.
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Academic Article
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Anti-mouse CD154 antibody treatment facilitates generation of mixed xenogeneic rat hematopoietic chimerism, prevents wasting disease and prolongs xenograft survival in mice.
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Academic Article
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ART2, a T cell surface mono-ADP-ribosyltransferase, generates extracellular poly(ADP-ribose).
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Academic Article
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Rapid quantification of naive alloreactive T cells by TNF-alpha production and correlation with allograft rejection in mice.
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Academic Article
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A regulatory CD4+ T cell subset in the BB rat model of autoimmune diabetes expresses neither CD25 nor Foxp3.
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Academic Article
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Humanized mice in translational biomedical research.
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Academic Article
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Development of new-generation HU-PBMC-NOD/SCID mice to study human islet alloreactivity.
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Academic Article
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Refinement of the Iddm4 diabetes susceptibility locus reveals TCRVbeta4 as a candidate gene.
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Academic Article
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Biochemical studies of RT6 alloantigens in BB/Wor and normal rats. Evidence for intact unexpressed RT6a structural gene in diabetes-prone BB rats.
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Academic Article
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Adoptive transfer of autoimmune diabetes and thyroiditis to athymic rats.
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Academic Article
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Determinants of memory in experimental filarial infections in mice.
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Academic Article
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A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene.
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Academic Article
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Prevention of diabetes in the BB rat by essential fatty acid deficiency. Relationship between physiological and biochemical changes.
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Academic Article
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Protein kinase C signaling during T cell activation induces the endoplasmic reticulum stress response.
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Academic Article
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Humanized SCID mouse models for biomedical research.
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Academic Article
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A new immunodeficient hyperglycaemic mouse model based on the Ins2Akita mutation for analyses of human islet and beta stem and progenitor cell function.
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Academic Article
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Expanded CD34+ human umbilical cord blood cells generate multiple lymphohematopoietic lineages in NOD-scid IL2rgamma(null) mice.
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Academic Article
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T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice.
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Academic Article
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Human BLyS facilitates engraftment of human PBL derived B cells in immunodeficient mice.
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Academic Article
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Viral infection: a potent barrier to transplantation tolerance.
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Academic Article
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Humanized mice for the study of type 1 diabetes and beta cell function.
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Academic Article
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Role of innate immunity in transplantation tolerance.
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Academic Article
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Analysis of the rat Iddm14 diabetes susceptibility locus in multiple rat strains: identification of a susceptibility haplotype in the Tcrb-V locus.
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Academic Article
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T cell lines derived from the spinal cords of mice with experimental allergic encephalomyelitis are self reactive.
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Academic Article
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TLR agonists prevent the establishment of allogeneic hematopoietic chimerism in mice treated with costimulation blockade.
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Academic Article
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Failure of alpha-galactosylceramide to prevent diabetes in virus-inducible models of type 1 diabetes in the rat.
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Academic Article
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CHOP mediates endoplasmic reticulum stress-induced apoptosis in Gimap5-deficient T cells.
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Academic Article
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Development of novel major histocompatibility complex class I and class II-deficient NOD-SCID IL2R gamma chain knockout mice for modeling human xenogeneic graft-versus-host disease.
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Academic Article
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Targeted delivery of small interfering RNA to human dendritic cells to suppress dengue virus infection and associated proinflammatory cytokine production.
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Academic Article
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NOD-scid IL2rgamma(null) mouse model of human skin transplantation and allograft rejection.
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Academic Article
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Preparation of (111)In-DTPA morpholino oligomer for low abdominal accumulation.
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Academic Article
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Human immune system development and rejection of human islet allografts in spontaneously diabetic NOD-Rag1null IL2rgammanull Ins2Akita mice.
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Academic Article
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A novel role for the centrosomal protein, pericentrin, in regulation of insulin secretory vesicle docking in mouse pancreatic beta-cells.
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Academic Article
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Leptin treatment confers clinical benefit at multiple stages of virally induced type 1 diabetes in BB rats.
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Academic Article
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Humanized nonobese diabetic-scid IL2rgammanull mice are susceptible to lethal Salmonella Typhi infection.
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Academic Article
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Dynamic glucoregulation and mammalian-like responses to metabolic and developmental disruption in zebrafish.
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Academic Article
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Haptoglobin as an early serum biomarker of virus-induced autoimmune type 1 diabetes in biobreeding diabetes resistant and LEW1.WR1 rats.
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Academic Article
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Prevention of diabetes in BB/Wor rat by single transfusion of spleen cells. Parameters that affect degree of protection.
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Academic Article
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Maturation-dependent licensing of naive T cells for rapid TNF production.
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Academic Article
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Depletion of RT6+ T lymphocytes prolongs skin allograft in rats.
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Academic Article
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Unexpected side products in the conjugation of an amine-derivatized morpholino oligomer with p-isothiocyanate benzyl DTPA and their removal.
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Academic Article
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The role of JNK in the development of hepatocellular carcinoma.
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Academic Article
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Hyperglycemia-induced proliferation of adult human beta cells engrafted into spontaneously diabetic immunodeficient NOD-Rag1null IL2r?null Ins2Akita mice.
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Academic Article
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Targeted disruption of the CCR5 gene in human hematopoietic stem cells stimulated by peptide nucleic acids.
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Academic Article
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T-cell activation and transplantation tolerance.
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Academic Article
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Humanized mice as a preclinical tool for infectious disease and biomedical research.
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Academic Article
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Humanized mice for the study of type 1 and type 2 diabetes.
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Academic Article
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Investigations of T-lymphocyte subpopulations in the rat using alloantigenic markers.
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Academic Article
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Advancing animal models of human type 1 diabetes by engraftment of functional human tissues in immunodeficient mice.
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Academic Article
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Systemic delivery of triplex-forming PNA and donor DNA by nanoparticles mediates site-specific genome editing of human hematopoietic cells in vivo.
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Academic Article
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Islet-specific CTL cloned from a type 1 diabetes patient cause beta-cell destruction after engraftment into HLA-A2 transgenic NOD/scid/IL2RG null mice.
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Academic Article
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Alloreactive CD8 T cells rescued from apoptosis during co-stimulation blockade by Toll-like receptor stimulation remain susceptible to Fas-induced cell death.
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Academic Article
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Transfusions enriched for W3/25+ helper/inducer T lymphocytes prevent spontaneous diabetes in the BB/W rat.
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Academic Article
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Monoclonal antibodies to RT7 and LCA antigens in the rat: cell distribution and segregation analysis.
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Academic Article
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Generation of islet-like cells from mouse gall bladder by direct ex vivo reprogramming.
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Academic Article
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Humanized mice for the study of infectious diseases.
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Academic Article
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Monoclonal antibody analysis of Listeria monocytogenes-induced cytotoxic lymphocytes.
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Academic Article
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Regulatory T cell control of autoimmune destruction of beta cells in the BB rat.
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Academic Article
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Rat immunoglobulin genes have comparable patterns of JH rearrangement in normal peripheral B cells and in pre-B and cultured TdT+ cells from bone marrow.
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Academic Article
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Role of host immune system in BB/Wor rat. Predisposition to diabetes resides in bone marrow.
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Academic Article
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Depletion of RT6.1+ T lymphocytes induces diabetes in resistant biobreeding/Worcester (BB/W) rats.
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Academic Article
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Defective lymphopoiesis in the bone marrow of motheaten (me/me) and viable motheaten (mev/mev) mutant mice. III. Normal mouse bone marrow cells enable mev/mev prothymocytes to generate thymocytes after intravenous transfer.
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Academic Article
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Developmental abnormalities of terminal deoxynucleotidyl transferase positive bone marrow cells and thymocytes in New Zealand mice: effects of prostaglandin E1.
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Academic Article
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Phenotypic heterogeneity of Gross virus-induced thymic lymphomas in the rat: cellular origins and migratory properties.
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Academic Article
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Identification of thymocyte progenitors in hemopoietic tissues of the rat. I. A quantitative assay system for thymocyte regeneration.
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Academic Article
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Genetic linkage and cell distribution analysis of T cell alloantigens in the rat.
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Academic Article
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Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand.
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Academic Article
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DR-BB rat thymus contains thymocyte populations predisposed to autoreactivity.
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Academic Article
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Improved engraftment of human spleen cells in NOD/LtSz-scid/scid mice as compared with C.B-17-scid/scid mice.
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Academic Article
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B lymphocytes are not required for murine resistance to the human filarial parasite, Brugia malayi.
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Academic Article
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A selective culture system for generating terminal deoxynucleotidyl transferase-positive lymphoid precursor cells in vitro. IV. Properties and developmental relationships of the lymphoid cells in the adherent and nonadherent compartments of the culture.
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Academic Article
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Thymic epithelial defects and predisposition to autoimmune disease in BB rats.
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Academic Article
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Human autoimmune diabetes mellitus: lessons from BB rats and NOD mice--Caveat emptor.
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Academic Article
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Localization of prothymocytes from wild-type and viable motheaten mice following intravenous injection into irradiated adoptive recipients.
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Academic Article
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Mercury-induced renal autoimmunity in BN-->LEW.1N chimeric rats.
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Academic Article
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The RT6 rat lymphocyte alloantigen circulates in soluble form.
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Academic Article
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Multiple low-dose streptozocin-induced diabetes in NOD-scid/scid mice in the absence of functional lymphocytes.
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Academic Article
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Major histocompatibility complex class I-deficient NOD-B2mnull mice are diabetes and insulitis resistant.
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Academic Article
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Mercury-induced renal autoimmunity: changes in RT6+ T-lymphocytes of susceptible and resistant rats.
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Academic Article
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High stimulatory activity of dendritic cells from diabetes-prone BioBreeding/Worcester rats exposed to macrophage-derived factors.
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Concept
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Disease Models, Animal
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Concept
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Animals, Newborn
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Concept
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Animals
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Concept
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Animals, Genetically Modified
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Concept
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Models, Animal
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Academic Article
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Salicylate prevents virus-induced type 1 diabetes in the BBDR rat.
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Academic Article
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Overcoming current limitations in humanized mouse research.
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Academic Article
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Comparison between two labeled agents in mice using a coinjection-ratio approach in contrast to a conventional group approach.
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Academic Article
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CD28 and ITK signals regulate autoreactive T cell trafficking.
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Academic Article
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Engrafted human cells generate adaptive immune responses to Mycobacterium bovis BCG infection in humanized mice.
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Academic Article
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c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells.
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Academic Article
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An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia.
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Academic Article
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Blockade of the programmed death-1 (PD1) pathway undermines potent genetic protection from type 1 diabetes.
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Academic Article
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NOD-scidIl2rg (tm1Wjl) and NOD-Rag1 (null) Il2rg (tm1Wjl) : a model for stromal cell-tumor cell interaction for human colon cancer.
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Academic Article
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Subcapsular transplantation of tissue in the kidney.
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Academic Article
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Human cancer growth and therapy in immunodeficient mouse models.
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Academic Article
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Viral infection of engrafted human islets leads to diabetes.
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Academic Article
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Generation of improved humanized mouse models for human infectious diseases.
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Academic Article
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GABA promotes human ?-cell proliferation and modulates glucose homeostasis.
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Academic Article
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Inhibition of bromodomain proteins for the treatment of human diffuse large B-cell lymphoma.
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Academic Article
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Generation of functional human pancreatic ? cells in vitro.
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Academic Article
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Dengue virus infection induces broadly cross-reactive human IgM antibodies that recognize intact virions in humanized BLT-NSG mice.
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Academic Article
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Generation of ? cell-specific human cytotoxic T cells by lentiviral transduction and their survival in immunodeficient human leucocyte antigen-transgenic mice.
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Academic Article
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Extensive double humanization of both liver and hematopoiesis in FRGN mice.
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Academic Article
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Efficient generation of NKX6-1+ pancreatic progenitors from multiple human pluripotent stem cell lines.
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Academic Article
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Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates.
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Academic Article
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Quantitative Correlation of in Vivo Properties with in Vitro Assay Results: The in Vitro Binding of a Biotin-DNA Analogue Modifier with Streptavidin Predicts the in Vivo Avidin-Induced Clearability of the Analogue-Modified Antibody.
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Academic Article
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The Presence and Preferential Activation of Regulatory T Cells Diminish Adoptive Transfer of Autoimmune Diabetes by Polyclonal Nonobese Diabetic (NOD) T Cell Effectors into NSG versus NOD-scid Mice.
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Academic Article
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Neutrophil Responses to Sterile Implant Materials.
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Academic Article
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Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection.
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Academic Article
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Efficient and Targeted Transduction of Nonhuman Primate Liver With Systemically Delivered Optimized AAV3B Vectors.
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Academic Article
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P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer.
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Academic Article
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Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic ?-cell function via glycogen synthase kinase-3?.
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Academic Article
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Humanized Mouse Models for Transplant Immunology.
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Academic Article
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Genetic ablation of lymphocytes and cytokine signaling in nonobese diabetic mice prevents diet-induced obesity and insulin resistance.
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Academic Article
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Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates.
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Academic Article
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Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice.
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Academic Article
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Stress-impaired transcription factor expression and insulin secretion in transplanted human islets.
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Academic Article
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Generation of Immunodeficient Mice Bearing Human Immune Systems by the Engraftment of Hematopoietic Stem Cells.
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Academic Article
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Genetically modified human CD4(+) T cells can be evaluated in?vivo without lethal graft-versus-host disease.
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Academic Article
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A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours.
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Academic Article
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Frontline Science: Splenic progenitors aid in maintaining high neutrophil numbers at sites of sterile chronic inflammation.
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Academic Article
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Cell-Extrinsic MHC Class I Molecule Engagement Augments Human NK Cell Education Programmed by Cell-Intrinsic MHC Class I.
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Academic Article
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Humanized mouse model of mast cell-mediated passive cutaneous anaphylaxis and passive systemic anaphylaxis.
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Academic Article
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End Sequence Analysis Toolkit (ESAT) expands the extractable information from single-cell RNA-seq data.
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Academic Article
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Distinct Differences on Neointima Formation in Immunodeficient and Humanized Mice after Carotid or Femoral Arterial Injury.
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Academic Article
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In vivo correction of anaemia in ?-thalassemic mice by ?PNA-mediated gene editing with nanoparticle delivery.
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Academic Article
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A novel transgenic mouse model of lysosomal storage disorder.
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Academic Article
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Humanized Mouse Models of Clinical Disease.
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Academic Article
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Impaired osteogenesis of T1DM bone marrow-derived stromal cells and periosteum-derived cells and their differential in-vitro responses to growth factor rescue.
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Academic Article
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Colony stimulating factor-1 receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human?primates.
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Academic Article
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A novel hemolytic complement-sufficient NSG mouse model supports studies of complement-mediated antitumor activity in vivo.
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Academic Article
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mRNA-mediated glycoengineering ameliorates deficient homing of human stem cell-derived hematopoietic progenitors.
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Academic Article
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Possible type 1 diabetes risk prediction: Using ultrasound imaging to assess pancreas inflammation in the inducible autoimmune diabetes BBDR model.
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Academic Article
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Age-dependent human ? cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling.
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Academic Article
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a Cell Function and Gene Expression Are Compromised in Type 1 Diabetes.
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Academic Article
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Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells.
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Academic Article
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Lack of acute xenogeneic graft- versus-host disease, but retention of T-cell function following engraftment of human peripheral blood mononuclear cells in NSG mice deficient in MHC class I and II expression.
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Academic Article
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Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunotherapy.
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Academic Article
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Ectonucleoside Triphosphate Diphosphohydrolase-3 Antibody Targets Adult Human Pancreatic ? Cells for In?Vitro and In?Vivo Analysis.
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Academic Article
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Ectopic high endothelial venules in pancreatic ductal adenocarcinoma: A unique site for targeted delivery.
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Academic Article
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Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics.
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Academic Article
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Survival Advantage of Both Human Hepatocyte Xenografts and Genome-Edited Hepatocytes for Treatment of a-1 Antitrypsin Deficiency.
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Academic Article
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Human Anti-HIV-1 gp120 Monoclonal Antibodies with Neutralizing Activity Cloned from Humanized Mice Infected with HIV-1.
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Academic Article
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Humanized mouse models of immunological diseases and precision medicine.
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Academic Article
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Long-term implant fibrosis prevention in rodents and non-human primates using crystallized drug formulations.
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Academic Article
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AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast Cell-Mediated Anaphylaxis in Mice.
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Academic Article
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Genome-wide Analysis of Salmonella enterica serovar Typhi in Humanized Mice Reveals Key Virulence Features.
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Academic Article
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Recovery of viable endocrine-specific cells and transcriptomes from human pancreatic islet-engrafted mice.
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Academic Article
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Tacrolimus- and sirolimus-induced human ? cell dysfunction is reversible and preventable.
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Academic Article
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A retrievable implant for the long-term encapsulation and survival of therapeutic xenogeneic cells.
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Academic Article
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Dapagliflozin Does Not Directly Affect Human a or ? Cells.
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Academic Article
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Modeling Type 1 Diabetes In?Vitro Using Human Pluripotent Stem Cells.
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Academic Article
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A rapid, sensitive, and reproducible in vivo PBMC humanized murine model for determining therapeutic-related cytokine release syndrome.
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Academic Article
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Direct Tumor Killing and Immunotherapy through Anti-SerpinB9 Therapy.
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Academic Article
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Prostaglandin E2 stimulates cAMP signaling and resensitizes human leukemia cells to glucocorticoid-induced cell death.
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Academic Article
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A therapeutic convection-enhanced macroencapsulation device for enhancing ? cell viability and insulin secretion.
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Academic Article
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Modeling human T1D-associated autoimmune processes.
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Academic Article
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Analysis of Salmonella Typhi Pathogenesis in a Humanized Mouse Model.
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Academic Article
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An Early Islet Transcriptional Signature Is Associated With Local Inflammation in Autoimmune Diabetes.
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Academic Article
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Enhanced development of functional human NK cells in NOD-scid-IL2rgnull mice expressing human IL15.
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Academic Article
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Humanized mouse models for immuno-oncology research.
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Academic Article
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I-Ag7 ?56/57 polymorphisms regulate non-cognate negative selection to CD4+ T cell orchestrators of type 1 diabetes.
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Academic Article
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NOD-scid IL2r?null mice lacking TLR4 support human immune system development and the study of human-specific innate immunity.
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Academic Article
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Simultaneous evaluation of treatment efficacy and toxicity for bispecific T-cell engager therapeutics in a humanized mouse model.
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Academic Article
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Identification of a humanized mouse model for functional testing of immune-mediated biomaterial foreign body response.
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Academic Article
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Nuclear factor kappa B-dependent persistence of Salmonella Typhi and Paratyphi in human macrophages.
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Academic Article
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Human insulin as both antigen and protector in type 1 diabetes.
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Academic Article
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IFN?-IL12 axis regulates intercellular crosstalk in metabolic dysfunction-associated steatotic liver disease.
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Academic Article
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Interruption of glucagon signaling augments islet non-alpha cell proliferation in SLC7A2- and mTOR-dependent manners.
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