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Academic Background

Dale Greiner is currently Professor of Molecular Medicine at the University of Massachusetts Medical School. His research focuses on three areas: transplantation, autoimmunity, and the use of humanized mice to study human diseases and infections. Dr. Greiner graduated from the University of Iowa with a Bachelor of Science degree and Medical Technology degree in 1974 and with a Doctor of Philosophy degree in 1978. He did postdoctoral fellowships at the University of Pittsburgh and at the University of Connecticut Health Center in Farmington, CT. He was appointed Assistant Professor at UConn in 1983, Associate Professor in 1989, joined the Department of Medicine at the University of Massachusetts as Professor in 1991 and abecame a Professor od Molecular Medicine in 2010. He became Co-Director with Dr. David Harlan of the Diabetes Center of Excellence in 2010 and the Dr. Eileen L. Berman and Stanley I. Berman Foundation Chair in Biomedical Research Professor in 2013.

To date, Dr. Greiner has co-authored more than 300 publications. He has served as a member of the editorial board of Diabetes, and as a regular member of the National Institutes of Health Immunology Sciences Study Section and the Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section. He has served as chair of the Veterans Administration Immunology Review Subcommittee B and has served as chair of many ad hoc NIH and JDRF study sections. He has also served as Chair of the Medical Science Review Committee for the Juvenile Diabetes Research Foundation, International, Chairman of the American Diabetes Association Scientific Sessions Committee, Program Chair of the American Diabetes Association Council on Immunology, Immunogenetics and Transplantation, and Council Chair, American Diabetes Association Council on Immunology, Immunogenetics and Transplantation.

Dr. Greiner has received numerous awards for his research, including the A.J. Julian Scholarship for Academic Excellence, the Basil O'Connor Scholar Research Award from the March of Dimes, and the Kayla and Gerald Grodsky and David Rumbough Awards from the Juvenile Diabetes Research Foundation, Int.   

Transplantation tolerance and autoimmune diabetes

Our major area of investigation is to understand the etiology and pathogenesis of autoimmune type 1 diabetes mellitus (T1D). Our approach focuses on two main areas, the understanding of the pathogenesis of type 1 diabetes so as to formulate means to prevent or reverse the disease, and the cure of those who are diabetic by induction of transplantation tolerance to islets of Langerhans. Over 25 years ago, we and others accomplished these goals in spontaneously diabetic mouse and rat models of T1D, but these accomplishments have not yet been successfully translated to humans. We believe there are two major obstacles that prevent the achievement of these goals in humans: 1) Lack of understanding of the biology of how human insulin-secreting beta cells die during the development of T1D. 2) Lack of understanding of how a human immune system mediates the destruction of human beta cells in vivo. Our laboratory is focusing on the development of “humanized” mice to study human T1D in collaboration with Dr. Leonard Shultz at The Jackson Laboratory. We have developed unique strains of mice that can be engrafted with functional human cells and tissues, including human islets and human immune systems. We are now using these mice to understand how human beta cells resist killing by a human autoimmune system in vivo, how human beta cells replicate and regenerate in vivo, how human autoreactive cells develop in a human diabetes-susceptible immune system, and how a human immune system targets and kills beta cells in vivo. These approaches are allowing us to understand and dissect mechanisms important in human T1D that cannot be studied directly in humans. Moreover, because these mice readily accept human cells and tissues, we are now using them to study human regenerative medicine, immunity, human-specific infectious agents and cancer. Our studies in humanized mice have the potential to guide human clinical trials by determining the mechanisms by which therapeutic approaches such as those based on the new technology of RNAi can act directly on human immune systems, islets, and cancers in vivo, facilitating the direct translation of these agents into the clinic.


One or more keywords matched the following items that are connected to Greiner, Dale

Item TypeName
Academic Article Cytokine gene expression in islets and thyroids of BB rats. IFN-gamma and IL-12p40 mRNA increase with age in both diabetic and insulin-treated nondiabetic BB rats.
Academic Article Thymus atrophy and changes in thymocyte subpopulations of BN rats with mercury-induced renal autoimmune disease.
Academic Article CD8+ T lymphocytes are not required for murine resistance to human filarial parasites.
Academic Article The T cell marker RT6 in a rat model of autoimmune diabetes.
Academic Article Effects of HgCl2 on the expression of autoimmune responses and disease in diabetes-prone (DP) BB rats.
Academic Article Animal models for immunodeficiency diseases.
Academic Article Cutting edge: sustained expansion of CD8+ T cells requires CD154 expression by Th cells in acute graft versus host disease.
Academic Article Diabetes-prone and diabetes-resistant BB rats share a common major diabetes susceptibility locus, iddm4: additional evidence for a "universal autoimmunity locus" on rat chromosome 4.
Academic Article Virus-induced abrogation of transplantation tolerance induced by donor-specific transfusion and anti-CD154 antibody.
Academic Article The BB/Wor rat and the balance hypothesis of autoimmunity.
Academic Article Thymic expression of insulin-related genes in an animal model of autoimmune type 1 diabetes.
Academic Article Dietary cow's milk protein does not alter the frequency of diabetes in the BB rat.
Academic Article NOD congenic mice genetically protected from autoimmune diabetes remain resistant to transplantation tolerance induction.
Academic Article Induction of tolerance for islet transplantation for type 1 diabetes.
Academic Article Non-major histocompatibility complex-linked diabetes susceptibility loci on chromosomes 4 and 13 in a backcross of the DP-BB/Wor rat to the WF rat.
Academic Article Comparative mapping of rat Iddm4 to segments on HSA7 and MMU6.
Academic Article Intravital dye-labeled diabetogenic rat T cells retain dye, home to the pancreas, and induce diabetes.
Academic Article Insulin dependent diabetes mellitus hypothesis of autoimmunity.
Academic Article The rat diabetes susceptibility locus Iddm4 and at least one additional gene are required for autoimmune diabetes induced by viral infection.
Academic Article NOD/LtSz-Rag1null mice: an immunodeficient and radioresistant model for engraftment of human hematolymphoid cells, HIV infection, and adoptive transfer of NOD mouse diabetogenic T cells.
Academic Article Experimental autoallergic sialadenitis in the LEW rat. I. Parameters of disease induction.
Academic Article Allogeneic hematopoietic chimerism in mice treated with sublethal myeloablation and anti-CD154 antibody: absence of graft-versus-host disease, induction of skin allograft tolerance, and prevention of recurrent autoimmunity in islet-allografted NOD/Lt mice.
Academic Article Costimulation and autoimmune diabetes in BB rats.
Academic Article beta2 microglobulin-deficient (B2m(null)) NOD/SCID mice are excellent recipients for studying human stem cell function.
Academic Article TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant rat.
Academic Article Humanized NOD/LtSz-scid IL2 receptor common gamma chain knockout mice in diabetes research.
Academic Article Fetal thymi from diabetes-prone but not diabetes-resistant BB/Wor rats fail to generate mature ART2+ T-cells in organ culture.
Academic Article Tuberculosis susceptibility of diabetic mice.
Academic Article Translating data from animal models into methods for preventing human autoimmune diabetes mellitus: caveat emptor and primum non nocere.
Academic Article Non-obese diabetic-recombination activating gene-1 (NOD-Rag1 null) interleukin (IL)-2 receptor common gamma chain (IL2r gamma null) null mice: a radioresistant model for human lymphohaematopoietic engraftment.
Academic Article Closing the circle between the bedside and the bench: Toll-like receptors in models of virally induced diabetes.
Academic Article Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex.
Academic Article Virus-induced autoimmune diabetes in the LEW.1WR1 rat requires Iddm14 and a genetic locus proximal to the major histocompatibility complex.
Academic Article Infection with viruses from several families triggers autoimmune diabetes in LEW*1WR1 rats: prevention of diabetes by maternal immunization.
Academic Article Effects of irradiation on diabetes in the BB/Wor rat.
Academic Article Humanized mouse models to study human diseases.
Academic Article Cardioprotection with postconditioning: loss of efficacy in murine models of type-2 and type-1 diabetes.
Academic Article Defects in the thymic epithelial stroma of diabetes prone BB rats.
Academic Article The pathogenesis of autoimmune diabetes mellitus.
Academic Article Prevention of type 1 diabetes in the rat with an allele-specific anti-T-cell receptor antibody: Vß13 as a therapeutic target and biomarker.
Academic Article T-lymphocyte requirement for diabetes in RT6-depleted diabetes-resistant BB rats.
Academic Article Humanized mice for immune system investigation: progress, promise and challenges.
Academic Article The iddm4 locus segregates with diabetes susceptibility in congenic WF.iddm4 rats.
Academic Article Survival of Onchocerca volvulus in nodules implanted in immunodeficient rodents.
Academic Article Infections that induce autoimmune diabetes in BBDR rats modulate CD4+CD25+ T cell populations.
Academic Article Absence of RT6+ T cells in diabetes-prone biobreeding/Worcester rats is due to genetic and cell developmental defects.
Academic Article Animal models of Sjögren's syndrome.
Academic Article Defective lymphopoiesis in bone marrow of motheaten (me/me) and viable motheaten (mev/mev) mutant mice. I. Analysis of development of prothymocytes, early B lineage cells, and terminal deoxynucleotidyl transferase-positive cells.
Academic Article Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice.
Academic Article Hematopoietic chimerism and central tolerance created by peripheral-tolerance induction without myeloablative conditioning.
Academic Article Experimental autoallergic sialadenitis in the LEW rat. III. Role of CD4+ T cells in EAS induction.
Academic Article Alloimmune injury and rejection of human skin grafts on human peripheral blood lymphocyte-reconstituted non-obese diabetic severe combined immunodeficient beta2-microglobulin-null mice.
Academic Article Lack of graft-versus-host-like pathology in mercury-induced autoimmunity of Brown Norway rats.
Academic Article High levels of human peripheral blood mononuclear cell engraftment and enhanced susceptibility to human immunodeficiency virus type 1 infection in NOD/LtSz-scid/scid mice.
Academic Article Emv30null NOD-scid mice. An improved host for adoptive transfer of autoimmune diabetes and growth of human lymphohematopoietic cells.
Academic Article Maternal influence on susceptibility of offspring to Brugia malayi infection in a murine model of filariasis.
Academic Article Adoptive transfer of autoimmune diabetes mellitus to athymic rats: synergy of CD4+ and CD8+ T cells and prevention by RT6+ T cells.
Academic Article Influence of gonadal steroids on susceptibility to Brugia malayi in scid mice.
Academic Article Relative susceptibility of SJL/J and B10.S mice to experimental allergic encephalomyelitis (EAE) is determined by the ability of prethymic cells in bone marrow to develop into EAE effector T cells.
Academic Article Deficiencies in gut NK cell number and function precede diabetes onset in BB rats.
Academic Article Rat models of type 1 diabetes: genetics, environment, and autoimmunity.
Academic Article Rejection of human islets and human HLA-A2.1 transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD-scid and NOD-Rag1(null)Prf1(null) mice.
Academic Article The immunodeficient scid mouse as a model for human lymphatic filariasis.
Academic Article LEW.1WR1 rats develop autoimmune diabetes spontaneously and in response to environmental perturbation.
Academic Article Experimental autoallergic sialadenitis in the LEW rat. II. Target antigens are associated with cell surface and intracellular particulate fractions derived from the submandibular gland.
Academic Article Anti-mouse CD154 antibody treatment facilitates generation of mixed xenogeneic rat hematopoietic chimerism, prevents wasting disease and prolongs xenograft survival in mice.
Academic Article A regulatory CD4+ T cell subset in the BB rat model of autoimmune diabetes expresses neither CD25 nor Foxp3.
Academic Article Humanized mice in translational biomedical research.
Academic Article Development of new-generation HU-PBMC-NOD/SCID mice to study human islet alloreactivity.
Academic Article Refinement of the Iddm4 diabetes susceptibility locus reveals TCRVbeta4 as a candidate gene.
Academic Article Adoptive transfer of autoimmune diabetes and thyroiditis to athymic rats.
Academic Article A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene.
Academic Article Prevention of diabetes in the BB rat by essential fatty acid deficiency. Relationship between physiological and biochemical changes.
Academic Article Humanized SCID mouse models for biomedical research.
Academic Article A new immunodeficient hyperglycaemic mouse model based on the Ins2Akita mutation for analyses of human islet and beta stem and progenitor cell function.
Academic Article T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice.
Academic Article Viral infection: a potent barrier to transplantation tolerance.
Academic Article Humanized mice for the study of type 1 diabetes and beta cell function.
Academic Article Analysis of the rat Iddm14 diabetes susceptibility locus in multiple rat strains: identification of a susceptibility haplotype in the Tcrb-V locus.
Academic Article T cell lines derived from the spinal cords of mice with experimental allergic encephalomyelitis are self reactive.
Academic Article Failure of alpha-galactosylceramide to prevent diabetes in virus-inducible models of type 1 diabetes in the rat.
Academic Article Development of novel major histocompatibility complex class I and class II-deficient NOD-SCID IL2R gamma chain knockout mice for modeling human xenogeneic graft-versus-host disease.
Academic Article Prevention of diabetes in BB/Wor rat by single transfusion of spleen cells. Parameters that affect degree of protection.
Academic Article Hyperglycemia-induced proliferation of adult human beta cells engrafted into spontaneously diabetic immunodeficient NOD-Rag1null IL2r?null Ins2Akita mice.
Academic Article Humanized mice as a preclinical tool for infectious disease and biomedical research.
Academic Article Humanized mice for the study of type 1 and type 2 diabetes.
Academic Article Advancing animal models of human type 1 diabetes by engraftment of functional human tissues in immunodeficient mice.
Academic Article Humanized mice for the study of infectious diseases.
Academic Article Regulatory T cell control of autoimmune destruction of beta cells in the BB rat.
Academic Article Depletion of RT6.1+ T lymphocytes induces diabetes in resistant biobreeding/Worcester (BB/W) rats.
Academic Article B lymphocytes are not required for murine resistance to the human filarial parasite, Brugia malayi.
Academic Article Thymic epithelial defects and predisposition to autoimmune disease in BB rats.
Academic Article Human autoimmune diabetes mellitus: lessons from BB rats and NOD mice--Caveat emptor.
Academic Article Major histocompatibility complex class I-deficient NOD-B2mnull mice are diabetes and insulitis resistant.
Concept Pancreatic Diseases
Concept Disease Models, Animal
Concept Virus Diseases
Concept Autoimmune Diseases
Concept Communicable Diseases
Concept Disease Progression
Concept Kidney Diseases
Concept Disease Susceptibility
Concept Acute Disease
Concept Genetic Predisposition to Disease
Concept Graft vs Host Disease
Concept Disease
Academic Article Overcoming current limitations in humanized mouse research.
Academic Article Blockade of the programmed death-1 (PD1) pathway undermines potent genetic protection from type 1 diabetes.
Academic Article NOD-scidIl2rg (tm1Wjl) and NOD-Rag1 (null) Il2rg (tm1Wjl) : a model for stromal cell-tumor cell interaction for human colon cancer.
Academic Article Human cancer growth and therapy in immunodeficient mouse models.
Academic Article Generation of improved humanized mouse models for human infectious diseases.
Academic Article Dengue virus infection induces broadly cross-reactive human IgM antibodies that recognize intact virions in humanized BLT-NSG mice.
Academic Article Efficient and Targeted Transduction of Nonhuman Primate Liver With Systemically Delivered Optimized AAV3B Vectors.
Academic Article Humanized Mouse Models for Transplant Immunology.
Academic Article Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice.
Academic Article Genetically modified human CD4(+) T cells can be evaluated in vivo without lethal graft-versus-host disease.
Academic Article Humanized Mouse Models of Clinical Disease.
Academic Article Lack of acute xenogeneic graft- versus-host disease, but retention of T-cell function following engraftment of human peripheral blood mononuclear cells in NSG mice deficient in MHC class I and II expression.
Academic Article Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics.
Academic Article Survival Advantage of Both Human Hepatocyte Xenografts and Genome-Edited Hepatocytes for Treatment of a-1 Antitrypsin Deficiency.
Academic Article Humanized mouse models of immunological diseases and precision medicine.

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