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Academic Background

Dale Greiner is currently Professor of Molecular Medicine at the University of Massachusetts Medical School. His research focuses on three areas: transplantation, autoimmunity, and the use of humanized mice to study human diseases and infections. Dr. Greiner graduated from the University of Iowa with a Bachelor of Science degree and Medical Technology degree in 1974 and with a Doctor of Philosophy degree in 1978. He did postdoctoral fellowships at the University of Pittsburgh and at the University of Connecticut Health Center in Farmington, CT. He was appointed Assistant Professor at UConn in 1983, Associate Professor in 1989, joined the Department of Medicine at the University of Massachusetts as Professor in 1991 and abecame a Professor od Molecular Medicine in 2010. He became Co-Director with Dr. David Harlan of the Diabetes Center of Excellence in 2010 and the Dr. Eileen L. Berman and Stanley I. Berman Foundation Chair in Biomedical Research Professor in 2013.

To date, Dr. Greiner has co-authored more than 300 publications. He has served as a member of the editorial board of Diabetes, and as a regular member of the National Institutes of Health Immunology Sciences Study Section and the Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section. He has served as chair of the Veterans Administration Immunology Review Subcommittee B and has served as chair of many ad hoc NIH and JDRF study sections. He has also served as Chair of the Medical Science Review Committee for the Juvenile Diabetes Research Foundation, International, Chairman of the American Diabetes Association Scientific Sessions Committee, Program Chair of the American Diabetes Association Council on Immunology, Immunogenetics and Transplantation, and Council Chair, American Diabetes Association Council on Immunology, Immunogenetics and Transplantation.

Dr. Greiner has received numerous awards for his research, including the A.J. Julian Scholarship for Academic Excellence, the Basil O'Connor Scholar Research Award from the March of Dimes, and the Kayla and Gerald Grodsky and David Rumbough Awards from the Juvenile Diabetes Research Foundation, Int.   

Transplantation tolerance and autoimmune diabetes

Our major area of investigation is to understand the etiology and pathogenesis of autoimmune type 1 diabetes mellitus (T1D). Our approach focuses on two main areas, the understanding of the pathogenesis of type 1 diabetes so as to formulate means to prevent or reverse the disease, and the cure of those who are diabetic by induction of transplantation tolerance to islets of Langerhans. Over 25 years ago, we and others accomplished these goals in spontaneously diabetic mouse and rat models of T1D, but these accomplishments have not yet been successfully translated to humans. We believe there are two major obstacles that prevent the achievement of these goals in humans: 1) Lack of understanding of the biology of how human insulin-secreting beta cells die during the development of T1D. 2) Lack of understanding of how a human immune system mediates the destruction of human beta cells in vivo. Our laboratory is focusing on the development of “humanized” mice to study human T1D in collaboration with Dr. Leonard Shultz at The Jackson Laboratory. We have developed unique strains of mice that can be engrafted with functional human cells and tissues, including human islets and human immune systems. We are now using these mice to understand how human beta cells resist killing by a human autoimmune system in vivo, how human beta cells replicate and regenerate in vivo, how human autoreactive cells develop in a human diabetes-susceptible immune system, and how a human immune system targets and kills beta cells in vivo. These approaches are allowing us to understand and dissect mechanisms important in human T1D that cannot be studied directly in humans. Moreover, because these mice readily accept human cells and tissues, we are now using them to study human regenerative medicine, immunity, human-specific infectious agents and cancer. Our studies in humanized mice have the potential to guide human clinical trials by determining the mechanisms by which therapeutic approaches such as those based on the new technology of RNAi can act directly on human immune systems, islets, and cancers in vivo, facilitating the direct translation of these agents into the clinic.

One or more keywords matched the following items that are connected to Greiner, Dale
Item TypeName
Academic Article Cytokine gene expression in islets and thyroids of BB rats. IFN-gamma and IL-12p40 mRNA increase with age in both diabetic and insulin-treated nondiabetic BB rats.
Academic Article Oral insulin does not prevent insulin-dependent diabetes mellitus in BB rats.
Academic Article Induction of insulin-dependent diabetes mellitus in PVG.RT1u rats.
Academic Article Thymic expression of insulin-related genes in an animal model of autoimmune type 1 diabetes.
Academic Article Insulin dependent diabetes mellitus hypothesis of autoimmunity.
Academic Article Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes.
Academic Article Human islet cell MORF/cMORF pretargeting in a xenogeneic murine transplant model.
Academic Article Isolation of mouse pancreatic alpha, beta, duct and acinar populations with cell surface markers.
Academic Article Pretargeting vs. direct targeting of human betalox5 islet cells subcutaneously implanted in mice using an anti-human islet cell antibody.
Academic Article Thioredoxin-interacting protein mediates ER stress-induced ? cell death through initiation of the inflammasome.
Academic Article Insulin treatment prevents diabetes mellitus but not thyroiditis in RT6-depleted diabetes resistant BB/Wor rats.
Academic Article A new immunodeficient hyperglycaemic mouse model based on the Ins2Akita mutation for analyses of human islet and beta stem and progenitor cell function.
Academic Article Humanized mice for the study of type 1 diabetes and beta cell function.
Academic Article A novel role for the centrosomal protein, pericentrin, in regulation of insulin secretory vesicle docking in mouse pancreatic beta-cells.
Academic Article Dynamic glucoregulation and mammalian-like responses to metabolic and developmental disruption in zebrafish.
Academic Article Hyperglycemia-induced proliferation of adult human beta cells engrafted into spontaneously diabetic immunodeficient NOD-Rag1null IL2r?null Ins2Akita mice.
Academic Article Islet-specific CTL cloned from a type 1 diabetes patient cause beta-cell destruction after engraftment into HLA-A2 transgenic NOD/scid/IL2RG null mice.
Academic Article Major histocompatibility complex class I-deficient NOD-B2mnull mice are diabetes and insulitis resistant.
Concept Insulin
Concept Insulin-Like Growth Factor I
Concept Insulin Resistance
Concept Insulin-Secreting Cells
Concept Insulin-Like Growth Factor II
Academic Article GABA promotes human ?-cell proliferation and modulates glucose homeostasis.
Academic Article Generation of functional human pancreatic ? cells in vitro.
Academic Article Generation of ? cell-specific human cytotoxic T cells by lentiviral transduction and their survival in immunodeficient human leucocyte antigen-transgenic mice.
Academic Article Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets.
Academic Article Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic ?-cell function via glycogen synthase kinase-3?.
Academic Article Genetic ablation of lymphocytes and cytokine signaling in nonobese diabetic mice prevents diet-induced obesity and insulin resistance.
Academic Article Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice.
Academic Article Stress-impaired transcription factor expression and insulin secretion in transplanted human islets.
Academic Article Impaired osteogenesis of T1DM bone marrow-derived stromal cells and periosteum-derived cells and their differential in-vitro responses to growth factor rescue.
Academic Article Age-dependent human ? cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling.
Academic Article ? Cell Function and Gene Expression Are Compromised in Type 1 Diabetes.
Academic Article Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells.
Academic Article Ectonucleoside Triphosphate Diphosphohydrolase-3 Antibody Targets Adult Human Pancreatic ? Cells for In Vitro and In Vivo Analysis.
Academic Article Recovery of viable endocrine-specific cells and transcriptomes from human pancreatic islet-engrafted mice.
Academic Article Tacrolimus- and sirolimus-induced human ? cell dysfunction is reversible and preventable.
Academic Article Dapagliflozin Does Not Directly Affect Human ? or ? Cells.
Academic Article Modeling Type 1 Diabetes In Vitro Using Human Pluripotent Stem Cells.
Academic Article A therapeutic convection-enhanced macroencapsulation device for enhancing ? cell viability and insulin secretion.
Academic Article Modeling human T1D-associated autoimmune processes.
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