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Academic Background

Dale Greiner is currently Professor of Molecular Medicine at the University of Massachusetts Medical School. His research focuses on three areas: transplantation, autoimmunity, and the use of humanized mice to study human diseases and infections. Dr. Greiner graduated from the University of Iowa with a Bachelor of Science degree and Medical Technology degree in 1974 and with a Doctor of Philosophy degree in 1978. He did postdoctoral fellowships at the University of Pittsburgh and at the University of Connecticut Health Center in Farmington, CT. He was appointed Assistant Professor at UConn in 1983, Associate Professor in 1989, joined the Department of Medicine at the University of Massachusetts as Professor in 1991 and abecame a Professor od Molecular Medicine in 2010. He became Co-Director with Dr. David Harlan of the Diabetes Center of Excellence in 2010 and the Dr. Eileen L. Berman and Stanley I. Berman Foundation Chair in Biomedical Research Professor in 2013.

To date, Dr. Greiner has co-authored more than 300 publications. He has served as a member of the editorial board of Diabetes, and as a regular member of the National Institutes of Health Immunology Sciences Study Section and the Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section. He has served as chair of the Veterans Administration Immunology Review Subcommittee B and has served as chair of many ad hoc NIH and JDRF study sections. He has also served as Chair of the Medical Science Review Committee for the Juvenile Diabetes Research Foundation, International, Chairman of the American Diabetes Association Scientific Sessions Committee, Program Chair of the American Diabetes Association Council on Immunology, Immunogenetics and Transplantation, and Council Chair, American Diabetes Association Council on Immunology, Immunogenetics and Transplantation.

Dr. Greiner has received numerous awards for his research, including the A.J. Julian Scholarship for Academic Excellence, the Basil O'Connor Scholar Research Award from the March of Dimes, and the Kayla and Gerald Grodsky and David Rumbough Awards from the Juvenile Diabetes Research Foundation, Int.   

Transplantation tolerance and autoimmune diabetes

Our major area of investigation is to understand the etiology and pathogenesis of autoimmune type 1 diabetes mellitus (T1D). Our approach focuses on two main areas, the understanding of the pathogenesis of type 1 diabetes so as to formulate means to prevent or reverse the disease, and the cure of those who are diabetic by induction of transplantation tolerance to islets of Langerhans. Over 25 years ago, we and others accomplished these goals in spontaneously diabetic mouse and rat models of T1D, but these accomplishments have not yet been successfully translated to humans. We believe there are two major obstacles that prevent the achievement of these goals in humans: 1) Lack of understanding of the biology of how human insulin-secreting beta cells die during the development of T1D. 2) Lack of understanding of how a human immune system mediates the destruction of human beta cells in vivo. Our laboratory is focusing on the development of “humanized” mice to study human T1D in collaboration with Dr. Leonard Shultz at The Jackson Laboratory. We have developed unique strains of mice that can be engrafted with functional human cells and tissues, including human islets and human immune systems. We are now using these mice to understand how human beta cells resist killing by a human autoimmune system in vivo, how human beta cells replicate and regenerate in vivo, how human autoreactive cells develop in a human diabetes-susceptible immune system, and how a human immune system targets and kills beta cells in vivo. These approaches are allowing us to understand and dissect mechanisms important in human T1D that cannot be studied directly in humans. Moreover, because these mice readily accept human cells and tissues, we are now using them to study human regenerative medicine, immunity, human-specific infectious agents and cancer. Our studies in humanized mice have the potential to guide human clinical trials by determining the mechanisms by which therapeutic approaches such as those based on the new technology of RNAi can act directly on human immune systems, islets, and cancers in vivo, facilitating the direct translation of these agents into the clinic.

One or more keywords matched the following items that are connected to Greiner, Dale
Item TypeName
Academic Article Lack of peripherally induced tolerance to established skin allografts in immunologically reconstituted scid mice.
Academic Article Role of natural killer cells on engraftment of human lymphoid cells and on metastasis of human T-lymphoblastoid leukemia cells in C57BL/6J-scid mice and in C57BL/6J-scid bg mice.
Academic Article Tolerance to islet xenografts induced by dual manipulation of antigen presentation and co-stimulation.
Academic Article Improved engraftment of human cord blood stem cells in NOD/LtSz-scid/scid mice after irradiation or multiple-day injections into unirradiated recipients.
Academic Article Enhanced human CD4+ T cell engraftment in beta2-microglobulin-deficient NOD-scid mice.
Academic Article CD8+ T lymphocytes are not required for murine resistance to human filarial parasites.
Academic Article Diethylcarbamazine (DEC) does not induce nitric oxide (NO) synthesis.
Academic Article SCID mouse models of human stem cell engraftment.
Academic Article Induction of immunological tolerance to islet allografts.
Academic Article Rat RT6.2 and mouse Rt6 locus 1 are NAD+: arginine ADP ribosyltransferases with auto-ADP ribosylation activity.
Academic Article HIV-1 infectivity of human T cells in a human/murine chimeric fetal thymic organ culture system.
Academic Article Animal models for immunodeficiency diseases.
Academic Article Prolonged skin allograft survival in mice treated with Flt3-ligand-induced dendritic cells and anti-CD154 monoclonal antibody.
Academic Article Cutting edge: sustained expansion of CD8+ T cells requires CD154 expression by Th cells in acute graft versus host disease.
Academic Article NOD mice have a generalized defect in their response to transplantation tolerance induction.
Academic Article Treatment of allograft recipients with donor-specific transfusion and anti-CD154 antibody leads to deletion of alloreactive CD8+ T cells and prolonged graft survival in a CTLA4-dependent manner.
Academic Article Virus-induced abrogation of transplantation tolerance induced by donor-specific transfusion and anti-CD154 antibody.
Academic Article Growth of the human filarial parasite Brugia malayi in mice lacking major histocompatibility complex class II antigen expression.
Academic Article Regulation of human cell engraftment and development of EBV-related lymphoproliferative disorders in Hu-PBL-scid mice.
Academic Article Viral infection abrogates CD8(+) T-cell deletion induced by costimulation blockade.
Academic Article Characterization of mouse Rt6.1 NAD:arginine ADP-ribosyltransferase.
Academic Article Thymic involution in viable motheaten (me(v)) mice is associated with a loss of intrathymic precursor activity.
Academic Article Variables to predict engraftment of umbilical cord blood into immunodeficient mice: usefulness of the non-obese diabetic--severe combined immunodeficient assay.
Academic Article Mouse RT6 locus 1 and rat RT6.2 are NAD+. Arginine ADP-ribosyltransferases with auto-ADP-ribosylation activity.
Academic Article Prolonged survival of mouse skin allografts in recipients treated with donor splenocytes and antibody to CD40 ligand.
Academic Article Expression in BALB/c and C57BL/6 mice of Rt6-1 and Rt6-2 ADP-ribosyltransferases that differ in enzymatic activity: C57BL/6 Rt6-1 is a natural transferase knockout.
Academic Article Blockade of CD40-CD154 interferes with human T cell engraftment in scid mice.
Academic Article Long-term survival of skin allografts induced by donor splenocytes and anti-CD154 antibody in thymectomized mice requires CD4(+) T cells, interferon-gamma, and CTLA4.
Academic Article Prolonged survival of rat islet and skin xenografts in mice treated with donor splenocytes and anti-CD154 monoclonal antibody.
Academic Article Improved skin allograft tolerance induced by treatment with donor splenocytes and an extended course of anti-CD154 monoclonal antibody.
Academic Article NOD congenic mice genetically protected from autoimmune diabetes remain resistant to transplantation tolerance induction.
Academic Article Blockade of CD40-mediated signaling is sufficient for inducing islet but not skin transplantation tolerance.
Academic Article Direct visualization of cross-reactive effector and memory allo-specific CD8 T cells generated in response to viral infections.
Academic Article Induction of tolerance for islet transplantation for type 1 diabetes.
Academic Article Genetic separation of the transplantation tolerance and autoimmune phenotypes in NOD mice.
Academic Article Islet cell autoimmunity and transplantation tolerance: two distinct mechanisms?
Academic Article Comparative mapping of rat Iddm4 to segments on HSA7 and MMU6.
Academic Article CTLA4 signals are required to optimally induce allograft tolerance with combined donor-specific transfusion and anti-CD154 monoclonal antibody treatment.
Academic Article The RT6 (Art2) family of ADP-ribosyltransferases in rat and mouse.
Academic Article Islet allograft survival induced by costimulation blockade in NOD mice is controlled by allelic variants of Idd3.
Academic Article Regulation of skin and islet allograft survival in mice treated with costimulation blockade is mediated by different CD4+ cell subsets and different mechanisms.
Academic Article Insulin dependent diabetes mellitus hypothesis of autoimmunity.
Academic Article Early growth response gene-2, a zinc-finger transcription factor, is required for full induction of clonal anergy in CD4+ T cells.
Academic Article Evaluation of donor-specific transfusion sources: unique failure of bone marrow cells to induce prolonged skin allograft survival with anti-CD154 monoclonal antibody.
Academic Article Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes.
Academic Article NOD/LtSz-Rag1null mice: an immunodeficient and radioresistant model for engraftment of human hematolymphoid cells, HIV infection, and adoptive transfer of NOD mouse diabetogenic T cells.
Academic Article Allogeneic hematopoietic chimerism in mice treated with sublethal myeloablation and anti-CD154 antibody: absence of graft-versus-host disease, induction of skin allograft tolerance, and prevention of recurrent autoimmunity in islet-allografted NOD/Lt mice.
Academic Article Effect of ex vivo cytokine treatment on human cord blood engraftment in NOD-scid mice.
Academic Article beta2 microglobulin-deficient (B2m(null)) NOD/SCID mice are excellent recipients for studying human stem cell function.
Academic Article Evidence for elevated prothymocyte activity in the bone marrow of New Zealand Black (NZB) mice. Elevated prothymocyte activity in NZB mice.
Academic Article Costimulatory blockade induces hyporesponsiveness in T cells that recognize alloantigen via indirect antigen presentation.
Academic Article Partial versus full allogeneic hemopoietic chimerization is a preferential means to inhibit type 1 diabetes as the latter induces generalized immunosuppression.
Academic Article Humanized NOD/LtSz-scid IL2 receptor common gamma chain knockout mice in diabetes research.
Academic Article Intrinsic cytotoxicity of natural killer cells to pancreatic islets in vitro.
Academic Article Different mechanisms control peripheral and central tolerance in hematopoietic chimeric mice.
Academic Article Tuberculosis susceptibility of diabetic mice.
Academic Article A novel alloantigen-specific CD8+PD1+ regulatory T cell induced by ICOS-B7h blockade in vivo.
Academic Article Type 1 IFN mediates cross-talk between innate and adaptive immunity that abrogates transplantation tolerance.
Academic Article Creation of "humanized" mice to study human immunity.
Academic Article Non-obese diabetic-recombination activating gene-1 (NOD-Rag1 null) interleukin (IL)-2 receptor common gamma chain (IL2r gamma null) null mice: a radioresistant model for human lymphohaematopoietic engraftment.
Academic Article Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice.
Academic Article TLR agonists abrogate co-stimulation blockade-induced mixed chimerism and transplantation tolerance.
Academic Article Depletion of the programmed death-1 receptor completely reverses established clonal anergy in CD4(+) T lymphocytes via an interleukin-2-dependent mechanism.
Academic Article Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex.
Academic Article Dengue virus infection and virus-specific HLA-A2 restricted immune responses in humanized NOD-scid IL2rgammanull mice.
Academic Article AATF mediates an antiapoptotic effect of the unfolded protein response through transcriptional regulation of AKT1.
Academic Article Skin allograft maintenance in a new synchimeric model system of tolerance.
Academic Article Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation.
Academic Article Humanized mouse models to study human diseases.
Academic Article Islet cell transplantation tolerance.
Academic Article T cell developmental defects in 'viable motheaten' mice deficient in SHP-1 protein-tyrosine phosphatase. Developmental defects are corrected in vitro in the presence of normal hematopoietic-origin stromal cells and in vivo by exogenous IL-7.
Academic Article Cardioprotection with postconditioning: loss of efficacy in murine models of type-2 and type-1 diabetes.
Academic Article Allografts stimulate cross-reactive virus-specific memory CD8 T cells with private specificity.
Academic Article Prevention of "Humanized" diabetogenic CD8 T-cell responses in HLA-transgenic NOD mice by a multipeptide coupled-cell approach.
Academic Article Rapid recruitment and activation of macrophages by anti-Gal/a-Gal liposome interaction accelerates wound healing.
Academic Article Human islet cell MORF/cMORF pretargeting in a xenogeneic murine transplant model.
Academic Article The pathogenesis of autoimmune diabetes mellitus.
Academic Article Isolation of mouse pancreatic alpha, beta, duct and acinar populations with cell surface markers.
Academic Article Imaging the pancreatic vasculature in diabetes models.
Academic Article Engraftment of human HSCs in nonirradiated newborn NOD-scid IL2r? null mice is enhanced by transgenic expression of membrane-bound human SCF.
Academic Article Pretargeting vs. direct targeting of human betalox5 islet cells subcutaneously implanted in mice using an anti-human islet cell antibody.
Academic Article Enhanced humoral and HLA-A2-restricted dengue virus-specific T-cell responses in humanized BLT NSG mice.
Academic Article JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate.
Academic Article Thioredoxin-interacting protein mediates ER stress-induced ? cell death through initiation of the inflammasome.
Academic Article A420983, a novel, small molecule inhibitor of LCK prevents allograft rejection.
Academic Article Humanized mice for immune system investigation: progress, promise and challenges.
Academic Article Survival of Onchocerca volvulus in nodules implanted in immunodeficient rodents.
Academic Article GLI1 regulates a novel neuropilin-2/a6?1 integrin based autocrine pathway that contributes to breast cancer initiation.
Academic Article Durable knockdown and protection from HIV transmission in humanized mice treated with gel-formulated CD4 aptamer-siRNA chimeras.
Academic Article Animal models of Sj?gren's syndrome.
Academic Article Studies of thymocytopoiesis in rats and mice. I. Kinetics of appearance of thymocytes using a direct intrathymic adoptive transfer assay for thymocyte precursors.
Academic Article Defective lymphopoiesis in bone marrow of motheaten (me/me) and viable motheaten (mev/mev) mutant mice. I. Analysis of development of prothymocytes, early B lineage cells, and terminal deoxynucleotidyl transferase-positive cells.
Academic Article Defective lymphopoiesis in the bone marrow of motheaten (me/me) and viable motheaten (mev/mev) mutant mice. II. Description of a microenvironmental defect for the generation of terminal deoxynucleotidyltransferase-positive bone marrow cells in vitro.
Academic Article Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice.
Academic Article Regulation of human short-term repopulating cell (STRC) engraftment in NOD/SCID mice by host CD122+ cells.
Academic Article Hematopoietic chimerism and central tolerance created by peripheral-tolerance induction without myeloablative conditioning.
Academic Article Alloimmune injury and rejection of human skin grafts on human peripheral blood lymphocyte-reconstituted non-obese diabetic severe combined immunodeficient beta2-microglobulin-null mice.
Academic Article NOD/LtSz-Rag1nullPfpnull mice: a new model system with increased levels of human peripheral leukocyte and hematopoietic stem-cell engraftment.
Academic Article Recapitulation of normal and abnormal BB rat immune system development in scid mouse/rat lymphohemopoietic chimeras.
Academic Article High levels of human peripheral blood mononuclear cell engraftment and enhanced susceptibility to human immunodeficiency virus type 1 infection in NOD/LtSz-scid/scid mice.
Academic Article Emv30null NOD-scid mice. An improved host for adoptive transfer of autoimmune diabetes and growth of human lymphohematopoietic cells.
Academic Article Maternal influence on susceptibility of offspring to Brugia malayi infection in a murine model of filariasis.
Academic Article CD4+ T-lymphocytes are not required for murine resistance to the human filarial parasite, Brugia malayi.
Academic Article Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice.
Academic Article Influence of gonadal steroids on susceptibility to Brugia malayi in scid mice.
Academic Article Relative susceptibility of SJL/J and B10.S mice to experimental allergic encephalomyelitis (EAE) is determined by the ability of prethymic cells in bone marrow to develop into EAE effector T cells.
Academic Article Prolonged survival of neonatal porcine islet xenografts in mice treated with a donor-specific transfusion and anti-CD154 antibody.
Academic Article Rejection of human islets and human HLA-A2.1 transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD-scid and NOD-Rag1(null)Prf1(null) mice.
Academic Article Autoimmune diabetes and resistance to xenograft transplantation tolerance in NOD mice.
Academic Article Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells.
Academic Article The immunodeficient scid mouse as a model for human lymphatic filariasis.
Academic Article TLR agonists abrogate costimulation blockade-induced prolongation of skin allografts.
Academic Article Anti-mouse CD154 antibody treatment facilitates generation of mixed xenogeneic rat hematopoietic chimerism, prevents wasting disease and prolongs xenograft survival in mice.
Academic Article Rapid quantification of naive alloreactive T cells by TNF-alpha production and correlation with allograft rejection in mice.
Academic Article Humanized mice in translational biomedical research.
Academic Article Development of new-generation HU-PBMC-NOD/SCID mice to study human islet alloreactivity.
Academic Article Determinants of memory in experimental filarial infections in mice.
Academic Article A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene.
Academic Article Protein kinase C signaling during T cell activation induces the endoplasmic reticulum stress response.
Academic Article Humanized SCID mouse models for biomedical research.
Academic Article A new immunodeficient hyperglycaemic mouse model based on the Ins2Akita mutation for analyses of human islet and beta stem and progenitor cell function.
Academic Article Expanded CD34+ human umbilical cord blood cells generate multiple lymphohematopoietic lineages in NOD-scid IL2rgamma(null) mice.
Academic Article T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice.
Academic Article Human BLyS facilitates engraftment of human PBL derived B cells in immunodeficient mice.
Academic Article Humanized mice for the study of type 1 diabetes and beta cell function.
Academic Article T cell lines derived from the spinal cords of mice with experimental allergic encephalomyelitis are self reactive.
Academic Article TLR agonists prevent the establishment of allogeneic hematopoietic chimerism in mice treated with costimulation blockade.
Academic Article Failure of alpha-galactosylceramide to prevent diabetes in virus-inducible models of type 1 diabetes in the rat.
Academic Article Development of novel major histocompatibility complex class I and class II-deficient NOD-SCID IL2R gamma chain knockout mice for modeling human xenogeneic graft-versus-host disease.
Academic Article Targeted delivery of small interfering RNA to human dendritic cells to suppress dengue virus infection and associated proinflammatory cytokine production.
Academic Article NOD-scid IL2rgamma(null) mouse model of human skin transplantation and allograft rejection.
Academic Article Human immune system development and rejection of human islet allografts in spontaneously diabetic NOD-Rag1null IL2rgammanull Ins2Akita mice.
Academic Article A novel role for the centrosomal protein, pericentrin, in regulation of insulin secretory vesicle docking in mouse pancreatic beta-cells.
Academic Article Humanized nonobese diabetic-scid IL2rgammanull mice are susceptible to lethal Salmonella Typhi infection.
Academic Article Dynamic glucoregulation and mammalian-like responses to metabolic and developmental disruption in zebrafish.
Academic Article Maturation-dependent licensing of naive T cells for rapid TNF production.
Academic Article Unexpected side products in the conjugation of an amine-derivatized morpholino oligomer with p-isothiocyanate benzyl DTPA and their removal.
Academic Article The role of JNK in the development of hepatocellular carcinoma.
Academic Article Hyperglycemia-induced proliferation of adult human beta cells engrafted into spontaneously diabetic immunodeficient NOD-Rag1null IL2r?null Ins2Akita mice.
Academic Article Targeted disruption of the CCR5 gene in human hematopoietic stem cells stimulated by peptide nucleic acids.
Academic Article Humanized mice as a preclinical tool for infectious disease and biomedical research.
Academic Article Humanized mice for the study of type 1 and type 2 diabetes.
Academic Article Advancing animal models of human type 1 diabetes by engraftment of functional human tissues in immunodeficient mice.
Academic Article Systemic delivery of triplex-forming PNA and donor DNA by nanoparticles mediates site-specific genome editing of human hematopoietic cells in vivo.
Academic Article Islet-specific CTL cloned from a type 1 diabetes patient cause beta-cell destruction after engraftment into HLA-A2 transgenic NOD/scid/IL2RG null mice.
Academic Article Alloreactive CD8 T cells rescued from apoptosis during co-stimulation blockade by Toll-like receptor stimulation remain susceptible to Fas-induced cell death.
Academic Article Generation of islet-like cells from mouse gall bladder by direct ex vivo reprogramming.
Academic Article Humanized mice for the study of infectious diseases.
Academic Article Defective lymphopoiesis in the bone marrow of motheaten (me/me) and viable motheaten (mev/mev) mutant mice. III. Normal mouse bone marrow cells enable mev/mev prothymocytes to generate thymocytes after intravenous transfer.
Academic Article Developmental abnormalities of terminal deoxynucleotidyl transferase positive bone marrow cells and thymocytes in New Zealand mice: effects of prostaglandin E1.
Academic Article Genetic linkage and cell distribution analysis of T cell alloantigens in the rat.
Academic Article Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand.
Academic Article Improved engraftment of human spleen cells in NOD/LtSz-scid/scid mice as compared with C.B-17-scid/scid mice.
Academic Article B lymphocytes are not required for murine resistance to the human filarial parasite, Brugia malayi.
Academic Article A selective culture system for generating terminal deoxynucleotidyl transferase-positive lymphoid precursor cells in vitro. IV. Properties and developmental relationships of the lymphoid cells in the adherent and nonadherent compartments of the culture.
Academic Article Human autoimmune diabetes mellitus: lessons from BB rats and NOD mice--Caveat emptor.
Academic Article Localization of prothymocytes from wild-type and viable motheaten mice following intravenous injection into irradiated adoptive recipients.
Academic Article Multiple low-dose streptozocin-induced diabetes in NOD-scid/scid mice in the absence of functional lymphocytes.
Academic Article Major histocompatibility complex class I-deficient NOD-B2mnull mice are diabetes and insulitis resistant.
Academic Article Mercury-induced renal autoimmunity: changes in RT6+ T-lymphocytes of susceptible and resistant rats.
Academic Article High stimulatory activity of dendritic cells from diabetes-prone BioBreeding/Worcester rats exposed to macrophage-derived factors.
Concept Mice, Inbred CBA
Concept Mice, Inbred BALB C
Concept Mice, Obese
Concept Mice, Knockout
Concept Mice, Inbred C3H
Concept Mice
Concept Mice, Inbred ICR
Concept Mice, Inbred C57BL
Concept Mice, Transgenic
Concept Mice, Inbred NOD
Concept Mice, Nude
Concept Mice, SCID
Concept Mice, Congenic
Concept Mice, Inbred Strains
Concept Mice, Inbred NZB
Concept Mice, Inbred DBA
Concept Mice, Mutant Strains
Academic Article Overcoming current limitations in humanized mouse research.
Academic Article Comparison between two labeled agents in mice using a coinjection-ratio approach in contrast to a conventional group approach.
Academic Article Site-specific Genome Editing in PBMCs With PLGA Nanoparticle-delivered PNAs Confers HIV-1 Resistance in Humanized Mice.
Academic Article CD28 and ITK signals regulate autoreactive T cell trafficking.
Academic Article Engrafted human cells generate adaptive immune responses to Mycobacterium bovis BCG infection in humanized mice.
Academic Article Improved function and proliferation of adult human beta cells engrafted in diabetic immunodeficient NOD-scid IL2r?(null) mice treated with alogliptin.
Academic Article c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells.
Academic Article An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia.
Academic Article Blockade of the programmed death-1 (PD1) pathway undermines potent genetic protection from type 1 diabetes.
Academic Article NOD-scidIl2rg (tm1Wjl) and NOD-Rag1 (null) Il2rg (tm1Wjl) : a model for stromal cell-tumor cell interaction for human colon cancer.
Academic Article Subcapsular transplantation of tissue in the kidney.
Academic Article Human cancer growth and therapy in immunodeficient mouse models.
Academic Article Differentiation between temporary and real non-clearability of biotinylated IgG antibody by avidin in mice.
Academic Article Viral infection of engrafted human islets leads to diabetes.
Academic Article Generation of improved humanized mouse models for human infectious diseases.
Academic Article GABA promotes human ?-cell proliferation and modulates glucose homeostasis.
Academic Article Inhibition of bromodomain proteins for the treatment of human diffuse large B-cell lymphoma.
Academic Article Generation of functional human pancreatic ? cells in vitro.
Academic Article Dengue virus infection induces broadly cross-reactive human IgM antibodies that recognize intact virions in humanized BLT-NSG mice.
Academic Article Generation of ? cell-specific human cytotoxic T cells by lentiviral transduction and their survival in immunodeficient human leucocyte antigen-transgenic mice.
Academic Article Extensive double humanization of both liver and hematopoiesis in FRGN mice.
Academic Article Efficient generation of NKX6-1+ pancreatic progenitors from multiple human pluripotent stem cell lines.
Academic Article Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates.
Academic Article Quantitative Correlation of in Vivo Properties with in Vitro Assay Results: The in Vitro Binding of a Biotin-DNA Analogue Modifier with Streptavidin Predicts the in Vivo Avidin-Induced Clearability of the Analogue-Modified Antibody.
Academic Article Lixisenatide accelerates restoration of normoglycemia and improves human beta-cell function and survival in diabetic immunodeficient NOD-scid IL-2rg(null) RIP-DTR mice engrafted with human islets.
Academic Article The Presence and Preferential Activation of Regulatory T Cells Diminish Adoptive Transfer of Autoimmune Diabetes by Polyclonal Nonobese Diabetic (NOD) T Cell Effectors into NSG versus NOD-scid Mice.
Academic Article Neutrophil Responses to Sterile Implant Materials.
Academic Article Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection.
Academic Article Efficient and Targeted Transduction of Nonhuman Primate Liver With Systemically Delivered Optimized AAV3B Vectors.
Academic Article P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer.
Academic Article Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic ?-cell function via glycogen synthase kinase-3?.
Academic Article Humanized Mouse Models for Transplant Immunology.
Academic Article Genetic ablation of lymphocytes and cytokine signaling in nonobese diabetic mice prevents diet-induced obesity and insulin resistance.
Academic Article Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice.
Academic Article Corrigendum: Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice.
Academic Article Stress-impaired transcription factor expression and insulin secretion in transplanted human islets.
Academic Article Generation of Immunodeficient Mice Bearing Human Immune Systems by the Engraftment of Hematopoietic Stem Cells.
Academic Article Genetically modified human CD4(+) T cells can be evaluated in?vivo without lethal graft-versus-host disease.
Academic Article Frontline Science: Splenic progenitors aid in maintaining high neutrophil numbers at sites of sterile chronic inflammation.
Academic Article Cell-Extrinsic MHC Class I Molecule Engagement Augments Human NK Cell Education Programmed by Cell-Intrinsic MHC Class I.
Academic Article Humanized mouse model of mast cell-mediated passive cutaneous anaphylaxis and passive systemic anaphylaxis.
Academic Article Distinct Differences on Neointima Formation in Immunodeficient and Humanized Mice after Carotid or Femoral Arterial Injury.
Academic Article In vivo correction of anaemia in ?-thalassemic mice by ?PNA-mediated gene editing with nanoparticle delivery.
Academic Article A novel transgenic mouse model of lysosomal storage disorder.
Academic Article Humanized Mouse Models of Clinical Disease.
Academic Article Colony stimulating factor-1 receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human?primates.
Academic Article A novel hemolytic complement-sufficient NSG mouse model supports studies of complement-mediated antitumor activity in vivo.
Academic Article mRNA-mediated glycoengineering ameliorates deficient homing of human stem cell-derived hematopoietic progenitors.
Academic Article Age-dependent human ? cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling.
Academic Article a Cell Function and Gene Expression Are Compromised in Type 1 Diabetes.
Academic Article Lack of acute xenogeneic graft- versus-host disease, but retention of T-cell function following engraftment of human peripheral blood mononuclear cells in NSG mice deficient in MHC class I and II expression.
Academic Article Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunotherapy.
Academic Article Ectonucleoside Triphosphate Diphosphohydrolase-3 Antibody Targets Adult Human Pancreatic ? Cells for In?Vitro and In?Vivo Analysis.
Academic Article Ectopic high endothelial venules in pancreatic ductal adenocarcinoma: A unique site for targeted delivery.
Academic Article Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics.
Academic Article Survival Advantage of Both Human Hepatocyte Xenografts and Genome-Edited Hepatocytes for Treatment of a-1 Antitrypsin Deficiency.
Academic Article Human Anti-HIV-1 gp120 Monoclonal Antibodies with Neutralizing Activity Cloned from Humanized Mice Infected with HIV-1.
Academic Article Humanized mouse models of immunological diseases and precision medicine.
Academic Article AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast Cell-Mediated Anaphylaxis in Mice.
Academic Article Genome-wide Analysis of Salmonella enterica serovar Typhi in Humanized Mice Reveals Key Virulence Features.
Academic Article Recovery of viable endocrine-specific cells and transcriptomes from human pancreatic islet-engrafted mice.
Academic Article Tacrolimus- and sirolimus-induced human ? cell dysfunction is reversible and preventable.
Academic Article A retrievable implant for the long-term encapsulation and survival of therapeutic xenogeneic cells.
Academic Article Dapagliflozin Does Not Directly Affect Human a or ? Cells.
Academic Article Modeling Type 1 Diabetes In?Vitro Using Human Pluripotent Stem Cells.
Academic Article A rapid, sensitive, and reproducible in vivo PBMC humanized murine model for determining therapeutic-related cytokine release syndrome.
Academic Article Direct Tumor Killing and Immunotherapy through Anti-SerpinB9 Therapy.
Academic Article Prostaglandin E2 stimulates cAMP signaling and resensitizes human leukemia cells to glucocorticoid-induced cell death.
Academic Article Modeling human T1D-associated autoimmune processes.
Academic Article Analysis of Salmonella Typhi Pathogenesis in a Humanized Mouse Model.
Academic Article Enhanced development of functional human NK cells in NOD-scid-IL2rgnull mice expressing human IL15.
Academic Article Humanized mouse models for immuno-oncology research.
Academic Article I-Ag7 ?56/57 polymorphisms regulate non-cognate negative selection to CD4+ T cell orchestrators of type 1 diabetes.
Academic Article NOD-scid IL2r?null mice lacking TLR4 support human immune system development and the study of human-specific innate immunity.
Academic Article Simultaneous evaluation of treatment efficacy and toxicity for bispecific T-cell engager therapeutics in a humanized mouse model.
Academic Article Identification of a humanized mouse model for functional testing of immune-mediated biomaterial foreign body response.
Academic Article Nuclear factor kappa B-dependent persistence of Salmonella Typhi and Paratyphi in human macrophages.
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