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Academic Background

Dale Greiner is currently Professor of Molecular Medicine at the University of Massachusetts Medical School. His research focuses on three areas: transplantation, autoimmunity, and the use of humanized mice to study human diseases and infections. Dr. Greiner graduated from the University of Iowa with a Bachelor of Science degree and Medical Technology degree in 1974 and with a Doctor of Philosophy degree in 1978. He did postdoctoral fellowships at the University of Pittsburgh and at the University of Connecticut Health Center in Farmington, CT. He was appointed Assistant Professor at UConn in 1983, Associate Professor in 1989, joined the Department of Medicine at the University of Massachusetts as Professor in 1991 and abecame a Professor od Molecular Medicine in 2010. He became Co-Director with Dr. David Harlan of the Diabetes Center of Excellence in 2010 and the Dr. Eileen L. Berman and Stanley I. Berman Foundation Chair in Biomedical Research Professor in 2013.

To date, Dr. Greiner has co-authored more than 300 publications. He has served as a member of the editorial board of Diabetes, and as a regular member of the National Institutes of Health Immunology Sciences Study Section and the Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section. He has served as chair of the Veterans Administration Immunology Review Subcommittee B and has served as chair of many ad hoc NIH and JDRF study sections. He has also served as Chair of the Medical Science Review Committee for the Juvenile Diabetes Research Foundation, International, Chairman of the American Diabetes Association Scientific Sessions Committee, Program Chair of the American Diabetes Association Council on Immunology, Immunogenetics and Transplantation, and Council Chair, American Diabetes Association Council on Immunology, Immunogenetics and Transplantation.

Dr. Greiner has received numerous awards for his research, including the A.J. Julian Scholarship for Academic Excellence, the Basil O'Connor Scholar Research Award from the March of Dimes, and the Kayla and Gerald Grodsky and David Rumbough Awards from the Juvenile Diabetes Research Foundation, Int.   

Transplantation tolerance and autoimmune diabetes

Our major area of investigation is to understand the etiology and pathogenesis of autoimmune type 1 diabetes mellitus (T1D). Our approach focuses on two main areas, the understanding of the pathogenesis of type 1 diabetes so as to formulate means to prevent or reverse the disease, and the cure of those who are diabetic by induction of transplantation tolerance to islets of Langerhans. Over 25 years ago, we and others accomplished these goals in spontaneously diabetic mouse and rat models of T1D, but these accomplishments have not yet been successfully translated to humans. We believe there are two major obstacles that prevent the achievement of these goals in humans: 1) Lack of understanding of the biology of how human insulin-secreting beta cells die during the development of T1D. 2) Lack of understanding of how a human immune system mediates the destruction of human beta cells in vivo. Our laboratory is focusing on the development of “humanized” mice to study human T1D in collaboration with Dr. Leonard Shultz at The Jackson Laboratory. We have developed unique strains of mice that can be engrafted with functional human cells and tissues, including human islets and human immune systems. We are now using these mice to understand how human beta cells resist killing by a human autoimmune system in vivo, how human beta cells replicate and regenerate in vivo, how human autoreactive cells develop in a human diabetes-susceptible immune system, and how a human immune system targets and kills beta cells in vivo. These approaches are allowing us to understand and dissect mechanisms important in human T1D that cannot be studied directly in humans. Moreover, because these mice readily accept human cells and tissues, we are now using them to study human regenerative medicine, immunity, human-specific infectious agents and cancer. Our studies in humanized mice have the potential to guide human clinical trials by determining the mechanisms by which therapeutic approaches such as those based on the new technology of RNAi can act directly on human immune systems, islets, and cancers in vivo, facilitating the direct translation of these agents into the clinic.


One or more keywords matched the following items that are connected to Greiner, Dale

Item TypeName
Academic Article Ontogeny and immunohistochemical localization of thymus-dependent and thymus-independent RT6+ cells in the rat.
Academic Article Lack of peripherally induced tolerance to established skin allografts in immunologically reconstituted scid mice.
Academic Article Role of natural killer cells on engraftment of human lymphoid cells and on metastasis of human T-lymphoblastoid leukemia cells in C57BL/6J-scid mice and in C57BL/6J-scid bg mice.
Academic Article Improved engraftment of human cord blood stem cells in NOD/LtSz-scid/scid mice after irradiation or multiple-day injections into unirradiated recipients.
Academic Article Enhanced human CD4+ T cell engraftment in beta2-microglobulin-deficient NOD-scid mice.
Academic Article Induction of insulin-dependent diabetes mellitus in PVG.RT1u rats.
Academic Article The T cell marker RT6 in a rat model of autoimmune diabetes.
Academic Article Diethylcarbamazine (DEC) does not induce nitric oxide (NO) synthesis.
Academic Article SCID mouse models of human stem cell engraftment.
Academic Article High frequency apoptosis of recent thymic emigrants in the liver of lymphopenic diabetes-prone BioBreeding rats.
Academic Article Induction of immunological tolerance to islet allografts.
Academic Article HIV-1 infectivity of human T cells in a human/murine chimeric fetal thymic organ culture system.
Academic Article Prolonged skin allograft survival in mice treated with Flt3-ligand-induced dendritic cells and anti-CD154 monoclonal antibody.
Academic Article Recapitulation of normal and abnormal BioBreeding rat T cell development in adult thymus organ culture.
Academic Article Cutting edge: sustained expansion of CD8+ T cells requires CD154 expression by Th cells in acute graft versus host disease.
Academic Article Treatment of allograft recipients with donor-specific transfusion and anti-CD154 antibody leads to deletion of alloreactive CD8+ T cells and prolonged graft survival in a CTLA4-dependent manner.
Academic Article The rat T-cell surface protein RT6 is associated with src family tyrosine kinases and generates an activation signal.
Academic Article Abnormalities in the export and fate of recent thymic emigrants in diabetes-prone BB/W rats.
Academic Article Regulation of human cell engraftment and development of EBV-related lymphoproliferative disorders in Hu-PBL-scid mice.
Academic Article Viral infection abrogates CD8(+) T-cell deletion induced by costimulation blockade.
Academic Article Characterization of mouse Rt6.1 NAD:arginine ADP-ribosyltransferase.
Academic Article Thymic involution in viable motheaten (me(v)) mice is associated with a loss of intrathymic precursor activity.
Academic Article Variables to predict engraftment of umbilical cord blood into immunodeficient mice: usefulness of the non-obese diabetic--severe combined immunodeficient assay.
Academic Article Nicotinamide adenine dinucleotide (NAD) and its metabolites inhibit T lymphocyte proliferation: role of cell surface NAD glycohydrolase and pyrophosphatase activities.
Academic Article Mouse RT6 locus 1 and rat RT6.2 are NAD+. Arginine ADP-ribosyltransferases with auto-ADP-ribosylation activity.
Academic Article Prolonged survival of mouse skin allografts in recipients treated with donor splenocytes and antibody to CD40 ligand.
Academic Article Blockade of CD40-CD154 interferes with human T cell engraftment in scid mice.
Academic Article Long-term survival of skin allografts induced by donor splenocytes and anti-CD154 antibody in thymectomized mice requires CD4(+) T cells, interferon-gamma, and CTLA4.
Academic Article Prolonged survival of rat islet and skin xenografts in mice treated with donor splenocytes and anti-CD154 monoclonal antibody.
Academic Article Blockade of CD40-mediated signaling is sufficient for inducing islet but not skin transplantation tolerance.
Academic Article Direct visualization of cross-reactive effector and memory allo-specific CD8 T cells generated in response to viral infections.
Academic Article Islet cells but not thyrocytes are susceptible to lysis by NK cells.
Academic Article Ian4 is required for mitochondrial integrity and T cell survival.
Academic Article Mechanisms of allograft prolongation in RT6 T cell-depleted rats.
Academic Article Islet cell autoimmunity and transplantation tolerance: two distinct mechanisms?
Academic Article Intravital dye-labeled diabetogenic rat T cells retain dye, home to the pancreas, and induce diabetes.
Academic Article The RT6 (Art2) family of ADP-ribosyltransferases in rat and mouse.
Academic Article A new isolation method for rat intraepithelial lymphocytes.
Academic Article Regulation of skin and islet allograft survival in mice treated with costimulation blockade is mediated by different CD4+ cell subsets and different mechanisms.
Academic Article Early growth response gene-2, a zinc-finger transcription factor, is required for full induction of clonal anergy in CD4+ T cells.
Academic Article Evaluation of donor-specific transfusion sources: unique failure of bone marrow cells to induce prolonged skin allograft survival with anti-CD154 monoclonal antibody.
Academic Article TLR activation synergizes with Kilham rat virus infection to induce diabetes in BBDR rats.
Academic Article The rat diabetes susceptibility locus Iddm4 and at least one additional gene are required for autoimmune diabetes induced by viral infection.
Academic Article Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes.
Academic Article Diabetes prone BB rats are severely deficient in natural killer T cells.
Academic Article Reduction of the RT6.2+ subset of T lymphocytes in brown Norway rats with mercury-induced renal autoimmunity.
Academic Article NOD/LtSz-Rag1null mice: an immunodeficient and radioresistant model for engraftment of human hematolymphoid cells, HIV infection, and adoptive transfer of NOD mouse diabetogenic T cells.
Academic Article Experimental autoallergic sialadenitis in the LEW rat. I. Parameters of disease induction.
Academic Article Effect of ex vivo cytokine treatment on human cord blood engraftment in NOD-scid mice.
Academic Article beta2 microglobulin-deficient (B2m(null)) NOD/SCID mice are excellent recipients for studying human stem cell function.
Academic Article Evidence for elevated prothymocyte activity in the bone marrow of New Zealand Black (NZB) mice. Elevated prothymocyte activity in NZB mice.
Academic Article Rat xenograft survival in mice treated with donor-specific transfusion and anti-CD154 antibody is enhanced by elimination of host CD4+ cells.
Academic Article Costimulatory blockade induces hyporesponsiveness in T cells that recognize alloantigen via indirect antigen presentation.
Academic Article Partial versus full allogeneic hemopoietic chimerization is a preferential means to inhibit type 1 diabetes as the latter induces generalized immunosuppression.
Academic Article TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant rat.
Academic Article Fetal thymi from diabetes-prone but not diabetes-resistant BB/Wor rats fail to generate mature ART2+ T-cells in organ culture.
Academic Article Intrinsic cytotoxicity of natural killer cells to pancreatic islets in vitro.
Academic Article BB rat thymocytes cultured in the presence of islets lose their ability to transfer autoimmune diabetes.
Academic Article Tuberculosis susceptibility of diabetic mice.
Academic Article A novel alloantigen-specific CD8+PD1+ regulatory T cell induced by ICOS-B7h blockade in vivo.
Academic Article Creation of "humanized" mice to study human immunity.
Academic Article Non-obese diabetic-recombination activating gene-1 (NOD-Rag1 null) interleukin (IL)-2 receptor common gamma chain (IL2r gamma null) null mice: a radioresistant model for human lymphohaematopoietic engraftment.
Academic Article Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice.
Academic Article An atypical population of NK cells that spontaneously secrete IFN-gamma and IL-4 is present in the intraepithelial lymphoid compartment of the rat.
Academic Article Depletion of the programmed death-1 receptor completely reverses established clonal anergy in CD4(+) T lymphocytes via an interleukin-2-dependent mechanism.
Academic Article Levels of Art2+ cells but not soluble Art2 protein correlate with expression of autoimmune diabetes in the BB rat.
Academic Article Dengue virus infection and virus-specific HLA-A2 restricted immune responses in humanized NOD-scid IL2rgammanull mice.
Academic Article AATF mediates an antiapoptotic effect of the unfolded protein response through transcriptional regulation of AKT1.
Academic Article Skin allograft maintenance in a new synchimeric model system of tolerance.
Academic Article Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation.
Academic Article Humanized mouse models to study human diseases.
Academic Article Islet cell transplantation tolerance.
Academic Article T cell developmental defects in 'viable motheaten' mice deficient in SHP-1 protein-tyrosine phosphatase. Developmental defects are corrected in vitro in the presence of normal hematopoietic-origin stromal cells and in vivo by exogenous IL-7.
Academic Article Allografts stimulate cross-reactive virus-specific memory CD8 T cells with private specificity.
Academic Article Prevention of "Humanized" diabetogenic CD8 T-cell responses in HLA-transgenic NOD mice by a multipeptide coupled-cell approach.
Academic Article Rapid recruitment and activation of macrophages by anti-Gal/a-Gal liposome interaction accelerates wound healing.
Academic Article Human islet cell MORF/cMORF pretargeting in a xenogeneic murine transplant model.
Academic Article Isolation of mouse pancreatic alpha, beta, duct and acinar populations with cell surface markers.
Academic Article Engraftment of human HSCs in nonirradiated newborn NOD-scid IL2r? null mice is enhanced by transgenic expression of membrane-bound human SCF.
Academic Article Pretargeting vs. direct targeting of human betalox5 islet cells subcutaneously implanted in mice using an anti-human islet cell antibody.
Academic Article Prevention of type 1 diabetes in the rat with an allele-specific anti-T-cell receptor antibody: Vß13 as a therapeutic target and biomarker.
Academic Article Enhanced humoral and HLA-A2-restricted dengue virus-specific T-cell responses in humanized BLT NSG mice.
Academic Article JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate.
Academic Article Thioredoxin-interacting protein mediates ER stress-induced ß cell death through initiation of the inflammasome.
Academic Article Viral abrogation of stem cell transplantation tolerance causes graft rejection and host death by different mechanisms.
Academic Article Humanized mice for immune system investigation: progress, promise and challenges.
Academic Article GLI1 regulates a novel neuropilin-2/a6ß1 integrin based autocrine pathway that contributes to breast cancer initiation.
Academic Article Type 1 cytokines polarize thymocytes during T cell development in adult thymus organ cultures.
Academic Article Infections that induce autoimmune diabetes in BBDR rats modulate CD4+CD25+ T cell populations.
Academic Article Absence of RT6+ T cells in diabetes-prone biobreeding/Worcester rats is due to genetic and cell developmental defects.
Academic Article Absence of the RT-6 T cell subset in diabetes-prone BB/W rats.
Academic Article Characterization of RT6 bearing rat lymphocytes. I. Ontogeny of the RT6+ subset.
Academic Article Prothymocyte development in diabetes-prone BB rats: description of a defect that predisposes to immune abnormalities.
Academic Article Studies of thymocytopoiesis in rats and mice. I. Kinetics of appearance of thymocytes using a direct intrathymic adoptive transfer assay for thymocyte precursors.
Academic Article Defective lymphopoiesis in bone marrow of motheaten (me/me) and viable motheaten (mev/mev) mutant mice. I. Analysis of development of prothymocytes, early B lineage cells, and terminal deoxynucleotidyl transferase-positive cells.
Academic Article Characterization of rat prothymocyte with monoclonal antibodies recognizing rat lymphocyte membrane antigenic determinants.
Academic Article Defective lymphopoiesis in the bone marrow of motheaten (me/me) and viable motheaten (mev/mev) mutant mice. II. Description of a microenvironmental defect for the generation of terminal deoxynucleotidyltransferase-positive bone marrow cells in vitro.
Academic Article Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice.
Academic Article Regulation of human short-term repopulating cell (STRC) engraftment in NOD/SCID mice by host CD122+ cells.
Academic Article Spleen cell transfusion in the Bio-Breeding/Worcester rat. Prevention of diabetes, major histocompatibility complex restriction, and long-term persistence of transfused cells.
Academic Article Characterization of RT6-bearing rat lymphocytes. II. Developmental relationships of RT6- and RT6+ T cells.
Academic Article Experimental autoallergic sialadenitis in the LEW rat. III. Role of CD4+ T cells in EAS induction.
Academic Article NOD/LtSz-Rag1nullPfpnull mice: a new model system with increased levels of human peripheral leukocyte and hematopoietic stem-cell engraftment.
Academic Article Identification of thymocyte progenitors in hemopoietic tissues of the rat. II. Enrichment of functional prothymocytes on the fluorescence-activated cell sorter.
Academic Article Characterization of monoclonal antibodies that define rat T cell alloantigens.
Academic Article Maturation of functional T-lymphocyte subpopulations in the rat.
Academic Article High levels of human peripheral blood mononuclear cell engraftment and enhanced susceptibility to human immunodeficiency virus type 1 infection in NOD/LtSz-scid/scid mice.
Academic Article Emv30null NOD-scid mice. An improved host for adoptive transfer of autoimmune diabetes and growth of human lymphohematopoietic cells.
Academic Article Adoptive transfer of autoimmune diabetes mellitus to athymic rats: synergy of CD4+ and CD8+ T cells and prevention by RT6+ T cells.
Academic Article Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice.
Academic Article Relative susceptibility of SJL/J and B10.S mice to experimental allergic encephalomyelitis (EAE) is determined by the ability of prethymic cells in bone marrow to develop into EAE effector T cells.
Academic Article Rat stem-cell factor induces splenocytes capable of regenerating the thymus.
Academic Article Deficiencies in gut NK cell number and function precede diabetes onset in BB rats.
Academic Article Prolonged survival of neonatal porcine islet xenografts in mice treated with a donor-specific transfusion and anti-CD154 antibody.
Academic Article Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells.
Academic Article The immunodeficient scid mouse as a model for human lymphatic filariasis.
Academic Article Experimental autoallergic sialadenitis in the LEW rat. II. Target antigens are associated with cell surface and intracellular particulate fractions derived from the submandibular gland.
Academic Article TLR agonists abrogate costimulation blockade-induced prolongation of skin allografts.
Academic Article ART2, a T cell surface mono-ADP-ribosyltransferase, generates extracellular poly(ADP-ribose).
Academic Article Rapid quantification of naive alloreactive T cells by TNF-alpha production and correlation with allograft rejection in mice.
Academic Article A regulatory CD4+ T cell subset in the BB rat model of autoimmune diabetes expresses neither CD25 nor Foxp3.
Academic Article Refinement of the Iddm4 diabetes susceptibility locus reveals TCRVbeta4 as a candidate gene.
Academic Article Biochemical studies of RT6 alloantigens in BB/Wor and normal rats. Evidence for intact unexpressed RT6a structural gene in diabetes-prone BB rats.
Academic Article Determinants of memory in experimental filarial infections in mice.
Academic Article Protein kinase C signaling during T cell activation induces the endoplasmic reticulum stress response.
Academic Article A new immunodeficient hyperglycaemic mouse model based on the Ins2Akita mutation for analyses of human islet and beta stem and progenitor cell function.
Academic Article Expanded CD34+ human umbilical cord blood cells generate multiple lymphohematopoietic lineages in NOD-scid IL2rgamma(null) mice.
Academic Article T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice.
Academic Article Human BLyS facilitates engraftment of human PBL derived B cells in immunodeficient mice.
Academic Article Humanized mice for the study of type 1 diabetes and beta cell function.
Academic Article Analysis of the rat Iddm14 diabetes susceptibility locus in multiple rat strains: identification of a susceptibility haplotype in the Tcrb-V locus.
Academic Article T cell lines derived from the spinal cords of mice with experimental allergic encephalomyelitis are self reactive.
Academic Article TLR agonists prevent the establishment of allogeneic hematopoietic chimerism in mice treated with costimulation blockade.
Academic Article CHOP mediates endoplasmic reticulum stress-induced apoptosis in Gimap5-deficient T cells.
Academic Article Targeted delivery of small interfering RNA to human dendritic cells to suppress dengue virus infection and associated proinflammatory cytokine production.
Academic Article A novel role for the centrosomal protein, pericentrin, in regulation of insulin secretory vesicle docking in mouse pancreatic beta-cells.
Academic Article Humanized nonobese diabetic-scid IL2rgammanull mice are susceptible to lethal Salmonella Typhi infection.
Academic Article Dynamic glucoregulation and mammalian-like responses to metabolic and developmental disruption in zebrafish.
Academic Article Prevention of diabetes in BB/Wor rat by single transfusion of spleen cells. Parameters that affect degree of protection.
Academic Article Maturation-dependent licensing of naive T cells for rapid TNF production.
Academic Article The role of JNK in the development of hepatocellular carcinoma.
Academic Article Hyperglycemia-induced proliferation of adult human beta cells engrafted into spontaneously diabetic immunodeficient NOD-Rag1null IL2r?null Ins2Akita mice.
Academic Article Targeted disruption of the CCR5 gene in human hematopoietic stem cells stimulated by peptide nucleic acids.
Academic Article T-cell activation and transplantation tolerance.
Academic Article Humanized mice for the study of type 1 and type 2 diabetes.
Academic Article Advancing animal models of human type 1 diabetes by engraftment of functional human tissues in immunodeficient mice.
Academic Article Systemic delivery of triplex-forming PNA and donor DNA by nanoparticles mediates site-specific genome editing of human hematopoietic cells in vivo.
Academic Article Islet-specific CTL cloned from a type 1 diabetes patient cause beta-cell destruction after engraftment into HLA-A2 transgenic NOD/scid/IL2RG null mice.
Academic Article Alloreactive CD8 T cells rescued from apoptosis during co-stimulation blockade by Toll-like receptor stimulation remain susceptible to Fas-induced cell death.
Academic Article Monoclonal antibodies to RT7 and LCA antigens in the rat: cell distribution and segregation analysis.
Academic Article Generation of islet-like cells from mouse gall bladder by direct ex vivo reprogramming.
Academic Article Monoclonal antibody analysis of Listeria monocytogenes-induced cytotoxic lymphocytes.
Academic Article Regulatory T cell control of autoimmune destruction of beta cells in the BB rat.
Academic Article Rat immunoglobulin genes have comparable patterns of JH rearrangement in normal peripheral B cells and in pre-B and cultured TdT+ cells from bone marrow.
Academic Article Defective lymphopoiesis in the bone marrow of motheaten (me/me) and viable motheaten (mev/mev) mutant mice. III. Normal mouse bone marrow cells enable mev/mev prothymocytes to generate thymocytes after intravenous transfer.
Academic Article Developmental abnormalities of terminal deoxynucleotidyl transferase positive bone marrow cells and thymocytes in New Zealand mice: effects of prostaglandin E1.
Academic Article Phenotypic heterogeneity of Gross virus-induced thymic lymphomas in the rat: cellular origins and migratory properties.
Academic Article Identification of thymocyte progenitors in hemopoietic tissues of the rat. I. A quantitative assay system for thymocyte regeneration.
Academic Article Genetic linkage and cell distribution analysis of T cell alloantigens in the rat.
Academic Article Improved engraftment of human spleen cells in NOD/LtSz-scid/scid mice as compared with C.B-17-scid/scid mice.
Academic Article A selective culture system for generating terminal deoxynucleotidyl transferase-positive lymphoid precursor cells in vitro. IV. Properties and developmental relationships of the lymphoid cells in the adherent and nonadherent compartments of the culture.
Academic Article Localization of prothymocytes from wild-type and viable motheaten mice following intravenous injection into irradiated adoptive recipients.
Academic Article Mercury-induced renal autoimmunity in BN-->LEW.1N chimeric rats.
Academic Article The RT6 rat lymphocyte alloantigen circulates in soluble form.
Academic Article Multiple low-dose streptozocin-induced diabetes in NOD-scid/scid mice in the absence of functional lymphocytes.
Academic Article High stimulatory activity of dendritic cells from diabetes-prone BioBreeding/Worcester rats exposed to macrophage-derived factors.
Concept Epithelial Cells
Concept Receptors, Antigen, T-Cell, alpha-beta
Concept Hybrid Cells
Concept Cell Lineage
Concept Receptors, Antigen, T-Cell
Concept Neoplastic Stem Cells
Concept Hematopoietic Stem Cell Transplantation
Concept Cell Nucleus
Concept Cell Division
Concept Cell Communication
Concept Hematopoietic Cell Growth Factors
Concept Cell Survival
Concept Receptors, Cell Surface
Concept Glucagon-Secreting Cells
Concept Cell Adhesion
Concept Blood Cell Count
Concept Jurkat Cells
Concept Dendritic Cells
Concept Blood Cells
Concept CHO Cells
Concept Leukemia-Lymphoma, Adult T-Cell
Concept Tumor Cells, Cultured
Concept Hematopoietic Stem Cell Mobilization
Concept Cell Differentiation
Concept Cell Line, Transformed
Concept Antibody-Producing Cells
Concept Bone Marrow Cells
Concept Cell Fractionation
Concept Insulin-Secreting Cells
Concept Cell Movement
Concept Cells, Cultured
Concept Stem Cells
Concept Cell Separation
Concept Receptors, Antigen, T-Cell, gamma-delta
Concept Cell Proliferation
Concept Leukemia, T-Cell
Concept Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Concept Hematopoietic Stem Cells
Concept Lymphoma, Large B-Cell, Diffuse
Concept Somatostatin-Secreting Cells
Concept Cord Blood Stem Cell Transplantation
Concept Cell Membrane
Concept Cell Aging
Concept Cell Culture Techniques
Concept Stem Cell Factor
Concept Clone Cells
Concept Peripheral Blood Stem Cell Transplantation
Concept Th1 Cells
Concept Cell Transformation, Neoplastic
Concept Induced Pluripotent Stem Cells
Concept Antigen-Presenting Cells
Concept Stromal Cells
Concept Th2 Cells
Concept Embryonic Stem Cells
Concept Cell Line
Concept Pluripotent Stem Cells
Concept Cell Transplantation
Concept NK Cell Lectin-Like Receptor Subfamily B
Concept Myeloid Cells
Concept Killer Cells, Natural
Concept Cell Line, Tumor
Concept Cell Count
Academic Article Regulated splicing of the a6 integrin cytoplasmic domain determines the fate of breast cancer stem cells.
Academic Article Comparison between two labeled agents in mice using a coinjection-ratio approach in contrast to a conventional group approach.
Academic Article CD28 and ITK signals regulate autoreactive T cell trafficking.
Academic Article Engrafted human cells generate adaptive immune responses to Mycobacterium bovis BCG infection in humanized mice.
Academic Article Improved function and proliferation of adult human beta cells engrafted in diabetic immunodeficient NOD-scid IL2r?(null) mice treated with alogliptin.
Academic Article c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells.
Academic Article An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia.
Academic Article Blockade of the programmed death-1 (PD1) pathway undermines potent genetic protection from type 1 diabetes.
Academic Article NOD-scidIl2rg (tm1Wjl) and NOD-Rag1 (null) Il2rg (tm1Wjl) : a model for stromal cell-tumor cell interaction for human colon cancer.
Academic Article A laminin 511 matrix is regulated by TAZ and functions as the ligand for the a6Bß1 integrin to sustain breast cancer stem cells.
Academic Article GABA promotes human ß-cell proliferation and modulates glucose homeostasis.
Academic Article Inhibition of bromodomain proteins for the treatment of human diffuse large B-cell lymphoma.
Academic Article Generation of functional human pancreatic ß cells in vitro.
Academic Article Generation of ß cell-specific human cytotoxic T cells by lentiviral transduction and their survival in immunodeficient human leucocyte antigen-transgenic mice.
Academic Article Extensive double humanization of both liver and hematopoiesis in FRGN mice.
Academic Article Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets.
Academic Article Efficient generation of NKX6-1+ pancreatic progenitors from multiple human pluripotent stem cell lines.
Academic Article IMP3 promotes stem-like properties in triple-negative breast cancer by regulating SLUG.
Academic Article Quantitative Correlation of in Vivo Properties with in Vitro Assay Results: The in Vitro Binding of a Biotin-DNA Analogue Modifier with Streptavidin Predicts the in Vivo Avidin-Induced Clearability of the Analogue-Modified Antibody.
Academic Article Lixisenatide accelerates restoration of normoglycemia and improves human beta-cell function and survival in diabetic immunodeficient NOD-scid IL-2rg(null) RIP-DTR mice engrafted with human islets.
Academic Article The Presence and Preferential Activation of Regulatory T Cells Diminish Adoptive Transfer of Autoimmune Diabetes by Polyclonal Nonobese Diabetic (NOD) T Cell Effectors into NSG versus NOD-scid Mice.
Academic Article Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection.
Academic Article Efficient and Targeted Transduction of Nonhuman Primate Liver With Systemically Delivered Optimized AAV3B Vectors.
Academic Article P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer.
Academic Article Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic ß-cell function via glycogen synthase kinase-3ß.
Academic Article Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice.
Academic Article Corrigendum: Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice.
Academic Article Generation of Immunodeficient Mice Bearing Human Immune Systems by the Engraftment of Hematopoietic Stem Cells.
Academic Article Genetically modified human CD4(+) T cells can be evaluated in vivo without lethal graft-versus-host disease.
Academic Article Cell-Extrinsic MHC Class I Molecule Engagement Augments Human NK Cell Education Programmed by Cell-Intrinsic MHC Class I.
Academic Article Humanized mouse model of mast cell-mediated passive cutaneous anaphylaxis and passive systemic anaphylaxis.
Academic Article End Sequence Analysis Toolkit (ESAT) expands the extractable information from single-cell RNA-seq data.
Academic Article Impaired osteogenesis of T1DM bone marrow-derived stromal cells and periosteum-derived cells and their differential in-vitro responses to growth factor rescue.
Academic Article mRNA-mediated glycoengineering ameliorates deficient homing of human stem cell-derived hematopoietic progenitors.
Academic Article Age-dependent human ß cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling.
Academic Article a Cell Function and Gene Expression Are Compromised in Type 1 Diabetes.
Academic Article Report of the Key Opinion Leaders Meeting on Stem Cell-Derived Beta Cells.
Academic Article Lack of acute xenogeneic graft- versus-host disease, but retention of T-cell function following engraftment of human peripheral blood mononuclear cells in NSG mice deficient in MHC class I and II expression.
Academic Article Ectonucleoside Triphosphate Diphosphohydrolase-3 Antibody Targets Adult Human Pancreatic ß Cells for In Vitro and In Vivo Analysis.
Academic Article Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics.
Academic Article Alginate encapsulation as long-term immune protection of allogeneic pancreatic islet cells transplanted into the omental bursa of macaques.
Academic Article AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast Cell-Mediated Anaphylaxis in Mice.
Academic Article Genome-wide Analysis of Salmonellaenterica serovar Typhi in Humanized Mice Reveals Key Virulence Features.
Academic Article Recovery of viable endocrine-specific cells and transcriptomes from human pancreatic islet-engrafted mice.
Academic Article Tacrolimus- and sirolimus-induced human ß cell dysfunction is reversible and preventable.
Academic Article Proteomic and Transcriptional Profiles of Human Stem Cell-Derived ß Cells Following Enteroviral Challenge.

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