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Search Results to Gregory J Pazour PhD

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Academic Background

BS: 1986, South Dakota State University

PhD: 1991, University of Minnesota

Post Doctoral Studies: Worcester Foundation for Biomedical Research

Function of the Mammalian Primary Cilium and Mechanisms of Eukaryotic Ciliary Assembly

The Pazour lab is interested in understanding the mechanism for assembly of eukaryotic cilia and the function that these organelles play in vertebrate health and development.  Across the eukaryotic kingdom, cilia function to produce force for cell motility and serve as cellular antennae allowing cells to sense the environment.  In vertebrates, cilia play critical roles in development by establishing the left-right pattern of organ development and in organizing hedgehog and other signaling pathways.  Ciliary dysfunction leads to a spectrum of structural birth defects affecting every organ of the body. In addition, our senses of sight and smell utilize ciliary localized receptors and thus ciliary defects can lead to anosmia and blindness.  Post development, cilia play critical roles in tissue homeostasis and ciliary dysfunction causes a number of serious adult onset diseases including polycystic kidney disease, obesity and cancers such as medulloblastoma and basal cell carcinoma.

In the kidney, the epithelial cells of uriniferous tubule have prominent primary cilia extending from their apical surface into the lumen.  The precise function of the cilia is unknown but they are thought to monitor the tubule diameter. If the cilia are defective, the tubule epithelial cell over proliferate and transform the normally narrow-lumen tubule into a large cyst.  For more information see "Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene Tg737, are required for assembly of cilia and flagella"

 Tg737 Scanning EM

 IFT20 Deletion Histology

In the heart, cilia (green in the image below) play critical roles in left-right patterning and hedgehog signaling.  Ciliary dysfunction causes severe structural cardiac malformations and is thought to be a major cause of structural heart disease in the human population.  For more information see "Global genetic analysis in mice unveils central role for cilia in congenital heart disease"

Chlamydomonas Flagellar Proteome

Rotation Projects

Potential Rotation Projects

Rotation projects in my laboratory will involve questions of how cilia are assembled and the function these organelles play in mammals.

Projects vary depending on ongoing work in the laboratory and interests of the rotation student. Rotations in my laboratory can give students exposure to a range of techniques from mouse breeding and histological analysis of mouse tissues to mammalian cell culture and other cell biological techniques.


One or more keywords matched the following items that are connected to Pazour, Gregory

Item TypeName
Academic Article Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella.
Academic Article The intraflagellar transport protein, IFT88, is essential for vertebrate photoreceptor assembly and maintenance.
Academic Article Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mice with polycystic kidney disease.
Academic Article The vertebrate primary cilium is a sensory organelle.
Academic Article Photoreceptor intersegmental transport and retinal degeneration: a conserved pathway common to motile and sensory cilia.
Academic Article Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization.
Academic Article A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney.
Academic Article Pericentrin forms a complex with intraflagellar transport proteins and polycystin-2 and is required for primary cilia assembly.
Academic Article Identification of predicted human outer dynein arm genes: candidates for primary ciliary dyskinesia genes.
Academic Article Characterization of mouse IFT complex B.
Academic Article The cytoplasmic tail of fibrocystin contains a ciliary targeting sequence.
Academic Article Primary cilia regulate proliferation of amplifying progenitors in adult hippocampus: implications for learning and memory.
Academic Article Intraflagellar transport and cilia-dependent diseases.
Academic Article Combined NGS approaches identify mutations in the intraflagellar transport gene IFT140 in skeletal ciliopathies with early progressive kidney Disease.
Academic Article IFT20 links kinesin II with a mammalian intraflagellar transport complex that is conserved in motile flagella and sensory cilia.
Academic Article Comparative genomics: prediction of the ciliary and basal body proteome.
Academic Article Intraflagellar transport and cilia-dependent renal disease: the ciliary hypothesis of polycystic kidney disease.
Academic Article Localization of transient receptor potential ion channels in primary and motile cilia of the female murine reproductive organs.
Academic Article Proteomic analysis of a eukaryotic cilium.
Academic Article PDGFRalphaalpha signaling is regulated through the primary cilium in fibroblasts.
Academic Article The intraflagellar transport protein IFT20 is associated with the Golgi complex and is required for cilia assembly.
Academic Article Nephrocystin specifically localizes to the transition zone of renal and respiratory cilia and photoreceptor connecting cilia.
Academic Article The Golgin GMAP210/TRIP11 anchors IFT20 to the Golgi complex.
Academic Article Targeting proteins to the ciliary membrane.
Academic Article The primary cilium coordinates early cardiogenesis and hedgehog signaling in cardiomyocyte differentiation.
Academic Article Primary cilia regulate branching morphogenesis during mammary gland development.
Academic Article Scanning electron microscopy to examine cells and organs.
Academic Article Disruption of Mks1 localization to the mother centriole causes cilia defects and developmental malformations in Meckel-Gruber syndrome.
Academic Article IFT20 is required for opsin trafficking and photoreceptor outer segment development.
Academic Article A unified taxonomy for ciliary dyneins.
Academic Article Disruption of IFT complex A causes cystic kidneys without mitotic spindle misorientation.
Academic Article IFT25 links the signal-dependent movement of Hedgehog components to intraflagellar transport.
Academic Article Analysis of ciliary membrane protein dynamics using SNAP technology.
Academic Article Loss of cilia suppresses cyst growth in genetic models of autosomal dominant polycystic kidney disease.
Concept Cilia
Academic Article Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton.
Academic Article Arf4 is required for Mammalian development but dispensable for ciliary assembly.
Academic Article Distinct functions for IFT140 and IFT20 in opsin transport.
Academic Article Casein kinase 1d functions at the centrosome and Golgi to promote ciliogenesis.
Academic Article Role of cilia in structural birth defects: insights from ciliopathy mutant mouse models.
Academic Article NPHP4 controls ciliary trafficking of membrane proteins and large soluble proteins at the transition zone.
Academic Article IFT27 links the BBSome to IFT for maintenance of the ciliary signaling compartment.
Academic Article Ciliary proteins Bbs8 and Ift20 promote planar cell polarity in the cochlea.
Academic Article Global genetic analysis in mice unveils central role for cilia in congenital heart disease.
Academic Article Intraflagellar transport 27 is essential for hedgehog signaling but dispensable for ciliogenesis during hair follicle morphogenesis.
Academic Article Novel Jbts17 mutant mouse model of Joubert syndrome with cilia transition zone defects and cerebellar and other ciliopathy related anomalies.
Academic Article Intraflagellar transport is essential for mammalian spermiogenesis but is absent in mature sperm.
Academic Article DNAH6 and Its Interactions with PCD Genes in Heterotaxy and Primary Ciliary Dyskinesia.
Academic Article A novel ICK mutation causes ciliary disruption and lethal endocrine-cerebro-osteodysplasia syndrome.
Academic Article BLOC-1 is required for selective membrane protein trafficking from endosomes to primary cilia.
Academic Article INTU is essential for oncogenic Hh signaling through regulating primary cilia formation in basal cell carcinoma.
Academic Article Neurodevelopmental disease mechanisms, primary cilia, and endosomes converge on the BLOC-1 and BORC complexes.
Academic Article Super-resolution microscopy reveals that disruption of ciliary transition-zone architecture causes Joubert syndrome.
Academic Article A global analysis of IFT-A function reveals specialization for transport of membrane-associated proteins into cilia.
Academic Article Cilia in cystic kidney and other diseases.

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