Search Result Details

Back to Search Results

This page shows the details of why an item matched the keywords from your search.

Search Results

Pazour, Gregory

One or more keywords matched the following properties of Pazour, Gregory

Property	Value
overview	Academic Background BS: 1986, South Dakota State University PhD: 1991, University of Minnesota Post Doctoral Studies: Worcester Foundation for Biomedical Research Function of the Mammalian Primary Cilium and Mechanisms of Eukaryotic Ciliary Assembly The Pazour lab is interested in understanding the mechanism for assembly of eukaryotic cilia and the function that these organelles play in vertebrate health and development. Across the eukaryotic kingdom, cilia function to produce force for cell motility and serve as cellular antennae allowing cells to sense the environment. In vertebrates, cilia play critical roles in development by establishing the left-right pattern of organ development and in organizing hedgehog and other signaling pathways. Ciliary dysfunction leads to a spectrum of structural birth defects affecting every organ of the body. In addition, our senses of sight and smell utilize ciliary localized receptors and thus ciliary defects can lead to anosmia and blindness. Post development, cilia play critical roles in tissue homeostasis and ciliary dysfunction causes a number of serious adult onset diseases including polycystic kidney disease, obesity and cancers such as medulloblastoma and basal cell carcinoma. In the kidney, the epithelial cells of uriniferous tubule have prominent primary cilia extending from their apical surface into the lumen. The precise function of the cilia is unknown but they are thought to monitor the tubule diameter. If the cilia are defective, the tubule epithelial cell over proliferate and transform the normally narrow-lumen tubule into a large cyst. For more information see "Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene Tg737, are required for assembly of cilia and flagella" In the heart, cilia (green in the image below) play critical roles in left-right patterning and hedgehog signaling. Ciliary dysfunction causes severe structural cardiac malformations and is thought to be a major cause of structural heart disease in the human population. For more information see "Global genetic analysis in mice unveils central role for cilia in congenital heart disease"

Property

Value

overview

Academic Background

BS: 1986, South Dakota State University

PhD: 1991, University of Minnesota

Post Doctoral Studies: Worcester Foundation for Biomedical Research

Function of the Mammalian Primary Cilium and Mechanisms of Eukaryotic Ciliary Assembly

The Pazour lab is interested in understanding the mechanism for assembly of eukaryotic cilia and the function that these organelles play in vertebrate health and development. Across the eukaryotic kingdom, cilia function to produce force for cell motility and serve as cellular antennae allowing cells to sense the environment. In vertebrates, cilia play critical roles in development by establishing the left-right pattern of organ development and in organizing hedgehog and other signaling pathways. Ciliary dysfunction leads to a spectrum of structural birth defects affecting every organ of the body. In addition, our senses of sight and smell utilize ciliary localized receptors and thus ciliary defects can lead to anosmia and blindness. Post development, cilia play critical roles in tissue homeostasis and ciliary dysfunction causes a number of serious adult onset diseases including polycystic kidney disease, obesity and cancers such as medulloblastoma and basal cell carcinoma.

In the kidney, the epithelial cells of uriniferous tubule have prominent primary cilia extending from their apical surface into the lumen. The precise function of the cilia is unknown but they are thought to monitor the tubule diameter. If the cilia are defective, the tubule epithelial cell over proliferate and transform the normally narrow-lumen tubule into a large cyst. For more information see "Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene Tg737, are required for assembly of cilia and flagella"

In the heart, cilia (green in the image below) play critical roles in left-right patterning and hedgehog signaling. Ciliary dysfunction causes severe structural cardiac malformations and is thought to be a major cause of structural heart disease in the human population. For more information see "Global genetic analysis in mice unveils central role for cilia in congenital heart disease"

One or more keywords matched the following items that are connected to Pazour, Gregory

Item Type	Name
Academic Article	The vertebrate primary cilium is a sensory organelle.
Academic Article	Autosomal recessive polycystic kidney disease and congenital hepatic fibrosis: summary statement of a first National Institutes of Health/Office of Rare Diseases conference.
Academic Article	The cytoplasmic tail of fibrocystin contains a ciliary targeting sequence.
Academic Article	IFT20 links kinesin II with a mammalian intraflagellar transport complex that is conserved in motile flagella and sensory cilia.
Academic Article	Localization of transient receptor potential ion channels in primary and motile cilia of the female murine reproductive organs.
Academic Article	PDGFRalphaalpha signaling is regulated through the primary cilium in fibroblasts.
Academic Article	The primary cilium coordinates early cardiogenesis and hedgehog signaling in cardiomyocyte differentiation.
Academic Article	Intraflagellar transport is required for polarized recycling of the TCR/CD3 complex to the immune synapse.
Academic Article	IFT25 links the signal-dependent movement of Hedgehog components to intraflagellar transport.
Academic Article	Analysis of ciliary membrane protein dynamics using SNAP technology.
Concept	Receptors, Antigen, T-Cell
Concept	Receptor, Platelet-Derived Growth Factor alpha
Concept	Receptors, Cell Surface
Concept	Platelet-Derived Growth Factor
Concept	Receptors, G-Protein-Coupled
Concept	alpha-Galactosidase
Concept	Receptor Tyrosine Kinase-like Orphan Receptors
Concept	Receptors, Immunologic
Academic Article	Specific recycling receptors are targeted to the immune synapse by the intraflagellar transport system.
Academic Article	Arf4 is required for Mammalian development but dispensable for ciliary assembly.
Academic Article	IFT27 links the BBSome to IFT for maintenance of the ciliary signaling compartment.
Academic Article	Intraflagellar transport 27 is essential for hedgehog signaling but dispensable for ciliogenesis during hair follicle morphogenesis.
Academic Article	The small GTPase Rab8 interacts with VAMP-3 to regulate the delivery of recycling T-cell receptors to the immune synapse.
Academic Article	IFT20 controls LAT recruitment to the immune synapse and T-cell activation in vivo.
Academic Article	Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness.
Academic Article	BLOC-1 is required for selective membrane protein trafficking from endosomes to primary cilia.
Academic Article	Super-resolution microscopy reveals that disruption of ciliary transition-zone architecture causes Joubert?syndrome.
Academic Article	Intraflagellar transport is deeply integrated in hedgehog signaling.
Academic Article	Cilia in cystic kidney and other diseases.
Academic Article	Ubiquitin links smoothened to intraflagellar transport to regulate Hedgehog signaling.
Academic Article	E3 ubiquitin ligase Wwp1 regulates ciliary dynamics of the Hedgehog receptor Smoothened.
Concept	Patched Receptors
Concept	Patched-1 Receptor
Concept	Smoothened Receptor
Academic Article	Biallelic pathogenic variants in roundabout guidance receptor 1 associate with syndromic congenital anomalies of the kidney and urinary tract.
Academic Article	Arih2 regulates Hedgehog signaling through smoothened ubiquitylation and ER-associated degradation.

Search Criteria

Receptor
Platelet Derived Growth Factor
alpha