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Intraflagellar transport is required for polarized recycling of the TCR/CD3 complex to the immune synapse.
Specific recycling receptors are targeted to the immune synapse by the intraflagellar transport system.
The small GTPase Rab8 interacts with VAMP-3 to regulate the delivery of recycling T-cell receptors to the immune synapse.
IFT20 controls LAT recruitment to the immune synapse and T-cell activation in vivo.
Tethering of vesicles to the Golgi by GMAP210 controls LAT delivery to the immune synapse.