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Ruiz De Luzuriaga, Katherine

One or more keywords matched the following properties of Ruiz De Luzuriaga, Katherine

Property	Value
overview	Academic Background S.B., S.M. - Massachusetts Institute of Technology M.D. (1984) Tufts University Professor, Department of Pediatrics and Program in Molecular Medicine Virus-Host Dynamics in Persistent Viral Infections Research in my laboratory is focused on the viral and immunopathogenesis of persistent viral infections in humans, including human immunodeficiency virus (HIV), Epstein Barr virus (EBV), and cytomegalovirus (CMV). Ongoing studies are focused on: 1) examining the relationship between viral replication/viral gene expression and the development of the antiviral CD4+ and CD8+ T cell repertoires from acute through chronic infection; 2) characterization of the ontogeny of cell-mediated immune responses to viral infections in infants and children; and 3) the development of prophylactic and therapeutic vaccine strategies for HIV.

Property

Value

overview

Academic Background

S.B., S.M. - Massachusetts Institute of Technology

M.D. (1984) Tufts University

Professor,
Department of Pediatrics and Program in Molecular Medicine

Virus-Host Dynamics in Persistent Viral Infections

Research in my laboratory is focused on the viral and immunopathogenesis of persistent viral infections in humans, including human immunodeficiency virus (HIV), Epstein Barr virus (EBV), and cytomegalovirus (CMV). Ongoing studies are focused on: 1) examining the relationship between viral replication/viral gene expression and the development of the antiviral CD4+ and CD8+ T cell repertoires from acute through chronic infection; 2) characterization of the ontogeny of cell-mediated immune responses to viral infections in infants and children; and 3) the development of prophylactic and therapeutic vaccine strategies for HIV.

One or more keywords matched the following items that are connected to Ruiz De Luzuriaga, Katherine

Item Type	Name
Academic Article	A trial of three antiretroviral regimens in HIV-1-infected children.
Academic Article	HIV-1-specific CD8+ T cell responses and viral evolution in women and infants.
Academic Article	Peripheral B cells latently infected with Epstein-Barr virus display molecular hallmarks of classical antigen-selected memory B cells.
Academic Article	Early therapy of vertical human immunodeficiency virus type 1 (HIV-1) infection: control of viral replication and absence of persistent HIV-1-specific immune responses.
Academic Article	Influence of EBV on the peripheral blood memory B cell compartment.
Academic Article	On the dynamics of acute EBV infection and the pathogenesis of infectious mononucleosis.
Academic Article	Programmed Death-1 expression on Epstein Barr virus specific CD8+ T cells varies by stage of infection, epitope specificity, and T-cell receptor usage.
Academic Article	Persistence of Epstein-Barr virus in self-reactive memory B cells.
Academic Article	Pilot study on the immunogenicity of paired Env immunogens from mother-to-child transmitted HIV-1 isolates.
Academic Article	Demonstration of the Burkitt's lymphoma Epstein-Barr virus phenotype in dividing latently infected memory cells in vivo.
Academic Article	Acute infection with Epstein-Barr virus targets and overwhelms the peripheral memory B-cell compartment with resting, latently infected cells.
Academic Article	Cross-reactive influenza virus-specific CD8+ T cells contribute to lymphoproliferation in Epstein-Barr virus-associated infectious mononucleosis.
Academic Article	A virtual look at Epstein-Barr virus infection: biological interpretations.
Academic Article	Identification and characterization of HIV-1 CD8+ T cell escape variants with impaired fitness.
Academic Article	Identification of ongoing human immunodeficiency virus type 1 (HIV-1) replication in residual viremia during recombinant HIV-1 poxvirus immunizations in patients with clinically undetectable viral loads on durable suppressive highly active antiretroviral therapy.
Academic Article	Impaired generation of hepatitis B virus-specific memory B cells in HIV infected individuals following vaccination.
Academic Article	Infectious mononucleosis.
Academic Article	Broad cross-reactive TCR repertoires recognizing dissimilar Epstein-Barr and influenza A virus epitopes.
Academic Article	Genotypic and functional properties of early infant HIV-1 envelopes.
Concept	pol Gene Products, Human Immunodeficiency Virus
Concept	Epstein-Barr Virus Nuclear Antigens
Concept	Virus Integration
Concept	Virus Replication
Concept	Herpesvirus 4, Human
Concept	Receptors, Virus
Concept	gag Gene Products, Human Immunodeficiency Virus
Concept	nef Gene Products, Human Immunodeficiency Virus
Concept	Virus Latency
Concept	Virus Physiological Phenomena
Concept	Virus Activation
Concept	env Gene Products, Human Immunodeficiency Virus
Concept	Influenza A virus
Concept	Epstein-Barr Virus Infections
Academic Article	Epstein-Barr virus latent membrane protein 1 genetic variability in peripheral blood B cells and oropharyngeal fluids.
Academic Article	Dynamics of the resting CD4(+) T-cell latent HIV reservoir in infants initiating HAART less than 6 months of age.
Academic Article	Viremic relapse after HIV-1 remission in a perinatally infected child.
Academic Article	A Gene Expression Signature That Correlates with CD8+ T Cell Expansion in Acute EBV Infection.
Academic Article	Early Combination Antiretroviral Therapy Limits HIV-1 Persistence in Children.
Academic Article	Early Combination Antiretroviral Therapy Limits Exposure to HIV-1 Replication and Cell-Associated HIV-1 DNA Levels in Infants.
Academic Article	High Epstein-Barr Virus Load and Genomic Diversity Are Associated with Generation of gp350-Specific Neutralizing Antibodies following Acute Infectious Mononucleosis.
Academic Article	Unique influenza A?cross-reactive memory CD8 T-cell receptor repertoire has a potential to protect against EBV seroconversion.
Academic Article	Early Epstein-Barr Virus Genomic Diversity and Convergence toward the B95.8 Genome in Primary Infection.
Academic Article	Identification of Emerging Macrophage-Tropic HIV-1 R5 Variants in Brain Tissue of AIDS Patients without Severe Neurological Complications.
Academic Article	Paucity of Intact Non-Induced Provirus with Early, Long-Term Antiretroviral Therapy of Perinatal HIV Infection.
Academic Article	HIV-1 R5 Macrophage-Tropic Envelope Glycoprotein Trimers Bind CD4 with High Affinity, while the CD4 Binding Site on Non-macrophage-tropic, T-Tropic R5 Envelopes Is Occluded.
Academic Article	Ultradeep single-molecule real-time sequencing of HIV envelope reveals complete compartmentalization of highly macrophage-tropic R5 proviral variants in brain and CXCR4-using variants in immune and peripheral tissues.
Academic Article	Genetic complexity in the replication-competent latent HIV reservoir increases with untreated infection duration in infected youth.
Academic Article	Severity of Acute Infectious Mononucleosis Correlates with Cross-Reactive Influenza CD8 T-Cell Receptor Repertoires.
Academic Article	Influence of age at virologic control on peripheral blood human immunodeficiency virus reservoir size and serostatus in perinatally infected adolescents.
Academic Article	No detection of CD4-independent human immunodeficiency virus 1 envelope glycoproteins in brain tissue of patients with or without neurological complications.
Academic Article	Quantitative Human Immunodeficiency Virus (HIV)-1 Antibodies Correlate With Plasma HIV-1 RNA and Cell-associated DNA Levels in Children on Antiretroviral Therapy.
Academic Article	CDR3a?drives selection of the immunodominant Epstein Barr virus (EBV) BRLF1-specific CD8 T cell receptor repertoire in primary infection.
Academic Article	Epstein-Barr Virus Epitope-Major Histocompatibility Complex Interaction Combined with Convergent Recombination Drives Selection of Diverse T Cell Receptor a and ? Repertoires.
Academic Article	The EPIICAL project: an emerging global collaboration to investigate immunotherapeutic strategies in HIV-infected children.

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