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Ruiz De Luzuriaga, Katherine
One or more keywords matched the following properties of Ruiz De Luzuriaga, Katherine
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Academic Background

S.B., S.M. - Massachusetts Institute of Technology

M.D. (1984) Tufts University

Professor,
Department of Pediatrics and Program in Molecular Medicine

Virus-Host Dynamics in Persistent Viral Infections

Dr. Luzuriaga

Research in my laboratory is focused on the viral and immunopathogenesis of persistent viral infections in humans, including human immunodeficiency virus (HIV), Epstein Barr virus (EBV), and cytomegalovirus (CMV). Ongoing studies are focused on: 1) examining the relationship between viral replication/viral gene expression and the development of the antiviral CD4+ and CD8+ T cell repertoires from acute through chronic infection; 2) characterization of the ontogeny of cell-mediated immune responses to viral infections in infants and children; and 3) the development of prophylactic and therapeutic vaccine strategies for HIV.
One or more keywords matched the following items that are connected to Ruiz De Luzuriaga, Katherine
Item TypeName
Academic Article HIV-1-specific CD8+ T cell responses and viral evolution in women and infants.
Academic Article Early therapy of vertical human immunodeficiency virus type 1 (HIV-1) infection: control of viral replication and absence of persistent HIV-1-specific immune responses.
Academic Article Pilot study on the immunogenicity of paired Env immunogens from mother-to-child transmitted HIV-1 isolates.
Academic Article Identification and characterization of HIV-1 CD8+ T cell escape variants with impaired fitness.
Academic Article Identification of ongoing human immunodeficiency virus type 1 (HIV-1) replication in residual viremia during recombinant HIV-1 poxvirus immunizations in patients with clinically undetectable viral loads on durable suppressive highly active antiretroviral therapy.
Academic Article Genotypic and functional properties of early infant HIV-1 envelopes.
Concept pol Gene Products, Human Immunodeficiency Virus
Concept Acquired Immunodeficiency Syndrome
Concept gag Gene Products, Human Immunodeficiency Virus
Concept nef Gene Products, Human Immunodeficiency Virus
Concept env Gene Products, Human Immunodeficiency Virus
Academic Article Identification of Emerging Macrophage-Tropic HIV-1 R5 Variants in Brain Tissue of AIDS Patients without Severe Neurological Complications.
Academic Article HIV-1 R5 Macrophage-Tropic Envelope Glycoprotein Trimers Bind CD4 with High Affinity, while the CD4 Binding Site on Non-macrophage-tropic, T-Tropic R5 Envelopes Is Occluded.
Academic Article Ultradeep single-molecule real-time sequencing of HIV envelope reveals complete compartmentalization of highly macrophage-tropic R5 proviral variants in brain and CXCR4-using variants in immune and peripheral tissues.
Academic Article Genetic complexity in the replication-competent latent HIV reservoir increases with untreated infection duration in infected youth.
Academic Article Influence of age at virologic control on peripheral blood human immunodeficiency virus reservoir size and serostatus in perinatally infected adolescents.
Academic Article No detection of CD4-independent human immunodeficiency virus 1 envelope glycoproteins in brain tissue of patients with or without neurological complications.
Academic Article Quantitative Human Immunodeficiency Virus (HIV)-1 Antibodies Correlate With Plasma HIV-1 RNA and Cell-associated DNA Levels in Children on Antiretroviral Therapy.
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