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One or more keywords matched the following properties of Tissenbaum, Heidi
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Academic Background

Heidi Tissenbaum received her B.S. in Biology from Concordia University in Montreal, Quebec, Canada and an M.S. degree in Physiology from the University of Ottawa, in Ontario, Canada. In 1997, she graduated with a Ph.D. in Genetics from Harvard Medical School. From 1997 to 2001, she was a post-doc at MIT where she was supported by the Helen Hay Whitney Foundation. In 2001, Dr. Tissenbaum joined the Program in Gene Function and Expression at the University of Massachusetts Medical School, and also received a Career Award in the Biomedical Sciences from the Burroughs Wellcome Fund. Dr. Tissenbaum has received funding from the American Federation of Aging Research, the Worcester Foundation for Biomedical Research, the Concern Foundation, and the National Institute of Aging. Dr. Tissenbaum is also a William Randolph Hearst Young Investigator.

 

Defining healthy aging

Photo: Heidi 
Tissenbaum

We age. Some of us age better than others. Some of us show prolonged health. Our research focuses on understanding the fundamental processes that define how we age. We use a combination of molecular biology, genetics, biochemistry, and genomics to define: what contributes to lifespan? What defines healthy aging (healthspan)? What dictates metabolic health? How does the environment contribute? What about nutrition/diet? Overall, we want to determine the critical pathways/genes that define health. 

Specific Interests

  1. In C. elegans, the insulin/IGF-1 signaling pathway plays a central role in regulating lifespan, fat storage, stress and development. What are all the genes involved? How is each specific phenotype modulated? Are they modulated together?
  2. How do multiple conserved signaling pathways couple to the insulin/IGF-1 pathway to regulate lifespan? Fat storage? Stress? Development?
  3. How does the forkhead transcription factor DAF-16 function as a central mediator in C. elegans?

 

Photo: Heidi 
Tissenbaum

One or more keywords matched the following items that are connected to Tissenbaum, Heidi
Item TypeName
Academic Article An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans.
Academic Article A common muscarinic pathway for diapause recovery in the distantly related nematode species Caenorhabditis elegans and Ancylostoma caninum.
Academic Article daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans.
Academic Article The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans.
Academic Article C. elegans tubby regulates life span and fat storage by two independent mechanisms.
Academic Article A PP2A regulatory subunit regulates C. elegans insulin/IGF-1 signaling by modulating AKT-1 phosphorylation.
Academic Article Converging pathways in lifespan regulation.
Academic Article InAKTivation of insulin/IGF-1 signaling by dephosphorylation.
Academic Article Complex expression dynamics and robustness in C. elegans insulin networks.
Academic Article Worming pathways to and from DAF-16/FOXO.
Academic Article Serotonin's SOS signal.
Academic Article Reproduction and longevity: secrets revealed by C. elegans.
Academic Article A new DAF-16 isoform regulates longevity.
Academic Article PDP-1 links the TGF-? and IIS pathways to regulate longevity, development, and metabolism.
Academic Article Noncanonical control of C. elegans germline apoptosis by the insulin/IGF-1 and Ras/MAPK signaling pathways.
Concept Insulin
Concept Insulin-Like Growth Factor I
Concept Receptor, Insulin
Academic Article Global Cysteine-Reactivity Profiling during Impaired Insulin/IGF-1 Signaling in C. elegans Identifies Uncharacterized Mediators of Longevity.
Search Criteria
  • Insulin